[Home] | [Total List]

[194041_s_at] Cofilin/tropomyosin-type actin-binding proteins, Src homology domain 3

Description K08E3.4 /REP_DB=WormBase Gene ID /WP=CE18868 /TR=Q9XUT0 /GB=CAB04592.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=Cofilin-tropomyosin-type actin-binding proteins, Src homology domain 3
Cluster 6grp_highest_10_10 > 81      6grp_high1_10_10 > 28      4grp_highest_8_8 > 09      4grp_high_8_8 > 53      6grp_highest_nonorm > 86      6grp_total > 18      4grp_total > 58      6grp_highest_sub > Cu      6grp_high1_sub > De      6grp_total_sub > Decrease      4grp_rule_based > L2      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 837
1 2 3 4 range
A 765.4
(-1.3)
P 		1270.7
(3)
P 		1243
(2.8)
P 		568
(-3)
P 		703
B 890.4
(-0.6)
P 		1254.1
(2.6)
P 		1294.1
(3)
P 		611.9
(-3)
P 		682
C 732.1
(-0.9)
P 		1251.2
(3)
P 		1167.8
(2.4)
P 		456.8
(-3)
P 		794
avr 796
(-0.9) 		1258.7
(3) 		1235
(2.8) 		545.6
(-3) 		713

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 669
1 2 3 4 5 6 range
A 1270.2
(3)
P 		1053
(0.7)
P 		711.1
(-3)
P 		915.4
(-0.8)
P 		973.5
(-0.2)
P 		1180.4
(2)
P 		559
B 1162.7
(3)
P 		950.9
(-1.1)
P 		851.4
(-3)
P 		956.9
(-1)
P 		854.7
(-2.9)
P 		963.7
(-0.8)
P 		311
C 1344.4
(3)
P 		898.6
(-1)
P 		1095
(0.8)
P 		804.9
(-1.8)
P 		1032.9
(0.2)
P 		675
(-3)
P 		669
avr 1259.1
(3) 		967.5
(-1.7) 		885.8
(-3) 		892.4
(-2.9) 		953.7
(-1.9) 		939.7
(-2.1) 		373
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 330
1 2 3 4 range
A 278.7
(1.9)
P 		275.8
(1.8)
P 		325
(3)
P 		83.1
(-3)
P 		242
B 283.9
(2.1)
P 		309.7
(3)
P 		299.9
(2.7)
P 		130.4
(-3)
P 		179
C 242.3
(0)
P 		359.7
(2.1)
P 		407
(3)
P 		77
(-3)
P 		330
avr 268.3
(1.2) 		315.1
(2.3) 		344
(3) 		96.8
(-3) 		247

