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[194191_x_at] Na(+)/K(+) ATPase alpha subunit

Description CEK045B5R_rc /REP_DB=TREMBL Accession /GB=D34380 /CHR=5 /FEA=Genomic Cluster /DEF=C.elegans cDNA clone yk45b5 : 3prime end, single read.
Cluster 6grp_highest_10_10 > 41      6grp_high1_10_10 > 03      4grp_highest_8_8 > 48      4grp_high_8_8 > 34      6grp_highest_nonorm > 15      6grp_total > 25      4grp_total > 45      6grp_highest_sub > De      6grp_cgc > 33      6grp_high1_sub > De      6grp_cgc_sub > De      6grp_total_sub > Decrease      6grp_rule_based > S1      4grp_rule_based > L1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 2498
1 2 3 4 range
A 7961.7
(3)
P 		6525.7
(-0.6)
P 		5556.6
(-3)
P 		5709.5
(-2.6)
P 		2405
B 7180
(3)
P 		6944.4
(2.2)
P 		6500.5
(0.6)
P 		5463.4
(-3)
P 		1717
C 7580
(3)
P 		6747.6
(0.5)
P 		5564.5
(-3)
P 		5590.4
(-2.9)
P 		2016
avr 7573.9
(3) 		6739.2
(0.5) 		5873.9
(-2.1) 		5587.8
(-3) 		1986

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 4301
1 2 3 4 5 6 range
A 6959.6
(3)
P 		6192
(1.8)
P 		5857.6
(1.3)
P 		3105.8
(-3)
P 		4053.2
(-1.5)
P 		3381.9
(-2.6)
P 		3854
B 6707.8
(2.5)
P 		6967.3
(3)
P 		5252.5
(-0.6)
P 		4803.6
(-1.5)
P 		4072.3
(-3)
P 		4923.2
(-1.2)
P 		2895
C 7406.4
(3)
P 		6917.3
(2.2)
P 		4648.8
(-1.5)
P 		4135.4
(-2.3)
P 		4342.8
(-2)
P 		3716.1
(-3)
P 		3690
avr 7024.6
(3) 		6692.2
(2.3) 		5253
(-0.5) 		4014.9
(-3) 		4156.1
(-2.7) 		4007.1
(-3) 		3018
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 2063
1 2 3 4 range
A 2898.9
(3)
P 		1416.5
(-1.3)
P 		1452.6
(-1.2)
P 		835.8
(-3)
P 		2063
B 2289.7
(3)
P 		1715.1
(-0.1)
P 		1506.3
(-1.2)
P 		1164.2
(-3)
P 		1126
C 2509.2
(3)
P 		1940
(0.8)
P 		1939.4
(0.8)
P 		942.6
(-3)
P 		1567
avr 2565.9
(3) 		1690.5
(-0.3) 		1632.8
(-0.5) 		980.9
(-3) 		1585

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1958
1 2 3 4 5 6 range
A 1282.9
(-0.9)
P 		2202.2
(3)
P 		1275.7
(-0.9)
P 		787.7
(-3)
P 		1223.1
(-1.2)
P 		823.4
(-2.8)
P 		1415
B 2334
(3)
P 		2319.1
(2.9)
P 		1275.5
(-3)
P 		1272.3
(-3)
P 		1654.5
(-0.8)
P 		1835.8
(0.2)
P 		1062
C 2745.2
(3)
P 		2110.7
(1)
P 		1183.2
(-1.9)
P 		831.6
(-3)
P 		1405.3
(-1.2)
P 		1244
(-1.7)
P 		1914
avr 2120.7
(2.6) 		2210.7
(3) 		1244.8
(-1.6) 		963.9
(-3) 		1427.6
(-0.8) 		1301.1
(-1.4) 		1247
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 194191_x_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.21869
Sequence Type Exemplar sequence
Representative Public ID CEK045B5R NCBI
Target Description CEK045B5R_rc /REP_DB=TREMBL Accession /GB=D34380 /CHR=5 /FEA=Genomic Cluster /DEF=C.elegans cDNA clone yk45b5 : 3prime end, single read.
