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[193980_at] Natriuretic peptides receptors, guanylate cyclase

Description T03D8.5 /REP_DB=WormBase Gene ID /WP=CE18923 /GEN=gcy-22 /TR=Q9XTY1 /GB=CAB07410.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=Natriuretic peptides receptors, guanylate cyclase
Cluster 6grp_total > 16      4grp_total > 30      6grp_cgc > 13      6grp_cgc_sub > De      6grp_total_sub > Decrease      6grp_rule_based > S1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 118
1 2 3 4 range
A 175.8
(3)
P 		115.9
(-1.3)
A 		92.2
(-3)
A 		130.4
(-0.3)
P 		84
B 147.8
(3)
P 		135.3
(1.5)
A 		99.4
(-3)
A 		111.9
(-1.5)
A 		48
C 156.7
(2.8)
P 		106.8
(-0.1)
P 		58
(-3)
M 		159.6
(3)
P 		102
avr 160.1
(3) 		119.3
(-0.2) 		83.2
(-3) 		134
(1) 		77

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 147
1 2 3 4 5 6 range
A 224.1
(3)
M 		110.4
(-1.9)
P 		86.2
(-3)
A 		106.1
(-2.1)
P 		93.9
(-2.7)
A 		115.2
(-1.7)
P 		138
B 157.7
(2.3)
P 		168.9
(3)
M 		125.3
(0.2)
A 		76.9
(-3)
A 		103.5
(-1.3)
A 		110.2
(-0.8)
P 		92
C 127.5
(0.4)
P 		161.9
(3)
P 		107.2
(-1.2)
A 		117.6
(-0.4)
A 		114
(-0.7)
P 		83.8
(-3)
P 		78
avr 169.8
(3) 		147.1
(1) 		106.2
(-2.5) 		100.2
(-3) 		103.8
(-2.7) 		103.1
(-2.8) 		70
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 45
1 2 3 4 range
A 64
(3)
P 		25.2
(-2.2)
A 		24.1
(-2.3)
A 		19.1
(-3)
P 		45
B 47.1
(3)
P 		33.4
(-0.4)
A 		23
(-3)
A 		23.9
(-2.8)
A 		24
C 51.9
(3)
P 		30.7
(-1)
P 		20.2
(-3)
M 		26.9
(-1.7)
P 		32
avr 54.3
(3) 		29.8
(-1.6) 		22.4
(-3) 		23.3
(-2.8) 		32

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 37
1 2 3 4 5 6 range
A 41.3
(3)
M 		39.3
(2.5)
P 		18.8
(-3)
A 		26.9
(-0.8)
P 		28.3
(-0.5)
A 		28
(-0.5)
P 		23
B 54.9
(2.8)
P 		56.2
(3)
M 		30.4
(-1.3)
A 		20.4
(-3)
A 		42.1
(0.6)
A 		41.1
(0.5)
P 		36
C 47.3
(2.5)
P 		49.4
(3)
P 		27.3
(-2.1)
A 		23.6
(-3)
A 		36.9
(0.1)
P 		28.1
(-2)
P 		26
avr 47.8
(2.9) 		48.3
(3) 		25.5
(-2.5) 		23.6
(-3) 		35.8
(-0) 		32.4
(-0.9) 		25
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193980_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.13223
Sequence Type Exemplar sequence
Representative Public ID T03D8.5 NCBI
Target Description T03D8.5 /REP_DB=WormBase Gene ID /WP=CE18923 /GEN=gcy-22 /TR=Q9XTY1 /GB=CAB07410.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=Natriuretic peptides receptors, guanylate cyclase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_075617(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_075617 NCBI Caenorhabditis elegans Guanylyl CYclase family member (gcy-22) (gcy-22) mRNA, complete cds. 11/11 None
SNAP00000040018 ENSEMBL cdna:SNAP chromosome:CEL140:V:20818456:20823079:-1 11/11 None
GENEFINDER00000040027 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:20818456:20823079:-1 11/11 None
T03D8.5 ENSEMBL cdna:known chromosome:CEL140:V:20818417:20823079:-1 gene:T03D8.5 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:20818455-20823079(-) 100.0 100.0
Public Domain and Genome References
Gene Title Natriuretic peptides receptors, guanylate cyclase
Gene Symbol gcy-22
Ensembl T03D8.5
Entrez Gene 180365 Entrez gene
SwissProt Q9XTY1 EMBL-EBI
WormBase CE18923 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4383 guanylate cyclase activity inferred from electronic annotation QuickGO AmiGO
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB07410 Hypothetical protein T03D8.5 [Caenorhabditis elegans] ref|NP_508018.1| Guanylyl CYclase family member (gcy-22) [Caenorhabditis elegans] 0.0
blast CAE61635 Hypothetical protein CBG05567 [Caenorhabditis briggsae] 0.0
blast CAE66058 Hypothetical protein CBG11271 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 2.1E-11
Pfam IPR001054 EMBL-EBI Guanylate cyclase 1.2E-89
Pfam IPR001828 EMBL-EBI Extracellular ligand-binding receptor 6.5E-11
Pfam IPR001828 EMBL-EBI Extracellular ligand-binding receptor 3.2E-13
Pfam IPR000719 EMBL-EBI Protein kinase 2.1E-11
Pfam IPR001054 EMBL-EBI Guanylate cyclase 1.2E-89
Pfam IPR001828 EMBL-EBI Extracellular ligand-binding receptor 5.3E-27
Pfam IPR000719 EMBL-EBI Protein kinase 2.1E-11
Pfam IPR001054 EMBL-EBI Guanylate cyclase 1.2E-89
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_508018.1 3 7-29,44-66,422-444
T03D8.5 3 7-29,44-66,422-444
SNAP00000040018 3 7-29,44-66,460-482
GENEFINDER00000040027 3 7-29,44-66,464-486
Sequence
Target Sequence 
>C. ELEGANS:193980_AT
tttgactgtgtcaccatcttcttttccgatgtcgtatcatttacgacattagcctcaaga
tgcactccacttcaagtagttaatcttttgaatgacttgtacacaactttcgatgcaatc
attgaacaacatgacgtttacaaggtagaaacaattggtgatggatatttatgtgtctcc
ggtttaccacatcgtaacggaaatgaacacgcaaaagaaatttcatcaatgtccttctcc
cttttgaaagccataaaaacattccgtgtaccccatttgccaaaggaacgaataaacatt
cgtgttggattacatacaggaccagtcgtaacaggagttgttggaatgactatgcctaga
tactgtttgtttggggattccgttaatactgcaagta

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TTTGACTGTGTCACCATCTTCTTTT 548 667 2461 Antisense
ATCTTCTTTTCCGATGTCGTATCAT 358 31 2476 Antisense
GTATCATTTACGACATTAGCCTCAA 155 455 2494 Antisense
CTCAAGATGCACTCCACTTCAAGTA 554 227 2514 Antisense
GATATTTATGTGTCTCCGGTTTACC 228 425 2624 Antisense
TCTCCGGTTTACCACATCGTAACGG 134 609 2636 Antisense
TCCTTCTCCCTTTTGAAAGCCATAA 36 593 2692 Antisense
CATAAAAACATTCCGTGTACCCCAT 654 211 2712 Antisense
CAGGACCAGTCGTAACAGGAGTTGT 284 207 2777 Antisense
GACTATGCCTAGATACTGTTTGTTT 317 373 2808 Antisense
GGGGATTCCGTTAATACTGCAAGTA 332 497 2833 Antisense
Sequence Source Affymetrix Proprietary Database