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[194107_at] Src homology domain 2, Src homology domain 3, protein tyrosine kinase (src subfamily)

Description F49B2.5 /REP_DB=WormBase Gene ID /WP=CE24991 /GEN=kin-22 /TR=O45539 /GB=CAB04427.2 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=Src homology domain 2, Src homology domain 3, protein tyrosine kinase (src subfamily)
Cluster 6grp_total > 04      4grp_total > 51      6grp_cgc > 10      4grp_rule_based > L2      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 432
1 2 3 4 range
A 287.4
(1)
P 		405.8
(3)
P 		334.1
(1.8)
P 		57.1
(-3)
A 		349
B 303.1
(1.7)
P 		362.4
(3)
P 		349.7
(2.7)
P 		81.3
(-3)
A 		281
C 229.1
(-1.1)
P 		489.1
(3)
P 		348.1
(0.8)
P 		110.6
(-3)
A 		379
avr 273.2
(0.4) 		419.1
(3) 		344
(1.7) 		83
(-3) 		336

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 348
1 2 3 4 5 6 range
A 361.9
(3)
P 		221.6
(0.1)
P 		173.8
(-0.9)
P 		231.5
(0.3)
P 		145.4
(-1.5)
A 		74.6
(-3)
A 		287
B 276.4
(3)
P 		210.7
(1.1)
P 		195.2
(0.7)
P 		196.9
(0.8)
P 		139.9
(-0.9)
P 		63.7
(-3)
A 		213
C 339.4
(3)
P 		199.1
(0.4)
P 		192.4
(0.3)
P 		197.5
(0.4)
P 		142.5
(-0.6)
P 		13.8
(-3)
A 		326
avr 325.9
(3) 		210.5
(0.5) 		187.1
(-0) 		208.6
(0.4) 		142.6
(-1) 		50.7
(-3) 		275
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 132
1 2 3 4 range
A 104.7
(3)
P 		88.1
(2)
P 		87.4
(1.9)
P 		8.4
(-3)
A 		96
B 96.7
(3)
P 		89.5
(2.5)
P 		81
(1.8)
P 		17.3
(-3)
A 		79
C 75.8
(-0.2)
P 		140.6
(3)
P 		121.3
(2.1)
P 		18.6
(-3)
A 		122
avr 92.4
(2.1) 		106.1
(3) 		96.6
(2.4) 		14.8
(-3) 		91

