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[194018_s_at] dihyrolipoamide acetyltransferase component (pyruvate dehydrogenase complex)

Description F23B12.5 /REP_DB=WormBase Gene ID /WP=CE09597 /TR=Q19749 /GB=CAB01163.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=dihyrolipoamide acetyltransferase component (pyruvate dehydrogenase complex)
Cluster 6grp_highest_10_10 > 03      6grp_high1_10_10 > 22      4grp_highest_8_8 > 25      4grp_high_8_8 > 60      6grp_highest_nonorm > 25      6grp_total > 32      4grp_total > 60      6grp_highest_sub > De      6grp_high1_sub > De      6grp_total_sub > Hat      6grp_rule_based > S2      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 5184
1 2 3 4 range
A 5315.3
(2.4)
P 		5237
(2.3)
P 		5819.8
(3)
P 		1129.4
(-3)
P 		4690
B 5100.9
(1.5)
P 		5175.7
(1.6)
P 		6313.6
(3)
P 		1497.9
(-3)
P 		4816
C 5068.3
(2.3)
P 		5385.2
(2.7)
P 		5614
(3)
P 		1169.9
(-3)
P 		4444
avr 5161.5
(2) 		5266
(2.2) 		5915.8
(3) 		1265.7
(-3) 		4650

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 3945
1 2 3 4 5 6 range
A 3865
(-0.8)
P 		5394.7
(3)
P 		3937.3
(-0.6)
P 		4444.9
(0.7)
P 		3568.1
(-1.5)
P 		2952.5
(-3)
P 		2442
B 4797.8
(2.6)
P 		4995.7
(3)
P 		4738.4
(2.4)
P 		4258.5
(1.4)
P 		3384.9
(-0.6)
P 		2309.6
(-3)
P 		2686
C 4871.3
(1.4)
P 		4427.6
(0.7)
P 		5925.8
(3)
P 		4126.7
(0.3)
P 		3772.9
(-0.3)
P 		1980.9
(-3)
P 		3945
avr 4511.4
(2) 		4939.3
(3) 		4867.2
(2.8) 		4276.7
(1.4) 		3575.3
(-0.2) 		2414.3
(-3) 		2525
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1791
1 2 3 4 range
A 1935.3
(3)
P 		1136.8
(0.3)
P 		1521.4
(1.6)
P 		165.3
(-3)
P 		1770
B 1626.6
(3)
P 		1278.3
(1.4)
P 		1463
(2.2)
P 		319.2
(-3)
P 		1307
C 1677.8
(2)
P 		1548.3
(1.6)
P 		1956.6
(3)
P 		197.3
(-3)
P 		1759
avr 1746.6
(3) 		1321.1
(1.3) 		1647
(2.6) 		227.3
(-3) 		1519

