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[193998_at] RNA recognition motif. (aka RRM, RBD, or RNP domain) (2 domains)

Description C17D12.2 /REP_DB=WormBase Gene ID /WP=CE18507 /TR=O62068 /GB=CAB03896.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=RNA recognition motif. (aka RRM, RBD, or RNP domain) (2 domains)
Cluster 6grp_total > 37      4grp_total > 21      6grp_cgc > 05      6grp_cgc_sub > Cu      6grp_total_sub > Cup      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 193
1 2 3 4 range
A 48.7
(-1.3)
A 		69.6
(-0.1)
A 		16.2
(-3)
A 		127.8
(3)
A 		112
B 143
(3)
A 		92.8
(0.6)
A 		17.5
(-3)
A 		100.6
(1)
A 		126
C 106.7
(-0.3)
A 		22.8
(-3)
A 		62.5
(-1.7)
A 		208.9
(3)
A 		186
avr 99.5
(0.6) 		61.7
(-1.4) 		32.1
(-3) 		145.8
(3) 		114

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 88
1 2 3 4 5 6 range
A 95.3
(3)
A 		7.4
(-3)
A 		30.5
(-1.4)
A 		10.1
(-2.8)
A 		14.6
(-2.5)
A 		14.8
(-2.5)
A 		88
B 51.9
(-0.2)
A 		91.8
(2.9)
A 		16.5
(-3)
A 		17.7
(-2.9)
A 		35.5
(-1.5)
A 		93.2
(3)
A 		77
C 27.4
(0.8)
A 		37.4
(3)
A 		15.7
(-1.8)
A 		19.5
(-0.9)
A 		10.2
(-3)
A 		11.8
(-2.6)
A 		27
avr 58.2
(3) 		45.5
(1.2) 		20.9
(-2.3) 		15.8
(-3) 		20.1
(-2.4) 		39.9
(0.4) 		42
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 42
1 2 3 4 range
A 17.7
(2.6)
A 		15.1
(1.5)
A 		4.2
(-3)
A 		18.7
(3)
A 		15
B 45.6
(3)
A 		22.9
(-0.3)
A 		4.1
(-3)
A 		21.4
(-0.5)
A 		42
C 35.3
(3)
A 		6.6
(-3)
A 		21.8
(0.2)
A 		35.2
(3)
A 		29
avr 32.9
(3) 		14.9
(-1.7) 		10
(-3) 		25.1
(1) 		23

