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[194139_s_at] Phorbol esters/diacylglycerol binding domain (C1 domain), GTPase-activator protein for Rho-like GTPases

Description K08E3.6 /REP_DB=WormBase Gene ID /WP=CE18872 /GEN=cyk-4 /TR=Q9XUS9 /GB=CAB04593.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=Phorbol esters-diacylglycerol binding domain (C1 domain), GTPase-activator protein for Rho-like GTPases
Cluster 6grp_highest_10_10 > 97      6grp_high1_10_10 > 78      4grp_high_8_8 > 45      6grp_highest_nonorm > 93      6grp_total > 78      4grp_total > 50      6grp_highest_sub > Cu      6grp_cgc > 59      6grp_high1_sub > Cu      6grp_cgc_sub > Da      6grp_total_sub > Increase      6grp_rule_based > S6      4grp_rule_based > L2      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 393
1 2 3 4 range
A 304.9
(-1.3)
P 		448.3
(3)
P 		357.7
(0.3)
P 		248.5
(-3)
A 		200
B 263.9
(-2)
P 		484.8
(3)
P 		460.1
(2.4)
P 		222.3
(-3)
P 		263
C 333.6
(-1.7)
P 		615.7
(3)
P 		388.8
(-0.8)
P 		257.9
(-3)
P 		358
avr 300.8
(-1.7) 		516.3
(3) 		402.2
(0.5) 		242.9
(-3) 		273

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 789
1 2 3 4 5 6 range
A 417.3
(-1.7)
P 		295.4
(-2.6)
P 		245.4
(-3)
P 		295.4
(-2.6)
P 		540.9
(-0.7)
P 		1023.8
(3)
P 		778
B 333.6
(-2)
P 		235.1
(-3)
P 		276.1
(-2.6)
P 		310
(-2.3)
P 		507.2
(-0.3)
P 		836.6
(3)
P 		602
C 361.1
(-1.5)
P 		310.1
(-2.3)
P 		263.2
(-3)
P 		284.1
(-2.7)
P 		640.5
(2.8)
P 		655.8
(3)
P 		393
avr 370.7
(-1.9) 		280.2
(-2.8) 		261.6
(-3) 		296.5
(-2.6) 		562.9
(0.1) 		838.7
(3) 		577
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 141
1 2 3 4 range
A 111
(3)
P 		97.3
(1.9)
P 		93.5
(1.6)
P 		36.4
(-3)
A 		75
B 84.2
(0.1)
P 		119.7
(3)
P 		106.6
(1.9)
P 		47.4
(-3)
P 		72
C 110.4
(0)
P 		177
(3)
P 		135.5
(1.1)
P 		43.5
(-3)
P 		134
avr 101.9
(1) 		131.3
(3) 		111.9
(1.7) 		42.4
(-3) 		89