Cluster Evidence This cluster is supported by a Genomic Cluster.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_073868(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_073868 NCBI Caenorhabditis elegans EATing: abnormal pharyngeal pumping family member (eat-6) (eat-6) mRNA, complete cds. 11/11 A B 
B0365.3.1 ENSEMBL cdna:known chromosome:CEL140:V:13128997:13132585:-1 gene:B0365.3 10/11 A 
B0365.3.2 ENSEMBL cdna:known chromosome:CEL140:V:13128997:13132587:-1 gene:B0365.3 11/11 A 
B0365.3.3 ENSEMBL cdna:known chromosome:CEL140:V:13129056:13132585:-1 gene:B0365.3 9/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
SNAP00000032430 4/11 Cross Hyb Matching Probes None
GENEFINDER00000032438 4/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:13129006-13129427(-) 100.0 100.0
Public Domain and Genome References
Gene Title Na(+)/K(+) ATPase alpha subunit
Gene Symbol eat-6
Ensembl B0365.3
Entrez Gene 179796 Entrez gene
SwissProt P90735 EMBL-EBI
WormBase CE07721 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.8375.1.S1_AT similar to Na+/K+ -ATPase alpha 3 subunit cfa
DROSOPHILA_2:1625719_AT Na pump subunit dm
DROSOPHILA_2:1639145_S_AT Na pump subunit dm
DROSGENOME1:142520_AT Na pump subunit dm
HUGENEFL:M37457_AT ATPase, Na+/K+ transporting, alpha 3 polypeptide hs
HUGENEFL:M37457_S_AT ATPase, Na+/K+ transporting, alpha 3 polypeptide hs
U133_X3P:HS.274371.0.S1_3P_X_AT ATPase, Na+/K+ transporting, alpha 3 polypeptide hs
U133_X3P:HS.274371.0.S1_3P_AT ATPase, Na+/K+ transporting, alpha 3 polypeptide hs
U133_X3P:214432_3P_AT ATPase, Na+/K+ transporting, alpha 3 polypeptide hs
HG-U133A_2:214432_AT ATPase, Na+/K+ transporting, alpha 3 polypeptide hs
HG-FOCUS:214432_AT ATPase, Na+/K+ transporting, alpha 3 polypeptide hs
HG-U133_PLUS_2:214432_AT ATPase, Na+/K+ transporting, alpha 3 polypeptide hs
HG-U133A:214432_AT ATPase, Na+/K+ transporting, alpha 3 polypeptide hs
HG-U95AV2:35670_AT ATPase, Na+/K+ transporting, alpha 3 polypeptide hs
MOUSE430_2:1427481_A_AT ATPase, Na+/K+ transporting, alpha 3 polypeptide mm
MOUSE430A_2:1427481_A_AT ATPase, Na+/K+ transporting, alpha 3 polypeptide mm
MOE430A:1427481_A_AT ATPase, Na+/K+ transporting, alpha 3 polypeptide mm
MU11KSUBB:MSA.11233.0_AT ATPase, Na+/K+ transporting, alpha 3 polypeptide mm
MG-U74BV2:106975_AT ATPase, Na+/K+ transporting, alpha 3 polypeptide mm
MOE430A:1424856_AT ATPase, Na+/K+ transporting, alpha 3 polypeptide mm
MOUSE430A_2:1424856_AT ATPase, Na+/K+ transporting, alpha 3 polypeptide mm
MOUSE430_2:1424856_AT ATPase, Na+/K+ transporting, alpha 3 polypeptide mm
RN-U34:M28648_S_AT ATPase, Na+/K+ transporting, alpha 3 polypeptide rn
RT-U34:M28648_S_AT ATPase, Na+/K+ transporting, alpha 3 polypeptide rn
RG-U34A:M28648_S_AT ATPase, Na+/K+ transporting, alpha 3 polypeptide rn
RG-U34A:D00189_AT ATPase, Na+/K+ transporting, alpha 3 polypeptide rn
RAE230A:1368701_AT ATPase, Na+/K+ transporting, alpha 3 polypeptide rn
