[Home] | [Total List]

[193966_s_at] Src homology domain 2, protein tyrosine kinase (ABL subfamily) /// Eukaryotic protein kinase domain

Description T25B9.5 /REP_DB=WormBase Gene ID /WP=CE06504 /TR=Q22766 /GB=CAA94373.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=Src homology domain 2, protein tyrosine kinase (ABL subfamily)
Cluster 6grp_total > 69      4grp_total > 17      6grp_total_sub > Cup      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 126
1 2 3 4 range
A 48.1
(-2.1)
A 		37.5
(-3)
A 		83.9
(0.8)
A 		110.5
(3)
P 		73
B 17.6
(-3)
A 		58
(3)
A 		38.7
(0.1)
A 		37.7
(-0)
P 		40
C 36.6
(-3)
A 		66
(-1.4)
A 		43.8
(-2.6)
A 		143.6
(3)
P 		107
avr 34.1
(-3) 		53.8
(-1.1) 		55.5
(-1) 		97.3
(3) 		63

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 94
1 2 3 4 5 6 range
A 62.1
(-0.5)
A 		46.4
(-1.8)
M 		93.5
(2.1)
P 		35.6
(-2.7)
M 		31.5
(-3)
A 		104.3
(3)
M 		73
B 66.5
(3)
A 		38.3
(-1.3)
M 		26.9
(-3)
A 		35
(-1.8)
M 		45.9
(-0.1)
M 		66.4
(3)
P 		40
C 14.9
(-2.6)
A 		49.6
(0.9)
A 		10.4
(-3)
A 		25.4
(-1.5)
A 		70.6
(3)
P 		47.3
(0.7)
P 		60
avr 47.8
(-0.7) 		44.8
(-1.1) 		43.6
(-1.3) 		32
(-3) 		49.3
(-0.4) 		72.7
(3) 		41
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 19
1 2 3 4 range
A 17.5
(1.1)
A 		8.1
(-3)
A 		21.9
(3)
A 		16.2
(0.5)
P 		14
B 5.6
(-3)
A 		14.3
(3)
A 		9
(-0.7)
A 		8
(-1.3)
P 		9
C 12.1
(-3)
A 		19
(0.4)
A 		15.3
(-1.4)
A 		24.2
(3)
P 		12
avr 11.7
(-3) 		13.8
(-0.1) 		15.4
(2) 		16.1
(3) 		4