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 343
1 2 3 4 5 6 range
A 234.2
(-0.8)
P 		374.5
(3)
P 		154.9
(-3)
P 		232.2
(-0.9)
P 		293.8
(0.8)
P 		287.4
(0.6)
P 		220
B 404.6
(3)
P 		316.5
(0.3)
P 		206.7
(-3)
P 		253.5
(-1.6)
P 		347.3
(1.3)
P 		359.4
(1.6)
P 		198
C 498.3
(3)
P 		274.2
(-1)
P 		278.7
(-0.9)
P 		161.9
(-3)
P 		334.2
(0.1)
P 		226
(-1.9)
P 		336
avr 379
(3) 		321.7
(0.9) 		213.4
(-3) 		215.9
(-2.9) 		325.1
(1) 		290.9
(-0.2) 		166
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 194041_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.6320
Sequence Type Exemplar sequence
Representative Public ID K08E3.4 NCBI
Target Description K08E3.4 /REP_DB=WormBase Gene ID /WP=CE18868 /TR=Q9XUT0 /GB=CAB04592.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=Cofilin-tropomyosin-type actin-binding proteins, Src homology domain 3
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_067439(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_067439 NCBI Caenorhabditis elegans K08E3.4 (K08E3.4) mRNA, complete cds. 11/11 None
SNAP00000031964 ENSEMBL cdna:SNAP chromosome:CEL140:III:13758874:13761585:-1 11/11 None
GENEFINDER00000031971 ENSEMBL cdna:GeneFinder chromosome:CEL140:III:13759137:13761585:-1 11/11 None
K08E3.4.2 ENSEMBL cdna:known chromosome:CEL140:III:13758804:13761585:-1 gene:K08E3.4 11/11 None
K08E3.4.1 ENSEMBL cdna:known chromosome:CEL140:III:13758977:13761585:-1 gene:K08E3.4 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:13759132-13761581(-) 100.0 100.0
Public Domain and Genome References
Gene Title Cofilin/tropomyosin-type actin-binding proteins, Src homology domain 3
Ensembl K08E3.4
Entrez Gene 176813 Entrez gene
SwissProt Q9XUT0 EMBL-EBI
WormBase CE18868 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1583461_AT similar to drebrin-like isoform a cfa
CANINE_2:CFA.12221.1.A1_AT similar to drebrin-like isoform a cfa
CANINE_2:CFAAFFX.5216.1.S1_S_AT similar to drebrin-like isoform a cfa
DROSOPHILA_2:1633108_AT dm
DROSGENOME1:148717_AT dm
HG-U133_PLUS_2:222429_AT drebrin-like hs
HG-U133B:222429_AT drebrin-like hs
HU35KSUBA:RC_AA496904_AT drebrin-like hs
HU35KSUBA:AA353903_S_AT drebrin-like hs
U133_X3P:G8885629_3P_AT drebrin-like hs
HG-U95B:48577_AT drebrin-like hs
HG-U95E:67173_AT drebrin-like hs
HG-U95E:88842_R_AT drebrin-like hs
HG-U95E:69604_I_AT Drebrin-like hs
HG-U95E:69606_R_AT Drebrin-like hs
HU35KSUBB:RC_R68568_AT Drebrin-like hs
MU11KSUBA:U58884_S_AT drebrin-like mm
MG-U74AV2:95529_AT drebrin-like mm
MOE430A:1460334_AT drebrin-like mm
MOUSE430A_2:1460334_AT drebrin-like mm
MOUSE430_2:1460334_AT drebrin-like mm
RG-U34A:RC_AA800743_AT drebrin-like rn
RG-U34C:RC_AI071800_AT drebrin-like rn
RAE230A:1368274_AT drebrin-like rn
RAT230_2:1368274_AT drebrin-like rn
YEAST_2:1769779_AT Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization Sc
Gene Ontology
GO Cellular Component (view graph)
ID Description Evidence Links
5622 intracellular inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
3779 actin binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB04592 Hypothetical protein K08E3.4 [Caenorhabditis elegans] ref|NP_499840.1| K08E3.4 [Caenorhabditis elegans] 0.0
blast CAE71362 Hypothetical protein CBG18266 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR002108 EMBL-EBI Actin-binding, cofilin/tropomyosin type 4.2E-7
Pfam IPR001452 EMBL-EBI SH3 1.5E-18
Pfam IPR001452 EMBL-EBI SH3 2.0E-9
Sequence
Target Sequence 
>C. ELEGANS:194041_S_AT
gagccaatggtttacaagcccgaggctatgaaacctgccgtctcttacgatgcatacgaa
gagccaccagcagagccagctccacctacattccttgctccaaccccggtcattgctcca
cctccacctgagccaactccagctccatcgcattacgcctcccagtacgatgctccaccg
gttcacgagtctttcgaaccagctgtacctccagtttcagctccttcccactatgcgtct
cagtatgatgctccgccggagccgatcgactctcactcatcgagctctcaactgccagct
cacatcgcctcacagtatgacatgcctccagtgatgccagaggagcccgtgtttgcaccg
aaatcctcgccaataaaagtcgctgctccaccaattgatcagtacgatttcccgccggcg
gtcgccgagcagaacgcgatggctc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GAGCCAATGGTTTACAAGCCCGAGG 197 385 1345 Antisense
CTGCCGTCTCTTACGATGCATACGA 101 237 1379 Antisense
ATACGAAGAGCCACCAGCAGAGCCA 300 23 1398 Antisense
TTCACGAGTCTTTCGAACCAGCTGT 220 685 1526 Antisense
CCAGCTGTACCTCCAGTTTCAGCTC 539 273 1543 Antisense
ATGCGTCTCAGTATGATGCTCCGCC 154 43 1577 Antisense
ACATCGCCTCACAGTATGACATGCC 343 107 1646 Antisense
GACATGCCTCCAGTGATGCCAGAGG 385 369 1663 Antisense
TTTGCACCGAAATCCTCGCCAATAA 146 669 1696 Antisense
CAATAAAAGTCGCTGCTCCACCAAT 351 181 1715 Antisense
GTCGCCGAGCAGAACGCGATGGCTC 545 475 1765 Antisense
Sequence Source Affymetrix Proprietary Database