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1256
1 2 3 4 5 6 range
A 712.5
(-3)
P 		1918.6
(3)
P 		857.5
(-2.3)
P 		1127.3
(-0.9)
P 		1076.7
(-1.2)
P 		718.8
(-3)
P 		1206
B 1669.4
(3)
P 		1662.9
(3)
P 		1150.6
(-0.9)
P 		1127.9
(-1)
P 		1375.2
(0.8)
P 		861.2
(-3)
P 		808
C 1805.6
(3)
P 		1351
(0.6)
P 		1508.2
(1.4)
P 		829.9
(-2.1)
P 		1220.8
(-0.1)
P 		663.1
(-3)
P 		1143
avr 1395.8
(1.3) 		1644.2
(3) 		1172.1
(-0.2) 		1028.4
(-1.1) 		1224.2
(0.2) 		747.7
(-3) 		897
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 194018_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.12697
Sequence Type Exemplar sequence
Representative Public ID F23B12.5 NCBI
Target Description F23B12.5 /REP_DB=WormBase Gene ID /WP=CE09597 /TR=Q19749 /GB=CAB01163.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=dihyrolipoamide acetyltransferase component (pyruvate dehydrogenase complex)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_074178(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_074178 NCBI Caenorhabditis elegans F23B12.5 (F23B12.5) mRNA, complete cds. 11/11 None
SNAP00000025805 ENSEMBL cdna:SNAP chromosome:CEL140:V:14448178:14449876:-1 11/11 None
GENEFINDER00000025813 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:14448178:14449876:-1 11/11 None
F23B12.5 ENSEMBL cdna:known chromosome:CEL140:V:14447913:14449879:-1 gene:F23B12.5 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:14448177-14449876(-) 100.0 100.0
Public Domain and Genome References
Gene Title dihyrolipoamide acetyltransferase component (pyruvate dehydrogenase complex)
Ensembl F23B12.5
Entrez Gene 179945 Entrez gene
SwissProt Q19749 EMBL-EBI
WormBase CE09597 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:262963_AT dihydrolipoamide S-acetyltransferase, putative at
ATGENOME1:18189_AT dihydrolipoamide S-acetyltransferase, putative at
CANINE_2:CFA.17725.1.S1_S_AT similar to dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) cfa
CANINE_2:CFAAFFX.21650.1.S1_AT similar to dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) cfa
DROSOPHILA_2:1638067_A_AT dm
DROSGENOME1:145955_AT dm
CHICKEN:GGA.8300.1.S1_AT similar to dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex); dihydrolipoamide S-acetyltransferase precursor gga
CHICKEN:GGA.8300.3.S1_AT similar to dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex); dihydrolipoamide S-acetyltransferase precursor gga
HG-U133_PLUS_2:213149_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) hs
HG-U133A_2:213149_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) hs
HG-U133A:213149_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) hs
HG-U133_PLUS_2:211150_S_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) hs
HG-U133A:211150_S_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) hs
HG-U133A_2:211150_S_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) hs
HG-U133A_2:212568_S_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) hs
HG-U133_PLUS_2:212568_S_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) hs
HG-U133A:212568_S_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) hs
HUGENEFL:Y00978_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) hs
U133_X3P:G619443_3P_A_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) hs
U133_X3P:HS.115285.1.S1_3P_A_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) hs
HG-U95AV2:39041_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) hs
HG-U95E:84706_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) hs
HG-U95C:51526_AT Dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) hs
MU11KSUBA:AA408955_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) mm
MU11KSUBB:MSA.17717.0_S_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) mm
MU11KSUBB:MSA.8069.0_S_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) mm
MG-U74AV2:96745_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) mm
MG-U74AV2:96746_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) mm
MG-U74BV2:105638_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) mm
MOE430A:1452005_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) mm
MOUSE430A_2:1452005_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) mm
MOUSE430_2:1452005_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) mm
MOE430A:1426265_X_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) mm
MOUSE430A_2:1426265_X_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) mm
MOUSE430_2:1426265_X_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) mm
MOE430A:1426264_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) mm
MOUSE430A_2:1426264_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) mm
MOUSE430_2:1426264_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) mm
MU19KSUBC:TC39657_AT Dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) (Dlat), mRNA mm
MU19KSUBC:TC39658_AT Dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) (Dlat), mRNA mm
RG-U34A:D10655_G_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) rn
RG-U34A:D10655_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) rn
RG-U34A:D00092_S_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) rn
RG-U34C:RC_AI172135_I_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) rn
RAE230A:1388194_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) rn
RAT230_2:1388194_AT dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) rn
RG-U34A:RC_AA892485_AT Dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) rn
YEAST_2:1776215_AT Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6096 glycolysis inferred from electronic annotation QuickGO AmiGO
8152 metabolism inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
45254 pyruvate dehydrogenase complex inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4742 dihydrolipoyllysine-residue acetyltransferase activity inferred from electronic annotation QuickGO AmiGO
5515 protein binding inferred from electronic annotation QuickGO AmiGO
8415 acyltransferase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB01163 Hypothetical protein F23B12.5 [Caenorhabditis elegans] ref|NP_506579.1| F23B12.5 [Caenorhabditis elegans] 0.0
blast CAE60897 Hypothetical protein CBG04612 [Caenorhabditis briggsae] 0.0
blast XP_862015 PREDICTED: similar to dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) isoform 2 [Canis familiaris] 1.0E-127
Protein Domains
Database ID Description E-Value
Pfam IPR004167 EMBL-EBI E3 binding 4.3E-21
Pfam IPR001078 EMBL-EBI Catalytic domain of components of various dehydrogenase complexes 1.0E-126
Pfam IPR000089 EMBL-EBI Biotin/lipoyl attachment 3.5E-19
Sequence
Target Sequence 
>C. ELEGANS:194018_S_AT
gaaaagctcaacggtcttcttgcaaagggaacatcgggacaagccactaagatctcaatc
aatgactttatcatcaaagcttctgctcttgcatgtcaacgagttccagaagccaacagc
tattggatggactcgttcattcgtgagaatcatcacgtcgatgtttctgtagctgtcagc
accccagccggtcttattactccaattatcttcaatgctcacgctaagggactcgccacg
attgcctcagaaattgtagaattggcgcaaagagcacgcgaaggaaaattgcagcctcat
gagttccaaggaggtactttcaccgtctcgaacctcggaatgttcggatctgtatctgat
ttcaccgcgatcatcaacccaccacaatcatgcattttggctatcggaggagcatctgat
aagctggtcccagacgaggctgaaggatataagaagattaagactatgaaggtaacattg
tcatgcgatcacaggactgttgatggagctgttggagccgtctggcttcgtcacttcaag
gagttc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GAAAAGCTCAACGGTCTTCTTGCAA 704 353 961 Antisense
AAAGCTTCTGCTCTTGCATGTCAAC 430 123 1036 Antisense
GATGTTTCTGTAGCTGTCAGCACCC 670 409 1120 Antisense
CAATGCTCACGCTAAGGGACTCGCC 302 183 1173 Antisense
TCGCCACGATTGCCTCAGAAATTGT 691 597 1193 Antisense
CCAAGGAGGTACTTTCACCGTCTCG 236 277 1266 Antisense
TCACCGTCTCGAACCTCGGAATGTT 92 625 1280 Antisense
GATCTGTATCTGATTTCACCGCGAT 56 419 1307 Antisense
CAACCCACCACAATCATGCATTTTG 611 187 1335 Antisense
GGAGCATCTGATAAGCTGGTCCCAG 17 521 1369 Antisense
CTGGCTTCGTCACTTCAAGGAGTTC 222 241 1482 Antisense
Sequence Source Affymetrix Proprietary Database