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 32
1 2 3 4 5 6 range
A 17.6
(3)
A 		2.6
(-3)
A 		6.6
(-1.4)
A 		2.6
(-3)
A 		4.4
(-2.3)
A 		3.6
(-2.6)
A 		15
B 18.1
(-0.3)
A 		30.6
(2.2)
A 		4
(-3)
A 		4.7
(-2.9)
A 		14.4
(-1)
A 		34.8
(3)
A 		31
C 10.2
(2.1)
A 		11.4
(3)
A 		4
(-2.5)
A 		3.9
(-2.6)
A 		3.3
(-3)
A 		4
(-2.5)
A 		8
avr 15.3
(3) 		14.9
(2.8) 		4.9
(-2.4) 		3.7
(-3) 		7.4
(-1.1) 		14.1
(2.4) 		12
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193998_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.1417
Sequence Type Exemplar sequence
Representative Public ID C17D12.2 NCBI
Target Description C17D12.2 /REP_DB=WormBase Gene ID /WP=CE18507 /TR=O62068 /GB=CAB03896.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=RNA recognition motif. (aka RRM, RBD, or RNP domain) (2 domains)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_060557(9)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_060557 NCBI Caenorhabditis elegans UNCoordinated family member (unc-75) (unc-75) mRNA, complete cds. 9/11 None
C17D12.2 ENSEMBL cdna:known chromosome:CEL140:I:11600424:11609727:1 gene:C17D12.2 9/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
SNAP00000011113 2/11 Cross Hyb Matching Probes None
GENEFINDER00000011120 6/11 Cross Hyb Matching Probes None
SNAP00000011114 7/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:11604999-11609376(+) 97.9 100.0
Public Domain and Genome References
Gene Title RNA recognition motif. (aka RRM, RBD, or RNP domain) (2 domains)
Gene Symbol unc-75
Ensembl C17D12.2
Entrez Gene 182722 Entrez gene
SwissProt O62068 EMBL-EBI
WormBase CE36103 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:264822_AT RNA-binding protein, putative at
ATGENOME1:18781_AT RNA-binding protein, putative at
CANINE_2:CFAAFFX.19830.1.S1_AT similar to trinucleotide repeat containing 4 cfa
CANINE_2:CFAAFFX.19849.1.S1_S_AT similar to trinucleotide repeat containing 4 cfa
HG-U95AV2:34547_AT trinucleotide repeat containing 4 hs
HG-U133_PLUS_2:206817_X_AT trinucleotide repeat containing 4 hs
HG-U133A:206817_X_AT trinucleotide repeat containing 4 hs
HG-FOCUS:206817_X_AT trinucleotide repeat containing 4 hs
HG-U133A_2:206817_X_AT trinucleotide repeat containing 4 hs
HG-U133_PLUS_2:215045_AT trinucleotide repeat containing 4 hs
HG-U133A_2:215045_AT trinucleotide repeat containing 4 hs
HG-U133A:215045_AT trinucleotide repeat containing 4 hs
HU35KSUBA:RC_AA065094_AT trinucleotide repeat containing 4 hs
HU35KSUBA:RC_AA054152_AT trinucleotide repeat containing 4 hs
U133_X3P:G6005724_3P_S_AT trinucleotide repeat containing 4 hs
U133_X3P:HS.332322.0.S1_3P_AT trinucleotide repeat containing 4 hs
HG-U95B:43195_F_AT trinucleotide repeat containing 4 hs
HG-U95B:43196_R_AT trinucleotide repeat containing 4 hs
HG-U95C:51971_AT trinucleotide repeat containing 4 hs
MOE430B:1452851_AT trinucleotide repeat containing 4 mm
MOUSE430_2:1452851_AT trinucleotide repeat containing 4 mm
RAE230A:1377511_AT Similar to trinucleotide repeat containing 4 rn
RAT230_2:1377511_AT Similar to trinucleotide repeat containing 4 rn
RAE230B:1397183_AT Similar to trinucleotide repeat containing 4 rn
RAT230_2:1397183_AT Similar to trinucleotide repeat containing 4 rn
RG-U34C:RC_AI072466_AT Similar to trinucleotide repeat containing 4 rn
Protein Similarities
Method ID Description E-Value
blast CAB03896 Hypothetical protein C17D12.2 [Caenorhabditis elegans] ref|NP_492958.3| UNCoordinated family member (unc-75) [Caenorhabditis elegans] gb|AAQ19851.1| putative RNA-binding protein [Caenorhabditis elegans] 0.0
blast CAE69303 Hypothetical protein CBG15358 [Caenorhabditis briggsae] 1.0E-113
blast BAD93011.1 bruno-like 4, RNA binding protein variant [Homo sapiens] 3.0E-73
Protein Domains
Database ID Description E-Value
Pfam IPR000504 EMBL-EBI RNA-binding region RNP-1 (RNA recognition motif) 1.4E-13
Pfam IPR000504 EMBL-EBI RNA-binding region RNP-1 (RNA recognition motif) 1.2E-11
Pfam IPR000504 EMBL-EBI RNA-binding region RNP-1 (RNA recognition motif) 3.5E-21
Sequence
Target Sequence 
>C. ELEGANS:193998_AT
cagactgctcaggtgacatcgacggcttcacatgctcagactgagaatcctgccgcgagt
agctatggaagcttggcggctgcggctgctgcagcaaactatagcagtttgttaagtggg
atggaaagccagcacagccagttttctttgttttgcaaatcattattttttcgtgaaaaa
cctgtgaaattttatctgtgccgaaaatatattcgatcgattgttgtgcggtcatcacat
atcttttttcatattttttattttatttttccatattctgatttctctcaatattttttc
tcactcccttctcaatttgacgcttgtgatggtagttgtacagtgcttggtcccgatggc
tgcaaccttttcatctatcacctgccgcaagagtttggcgacgcggagctcattcaaatg
ttcgccccgttcggccacatcgtgtccgccaaagtgtttgtcgaccgtgccactaatcag
agcaagtgcttcggtttcgtgtcgtacgacaacatccattcgtcacaagctgctatcacc
gccatgaatggct

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
CAGACTGCTCAGGTGACATCGACGG 587 205 772 Antisense
CTCAGACTGAGAATCCTGCCGCGAG 545 227 806 Antisense
GCACAGCCAGTTTTCTTTGTTTTGC 390 317 903 Antisense
TGCGGTCATCACATATCTTTTTTCA 582 583 998 Antisense
GATGGCTGCAACCTTTTCATCTATC 342 407 1126 Antisense
CATCTATCACCTGCCGCAAGAGTTT 441 213 1143 Antisense
GTGTCCGCCAAAGTGTTTGTCGACC 345 485 1213 Antisense
TGTCGACCGTGCCACTAATCAGAGC 519 555 1230 Antisense
CAGAGCAAGTGCTTCGGTTTCGTGT 300 205 1249 Antisense
ATCCATTCGTCACAAGCTGCTATCA 650 39 1285 Antisense
GCTGCTATCACCGCCATGAATGGCT 54 297 1300 Antisense
Sequence Source Affymetrix Proprietary Database