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 23
1 2 3 4 5 6 range
A 11.5
(-2.1)
A 		16.5
(-0.3)
M 		20.4
(1.2)
P 		9
(-3)
M 		9.5
(-2.8)
A 		25.4
(3)
M 		16
B 23.1
(2.4)
A 		12.7
(-1)
M 		6.5
(-3)
A 		9.3
(-2.1)
M 		18.7
(1)
M 		24.8
(3)
P 		18
C 5.5
(-2.1)
A 		15.1
(0.7)
A 		2.6
(-3)
A 		5.1
(-2.3)
A 		22.9
(3)
P 		15.8
(0.9)
P 		20
avr 13.4
(-0.6) 		14.8
(-0) 		9.8
(-2.2) 		7.8
(-3) 		17
(0.9) 		22
(3) 		14
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 193966_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.9413
Sequence Type Exemplar sequence
Representative Public ID T25B9.5 NCBI
Target Description T25B9.5 /REP_DB=WormBase Gene ID /WP=CE06504 /TR=Q22766 /GB=CAA94373.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=Src homology domain 2, protein tyrosine kinase (ABL subfamily)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_069639(11), NM_069592(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_069639 NCBI Caenorhabditis elegans Y69E1A.3 (Y69E1A.3) mRNA, complete cds. 11/11 None
NM_069592 NCBI Caenorhabditis elegans T25B9.5 (T25B9.5) mRNA, complete cds. 11/11 None
SNAP00000037373 ENSEMBL cdna:SNAP chromosome:CEL140:IV:10952329:10954600:1 11/11 None
GENEFINDER00000037383 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:10952329:10954600:1 11/11 None
SNAP00000044112 ENSEMBL cdna:SNAP chromosome:CEL140:IV:10752402:10754675:-1 11/11 None
GENEFINDER00000044121 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:10752402:10754675:-1 11/11 None
T25B9.5 ENSEMBL cdna:known chromosome:CEL140:IV:10752402:10754561:-1 gene:T25B9.5 11/11 None
Y69E1A.3 ENSEMBL cdna:known chromosome:CEL140:IV:10952438:10954600:1 gene:Y69E1A.3 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:10952443-10954606(+) 97.79 97.79
chrIV:10752407-10754567(-) 100.0 100.0
Public Domain and Genome References
Gene Title Src homology domain 2, protein tyrosine kinase (ABL subfamily)
Eukaryotic protein kinase domain
Ensembl T25B9.5
Y69E1A.3
Entrez Gene 188883 Entrez gene
190549 Entrez gene
SwissProt Q22766 EMBL-EBI
Q9XW34 EMBL-EBI
WormBase CE06504 Wormbase
CE22810 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA22261 Hypothetical protein Y69E1A.3 [Caenorhabditis elegans] ref|NP_502040.1| Y69E1A.3 [Caenorhabditis elegans] 0.0
blast CAA94373 Hypothetical protein T25B9.5 [Caenorhabditis elegans] ref|NP_501993.1| T25B9.5 [Caenorhabditis elegans] 0.0
blast AAF60752 Hypothetical protein Y52D5A.2 [Caenorhabditis elegans] ref|NP_500813.2| Y52D5A.2 [Caenorhabditis elegans] 0.0
Protein Families
Method ID Description E-Value
hanks 1.1.18 AGC group; AGC I Cyclic nucleotide regulated protein kinase (PKA & PKG); DG2 6.0E-62
hanks 1.1.18 AGC group; AGC I Cyclic nucleotide regulated protein kinase (PKA & PKG); DG2 5.0E-62
hanks 1.1.18 AGC group; AGC I Cyclic nucleotide regulated protein kinase (PKA & PKG); DG2 1.0E-63
Protein Domains
Database ID Description E-Value
scop a.2.11.Fe,Mn superoxide dismutase (SOD), N-terminal domain All alpha proteins; Long alpha-hairpin; Fe,Mn superoxide dismutase (SOD), N-terminal domain; Fe,Mn superoxide dismutase (SOD), N-terminal domain 0.649999976158142
Pfam IPR000719 EMBL-EBI Protein kinase 5.3E-57
Pfam IPR000719 EMBL-EBI Protein kinase 1.5E-54
Pfam IPR000719 EMBL-EBI Protein kinase 1.5E-54
Pfam IPR000719 EMBL-EBI Protein kinase 5.3E-57
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_502040.1 1 13-32
Y69E1A.3 1 13-32
Sequence
Target Sequence 
>C. ELEGANS:193966_S_AT
tcagatggttggcaccggaatcgctgaaatctggaatgtttaatgagaagacagatgttt
ggtcgtacggagtgttcctcacggagcttatggcaagatgtgagcacgatccattgtacc
caaaaagtctcaaagatgccaaagcctggattttgacagaagaacgcccacataagatgg
agaatggagatccgaaagaactgatggttctcattgatgcgtgctgtgaaaggaacccga
acgaacggctcaatttcaatacggtgaagcgacaaatcacagacatctatatggaagcat
tgaacaaaggtccccaggatggtcgaaaaccagaaaactcagctatgactgtgttgactt
caaaaacatcagaagatcgaaccaggatttcattgaatcgcaagaaatctgttgatagac
agaagatcccgtcgtcaagtaaacgaagcttcttttcatctcttcgtaagaaaaacaagg
atcaagtcacactgccagccggaatgtctatcagcccatcaactaattcagccaaaccac
catcatcagaaacgccaaacact

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TCAGATGGTTGGCACCGGAATCGCT 426 621 1028 Antisense
AGCACGATCCATTGTACCCAAAAAG 370 77 1130 Antisense
GATGGTTCTCATTGATGCGTGCTGT 33 409 1230 Antisense
TGCGTGCTGTGAAAGGAACCCGAAC 215 581 1245 Antisense
CGAACGGCTCAATTTCAATACGGTG 199 253 1269 Antisense
GAACAAAGGTCCCCAGGATGGTCGA 223 321 1329 Antisense
CAGAAGATCCCGTCGTCAAGTAAAC 80 203 1447 Antisense
TAAACGAAGCTTCTTTTCATCTCTT 522 639 1467 Antisense
CTGCCAGCCGGAATGTCTATCAGCC 38 237 1519 Antisense
TCAGCCCATCAACTAATTCAGCCAA 306 625 1538 Antisense
ACCATCATCAGAAACGCCAAACACT 332 85 1566 Antisense
Sequence Source Affymetrix Proprietary Database