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[194048_at] 3-HYDROXYISOBUTYRATE DEHYDROGENASE PRECURSOR (EC 1.1.1.31) (HIBADH) (FRAGMENT)

Description B0250.5 /REP_DB=WormBase Gene ID /WP=CE18481 /TR=SW:Q9XTI0 /GB=CAA21003.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=3-HYDROXYISOBUTYRATE DEHYDROGENASE PRECURSOR (EC 1.1.1.31) (HIBADH) (FRAGMENT)
Cluster 6grp_highest_10_10 > 03      6grp_high1_10_10 > 10      4grp_highest_8_8 > 24      4grp_high_8_8 > 51      6grp_highest_nonorm > 66      6grp_total > 32      4grp_total > 60      6grp_highest_sub > De      6grp_total_sub > Hat      4grp_rule_based > L2      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1903
1 2 3 4 range
A 1964.1
(2.6)
P 		2073.7
(3)
P 		2042.8
(2.9)
P 		195
(-3)
P 		1879
B 1839.6
(2.6)
P 		1790.5
(2.5)
P 		1943.6
(3)
P 		170.9
(-3)
P 		1773
C 1815.2
(2.7)
P 		1906.1
(3)
P 		1750.3
(2.4)
P 		269.7
(-3)
P 		1636
avr 1873
(2.8) 		1923.4
(3) 		1912.2
(3) 		211.9
(-3) 		1712

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1236
1 2 3 4 5 6 range
A 2049.9
(3)
P 		1384.8
(-0.8)
P 		1520.2
(-0.1)
P 		1528.6
(-0)
P 		1291.3
(-1.4)
P 		1012
(-3)
P 		1038
B 1448.3
(1.9)
P 		1368.1
(1.2)
P 		1597.3
(3)
P 		1428.8
(1.7)
P 		1510
(2.3)
P 		816.5
(-3)
P 		781
C 1457.1
(0.6)
P 		1352.8
(0)
P 		1886.6
(3)
P 		1498.2
(0.8)
P 		1271.7
(-0.4)
P 		814.4
(-3)
P 		1072
avr 1651.8
(2.9) 		1368.6
(0.7) 		1668
(3) 		1485.2
(1.6) 		1357.7
(0.6) 		881
(-3) 		787
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 687
1 2 3 4 range
A 715.1
(3)
P 		450.2
(0.7)
P 		534
(1.4)
P 		28.5
(-3)
P 		687
B 586.6
(3)
P 		442.2
(1.4)
P 		450.4
(1.5)
P 		36.4
(-3)
P 		550
C 600.9
(2.9)
P 		548
(2.3)
P 		610
(3)
P 		45.5
(-3)
P 		565
avr 634.2
(3) 		480.1
(1.5) 		531.5
(2) 		36.8
(-3) 		597

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 367
1 2 3 4 5 6 range
A 377.9
(0.2)
P 		492.5
(3)
P 		331.1
(-0.9)
P 		387.7
(0.4)
P 		389.7
(0.5)
P 		246.4
(-3)
P 		246
B 503.9
(0.9)
P 		455.4
(-0.1)
P 		387.9
(-1.4)
P 		378.4
(-1.6)
P 		613.5
(3)
P 		304.5
(-3)
P 		309
C 540.1
(3)
P 		412.8
(0.1)
P 		480.2
(1.7)
P 		301.3
(-2.4)
P 		411.5
(0.1)
P 		272.6
(-3)
P 		268
avr 474
(3) 		453.6
(2.4) 		399.7
(0.8) 		355.8
(-0.6) 		471.6
(2.9) 		274.5
(-3) 		200
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 194048_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.14063
Sequence Type Exemplar sequence
Representative Public ID B0250.5 NCBI
Target Description B0250.5 /REP_DB=WormBase Gene ID /WP=CE18481 /TR=SW:Q9XTI0 /GB=CAA21003.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=3-HYDROXYISOBUTYRATE DEHYDROGENASE PRECURSOR (EC 1.1.1.31) (HIBADH) (FRAGMENT)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_075542(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_075542 NCBI Caenorhabditis elegans B0250.5 (B0250.5) mRNA, complete cds. 11/11 None
