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[194071_at] Src homology domain 2, tyrosine-protein kinase (FES/FPS subfamily)

Description T13H10.1 /REP_DB=WormBase Gene ID /WP=CE06444 /GEN=kin-5 /TR=Q18684 /GB=CAA93112.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=Src homology domain 2, tyrosine-protein kinase (FES-FPS subfamily)
Cluster 6grp_total > 88      4grp_total > 19      6grp_cgc > 59      6grp_cgc_sub > Da      6grp_total_sub > Increase      6grp_rule_based > S6      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 83
1 2 3 4 range
A 11.8
(-3)
A 		27.4
(-1.4)
A 		13.2
(-2.9)
A 		69.8
(3)
A 		58
B 13.1
(-3)
A 		25.4
(-1.1)
A 		15.8
(-2.6)
A 		51.9
(3)
A 		39
C 40.8
(-0.5)
A 		38.6
(-0.6)
A 		6.1
(-3)
A 		88.9
(3)
A 		83
avr 21.9
(-2) 		30.5
(-1.1) 		11.7
(-3) 		70.2
(3) 		59

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 222
1 2 3 4 5 6 range
A 13
(-2.9)
A 		33.3
(-2.4)
A 		10.2
(-3)
A 		17
(-2.8)
A 		108.1
(-0.4)
A 		232.5
(3)
P 		222
B 64.6
(-2.8)
A 		65
(-2.7)
A 		61.4
(-3)
A 		63.4
(-2.9)
A 		105.7
(0.2)
A 		143.4
(3)
P 		82
C 11.5
(-3)
A 		62
(-0.9)
A 		43.9
(-1.7)
A 		55.6
(-1.2)
A 		123.3
(1.6)
A 		156.7
(3)
P 		145
avr 29.7
(-3) 		53.4
(-2) 		38.5
(-2.6) 		45.3
(-2.4) 		112.4
(0.4) 		177.5
(3) 		148
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 13
1 2 3 4 range
A 4.3
(-2.2)
A 		5.9
(-0.8)
A 		3.4
(-3)
A 		10.2
(3)
A 		7
B 4.2
(-2.6)
A 		6.3
(-0.9)
A 		3.7
(-3)
A 		11.1
(3)
A 		7
C 13.5
(2.3)
A 		11.1
(1.2)
A 		2.1
(-3)
A 		15
(3)
A 		13
avr 7.3
(-0.2) 		7.8
(0.1) 		3.1
(-3) 		12.1
(3) 		9

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 54
1 2 3 4 5 6 range
A 2.4
(-3)
A 		11.8
(-1.9)
A 		2.2
(-3)
A 		4.3
(-2.8)
A 		32.6
(0.4)
A 		56.6
(3)
P 		54
B 22.5
(-1.8)
A 		21.6
(-2)
A 		14.9
(-3)
A 		16.8
(-2.7)
A 		43
(1.4)
A 		53.5
(3)
P 		39
C 4.3
(-3)
A 		18.9
(-1.2)
A 		11.2
(-2.1)
A 		11.2
(-2.1)
A 		39.9
(1.4)
A 		52.5
(3)
P 		48
avr 9.7
(-3) 		17.4
(-1.9) 		9.4
(-3) 		10.8
(-2.8) 		38.5
(0.9) 		54.2
(3) 		45
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 194071_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.10133
Sequence Type Exemplar sequence
Representative Public ID T13H10.1 NCBI
Target Description T13H10.1 /REP_DB=WormBase Gene ID /WP=CE06444 /GEN=kin-5 /TR=Q18684 /GB=CAA93112.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=Src homology domain 2, tyrosine-protein kinase (FES-FPS subfamily)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_069392(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_069392 NCBI Caenorhabditis elegans protein KINase family member (kin-5) (kin-5) mRNA, complete cds. 11/11 None
T13H10.1 ENSEMBL cdna:known chromosome:CEL140:IV:9967077:9969152:-1 gene:T13H10.1 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:9967082-9969043(-) 100.0 100.0
Public Domain and Genome References
Gene Title Src homology domain 2, tyrosine-protein kinase (FES/FPS subfamily)
Gene Symbol kin-5
Ensembl T13H10.1
Entrez Gene 188489 Entrez gene
SwissProt Q18684 EMBL-EBI
WormBase CE06444 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA93112 Hypothetical protein T13H10.1 [Caenorhabditis elegans] emb|CAA93289.1| Hypothetical protein T13H10.1 [Caenorhabditis elegans] ref|NP_501793.1| protein KINase family member (kin-5) [Caenorhabditis elegans] 0.0
blast CAE64332 Hypothetical protein CBG09015 [Caenorhabditis briggsae] 0.0
blast CAE63903 Hypothetical protein CBG08474 [Caenorhabditis briggsae] 0.0
Protein Families
Method ID Description E-Value
hanks 2.1.8 CaMK Group; CaMK I Regulated by Ca2+/CaM and close relatives; DdMLCK 3.0E-64
Protein Domains
Database ID Description E-Value
Pfam IPR000980 EMBL-EBI SH2 motif 2.0E-23
Pfam IPR000719 EMBL-EBI Protein kinase 1.3E-58
Sequence
Target Sequence 
>C. ELEGANS:194071_AT
catttgaagctaacgtcccaccagccattgtcagattcattacgtatagaatctgtgctg
gtgccgaagaggaaagggtcacaatgagtgaagcagttcgtgaacttttaactctcgaag
gatttgatcaagctccaggatccaacagctactttgaacttcccgatcatattccaatgg
agaatattgagcaaccaaaaaagattcaagtctcgaacattcttccgtatatgtccaaac
cagttgctccaccttttgaacctgaacgccaggaaaaaacacaagaaatgagaaaatcga
tgagcaattcggcggaagaaggagtaaagaagaatcggcgtccagttcgaactcgcatac
gcaatggtaactctccaagtcccggtttcaaaagtcagagcagatcagcggcggaaaatc
agaataaatcaaacctgaaagctgttcagaaaaagaagaacaataagcagtcatcctcta
tttccggtgatgctccttcaaccttttcagttcttggt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
CATTTGAAGCTAACGTCCCACCAGC 45 215 1034 Antisense
CCACCAGCCATTGTCAGATTCATTA 418 273 1051 Antisense
CCAACAGCTACTTTGAACTTCCCGA 196 275 1175 Antisense
GAACTTCCCGATCATATTCCAATGG 658 349 1189 Antisense
TCAAGTCTCGAACATTCTTCCGTAT 96 633 1239 Antisense
TATATGTCCAAACCAGTTGCTCCAC 550 659 1261 Antisense
CCACCTTTTGAACCTGAACGCCAGG 152 231 1282 Antisense
AAGAATCGGCGTCCAGTTCGAACTC 89 153 1363 Antisense
CGCAATGGTAACTCTCCAAGTCCCG 15 249 1393 Antisense
AATAAGCAGTCATCCTCTATTTCCG 650 171 1495 Antisense
TCCTTCAACCTTTTCAGTTCTTGGT 10 591 1527 Antisense
Sequence Source Affymetrix Proprietary Database