RAT230_2:1368701_AT ATPase, Na+/K+ transporting, alpha 3 polypeptide rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6812 cation transport inferred from electronic annotation QuickGO AmiGO
8152 metabolism inferred from electronic annotation QuickGO AmiGO
15672 monovalent inorganic cation transport inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
16021 integral to membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
3824 catalytic activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
15077 monovalent inorganic cation transporter activity inferred from electronic annotation QuickGO AmiGO
15662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism inferred from electronic annotation QuickGO AmiGO
16820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB02694 Hypothetical protein B0365.3 [Caenorhabditis elegans] ref|NP_506269.1| EATing: abnormal pharyngeal pumping family member (eat-6) [Caenorhabditis elegans] 0.0
blast AAB02615 Na,K-ATPase alpha subunit 0.0
blast CAE64662 Hypothetical protein CBG09434 [Caenorhabditis briggsae] 0.0
Protein Families
Method ID Description E-Value
ec A1A1_HUMAN (P05023) Sodium/potassium-transporting ATPase alpha-1 chain precursor (EC 3.6.3.9) (Sodium pump 1) (Na+/K+ ATPase 1) 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR006068 EMBL-EBI Cation transporting ATPase, C-terminal 4.7E-74
Pfam IPR008250 EMBL-EBI E1-E2 ATPase-associated region 1.4E-117
Pfam IPR005834 EMBL-EBI Haloacid dehalogenase-like hydrolase 8.3E-9
Pfam IPR005834 EMBL-EBI Haloacid dehalogenase-like hydrolase 2.0E-11
Pfam IPR004014 EMBL-EBI Cation transporting ATPase, N-terminal 3.8E-32
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_506269.1 8 73-95,108-127,269-291,301-323,823-845,886-905,925-947,957-974
B0365.3.1 8 73-95,108-127,269-291,301-323,823-845,886-905,925-947,957-974
B0365.3.2 8 73-95,108-127,269-291,301-323,823-845,886-905,925-947,957-974
B0365.3.3 8 73-95,108-127,269-291,301-323,823-845,886-905,925-947,957-974
Sequence
Target Sequence 
>C. ELEGANS:194191_X_AT
gtacggatcagattctcctggtggttctgtgcccttccattctcaatcctcatcttcgtc
tacgacgagatccgtcgtttcttgattcgcagatatccaggaggatgggtcgagcgtgag
acctactactaaagaacagcttgtgaatctttgtagaattttctattttttatcttagtt
ttttattgtttcccatctcattccgatctaataatttctttcatttagtgatgctacttt
ctgtcgtcgttttgtgaactttgtattgcattctcgaaaattcaagtcgacagaaagtcc
cgtcctat

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GTACGGATCAGATTCTCCTGGTGGT 188 459 15 Antisense
ATCCTCATCTTCGTCTACGACGAGA 433 39 60 Antisense
ATCCGTCGTTTCTTGATTCGCAGAT 416 39 84 Antisense
CCAGGAGGATGGGTCGAGCGTGAGA 104 269 111 Antisense
TCGAGCGTGAGACCTACTACTAAAG 195 601 124 Antisense
AGTTTTTTATTGTTTCCCATCTCAT 12 63 191 Antisense
TTCCCATCTCATTCCGATCTAATAA 545 697 204 Antisense
TTAGTGATGCTACTTTCTGTCGTCG 305 681 239 Antisense
TTCTGTCGTCGTTTTGTGAACTTTG 66 695 253 Antisense
GTGAACTTTGTATTGCATTCTCGAA 111 483 268 Antisense
AAGTCGACAGAAAGTCCCGTCCTAT 679 157 298 Antisense
Sequence Source Affymetrix Proprietary Database