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[194137_at] Caspase recruitment domain, ICE-like protease (caspase) p20 domain., ICE-like protease (caspase) p10 domain.

Description C48D1.2 /REP_DB=WormBase Gene ID /WP=CE24858 /GEN=ced-3 /TR=Q9NAQ8 /GB=CAB61001.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=Caspase recruitment domain, ICE-like protease (caspase) p20 domain., ICE-like protease (caspase) p10 domain.
Cluster 6grp_total > 94      4grp_total > 38      6grp_cgc > 88      6grp_total_sub > Hat      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 10
1 2 3 4 range
A 10.3
(2.1)
A 		11.2
(3)
A 		4.9
(-3)
A 		5.4
(-2.5)
A 		6
B 11.7
(3)
A 		5.6
(-1.3)
A 		4.3
(-2.2)
A 		3.1
(-3)
A 		9
C 5.1
(-2.6)
A 		4.6
(-3)
A 		7.3
(-1)
A 		12.6
(3)
A 		8
avr 9
(3) 		7.1
(-0.3) 		5.5
(-3) 		7
(-0.4) 		4

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 17
1 2 3 4 5 6 range
A 5
(-2.2)
A 		3.7
(-2.8)
A 		3.4
(-3)
A 		6.3
(-1.5)
A 		14.2
(2.7)
A 		14.7
(3)
A 		11
B 4.5
(-0.1)
A 		5.8
(1.7)
A 		2.5
(-3)
A 		6.7
(3)
A 		3.1
(-2.1)
A 		4.6
(-0)
A 		4
C 1.8
(-3)
A 		7
(-1.2)
A 		4.3
(-2.1)
A 		14.5
(1.4)
A 		19.2
(3)
A 		6.6
(-1.3)
A 		17
avr 3.8
(-2.7) 		5.5
(-1.6) 		3.4
(-3) 		9.2
(1) 		12.2
(3) 		8.6
(0.5) 		9
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 3
1 2 3 4 range
A 3.7
(3)
A 		2.4
(0.3)
A 		1.3
(-2)
A 		0.8
(-3)
A 		3
B 3.7
(3)
A 		1.4
(-1.6)
A 		1
(-2.4)
A 		0.7
(-3)
A 		3
C 1.7
(-1)
A 		1.3
(-3)
A 		2.5
(3)
A 		2.1
(1)
A 		1
avr 3
(3) 		1.7
(-1.3) 		1.6
(-1.7) 		1.2
(-3) 		2

