[Home] | [Total List]

[194016_at] Src homology domain 2, tyrosine-protein kinase (FES/FPS subfamily)

Description T04B2.2 /REP_DB=WormBase Gene ID /WP=CE03609 /GEN=frk-1 /TR=Q22146 /GB=CAA92609.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=Src homology domain 2, tyrosine-protein kinase (FES-FPS subfamily)
Cluster 6grp_total > 97      4grp_total > 21      6grp_cgc > 69      6grp_cgc_sub > Da      6grp_total_sub > Increase      6grp_rule_based > S6      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 46
1 2 3 4 range
A 49.3
(0.4)
P 		22.9
(-3)
A 		30.1
(-2.1)
A 		68.9
(3)
P 		46
B 47
(0.9)
P 		29.6
(-3)
A 		32.9
(-2.3)
A 		56.5
(3)
P 		27
C 47.5
(0.4)
P 		62
(3)
A 		27.9
(-3)
A 		30.4
(-2.6)
A 		34
avr 47.9
(1.9) 		38.2
(-0.8) 		30.3
(-3) 		51.9
(3) 		22

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 120
1 2 3 4 5 6 range
A 10.9
(-2.8)
A 		6.6
(-3)
A 		27.3
(-2)
A 		53.5
(-0.7)
P 		46.7
(-1)
P 		127
(3)
P 		120
B 40.6
(-1.2)
A 		17.2
(-3)
A 		25
(-2.4)
A 		27.6
(-2.2)
A 		93.7
(2.8)
P 		96.7
(3)
P 		80
C 8.7
(-3)
A 		27
(-1.9)
A 		54.5
(-0.2)
P 		33.9
(-1.5)
A 		95
(2.3)
P 		107.3
(3)
P 		99
avr 20.1
(-2.8) 		16.9
(-3) 		35.6
(-1.8) 		38.3
(-1.6) 		78.5
(1) 		110.3
(3) 		93
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 13
1 2 3 4 range
A 17.9
(3)
P 		5
(-3)
A 		7.9
(-1.7)
A 		10.1
(-0.6)
P 		13
B 15
(3)
P 		7.3
(-3)
A 		7.6
(-2.8)
A 		12
(0.7)
P 		8
C 15.7
(2)
P 		17.8
(3)
A 		9.7
(-0.8)
A 		5.1
(-3)
A 		13
avr 16.2
(3) 		10
(-1.8) 		8.4
(-3) 		9.1
(-2.5) 		8

