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[194046_s_at] tyrosine-protein kinase (Epidermal growth factor receptor subfamily)

Description ZK1067.1 /REP_DB=WormBase Gene ID /WP=CE25678 /GEN=let-23 /TR=SW:P24348 /GB=CAA93882.2 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=tyrosine-protein kinase (Epidermal growth factor receptor subfamily)
Cluster 6grp_highest_10_10 > 83      6grp_high1_10_10 > 47      4grp_high_8_8 > 17      6grp_highest_nonorm > 90      6grp_total > 47      4grp_total > 39      6grp_highest_sub > Cu      6grp_cgc > 17      6grp_high1_sub > Cu      6grp_cgc_sub > Cu      6grp_total_sub > Cup      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 322
1 2 3 4 range
A 367.1
(3)
P 		172.2
(-1.1)
P 		80.5
(-3)
A 		191.2
(-0.7)
P 		287
B 332.4
(3)
P 		134.2
(-2.6)
M 		119.1
(-3)
M 		272.4
(1.3)
P 		213
C 398.7
(3)
P 		126.5
(-2.1)
P 		77
(-3)
P 		183.6
(-1)
P 		322
avr 366.1
(3) 		144.3
(-1.9) 		92.2
(-3) 		215.7
(-0.3) 		274

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 122
1 2 3 4 5 6 range
A 267.1
(3)
P 		223.1
(0.8)
P 		149.1
(-2.8)
P 		175.7
(-1.5)
P 		145.9
(-3)
P 		243.6
(1.8)
P 		121
B 245.1
(3)
P 		173.6
(-1.3)
P 		144.7
(-3)
P 		179.7
(-0.9)
P 		165.4
(-1.8)
P 		243.2
(2.9)
P 		100
C 235.6
(2.2)
P 		173.6
(-1.9)
P 		171.7
(-2.1)
P 		199.7
(-0.2)
P 		157.6
(-3)
P 		248.3
(3)
P 		91
avr 249.3
(3) 		190.1
(-0.8) 		155.2
(-3) 		185
(-1.1) 		156.3
(-2.9) 		245
(2.7) 		94
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 113
1 2 3 4 range
A 133.7
(3)
P 		37.4
(-2.1)
P 		21
(-3)
A 		28
(-2.6)
P 		113
B 106
(3)
P 		33.1
(-2.6)
M 		27.6
(-3)
M 		58.1
(-0.7)
P 		78
C 132
(3)
P 		36.4
(-2.5)
P 		26.9
(-3)
P 		31
(-2.8)
P 		105
avr 123.9
(3) 		35.6
(-2.4) 		25.2
(-3) 		39
(-2.2) 		99