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 6
1 2 3 4 5 6 range
A 0.9
(-2.7)
A 		1.3
(-2)
A 		0.7
(-3)
A 		1.6
(-1.5)
A 		4.3
(3)
A 		3.6
(1.8)
A 		4
B 1.6
(1.6)
A 		1.9
(3)
A 		0.6
(-3)
A 		1.8
(2.5)
A 		1.3
(0.2)
A 		1.7
(2.1)
A 		1
C 0.7
(-3)
A 		2.1
(-1.5)
A 		1.1
(-2.6)
A 		2.9
(-0.6)
A 		6.2
(3)
A 		2.2
(-1.4)
A 		6
avr 1.1
(-2.4) 		1.8
(-1.1) 		0.8
(-3) 		2.1
(-0.5) 		3.9
(3) 		2.5
(0.3) 		3
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 194137_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.8962
Sequence Type Exemplar sequence
Representative Public ID C48D1.2 NCBI
Target Description C48D1.2 /REP_DB=WormBase Gene ID /WP=CE24858 /GEN=ced-3 /TR=Q9NAQ8 /GB=CAB61001.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=Caspase recruitment domain, ICE-like protease (caspase) p20 domain., ICE-like protease (caspase) p10 domain.
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_070137(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_070137 NCBI Caenorhabditis elegans CEll Death abnormality family member (ced-3) (ced-3) mRNA, complete cds. 11/11 A 
SNAP00000028975 ENSEMBL cdna:SNAP chromosome:CEL140:IV:13199199:13204035:-1 11/11 None
GENEFINDER00000028983 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:13199199:13204032:-1 11/11 None
C48D1.2 ENSEMBL cdna:known chromosome:CEL140:IV:13198254:13204098:-1 gene:C48D1.2 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:13199204-13204038(-) 100.0 100.0
Public Domain and Genome References
Gene Title Caspase recruitment domain, ICE-like protease (caspase) p20 domain., ICE-like protease (caspase) p10 domain.
Gene Symbol ced-3
Ensembl C48D1.2
Entrez Gene 178272 Entrez gene
SwissProt P42573 EMBL-EBI
WormBase CE29088 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1584802_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) cfa
CANINE_2:CFA.12400.1.A1_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) cfa
CANINE_2:CFA.6392.1.A1_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) cfa
CANINE_2:CFAAFFX.6401.1.S1_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) cfa
CANINE_2:CFAAFFX.6401.1.S1_S_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) cfa
CHICKEN:GGA.504.1.S1_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) gga
HG-U133A:34449_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133A_2:34449_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-FOCUS:34449_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133_PLUS_2:34449_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U95AV2:34449_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U95AV2:1239_S_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HC-G110:1239_S_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U95AV2:1240_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HC-G110:1240_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133A:209812_X_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133_PLUS_2:209812_X_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133A_2:209812_X_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133A:209811_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133_PLUS_2:209811_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133A_2:209811_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133_PLUS_2:208050_S_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133A:208050_S_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133A_2:208050_S_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HU35KSUBA:AA243486_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HU35KSUBA:RC_AA481283_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HU35KSUBA:U13021_S_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HUGENEFL:U13021_S_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HUGENEFL:U13022_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133A:211140_S_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133_PLUS_2:211140_S_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133A_2:211140_S_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
U133_X3P:G4502574_3P_S_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
U133_X3P:G12642589_3P_S_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
U133_X3P:G12642589_3P_A_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
U133_X3P:HS.180552.0.A2_3P_X_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
U133_X3P:HS.180552.0.A2_3P_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
U133_X3P:HS.180552.0.A1_3P_X_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
U133_X3P:226036_3P_X_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
U133_X3P:209811_3P_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133_PLUS_2:226032_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133B:226032_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133_PLUS_2:226036_X_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U133B:226036_X_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U95AV2:34448_S_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U95B:48571_AT caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
HG-U95E:67372_AT Caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) hs
MU11KSUBA:D28492_S_AT caspase 2 mm
MG-U74AV2:99049_AT caspase 2 mm
MG-U74AV2:161263_F_AT caspase 2 mm
MOE430A:1448165_AT caspase 2 mm
MOUSE430A_2:1448165_AT caspase 2 mm
MOUSE430_2:1448165_AT caspase 2 mm
RAE230A:1367891_A_AT caspase 2 rn
RAT230_2:1367891_A_AT caspase 2 rn
RN-U34:U34684_S_AT caspase 2 rn
RT-U34:U34684_S_AT caspase 2 rn
RG-U34A:U34684_S_AT caspase 2 rn
RN-U34:AF025671_S_AT caspase 2 rn
RG-U34A:AF025671_S_AT caspase 2 rn
RN-U34:U77933_AT caspase 2 rn
RT-U34:U77933_AT caspase 2 rn
RG-U34A:U77933_AT caspase 2 rn
RAE230A:1367890_AT caspase 2 rn
RAT230_2:1367890_AT caspase 2 rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
42981 regulation of apoptosis inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5622 intracellular inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
5515 protein binding inferred from electronic annotation QuickGO AmiGO
30693 caspase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB61001 Hypothetical protein C48D1.2 [Caenorhabditis elegans] ref|NP_502538.1| CEll Death abnormality family member (ced-3) [Caenorhabditis elegans] gb|AAG42045.1| caspase CED-3 [Caenorhabditis elegans] gb|AAA27982.2| cell death protein [Caenorhabditis elegans] sp|P42573|CED3_CAEEL Cell death protein 3 precursor [Contains: Cell death protein 3 subunit 1; Cell death protein 3 subunit 2] 0.0
blast T20038 hypothetical protein C48D1.2 - Caenorhabditis elegans 0.0
blast CAE58645 Hypothetical protein CBG01813 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR001315 EMBL-EBI CARD interaction domain 2.8E-33
Pfam IPR001309 EMBL-EBI Caspase-1, p20 4.4E-105
Pfam IPR001315 EMBL-EBI CARD interaction domain 6.4E-29
Pfam IPR001309 EMBL-EBI Caspase-1, p20 2.5E-20
Pfam IPR001309 EMBL-EBI Caspase-1, p20 5.7E-75
Sequence
Target Sequence 
>C. ELEGANS:194137_AT
ctccccgtctggcgaataagccgaaaatcgtttttgtgcaggcttgtcgaggcgaacgtc
gtgacaatggattcccagtcttggattctgtcgacggagttcctgcatttcttcgtcgtg
gatgggacaatcgagacgggccattgttcaattttcttggatgtgtgcggccgcaagttc
agcaagtgtggagaaagaagccgagccaagctgacattctgattgcatacgcaacgacag
ctcaatatgtttcgtggagaaacagtgctcgtggatcatggttcattcaagccgtctgtg
aagtgttctcgacacacgcaaaggatatggatgttgttgagctgctgactgaagtcaata
agaaggtcgcttgtggatttcagacatcacagggatcgaatattttgaaacagatgccag
agatgacatcccgcctgctcaaaaagttctactt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
CTCCCCGTCTGGCGAATAAGCCGAA 261 233 1037 Antisense
TTGTGCAGGCTTGTCGAGGCGAACG 681 705 1070 Antisense
GGATTCCCAGTCTTGGATTCTGTCG 361 509 1105 Antisense
ATTCTGTCGACGGAGTTCCTGCATT 573 7 1121 Antisense
CTGCATTTCTTCGTCGTGGATGGGA 134 239 1139 Antisense
AATCGAGACGGGCCATTGTTCAATT 298 167 1165 Antisense
GGATGTGTGCGGCCGCAAGTTCAGC 501 513 1195 Antisense
GAAGCCGAGCCAAGCTGACATTCTG 47 345 1233 Antisense
AGTGCTCGTGGATCATGGTTCATTC 673 59 1300 Antisense
GCCGTCTGTGAAGTGTTCTCGACAC 695 283 1327 Antisense
CCCGCCTGCTCAAAAAGTTCTACTT 360 259 1466 Antisense
Sequence Source Affymetrix Proprietary Database