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 259
1 2 3 4 5 6 range
A 76.9
(-2.3)
P 		105
(-1.4)
P 		53.4
(-3)
P 		74.9
(-2.3)
P 		163.2
(0.4)
P 		249.3
(3)
P 		196
B 116.1
(-1.8)
P 		78.2
(-2.7)
P 		67
(-3)
P 		82.1
(-2.6)
P 		206.1
(0.4)
P 		311.9
(3)
P 		245
C 133.8
(-0.2)
P 		94.6
(-1.6)
P 		67
(-2.6)
P 		57.1
(-3)
P 		207.3
(2.5)
P 		219.5
(3)
P 		162
avr 108.9
(-1.6) 		92.6
(-2.1) 		62.5
(-3) 		71.4
(-2.7) 		192.2
(0.9) 		260.2
(3) 		198
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 194139_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.6528
Sequence Type Exemplar sequence
Representative Public ID K08E3.6 NCBI
Target Description K08E3.6 /REP_DB=WormBase Gene ID /WP=CE18872 /GEN=cyk-4 /TR=Q9XUS9 /GB=CAB04593.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=Phorbol esters-diacylglycerol binding domain (C1 domain), GTPase-activator protein for Rho-like GTPases
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_067444(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_067444 NCBI Caenorhabditis elegans CYtoKinesis defect family member (cyk-4) (cyk-4) mRNA, complete cds. 11/11 None
SNAP00000031966 ENSEMBL cdna:SNAP chromosome:CEL140:III:13768317:13770739:-1 11/11 None
GENEFINDER00000031973 ENSEMBL cdna:GeneFinder chromosome:CEL140:III:13768317:13770739:-1 11/11 None
K08E3.6.1 ENSEMBL cdna:known chromosome:CEL140:III:13768073:13770740:-1 gene:K08E3.6 11/11 None
K08E3.6.2 ENSEMBL cdna:known chromosome:CEL140:III:13768073:13770746:-1 gene:K08E3.6 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:13768312-13770735(-) 98.58 100.0
Public Domain and Genome References
Gene Title Phorbol esters/diacylglycerol binding domain (C1 domain), GTPase-activator protein for Rho-like GTPases
Gene Symbol cyk-4
Ensembl K08E3.6
Entrez Gene 176815 Entrez gene
SwissProt Q9XUS9 EMBL-EBI
WormBase CE18872 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.13263.1.S1_AT similar to Rac GTPase activating protein 1 cfa
DROSOPHILA_2:1634690_AT Saccharomyces cerevisiae UAS construct a of Sotillos dm
DROSGENOME1:147175_AT Saccharomyces cerevisiae UAS construct a of Sotillos dm
CHICKEN:GGA.11635.1.S1_AT Rac GTPase activating protein 1 gga
CHICKEN:GGA.11776.1.S1_S_AT Rac GTPase activating protein 1 gga
CHICKEN:GGA.1533.1.S1_S_AT Rac GTPase activating protein 1 gga
HU35KSUBA:RC_AA610073_AT Rac GTPase activating protein 1 hs
U133_X3P:HS.23900.1.S1_3P_A_AT Rac GTPase activating protein 1 hs
HG-U133A_2:222077_S_AT Rac GTPase activating protein 1 hs
HG-FOCUS:222077_S_AT Rac GTPase activating protein 1 hs
HG-U133_PLUS_2:222077_S_AT Rac GTPase activating protein 1 hs
HG-U133A:222077_S_AT Rac GTPase activating protein 1 hs
HG-U95B:50271_AT Rac GTPase activating protein 1 hs
HG-U95D:67797_R_AT Rac GTPase activating protein 1 hs
MOUSE430_2:1421546_A_AT Rac GTPase-activating protein 1 mm
MOE430A:1421546_A_AT Rac GTPase-activating protein 1 mm
MOUSE430A_2:1421546_A_AT Rac GTPase-activating protein 1 mm
MU11KSUBA:AA049623_S_AT Rac GTPase-activating protein 1 mm
MU11KSUBB:MSA.37104.0_S_AT Rac GTPase-activating protein 1 mm
MG-U74AV2:94953_AT Rac GTPase-activating protein 1 mm
MG-U74CV2:169204_I_AT Rac GTPase-activating protein 1 mm
MOE430A:1451358_A_AT Rac GTPase-activating protein 1 mm
MOUSE430A_2:1451358_A_AT Rac GTPase-activating protein 1 mm
MOUSE430_2:1451358_A_AT Rac GTPase-activating protein 1 mm
RG-U34B:RC_AA899520_AT Rac GTPase-activating protein 1 (predicted) rn
RAE230B:1384259_AT Rac GTPase-activating protein 1 (predicted) rn
RAT230_2:1384259_AT Rac GTPase-activating protein 1 (predicted) rn
RAE230A:1373658_AT Rac GTPase-activating protein 1 (predicted) rn
RAT230_2:1373658_AT Rac GTPase-activating protein 1 (predicted) rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6118 electron transport inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
5489 electron transporter activity inferred from electronic annotation QuickGO AmiGO
20037 heme binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB04593 Hypothetical protein K08E3.6 [Caenorhabditis elegans] ref|NP_499845.1| CYtoKinesis defect family member (cyk-4) [Caenorhabditis elegans] 0.0
blast CAE71360 Hypothetical protein CBG18263 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR002219 EMBL-EBI Protein kinase C, phorbol ester/diacylglycerol binding 3.2E-5
Pfam IPR000198 EMBL-EBI RhoGAP domain 8.8E-52
Sequence
Target Sequence 
>C. ELEGANS:194139_S_AT
tgggccttcacgacgttgaggtcatcacagacaccttgaaacggttcctaagagatctta
aagacccgttgatcccaagaacgtctcgtcaagagctcatcgttgctgcaaacctctact
ctacggatccagataatggacgtctcgccctgaatcgagtgatctgtgagctcccccaag
cgaatcgagacaccctcgcctaccttttcattcactggcgcaaagttatcgcacaatcga
gtcgcaacaagatgaactgcgaagcgatggcgcggatggtggctccggcggtgatgggtc
atccagtgaagcaatcgcagtcccaagcgatagctggcagagatgccacggattgccatc
gagcgatgactgctctatttgaatttgatgatgtatattggcaacgattcctagggacat
ctgcagtttccatggcttctaatcaaattgaaacggctcgacatcaggacaattttgctc
tctgtgatcgtagcatccttggaccagtta

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TGGGCCTTCACGACGTTGAGGTCAT 557 553 1457 Antisense
GAACGTCTCGTCAAGAGCTCATCGT 619 347 1535 Antisense
TCATCGTTGCTGCAAACCTCTACTC 253 611 1553 Antisense
TCCAGATAATGGACGTCTCGCCCTG 142 589 1584 Antisense
GAATCGAGTGATCTGTGAGCTCCCC 466 329 1608 Antisense
TCGCCTACCTTTTCATTCACTGGCG 423 599 1652 Antisense
CGCAGTCCCAAGCGATAGCTGGCAG 385 253 1772 Antisense
ATCTGCAGTTTCCATGGCTTCTAAT 662 33 1875 Antisense
GAAACGGCTCGACATCAGGACAATT 287 357 1906 Antisense
GGACAATTTTGCTCTCTGTGATCGT 437 527 1923 Antisense
GATCGTAGCATCCTTGGACCAGTTA 85 419 1942 Antisense
Sequence Source Affymetrix Proprietary Database