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 121
1 2 3 4 5 6 range
A 66.7
(1.8)
P 		78.8
(3)
P 		37.8
(-1.1)
P 		58.7
(1)
P 		43.9
(-0.5)
A 		18.2
(-3)
A 		61
B 96.2
(3)
P 		70.1
(0.8)
P 		47.4
(-1)
P 		52.1
(-0.6)
P 		56.8
(-0.3)
P 		23.7
(-3)
A 		73
C 125.8
(3)
P 		60.7
(-0.2)
P 		49
(-0.8)
P 		39.7
(-1.3)
P 		46.1
(-0.9)
P 		4.6
(-3)
A 		121
avr 96.2
(3) 		69.9
(1) 		44.7
(-0.8) 		50.2
(-0.4) 		48.9
(-0.5) 		15.5
(-3) 		81
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 194107_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.384
Sequence Type Exemplar sequence
Representative Public ID F49B2.5 NCBI
Target Description F49B2.5 /REP_DB=WormBase Gene ID /WP=CE24991 /GEN=kin-22 /TR=O45539 /GB=CAB04427.2 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=Src homology domain 2, Src homology domain 3, protein tyrosine kinase (src subfamily)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_061101(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_061101 NCBI Caenorhabditis elegans SRC oncogene related family member (src-2) (src-2) mRNA, complete cds. 11/11 None
GENEFINDER00000010615 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:14330405:14336953:1 11/11 None
F49B2.5 ENSEMBL cdna:known chromosome:CEL140:I:14330355:14337044:1 gene:F49B2.5 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
SNAP00000010608 8/11 Cross Hyb Matching Probes None
SNAP00000010609 3/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:14330335-14336884(+) 100.0 100.0
Public Domain and Genome References
Gene Title Src homology domain 2, Src homology domain 3, protein tyrosine kinase (src subfamily)
Gene Symbol src-2
Ensembl F49B2.5
Entrez Gene 173296 Entrez gene
SwissProt O45539 EMBL-EBI
WormBase CE24991 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1589956_AT fyn-related kinase cfa
CANINE_2:CFA.13163.1.A1_AT fyn-related kinase cfa
CANINE_2:CFAAFFX.7000.1.S1_AT fyn-related kinase cfa
DROSOPHILA_2:1629767_S_AT Src oncogene at 42A dm
DROSGENOME1:154725_AT Src oncogene at 42A dm
CHICKEN:GGAAFFX.9514.1.S1_AT similar to src related tyrosine kinase gga
HG-U95AV2:511_S_AT fyn-related kinase hs
HC-G110:511_S_AT fyn-related kinase hs
HG-U133_PLUS_2:207178_S_AT fyn-related kinase hs
HG-U133A:207178_S_AT fyn-related kinase hs
HG-FOCUS:207178_S_AT fyn-related kinase hs
HG-U133A_2:207178_S_AT fyn-related kinase hs
HU35KSUBA:U00803_S_AT fyn-related kinase hs
HUGENEFL:U22322_S_AT fyn-related kinase hs
U133_X3P:G4503786_3P_A_AT fyn-related kinase hs
HG-U95AV2:35023_AT fyn-related kinase hs
MU11KSUBB:Z48757_S_AT fyn-related kinase mm
MG-U74AV2:92959_AT fyn-related kinase mm
MOE430A:1421362_A_AT fyn-related kinase mm
MOUSE430A_2:1421362_A_AT fyn-related kinase mm
MOUSE430_2:1421362_A_AT fyn-related kinase mm
MOE430A:1426569_A_AT fyn-related kinase mm
MOUSE430A_2:1426569_A_AT fyn-related kinase mm
MOUSE430_2:1426569_A_AT fyn-related kinase mm
MOE430A:1426570_A_AT fyn-related kinase mm
MOUSE430A_2:1426570_A_AT fyn-related kinase mm
MOUSE430_2:1426570_A_AT fyn-related kinase mm
MOE430B:1436413_AT Fyn-related kinase, mRNA (cDNA clone MGC:6049 IMAGE:3601246) mm
MOUSE430_2:1436413_AT Fyn-related kinase, mRNA (cDNA clone MGC:6049 IMAGE:3601246) mm
MOUSE430_2:1440948_AT Fyn-related kinase, mRNA (cDNA clone MGC:6049 IMAGE:3601246) mm
MOE430B:1440948_AT Fyn-related kinase, mRNA (cDNA clone MGC:6049 IMAGE:3601246) mm
MG-U74CV2:166750_AT Fyn-related kinase, mRNA (cDNA clone MGC:6049 IMAGE:3601246) mm
RG-U34A:U09583_AT fyn-related kinase rn
RAE230A:1369156_AT fyn-related kinase rn
RAT230_2:1369156_AT fyn-related kinase rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB04427 Hypothetical protein F49B2.5 [Caenorhabditis elegans] ref|NP_493502.1| SRC oncogene related family member (src-2) [Caenorhabditis elegans] 0.0
blast CAE64122 Hypothetical protein CBG08738 [Caenorhabditis briggsae] 0.0
blast EAA10750 ENSANGP00000005994 [Anopheles gambiae str. PEST] ref|XP_316335.1| ENSANGP00000005994 [Anopheles gambiae str. PEST] 0.0
blast EAA10750 ENSANGP00000005994 [Anopheles gambiae str. PEST] ref|XP_316335.1| ENSANGP00000005994 [Anopheles gambiae str. PEST] 1.0E-161
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 2.0E-60
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 1.0E-60
hanks 2.1.14 CaMK Group; CaMK I Regulated by Ca2+/CaM and close relatives; MLCK-K 1.0E-67
hanks 2.1.13 CaMK Group; CaMK I Regulated by Ca2+/CaM and close relatives; ACMPK 1.0E-67
Protein Domains
Database ID Description E-Value
Pfam IPR000980 EMBL-EBI SH2 motif 5.0E-39
Pfam IPR001452 EMBL-EBI SH3 1.9E-21
Pfam IPR000719 EMBL-EBI Protein kinase 7.5E-86
Pfam IPR000980 EMBL-EBI SH2 motif 5.1E-17
Pfam IPR000719 EMBL-EBI Protein kinase 7.5E-86
Sequence
Target Sequence 
>C. ELEGANS:194107_AT
gcagtctgcacacgtgatgagccgattcttatagtcaccgagctaatgcaggagaatctg
ctcacattcttacagcgacgaggtcggcagtgtcagatgcctcagctggtggagatctcg
gcgcaggttgccgctggaatggcctacctagaggagatgaatttcatccatcgagaccta
gcagcacgaaacatccttatcaacaactccctatctgtaaaaatcgcagatttcgggtta
gccaggatattgatgaaggagaacgagtacgaagcaagaaccggagcacggtttccgata
aaatggacggcgcccgaggcggcgaactataatcgattcacaaccaagtcggatgtctgg
agttttggaatcctgctcaccgagattgtcacgttcggacggttaccctatccaggtatg
acaaacgccgaagtcctacaacaagtcgacgccgggtaccgtatgccgtgcccagccggg
tgcccagtcaccctttacgacataatgcaacagtgctggagaagcgacccggacaaacgg
ccaacctttgagaccctccaatggaagttggaggatctgttcaatctggactcttcc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GCAGTCTGCACACGTGATGAGCCGA 575 311 910 Antisense
GAATCTGCTCACATTCTTACAGCGA 461 329 963 Antisense
GGTCGGCAGTGTCAGATGCCTCAGC 667 501 991 Antisense
TGGAGATCTCGGCGCAGGTTGCCGC 502 547 1019 Antisense
TTGCCGCTGGAATGGCCTACCTAGA 478 697 1037 Antisense
TTTCATCCATCGAGACCTAGCAGCA 669 671 1071 Antisense
CGAAACATCCTTATCAACAACTCCC 270 253 1096 Antisense
ATCCTGCTCACCGAGATTGTCACGT 541 39 1279 Antisense
CAAACGCCGAAGTCCTACAACAAGT 114 193 1331 Antisense
CAACCTTTGAGACCCTCCAATGGAA 286 185 1451 Antisense
GGATCTGTTCAATCTGGACTCTTCC 148 513 1482 Antisense
Sequence Source Affymetrix Proprietary Database