B0250.5 ENSEMBL cdna:known chromosome:CEL140:V:20491975:20495334:1 gene:B0250.5 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
SNAP00000041311 6/11 Cross Hyb Matching Probes None
GENEFINDER00000041353 6/11 Cross Hyb Matching Probes None
SNAP00000043594 4/11 Cross Hyb Matching Probes None
GENEFINDER00000043595 4/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:20491981-20495222(+) 100.0 100.0
Public Domain and Genome References
Gene Title 3-HYDROXYISOBUTYRATE DEHYDROGENASE PRECURSOR (EC 1.1.1.31) (HIBADH) (FRAGMENT)
Ensembl B0250.5
Entrez Gene 180344 Entrez gene
SwissProt Q9XTI0 EMBL-EBI
WormBase CE18481 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:254445_AT 3-hydroxyisobutyrate dehydrogenase, putative at
CANINE:1598601_AT similar to 3-hydroxyisobutyrate dehydrogenase, mitochondrial precursor (HIBADH) cfa
CANINE:1592927_AT similar to 3-hydroxyisobutyrate dehydrogenase, mitochondrial precursor (HIBADH) cfa
CANINE_2:CFA.2048.1.S1_AT similar to 3-hydroxyisobutyrate dehydrogenase, mitochondrial precursor (HIBADH) cfa
CANINE_2:CFA.2048.2.S1_AT similar to 3-hydroxyisobutyrate dehydrogenase, mitochondrial precursor (HIBADH) cfa
CANINE_2:CFAAFFX.5402.1.S1_S_AT similar to 3-hydroxyisobutyrate dehydrogenase, mitochondrial precursor (HIBADH) cfa
DROSOPHILA_2:1630236_S_AT dm
DROSGENOME1:152083_AT dm
CHICKEN:GGAAFFX.11848.1.S1_S_AT 3-hydroxyisobutyrate dehydrogenase gga
CHICKEN:GGAAFFX.7036.2.S1_AT 3-hydroxyisobutyrate dehydrogenase gga
HG-U133_PLUS_2:234452_AT 3-hydroxyisobutyrate dehydrogenase hs
HG-U133B:234452_AT 3-hydroxyisobutyrate dehydrogenase hs
HU35KSUBA:N77326_AT 3-hydroxyisobutyrate dehydrogenase hs
HU35KSUBD:RC_W33167_AT 3-hydroxyisobutyrate dehydrogenase hs
U133_X3P:HS.284170.2.S1_3P_A_AT 3-hydroxyisobutyrate dehydrogenase hs
U133_X3P:HS.284170.1.S1_3P_AT 3-hydroxyisobutyrate dehydrogenase hs
U133_X3P:HS.284170.0.S1_3P_AT 3-hydroxyisobutyrate dehydrogenase hs
HG-U133_PLUS_2:224812_AT 3-hydroxyisobutyrate dehydrogenase hs
HG-U133B:224812_AT 3-hydroxyisobutyrate dehydrogenase hs
HG-U133_PLUS_2:231955_S_AT 3-hydroxyisobutyrate dehydrogenase hs
HG-U133B:231955_S_AT 3-hydroxyisobutyrate dehydrogenase hs
HG-U95B:55758_AT 3-hydroxyisobutyrate dehydrogenase hs
HG-U95D:68124_AT 3-hydroxyisobutyrate dehydrogenase hs
HG-U133_PLUS_2:215316_AT 3-hydroxyisobutyrate dehydrogenase hs
HG-U133A_2:215316_AT 3-hydroxyisobutyrate dehydrogenase hs
HG-U133A:215316_AT 3-hydroxyisobutyrate dehydrogenase hs
HG-U95AV2:32325_AT 3-hydroxyisobutyrate dehydrogenase hs
HG-U95D:85740_AT 3-hydroxyisobutyrate dehydrogenase hs
HU35KSUBD:RC_AA620705_AT 3-hydroxyisobutyrate dehydrogenase hs
MOUSE430_2:1435967_S_AT 3-hydroxyisobutyrate dehydrogenase mm
MOE430A:1435967_S_AT 3-hydroxyisobutyrate dehydrogenase mm
MOUSE430A_2:1435967_S_AT 3-hydroxyisobutyrate dehydrogenase mm
MG-U74AV2:97279_AT 3-hydroxyisobutyrate dehydrogenase mm
