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[194070_at] Src homology domain 2, tyrosine-protein kinase (FES/FPS subfamily)

Description F22D6.1 /REP_DB=WormBase Gene ID /WP=CE05682 /GEN=kin-14 /TR=Q19726 /GB=CAA95813.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=Src homology domain 2, tyrosine-protein kinase (FES-FPS subfamily)
Cluster 6grp_total > 85      4grp_total > 10      6grp_cgc > 77      6grp_cgc_sub > 04_05_06      4grp_rule_based > L4      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 249
1 2 3 4 range
A 22.2
(-2.6)
A 		63.1
(-1.1)
A 		11.2
(-3)
A 		176.1
(3)
P 		165
B 8.4
(-3)
A 		30.1
(-2.5)
A 		23.3
(-2.6)
A 		251.9
(3)
P 		244
C 16.8
(-3)
A 		26.9
(-2.7)
A 		50.9
(-2.1)
A 		256.9
(3)
P 		240
avr 15.8
(-3) 		40
(-2.3) 		28.5
(-2.6) 		228.3
(3) 		213

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 105
1 2 3 4 5 6 range
A 69.7
(1.3)
A 		32.7
(-3)
A 		84.7
(3)
P 		68.8
(1.2)
P 		74
(1.8)
P 		81.8
(2.7)
P 		52
B 45.6
(-3)
A 		67.6
(0.1)
A 		70.7
(0.5)
P 		88.8
(3)
A 		86.7
(2.7)
P 		76
(1.2)
P 		43
C 74.8
(-0.4)
A 		30.4
(-3)
A 		29.6
(-3)
A 		134.9
(3)
P 		121.5
(2.2)
P 		127.8
(2.6)
P 		105
avr 63.4
(-0.8) 		43.6
(-3) 		61.7
(-1) 		97.5
(3) 		94.1
(2.6) 		95.2
(2.7) 		54
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 51
1 2 3 4 range
A 8.1
(-1.6)
A 		13.7
(-0.2)
A 		2.9
(-3)
A 		25.8
(3)
P 		23
B 2.7
(-3)
A 		7.4
(-2.4)
A 		5.4
(-2.7)
A 		53.7
(3)
P 		51
C 5.6
(-3)
A 		7.7
(-2.7)
A 		17.7
(-1.1)
A 		43.3
(3)
P 		38
avr 5.5
(-3) 		9.6
(-2.3) 		8.7
(-2.5) 		40.9
(3) 		35

