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[193965_s_at] Src homology domain 2, protein tyrosine kinase (ABL subfamily)

Description T25B9.4 /REP_DB=WormBase Gene ID /WP=CE06503 /TR=Q22765 /GB=CAA94372.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=Src homology domain 2, protein tyrosine kinase (ABL subfamily)
Cluster 6grp_total > 77      4grp_total > 10      6grp_total_sub > Increase      6grp_rule_based > S6      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 76
1 2 3 4 range
A 7.2
(-3)
A 		8
(-2.9)
A 		11.1
(-2.7)
A 		80.2
(3)
A 		73
B 5.4
(-3)
A 		9.8
(-1.9)
A 		5.9
(-2.9)
A 		29.7
(3)
A 		24
C 7.2
(-1.7)
A 		12.9
(0.7)
A 		4.2
(-3)
A 		18.2
(3)
A 		14
avr 6.6
(-3) 		10.2
(-2.4) 		7.1
(-2.9) 		42.7
(3) 		36

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 52
1 2 3 4 5 6 range
A 7.8
(-2.6)
A 		9
(-2.5)
A 		5.6
(-2.9)
A 		4.3
(-3)
A 		7.3
(-2.7)
A 		56.6
(3)
A 		52
B 8.4
(-1.1)
A 		4.3
(-3)
A 		7
(-1.8)
A 		10.4
(-0.2)
A 		17.5
(3)
A 		10.2
(-0.3)
A 		13
C 4.9
(-3)
A 		5.7
(-2.9)
A 		6.1
(-2.8)
A 		6.8
(-2.7)
A 		7.9
(-2.6)
A 		46.8
(3)
A 		42
avr 7
(-2.8) 		6.3
(-3) 		6.2
(-3) 		7.2
(-2.8) 		10.9
(-2.1) 		37.9
(3) 		32
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 10
1 2 3 4 range
A 2.6
(-2.5)
A 		1.7
(-3)
A 		2.9
(-2.3)
A 		11.7
(3)
A 		10
B 1.7
(-2.6)
A 		2.4
(-1.8)
A 		1.4
(-3)
A 		6.3
(3)
A 		5
C 2.4
(-0.5)
A 		3.7
(3)
A 		1.5
(-3)
A 		3.1
(1.4)
A 		2
avr 2.2
(-2.6) 		2.6
(-2.2) 		1.9
(-3) 		7
(3) 		5

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 15
1 2 3 4 5 6 range
A 1.4
(-2.9)
A 		3.2
(-2)
A 		1.2
(-3)
A 		1.1
(-3)
A 		2.2
(-2.5)
A 		13.8
(3)
A 		13
B 2.9
(-1.4)
A 		1.4
(-3)
A 		1.7
(-2.7)
A 		2.8
(-1.5)
A 		7.1
(3)
A 		3.8
(-0.5)
A 		6
C 1.8
(-2.8)
A 		1.8
(-2.8)
A 		1.5
(-3)
A 		1.4
(-3)
A 		2.6
(-2.5)
A 		15.7
(3)
A 		14
avr 2
(-2.7) 		2.1
(-2.6) 		1.5
(-3) 		1.8
(-2.8) 		4
(-1.4) 		11.1
(3) 		10
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 193965_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.9605
Sequence Type Exemplar sequence
Representative Public ID T25B9.4 NCBI
Target Description T25B9.4 /REP_DB=WormBase Gene ID /WP=CE06503 /TR=Q22765 /GB=CAA94372.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=Src homology domain 2, protein tyrosine kinase (ABL subfamily)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_069636(11), NM_069593(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_069636 NCBI Caenorhabditis elegans ZK593.9 (ZK593.9) mRNA, complete cds. 11/11 A 
NM_069593 NCBI Caenorhabditis elegans T25B9.4 (T25B9.4) mRNA, complete cds. 11/11 A 
SNAP00000042099 ENSEMBL cdna:SNAP chromosome:CEL140:IV:10940929:10942837:1 11/11 None
GENEFINDER00000042103 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:10940929:10942837:1 11/11 None
SNAP00000044113 ENSEMBL cdna:SNAP chromosome:CEL140:IV:10755732:10757644:-1 11/11 None
GENEFINDER00000044126 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:10755732:10757644:-1 11/11 None
T25B9.4 ENSEMBL cdna:known chromosome:CEL140:IV:10755732:10757688:-1 gene:T25B9.4 11/11 A 
ZK593.9 ENSEMBL cdna:known chromosome:CEL140:IV:10940929:10942837:1 gene:ZK593.9 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:10940934-10942835(+) 91.96 91.96
chrIV:10755737-10757650(-) 100.0 100.0
Public Domain and Genome References
Gene Title Src homology domain 2, protein tyrosine kinase (ABL subfamily)
tyrosine-protein kinase
Ensembl T25B9.4
ZK593.9
Entrez Gene 188882 Entrez gene
191356 Entrez gene
SwissProt Q22765 EMBL-EBI
Q23538 EMBL-EBI
WormBase CE06503 Wormbase
CE06630 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA93423 Hypothetical protein ZK593.9 [Caenorhabditis elegans] ref|NP_502037.1| ZK593.9 [Caenorhabditis elegans] 0.0
blast CAA94372 Hypothetical protein T25B9.4 [Caenorhabditis elegans] ref|NP_501994.1| T25B9.4 [Caenorhabditis elegans] 0.0
blast CAE65127 Hypothetical protein CBG09992 [Caenorhabditis briggsae] 0.0
Protein Families
Method ID Description E-Value
hanks 1.9.5 AGC group; AGC Other; DdK2 2.0E-62
hanks 1.9.5 AGC group; AGC Other; DdK2 4.0E-63
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 2.7E-60
Pfam IPR000719 EMBL-EBI Protein kinase 3.4E-57
Sequence
Target Sequence 
>C. ELEGANS:193965_S_AT
agcaaaacggtatattctctctggagcattccccaacttcactaaacaggctccaccgga
attgaacgaaatagtcaaaaagagtatatatcaattggatccagccaagagagacacaat
gaaagtgatagtcaaaaagttggagacttggttggatgttgaacttgttcttgatgagaa
cgaaaaacctgatattgatccagaatcgaatcgtttcaatggaaatatgccaatccgagt
agattcatcgacaaagaagatgcgcaatgacacagtgtgtatcccaccaccagaaacagc
tacagttgcgcttccaaactcattgcctccaatcacagtgtcagctcgcagcaagaactc
gagaaaatccactctaaagaggaagaagaagaagacttcgaaggactcctcgatgacaac
aactacaacgaatacaaatgagagcgagccgcctgctgatggtcaagtaatt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AGCAAAACGGTATATTCTCTCTGGA 595 75 1029 Antisense
TATATTCTCTCTGGAGCATTCCCCA 522 661 1039 Antisense
CATTCCCCAACTTCACTAAACAGGC 511 213 1055 Antisense
TCACTAAACAGGCTCCACCGGAATT 545 623 1067 Antisense
GGCTCCACCGGAATTGAACGAAATA 98 541 1077 Antisense
GAGTATATATCAATTGGATCCAGCC 510 399 1110 Antisense
GGATCCAGCCAAGAGAGACACAATG 194 513 1125 Antisense
GAAGAAGACTTCGAAGGACTCCTCG 222 339 1416 Antisense
GGACTCCTCGATGACAACAACTACA 613 521 1431 Antisense
CAAATGAGAGCGAGCCGCCTGCTGA 581 193 1463 Antisense
GCCGCCTGCTGATGGTCAAGTAATT 576 285 1476 Antisense
Sequence Source Affymetrix Proprietary Database