MG-U74CV2:168493_AT 3-hydroxyisobutyrate dehydrogenase mm
MOE430A:1423780_AT 3-hydroxyisobutyrate dehydrogenase mm
MOUSE430A_2:1423780_AT 3-hydroxyisobutyrate dehydrogenase mm
MOUSE430_2:1423780_AT 3-hydroxyisobutyrate dehydrogenase mm
MOE430B:1446297_AT 3-hydroxyisobutyrate dehydrogenase (Hibadh), mRNA mm
MOUSE430_2:1446297_AT 3-hydroxyisobutyrate dehydrogenase (Hibadh), mRNA mm
MG-U74CV2:129039_AT 3-hydroxyisobutyrate dehydrogenase (Hibadh), mRNA mm
MG-U74CV2:129040_G_AT 3-hydroxyisobutyrate dehydrogenase (Hibadh), mRNA mm
MOE430B:1442848_AT 3-hydroxyisobutyrate dehydrogenase (Hibadh), mRNA mm
MOUSE430_2:1442848_AT 3-hydroxyisobutyrate dehydrogenase (Hibadh), mRNA mm
MU19KSUBA:TC23229_S_AT 3-hydroxyisobutyrate dehydrogenase (Hibadh), mRNA mm
MU19KSUBB:TC33924_AT 3-hydroxyisobutyrate dehydrogenase (Hibadh), mRNA mm
RG-U34A:RC_AI013861_AT 3-hydroxyisobutyrate dehydrogenase rn
RAE230A:1388118_AT 3-hydroxyisobutyrate dehydrogenase rn
RAT230_2:1388118_AT 3-hydroxyisobutyrate dehydrogenase rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6573 valine metabolism inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
8442 3-hydroxyisobutyrate dehydrogenase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB03798 Hypothetical protein B0250.5 [Caenorhabditis elegans] emb|CAA21003.1| Hypothetical protein B0250.5 [Caenorhabditis elegans] ref|NP_507943.1| B0250.5 [Caenorhabditis elegans] sp|Q9XTI0|3HIDH_CAEEL Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) 1.0E-166
blast CAE61659 Hypothetical protein CBG05595 [Caenorhabditis briggsae] 1.0E-157
blast AAH70849 MGC84587 protein [Xenopus laevis] 4.0E-88
Sequence
Target Sequence 
>C. ELEGANS:194048_AT
tgtcactggaagttgctcaggccgccgctttgctcaaagccgagtatatcgacgccccaa
tctccggtggagtcactggcgcccagcaagctacactaacatttatggttggagccggaa
acgatgcaactttcaagcgtgccgaagcggttttaagccttatgggcaaaaatatcgtga
atttgggagccgtcggcaacggaacagccgccaaaatctgcaataatatgcttttgggaa
tccagatggtcgctgtcgcggagactatgaatttaggcatctcaatgggtctcgacgcga
aagcgcttgccggaatcgtgaatacatcgtcaggaaggtgttggtcgtcggacacgtaca
atccagtacccggagtcattgaaaacatcccttcgtgcaggggttatgctggcggcttcg
gaacgactctaatggcaaaagacctttcattggctcaaaatgcttcaacaaatactcaag
caccaactccaatgggctcactggctcatcaaatctaccgtattctggctcgtgatccac
agta

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TGTCACTGGAAGTTGCTCAGGCCGC 191 559 314 Antisense
AACTTTCAAGCGTGCCGAAGCGGTT 466 83 441 Antisense
GGAGCCGTCGGCAACGGAACAGCCG 355 513 499 Antisense
AGATGGTCGCTGTCGCGGAGACTAT 142 69 557 Antisense
TTAGGCATCTCAATGGGTCTCGACG 232 681 586 Antisense
TCTCGACGCGAAAGCGCTTGCCGGA 710 609 603 Antisense
GTTGGTCGTCGGACACGTACAATCC 211 435 653 Antisense
GCGGCTTCGGAACGACTCTAATGGC 401 291 725 Antisense
TCAAGCACCAACTCCAATGGGCTCA 526 631 789 Antisense
CTCACTGGCTCATCAAATCTACCGT 617 227 810 Antisense
GTATTCTGGCTCGTGATCCACAGTA 74 453 833 Antisense
Sequence Source Affymetrix Proprietary Database