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 35
1 2 3 4 5 6 range
A 12.8
(-2.3)
A 		11.6
(-3)
A 		18.4
(0.8)
P 		17.4
(0.3)
P 		22.3
(3)
P 		19.9
(1.7)
P 		11
B 15.9
(-3)
A 		22.5
(-0.9)
A 		17.2
(-2.6)
P 		23.5
(-0.6)
A 		35.2
(3)
P 		28.3
(0.9)
P 		19
C 27.7
(0.4)
A 		9.3
(-2.7)
A 		7.5
(-3)
A 		27.1
(0.3)
P 		39.3
(2.4)
P 		42.8
(3)
P 		35
avr 18.8
(-1.5) 		14.5
(-3) 		14.4
(-3) 		22.7
(-0.2) 		32.3
(3) 		30.3
(2.3) 		18
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 194070_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.990
Sequence Type Exemplar sequence
Representative Public ID F22D6.1 NCBI
Target Description F22D6.1 /REP_DB=WormBase Gene ID /WP=CE05682 /GEN=kin-14 /TR=Q19726 /GB=CAA95813.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=Src homology domain 2, tyrosine-protein kinase (FES-FPS subfamily)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_059603(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_059603 NCBI Caenorhabditis elegans protein KINase family member (kin-14) (kin-14) mRNA, complete cds. 11/11 None
SNAP00000037646 ENSEMBL cdna:SNAP chromosome:CEL140:I:7084075:7086903:-1 9/11 None
GENEFINDER00000037664 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:7084075:7087570:-1 11/11 None
F22D6.1 ENSEMBL cdna:known chromosome:CEL140:I:7084064:7087570:-1 gene:F22D6.1 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:7084005-7087501(-) 100.0 100.0
Public Domain and Genome References
Gene Title Src homology domain 2, tyrosine-protein kinase (FES/FPS subfamily)
Gene Symbol kin-14
Ensembl F22D6.1
Entrez Gene 172440 Entrez gene
SwissProt Q19726 EMBL-EBI
WormBase CE05682 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:252177_AT protein kinase, putative at
CANINE_2:CFA.20624.1.S1_AT similar to V-FES feline sarcoma viral/V-FPS fujinami avian sarcoma viral oncogene homolog cfa
CANINE_2:CFAAFFX.19129.1.S1_S_AT similar to V-FES feline sarcoma viral/V-FPS fujinami avian sarcoma viral oncogene homolog cfa
HG-U95AV2:1976_S_AT feline sarcoma oncogene hs
HC-G110:1976_S_AT feline sarcoma oncogene hs
HU35KSUBC:RC_T27601_S_AT feline sarcoma oncogene hs
HUGENEFL:X52192_AT feline sarcoma oncogene hs
HG-U133A:205418_AT feline sarcoma oncogene hs
HG-U133_PLUS_2:205418_AT feline sarcoma oncogene hs
HG-FOCUS:205418_AT feline sarcoma oncogene hs
HG-U133A_2:205418_AT feline sarcoma oncogene hs
U133_X3P:G13376997_3P_AT feline sarcoma oncogene hs
MOE430A:1427368_X_AT feline sarcoma oncogene mm
MOUSE430_2:1427368_X_AT feline sarcoma oncogene mm
MOUSE430A_2:1427368_X_AT feline sarcoma oncogene mm
MOUSE430_2:1452410_A_AT feline sarcoma oncogene mm
MOE430A:1452410_A_AT feline sarcoma oncogene mm
MOUSE430A_2:1452410_A_AT feline sarcoma oncogene mm
MU11KSUBB:X12616_S_AT feline sarcoma oncogene mm
MG-U74AV2:92188_S_AT feline sarcoma oncogene mm
MG-U74CV2:171248_F_AT feline sarcoma oncogene mm
RAE230B:1380621_AT Similar to tyrosine kinase Fps/Fes rn
RAT230_2:1380621_AT Similar to tyrosine kinase Fps/Fes rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA95813 Hypothetical protein F22D6.1 [Caenorhabditis elegans] ref|NP_492004.1| protein KINase family member (kin-14) [Caenorhabditis elegans] 0.0
blast CAE73101 Hypothetical protein CBG20481 [Caenorhabditis briggsae] 1.0E-163
blast CAE73101 Hypothetical protein CBG20481 [Caenorhabditis briggsae] 1.0E-158
blast CAA92609 Hypothetical protein T04B2.2 [Caenorhabditis elegans] ref|NP_501818.1| Fer oncogene Related Kinase family member (frk-1) [Caenorhabditis elegans] 1.0E-112
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 6.0E-59
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 7.0E-52
hanks 1.8.7 AGC group; AGC VIII Flowering plant PVPK1 homologs; PsPK5 1.0E-60
Protein Domains
Database ID Description E-Value
Pfam IPR000980 EMBL-EBI SH2 motif 4.8E-16
Pfam IPR000719 EMBL-EBI Protein kinase 1.1E-55
Pfam IPR000719 EMBL-EBI Protein kinase 1.8E-11
Pfam IPR000719 EMBL-EBI Protein kinase 7.5E-36
Sequence
Target Sequence 
>C. ELEGANS:194070_AT
ggtttggcagtagatgctcatccactaatgattgtaatggagatgtgcccacatggatca
cttctttcatttcttcgtaagaacaaagggaaaacgacactttccgaacgtcttcgtttt
tgtattgaatcagccgatggtcttgcatatcttgagaaaaaacaatgtcttcatcgtgat
attgcagccagaaattgtttactttcgatcaccgatcaaattaaaatttcggattttggt
ctttcggatgacaaacgaactgaaatgcatgatgacacactcgataaggtaccagtgaaa
tggttggctccggaagttatgcaggataaattgtattcattgaaaagtgatgtttgggca
tttggagtgctcatgtgggagatatatgcagatggagctgatccatatccgggaatgaca
aacttagttacgagagccaagatcttctgcgatgattacagaatgacttttcctgagact
accccaccaaccatttctgaaatcgctttgaaacaatgctgggcgaaacttccatcggat
cgtgccacgatgaagactgtgcatcataagcttaaagacctctcaatgccaatgtcgga

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GGTTTGGCAGTAGATGCTCATCCAC 609 505 640 Antisense
AGATGTGCCCACATGGATCACTTCT 526 67 680 Antisense
ATCACTTCTTTCATTTCTTCGTAAG 658 27 696 Antisense
GAATCAGCCGATGGTCTTGCATATC 664 327 766 Antisense
GTCTTCATCGTGATATTGCAGCCAG 95 469 806 Antisense
AAATTGTTTACTTTCGATCACCGAT 67 115 831 Antisense
ATTTCGGATTTTGGTCTTTCGGATG 200 17 865 Antisense
ACGAGAGCCAAGATCTTCTGCGATG 566 93 1069 Antisense
AGAATGACTTTTCCTGAGACTACCC 362 75 1099 Antisense
ATGCTGGGCGAAACTTCCATCGGAT 283 41 1155 Antisense
AAGACCTCTCAATGCCAATGTCGGA 394 153 1214 Antisense
Sequence Source Affymetrix Proprietary Database