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 58
1 2 3 4 5 6 range
A 49.2
(-0.9)
P 		79.3
(3)
P 		32.5
(-3)
P 		44.6
(-1.4)
P 		44
(-1.5)
P 		59.3
(0.4)
P 		47
B 85.3
(2.4)
P 		57.8
(-0.6)
P 		35.1
(-3)
P 		47.6
(-1.7)
P 		67.2
(0.5)
P 		90.7
(3)
P 		56
C 87.3
(3)
P 		53
(-1.4)
P 		43.7
(-2.6)
P 		40.2
(-3)
P 		51
(-1.6)
P 		83.1
(2.5)
P 		47
avr 73.9
(2.4) 		63.4
(0.9) 		37.1
(-3) 		44.1
(-2) 		54.1
(-0.5) 		77.7
(3) 		41
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 194046_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.3696
Sequence Type Exemplar sequence
Representative Public ID ZK1067.1 NCBI
Target Description ZK1067.1 /REP_DB=WormBase Gene ID /WP=CE25678 /GEN=let-23 /TR=SW:P24348 /GB=CAA93882.2 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=tyrosine-protein kinase (Epidermal growth factor receptor subfamily)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_063561(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_063561 NCBI Caenorhabditis elegans LEThal family member (let-23) (let-23) mRNA, complete cds. 11/11 None
SNAP00000014740 ENSEMBL cdna:SNAP chromosome:CEL140:II:9199100:9206849:1 11/11 None
GENEFINDER00000014744 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:9197429:9206849:1 11/11 None
ZK1067.1 ENSEMBL cdna:known chromosome:CEL140:II:9198179:9207119:1 gene:ZK1067.1 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:9197425-9206846(+) 97.9 100.0
Public Domain and Genome References
Gene Title tyrosine-protein kinase (Epidermal growth factor receptor subfamily)
Gene Symbol let-23
Ensembl ZK1067.1
Entrez Gene 174462 Entrez gene
WormBase CE03840 Wormbase
Functional Annotations
Ortholog
ID Title Organism
DROSGENOME1:151735_AT Epidermal growth factor receptor dm
DROSOPHILA_2:1633948_A_AT Epidermal growth factor receptor dm
DROSGENOME1:142966_AT Epidermal growth factor receptor dm
CHICKEN:GGA.857.1.S1_AT epidermal growth factor receptor gga
CHICKEN:GGA.857.2.S1_S_AT epidermal growth factor receptor gga
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6118 electron transport inferred from electronic annotation QuickGO AmiGO
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7169 transmembrane receptor protein tyrosine kinase signaling pathway inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
16323 basolateral plasma membrane inferred from direct assay QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
4714 transmembrane receptor protein tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5006 epidermal growth factor receptor activity inferred from electronic annotation QuickGO AmiGO
5489 electron transporter activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
20037 heme binding inferred from electronic annotation QuickGO AmiGO
5006 epidermal growth factor receptor activity inferred from sequence similarity QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast BAA09729.1 receptor tyrosine kinase [Caenorhabditis elegans] 0.0
blast CAA93882 Hypothetical protein ZK1067.1 [Caenorhabditis elegans] ref|NP_495962.2| LEThal family member (let-23) [Caenorhabditis elegans] pir||E88257 protein let-23 [imported] - Caenorhabditis elegans prf||1703413A Tyr kinase 0.0
blast P24348 Let-23 receptor tyrosine-protein kinase precursor (Lethal protein 23) 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR006211 EMBL-EBI Furin-like cysteine rich region 2.2E-89
Pfam IPR000719 EMBL-EBI Protein kinase 3.8E-57
Pfam IPR000494 EMBL-EBI Epidermal growth-factor receptor (EGFR), L domain 4.1E-46
Pfam IPR000494 EMBL-EBI Epidermal growth-factor receptor (EGFR), L domain 1.3E-38
Pfam IPR008627 EMBL-EBI GETHR pentapeptide 3.3E-5
Pfam IPR008627 EMBL-EBI GETHR pentapeptide 2.3E-5
Pfam IPR008627 EMBL-EBI GETHR pentapeptide 2.9E-9
Pfam IPR008627 EMBL-EBI GETHR pentapeptide 3.2E-9
Pfam IPR008627 EMBL-EBI GETHR pentapeptide 3.2E-7
Pfam IPR008627 EMBL-EBI GETHR pentapeptide 5.7E-9
Pfam IPR006211 EMBL-EBI Furin-like cysteine rich region 2.2E-89
Pfam IPR000719 EMBL-EBI Protein kinase 3.8E-57
Pfam IPR000494 EMBL-EBI Epidermal growth-factor receptor (EGFR), L domain 4.1E-46
Pfam IPR000494 EMBL-EBI Epidermal growth-factor receptor (EGFR), L domain 1.3E-38
Pfam IPR006211 EMBL-EBI Furin-like cysteine rich region 2.2E-89
Pfam IPR000719 EMBL-EBI Protein kinase 3.8E-57
Pfam IPR000494 EMBL-EBI Epidermal growth-factor receptor (EGFR), L domain 4.1E-46
Pfam IPR000494 EMBL-EBI Epidermal growth-factor receptor (EGFR), L domain 1.3E-38
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_495962.2 2 7-29,819-841
ZK1067.1 2 7-29,819-841
SNAP00000014740 1 758-780
GENEFINDER00000014744 1 1033-1055
Sequence
Target Sequence 
>C. ELEGANS:194046_S_AT
gagcttctgagatgttggatggcggatccaaagtctcgtcctggttttgaaatattatat
gaaagatttaaagaattctgtaaggttccccaacttttcctggaaaattccaacaagatt
tctgaatctgatttgtcagctgaagaacgttttcaaacggaaagaatccgagaaatgttt
gatggaaatatcgatccacagatgtactttgatcaaggaagtttaccaagtatgccaagt
tctccaacttctatggcaacgttcacaattccacatggtgatctgatgaatcgaatgcaa
tcagtaaactcatctaggtacaaaacggagccttttgattatgggtcaaccgcacaggaa
gataattcatatcttattccaaaaaccaaagaagttcagcagtcagcagttttgtataca
gctgttacaaatgaagatggtcaaaccgagctatccccatcaaatggcgattactacaac
caaccaaacactccttcatcttcctctggatattacaatg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GAGCTTCTGAGATGTTGGATGGCGG 78 389 3499 Antisense
GGATGGCGGATCCAAAGTCTCGTCC 579 513 3515 Antisense
AAGTCTCGTCCTGGTTTTGAAATAT 29 157 3529 Antisense
ATATCGATCCACAGATGTACTTTGA 97 21 3686 Antisense
GTATGCCAAGTTCTCCAACTTCTAT 561 455 3728 Antisense
CACAATTCCACATGGTGATCTGATG 85 195 3762 Antisense
TGGGTCAACCGCACAGGAAGATAAT 6 553 3840 Antisense
AGTTCAGCAGTCAGCAGTTTTGTAT 507 63 3891 Antisense
GCTATCCCCATCAAATGGCGATTAC 249 303 3948 Antisense
GATTACTACAACCAACCAAACACTC 367 425 3967 Antisense
TCATCTTCCTCTGGATATTACAATG 167 621 3994 Antisense
Sequence Source Affymetrix Proprietary Database