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[194031_at] Src homology domain 3, tyrosine-protein kinase (ACK subfamily)

Description C01C7.1 /REP_DB=WormBase Gene ID /WP=CE26967 /GEN=ark-1 /TR=O45232 /GB=CAB05120.2 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=Src homology domain 3, tyrosine-protein kinase (ACK subfamily)
Cluster 6grp_highest_10_10 > 41      6grp_high1_10_10 > 15      4grp_highest_8_8 > 49      4grp_high_8_8 > 41      6grp_highest_nonorm > 50      6grp_total > 15      4grp_total > 54      6grp_highest_sub > De      6grp_cgc > 32      6grp_high1_sub > De      6grp_cgc_sub > De      6grp_total_sub > Decrease      6grp_rule_based > S1      4grp_rule_based > L1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 565
1 2 3 4 range
A 752.6
(3)
P 		646.9
(1.7)
P 		484.7
(-0.4)
P 		281.8
(-3)
P 		471
B 846.5
(3)
P 		468.7
(-1.7)
P 		424.1
(-2.3)
P 		364.5
(-3)
P 		482
C 668.5
(3)
P 		427.4
(-1.1)
P 		381.1
(-1.9)
P 		313.9
(-3)
P 		355
avr 755.9
(3) 		514.3
(-0.3) 		430
(-1.5) 		320.1
(-3) 		436

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 623
1 2 3 4 5 6 range
A 858.9
(3)
P 		681.9
(1.1)
P 		290.6
(-3)
P 		368.8
(-2.2)
P 		364.3
(-2.2)
P 		415.7
(-1.7)
P 		568
B 663.5
(2.1)
P 		725.7
(3)
P 		394.2
(-1.7)
P 		452.7
(-0.9)
P 		385.4
(-1.9)
P 		305.9
(-3)
P 		420
C 685.9
(2.6)
P 		718.9
(3)
P 		633.8
(1.9)
P 		383.2
(-1.2)
P 		413.5
(-0.8)
P 		235.6
(-3)
P 		483
avr 736.1
(3) 		708.8
(2.6) 		439.5
(-1.3) 		401.6
(-1.8) 		387.7
(-2) 		319.1
(-3) 		417
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 233
1 2 3 4 range
A 274
(3)
P 		140.4
(-0.4)
P 		126.7
(-0.8)
P 		41.2
(-3)
P 		233
B 269.9
(3)
P 		115.8
(-1.8)
P 		98.3
(-2.4)
P 		77.7
(-3)
P 		192
C 221.3
(3)
P 		122.9
(-0.5)
P 		132.8
(-0.2)
P 		52.9
(-3)
P 		168
avr 255.1
(3) 		126.4
(-0.9) 		119.3
(-1.1) 		57.3
(-3) 		198

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 191
1 2 3 4 5 6 range
A 158.3
(0.2)
P 		242.5
(3)
P 		63.3
(-3)
P 		93.5
(-2)
P 		109.9
(-1.4)
P 		101.2
(-1.7)
P 		179
B 230.9
(2.6)
P 		241.5
(3)
P 		95.7
(-3)
P 		119.9
(-2)
P 		156.6
(-0.5)
P 		114.1
(-2.2)
P 		146
C 254.2
(3)
P 		219.4
(1.8)
P 		161.3
(-0.1)
P 		77.1
(-3)
P 		133.8
(-1.1)
P 		78.9
(-2.9)
P 		177
avr 214.5
(2.1) 		234.5
(3) 		106.8
(-2.6) 		96.8
(-3) 		133.4
(-1.4) 		98.1
(-2.9) 		138
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 194031_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.8423
Sequence Type Exemplar sequence
Representative Public ID C01C7.1 NCBI
Target Description C01C7.1 /REP_DB=WormBase Gene ID /WP=CE26967 /GEN=ark-1 /TR=O45232 /GB=CAB05120.2 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=Src homology domain 3, tyrosine-protein kinase (ACK subfamily)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_070017(10)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_070017 NCBI Caenorhabditis elegans A Ras-regulating Kinase family member (ark-1) (ark-1) mRNA, complete cds. 10/11 A 
SNAP00000008366 ENSEMBL cdna:SNAP chromosome:CEL140:IV:12622454:12630937:-1 10/11 None
GENEFINDER00000008367 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:12622454:12630937:-1 11/11 None
C01C7.1 ENSEMBL cdna:known chromosome:CEL140:IV:12622064:12630993:-1 gene:C01C7.1 10/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:12622459-12630943(-) 100.0 100.0
Public Domain and Genome References
Gene Title Src homology domain 3, tyrosine-protein kinase (ACK subfamily)
Gene Symbol ark-1
Ensembl C01C7.1
Entrez Gene 178218 Entrez gene
SwissProt O45232 EMBL-EBI
WormBase CE26967 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB05120 Hypothetical protein C01C7.1 [Caenorhabditis elegans] emb|CAB65957.1| Ack related non-receptor tyrosine kinase [Caenorhabditis elegans] ref|NP_502418.1| A Ras-regulating Kinase family member (ark-1) [Caenorhabditis elegans] 0.0
blast CAE67920 Hypothetical protein CBG13518 [Caenorhabditis briggsae] 0.0
blast XP_624955 PREDICTED: similar to ENSANGP00000009263 [Apis mellifera] 1.0E-117
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 7.3E-72
Pfam IPR000095 EMBL-EBI PAK-box/P21-Rho-binding 2.1E-13
Sequence
Target Sequence 
>C. ELEGANS:194031_AT
taagcttcttgttgagtgtggaactaatctgaaacaggcttcagtatccccgccgccaat
gtcaccgacatcctcccgattatcgacactcgatcgatcaagcatctctccagcaccacc
acgacctgtaactccaccgctttcagtcagaaatgagacaatttcgatgagaaaatcgca
acaagaggagatggaacatgtgactgttgaggagaattctccaaaaagagtacacattat
tgagactaagcttatcgatggaccagcaagaggaatgagtcctattcagaaaaaaatctt
gcttgttgcaatgtactctctaaattttccaaattttttggaccgccacattccggcttt
cacgactccaatgtcaaatggctcatttcgtaaggctccagctccaacaccggtttctcc
tgctcctgctggctcaacagatcaaaagcctccgccgtgccgaccaccaaaaacccgcca
attcccgttggtaatcgacgaacgaaatctcgcatat

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TAAGCTTCTTGTTGAGTGTGGAACT 64 635 2604 Antisense
CTGAAACAGGCTTCAGTATCCCCGC 236 239 2632 Antisense
CCTCCCGATTATCGACACTCGATCG 62 267 2675 Antisense
ACTCCACCGCTTTCAGTCAGAAATG 313 99 2734 Antisense
GAGACTAAGCTTATCGATGGACCAG 278 393 2845 Antisense
TGCTTGTTGCAATGTACTCTCTAAA 613 579 2903 Antisense
CGGCTTTCACGACTCCAATGTCAAA 220 243 2957 Antisense
ATGGCTCATTTCGTAAGGCTCCAGC 465 53 2981 Antisense
GCTCAACAGATCAAAAGCCTCCGCC 1 303 3035 Antisense
CGCCAATTCCCGTTGGTAATCGACG 517 257 3079 Antisense
AATCGACGAACGAAATCTCGCATAT 300 169 3096 Antisense
Sequence Source Affymetrix Proprietary Database