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[193985_at] MYC family of helix-loop-helix transcription factors

Description C02B8.4 /REP_DB=WormBase Gene ID /WP=CE24777 /GEN=hlh-8 /TR=SW:Q11094 /GB=AAA81437.2 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=MYC family of helix-loop-helix transcription factors
Cluster 6grp_total > 09      4grp_total > 13      6grp_cgc > 0      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 88
1 2 3 4 range
A 98.7
(-1.6)
P 		79.6
(-3)
A 		85.3
(-2.6)
A 		160.8
(3)
A 		81
B 140.5
(3)
A 		75.9
(-3)
A 		103
(-0.5)
A 		135.7
(2.6)
A 		65
C 109.3
(0.9)
P 		121.2
(2.1)
A 		72.4
(-3)
M 		129.7
(3)
P 		57
avr 116.2
(0.2) 		92.2
(-2.4) 		86.9
(-3) 		142.1
(3) 		55

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 115
1 2 3 4 5 6 range
A 174.5
(3)
A 		103.4
(-1.3)
A 		74.7
(-3)
A 		126.1
(0.1)
P 		91.6
(-2)
M 		89.2
(-2.1)
A 		100
B 113.4
(1.3)
A 		90.2
(-0.6)
P 		66.8
(-2.4)
A 		135.4
(3)
P 		84.6
(-1)
P 		59.8
(-3)
A 		76
C 88.9
(-1.3)
P 		85.2
(-1.9)
M 		101.2
(0.5)
P 		118
(3)
A 		77.6
(-3)
P 		83.8
(-2.1)
A 		40
avr 125.6
(2.9) 		92.9
(-1.1) 		80.9
(-2.6) 		126.5
(3) 		84.6
(-2.1) 		77.6
(-3) 		49
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 28
1 2 3 4 range
A 36
(3)
P 		17.3
(-3)
A 		22.3
(-1.4)
A 		23.5
(-1)
A 		19
B 44.8
(3)
A 		18.7
(-3)
A 		23.9
(-1.8)
A 		28.9
(-0.7)
A 		26
C 36.2
(3)
P 		34.8
(2.4)
A 		25.2
(-1.6)
M 		21.9
(-3)
P 		14
avr 39
(3) 		23.6
(-3) 		23.8
(-2.9) 		24.8
(-2.5) 		15

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 23
1 2 3 4 5 6 range
A 32.2
(1.7)
A 		36.8
(3)
A 		16.3
(-3)
A 		32
(1.6)
P 		27.6
(0.3)
M 		21.7
(-1.4)
A 		21
B 39.5
(3)
A 		30
(0.6)
P 		16.2
(-3)
A 		35.9
(2.1)
P 		34.4
(1.7)
P 		22.3
(-1.4)
A 		23
C 32.9
(3)
P 		26
(-1.5)
M 		25.7
(-1.7)
P 		23.7
(-3)
A 		25.1
(-2.1)
P 		28
(-0.2)
A 		9
avr 34.9
(3) 		30.9
(1.5) 		19.4
(-3) 		30.5
(1.3) 		29
(0.7) 		24
(-1.2) 		16
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193985_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.17078
Sequence Type Exemplar sequence
Representative Public ID C02B8.4 NCBI
Target Description C02B8.4 /REP_DB=WormBase Gene ID /WP=CE24777 /GEN=hlh-8 /TR=SW:Q11094 /GB=AAA81437.2 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=MYC family of helix-loop-helix transcription factors
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_076966(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_076966 NCBI Caenorhabditis elegans Helix Loop Helix family member (hlh-8) (hlh-8) mRNA, complete cds. 11/11 None
GENEFINDER00000001649 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:8116321:8120046:1 11/11 None
C02B8.4 ENSEMBL cdna:known chromosome:CEL140:X:8116578:8120046:1 gene:C02B8.4 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
SNAP00000001636 8/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:8116576-8120045(+) 100.0 100.0
Public Domain and Genome References
Gene Title MYC family of helix-loop-helix transcription factors
Gene Symbol hlh-8
Ensembl C02B8.4
Entrez Gene 181069 Entrez gene
SwissProt Q11094 EMBL-EBI
WormBase CE24777 Wormbase
Functional Annotations
Protein Similarities
Method ID Description E-Value
blast AAA81437 Helix loop helix protein 8 [Caenorhabditis elegans] ref|NP_509367.1| Helix Loop Helix family member (hlh-8) [Caenorhabditis elegans] sp|Q11094|TWIST_CAEEL Twist-related protein (CeTwist) (Helix-loop-helix protein 8) gb|AAC26105.1| twist [Caenorhabditis elegans] 9.0E-74
blast AAA81437 Helix loop helix protein 8 [Caenorhabditis elegans] ref|NP_509367.1| Helix Loop Helix family member (hlh-8) [Caenorhabditis elegans] sp|Q11094|TWIST_CAEEL Twist-related protein (CeTwist) (Helix-loop-helix protein 8) gb|AAC26105.1| twist [Caenorhabditis elegans] 2.0E-73
blast CAE70353 Hypothetical protein CBG16905 [Caenorhabditis briggsae] 4.0E-62
blast CAE70353 Hypothetical protein CBG16905 [Caenorhabditis briggsae] 7.0E-62
blast T15373 hypothetical protein C02B8.4 - Caenorhabditis elegans 2.0E-14
blast T15373 hypothetical protein C02B8.4 - Caenorhabditis elegans 4.0E-14
Protein Domains
Database ID Description E-Value
Pfam IPR001092 EMBL-EBI Basic helix-loop-helix dimerization domain bHLH 4.4E-19
Pfam IPR001092 EMBL-EBI Basic helix-loop-helix dimerization domain bHLH 4.4E-19
Sequence
Target Sequence 
>C. ELEGANS:193985_AT
gcatgtgccaacagacgggaacgtcaaaggaccaaggaactcaatgacgctttcacactt
ttgcgtaaactgatcccgtcgatgccctcagacaagatgagcaagatccacacactacgc
attgcaaccgattacatatccttccttgacgagatgcaaaaaaatggatgcaaactgtat
ggccattcgatcttcgacgaaaaacgtggatacaatttacagtcggctttcaatatgtgg
aggggtaacaatggatacacaccaattgctggaccttcacagttgcctccactacaatct
gcacatattccccctcctgctccatccagcattcctccacactgtctgatgccccagcct
tggtatcagacttgtccgccgccaaaacaagaatttcatgaactgtgtcccatctcaac

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GCATGTGCCAACAGACGGGAACGTC 262 309 79 Antisense
GGAACTCAATGACGCTTTCACACTT 634 529 114 Antisense
TTTGCGTAAACTGATCCCGTCGATG 275 663 138 Antisense
CCGTCGATGCCCTCAGACAAGATGA 453 265 154 Antisense
CACACACTACGCATTGCAACCGATT 706 193 187 Antisense
CAACCGATTACATATCCTTCCTTGA 455 187 203 Antisense
AACTGTATGGCCATTCGATCTTCGA 298 143 251 Antisense
CAATTGCTGGACCTTCACAGTTGCC 505 179 341 Antisense
TCCACTACAATCTGCACATATTCCC 519 587 366 Antisense
CAGCCTTGGTATCAGACTTGTCCGC 251 203 433 Antisense
TTCATGAACTGTGTCCCATCTCAAC 571 687 473 Antisense
Sequence Source Affymetrix Proprietary Database