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 36
1 2 3 4 5 6 range
A 2
(-3)
A 		2.4
(-2.9)
A 		5.9
(-2.2)
A 		13.6
(-0.6)
P 		14.1
(-0.5)
P 		30.9
(3)
P 		29
B 14.1
(-1.4)
A 		5.7
(-3)
A 		6.1
(-2.9)
A 		7.3
(-2.7)
A 		38.1
(3)
P 		36
(2.6)
P 		32
C 3.2
(-3)
A 		8.2
(-2.1)
A 		13.9
(-1)
P 		6.8
(-2.3)
A 		30.8
(2.1)
P 		35.9
(3)
P 		33
avr 6.4
(-2.8) 		5.4
(-3) 		8.6
(-2.3) 		9.2
(-2.2) 		27.7
(1.6) 		34.3
(3) 		29
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 194016_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.9417
Sequence Type Exemplar sequence
Representative Public ID T04B2.2 NCBI
Target Description T04B2.2 /REP_DB=WormBase Gene ID /WP=CE03609 /GEN=frk-1 /TR=Q22146 /GB=CAA92609.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=Src homology domain 2, tyrosine-protein kinase (FES-FPS subfamily)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_069417(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_069417 NCBI Caenorhabditis elegans Fer oncogene Related Kinase family member (frk-1) (frk-1) mRNA, complete cds. 11/11 None
SNAP00000005413 ENSEMBL cdna:SNAP chromosome:CEL140:IV:10044235:10045570:1 11/11 None
GENEFINDER00000005423 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:10044235:10045570:1 11/11 None
T04B2.2 ENSEMBL cdna:known chromosome:CEL140:IV:10043941:10045620:1 gene:T04B2.2 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:10044240-10045576(+) 100.0 100.0
Public Domain and Genome References
Gene Title Src homology domain 2, tyrosine-protein kinase (FES/FPS subfamily)
Gene Symbol frk-1
Ensembl T04B2.2
Entrez Gene 191635 Entrez gene
SwissProt Q22146 EMBL-EBI
WormBase CE03609 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1582442_AT fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) cfa
CANINE_2:CFA.3618.1.S1_AT fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) cfa
CANINE_2:CFAAFFX.12026.1.S1_S_AT fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) cfa
DROSOPHILA_2:1639139_A_AT Fps oncogene analog dm
DROSGENOME1:143164_AT Fps oncogene analog dm
CHICKEN:GGA.2822.1.S1_S_AT fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) gga
HG-U133_PLUS_2:206412_AT fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) hs
HG-U133A:206412_AT fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) hs
HG-FOCUS:206412_AT fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) hs
HG-U133A_2:206412_AT fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) hs
U133_X3P:G4885230_3P_AT fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) hs
HG-U95AV2:35133_AT fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) hs
HG-U95B:44226_AT Fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) hs
HG-U95C:61158_AT Fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) hs
HU35KSUBC:RC_H89946_AT Fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) hs
HU35KSUBC:RC_W57875_AT Fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) hs
MOE430A:1426090_A_AT fer (fms/fps related) protein kinase, testis specific 2 mm
MOUSE430A_2:1426090_A_AT fer (fms/fps related) protein kinase, testis specific 2 mm
MOUSE430_2:1426090_A_AT fer (fms/fps related) protein kinase, testis specific 2 mm
MU11KSUBA:U76762_S_AT fer (fms/fps related) protein kinase, testis specific 2 mm
MG-U74AV2:99321_AT fer (fms/fps related) protein kinase, testis specific 2 mm
MOE430A:1421729_A_AT fer (fms/fps related) protein kinase, testis specific 2 mm
MOUSE430A_2:1421729_A_AT fer (fms/fps related) protein kinase, testis specific 2 mm
MOUSE430_2:1421729_A_AT fer (fms/fps related) protein kinase, testis specific 2 mm
RG-U34A:X13412CDS_AT tyrosine protein kinase FLK rn
RG-U34A:X13412CDS_G_AT tyrosine protein kinase FLK rn
RG-U34B:RC_AI044892_AT tyrosine protein kinase FLK rn
RAE230A:1382672_A_AT tyrosine protein kinase FLK rn
RAT230_2:1382672_A_AT tyrosine protein kinase FLK rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA92609 Hypothetical protein T04B2.2 [Caenorhabditis elegans] ref|NP_501818.1| Fer oncogene Related Kinase family member (frk-1) [Caenorhabditis elegans] 0.0
blast CAE67145 Hypothetical protein CBG12568 [Caenorhabditis briggsae] 0.0
blast CAA95813 Hypothetical protein F22D6.1 [Caenorhabditis elegans] ref|NP_492004.1| protein KINase family member (kin-14) [Caenorhabditis elegans] 1.0E-113
Protein Families
Method ID Description E-Value
hanks 1.1.18 AGC group; AGC I Cyclic nucleotide regulated protein kinase (PKA & PKG); DG2 5.0E-64
Protein Domains
Database ID Description E-Value
Pfam IPR000980 EMBL-EBI SH2 motif 7.8E-12
Pfam IPR000719 EMBL-EBI Protein kinase 4.3E-67
Sequence
Target Sequence 
>C. ELEGANS:194016_AT
gagattcacgactgaagctgccgacggaatcgcatacttggagagatctaagtgcattca
ccgtgacatcgctgctagaaattgccttttgtcagcgaaaaatgagctgaaaatctctga
tttcggaatgtcggataacaaggatgagattaaggatgaaacccttgaaaaggttcccat
taagtggttggcaccagagacaatgcaggagaaagtgtacactcataagactgatatctg
gacattcggagttctcgtttgggagatttattctgatggagctgagccatatccaggatt
gacgaaaattcaaactcgtgccaagatagttgtcaacgactacagaatgaaaatgccaga
cggaacacatccaactgttgctgacgttgtaactggaacctgttggc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GAGATTCACGACTGAAGCTGCCGAC 149 397 702 Antisense
AGCTGCCGACGGAATCGCATACTTG 233 81 717 Antisense
AAGTGCATTCACCGTGACATCGCTG 361 159 751 Antisense
CATCGCTGCTAGAAATTGCCTTTTG 473 211 768 Antisense
AAATCTCTGATTTCGGAATGTCGGA 653 117 812 Antisense
GGTTCCCATTAAGTGGTTGGCACCA 495 501 873 Antisense
CTGATGGAGCTGAGCCATATCCAGG 172 239 974 Antisense
GAAAATTCAAACTCGTGCCAAGATA 424 353 1005 Antisense
AATGCCAGACGGAACACATCCAACT 261 167 1053 Antisense
ACATCCAACTGTTGCTGACGTTGTA 193 103 1068 Antisense
GACGTTGTAACTGGAACCTGTTGGC 586 377 1084 Antisense
Sequence Source Affymetrix Proprietary Database