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[193990_s_at] Src homology domain 2, tyrosine-protein kinase (FES/FPS subfamily)

Description F26E4.5 /REP_DB=WormBase Gene ID /WP=CE09689 /TR=O01325 /GB=CAB03003.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=Src homology domain 2, tyrosine-protein kinase (FES-FPS subfamily)
Cluster 6grp_total > 89      4grp_total > 12      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 74
1 2 3 4 range
A 35.1
(1.2)
A 		26.3
(-0.7)
A 		15.1
(-3)
A 		43.7
(3)
A 		29
B 38.1
(-2.3)
A 		59
(0.1)
A 		32.3
(-3)
A 		84
(3)
M 		52
C 41.8
(0.1)
A 		10.3
(-3)
A 		21
(-2)
A 		71.9
(3)
A 		62
avr 38.3
(-0.9) 		31.9
(-1.8) 		22.8
(-3) 		66.5
(3) 		44

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 61
1 2 3 4 5 6 range
A 41
(0.5)
A 		29.6
(-0.9)
A 		12.8
(-3)
A 		17.9
(-2.4)
A 		43.8
(0.8)
A 		61.6
(3)
P 		49
B 24.8
(-0.9)
A 		52.7
(2)
A 		27
(-0.6)
A 		4
(-3)
A 		42.9
(1)
A 		62.7
(3)
P 		59
C 2.1
(-3)
A 		38.7
(1)
A 		19.8
(-1.1)
A 		30.6
(0.1)
A 		56.8
(3)
P 		52.1
(2.5)
P 		55
avr 22.6
(-2.3) 		40.3
(0.3) 		19.9
(-2.7) 		17.5
(-3) 		47.8
(1.4) 		58.8
(3) 		41
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 15
1 2 3 4 range
A 12.8
(3)
A 		5.7
(-1.8)
A 		3.9
(-3)
A 		6.4
(-1.3)
A 		9
B 12.2
(-0.3)
A 		14.6
(1.1)
A 		7.5
(-3)
A 		17.9
(3)
M 		10
C 13.8
(3)
A 		3
(-3)
A 		7.3
(-0.6)
A 		12.1
(2.1)
A 		11
avr 12.9
(3) 		7.8
(-1.6) 		6.2
(-3) 		12.1
(2.3) 		7

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 23
1 2 3 4 5 6 range
A 7.6
(-0.6)
A 		10.5
(0.8)
A 		2.8
(-3)
A 		4.5
(-2.2)
A 		13.2
(2.1)
A 		15
(3)
P 		12
B 8.6
(-1)
A 		17.5
(1.4)
A 		6.5
(-1.5)
A 		1.1
(-3)
A 		17.4
(1.4)
A 		23.4
(3)
P 		22
C 0.8
(-3)
A 		11.8
(0.8)
A 		5.1
(-1.5)
A 		6.1
(-1.2)
A 		18.4
(3)
P 		17.4
(2.7)
P 		18
avr 5.7
(-2.3) 		13.3
(0.8) 		4.8
(-2.6) 		3.9
(-3) 		16.3
(2.1) 		18.6
(3) 		15
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 193990_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.1958
Sequence Type Exemplar sequence
Representative Public ID F26E4.5 NCBI
Target Description F26E4.5 /REP_DB=WormBase Gene ID /WP=CE09689 /TR=O01325 /GB=CAB03003.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=Src homology domain 2, tyrosine-protein kinase (FES-FPS subfamily)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_060193(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_060193 NCBI Caenorhabditis elegans F26E4.5 (F26E4.5) mRNA, complete cds. 11/11 None
SNAP00000026224 ENSEMBL cdna:SNAP chromosome:CEL140:I:9777066:9779165:-1 11/11 None
GENEFINDER00000026241 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:9777233:9780681:-1 9/11 None
F26E4.5 ENSEMBL cdna:known chromosome:CEL140:I:9777066:9779187:-1 gene:F26E4.5 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:9776996-9778670(-) 100.0 100.0
Public Domain and Genome References
Gene Title Src homology domain 2, tyrosine-protein kinase (FES/FPS subfamily)
Ensembl F26E4.5
Entrez Gene 172828 Entrez gene
SwissProt O01325 EMBL-EBI
WormBase CE32638 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB03003 Hypothetical protein F26E4.5 [Caenorhabditis elegans] ref|NP_492594.2| F26E4.5 [Caenorhabditis elegans] 0.0
blast CAE60232 Hypothetical protein CBG03803 [Caenorhabditis briggsae] 0.0
blast CAB02998 Hypothetical protein F26E4.4 [Caenorhabditis elegans] ref|NP_492595.1| F26E4.4 [Caenorhabditis elegans] 0.0
blast AAB54162 Defective spermatogenesis protein 8 [Caenorhabditis elegans] ref|NP_490680.1| defective SPErmatogenesis family member (spe-8) [Caenorhabditis elegans] 4.0E-74
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 8.0E-52
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 3.0E-52
hanks 2.1.14 CaMK Group; CaMK I Regulated by Ca2+/CaM and close relatives; MLCK-K 2.0E-62
hanks 2.1.14 CaMK Group; CaMK I Regulated by Ca2+/CaM and close relatives; MLCK-K 4.0E-64
Protein Domains
Database ID Description E-Value
Pfam IPR000980 EMBL-EBI SH2 motif 3.8E-20
Pfam IPR000719 EMBL-EBI Protein kinase 6.2E-67
Pfam IPR000980 EMBL-EBI SH2 motif 3.8E-20
Pfam IPR000719 EMBL-EBI Protein kinase 4.8E-68
Sequence
Target Sequence 
>C. ELEGANS:193990_S_AT
ggaattatgttctggtggatgcttgaaaagtcgaatcgagaagaaagatgaacaattgag
tgatgtgttgaaaagaaaatattgcaaacaaattgcaaaagggatgagatatctagagaa
aaaacaagttattcacagagatttggcagctcgtaatgtacttcttgataaatccgacaa
ttgtaagatcagtgattttggtctttctctcttcggaaaattgcacaaggagcagaaact
catgaaggttccaatcagatggttagcaccagaaactcttctaaaaggaatttattcatc
aaaatctgatgtttggagttttggagttgtgatgtttgaagtgttcagtggagaatatcc
atatgcagatgttaaggtattgaaagaacttcgacgaaaagttgctcacgaaaacctgcg
tttgaaacctccaagtgatatgccaactgatgatgcaaaagtcatggaaatgtgctttga
gccagtcgataatagagcaacatttgtgcaagtctgcaacaggtacaaagatctcacaag
cccattgcctacatgga

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GGAATTATGTTCTGGTGGATGCTTG 255 533 552 Antisense
GGCAGCTCGTAATGTACTTCTTGAT 556 523 696 Antisense
ATGGTTAGCACCAGAAACTCTTCTA 33 51 810 Antisense
GGAGTTTTGGAGTTGTGATGTTTGA 480 517 866 Antisense
AAAGTTGCTCACGAAAACCTGCGTT 590 121 949 Antisense
AACCTGCGTTTGAAACCTCCAAGTG 651 135 964 Antisense
ACCTCCAAGTGATATGCCAACTGAT 117 89 978 Antisense
TGTGCTTTGAGCCAGTCGATAATAG 191 543 1022 Antisense
GAGCAACATTTGTGCAAGTCTGCAA 42 391 1046 Antisense
ACAGGTACAAAGATCTCACAAGCCC 232 107 1070 Antisense
CTCACAAGCCCATTGCCTACATGGA 45 229 1084 Antisense
Sequence Source Affymetrix Proprietary Database