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[193964_at] Src homology domain 2, protein tyrosine kinase (ABL subfamily)

Description T25B9.4 /REP_DB=WormBase Gene ID /WP=CE06503 /TR=Q22765 /GB=CAA94372.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=Src homology domain 2, protein tyrosine kinase (ABL subfamily)
Cluster 6grp_total > 88      4grp_total > 54      6grp_total_sub > Increase      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 50
1 2 3 4 range
A 57.7
(3)
A 		7.4
(-3)
A 		29.4
(-0.4)
A 		17.8
(-1.8)
A 		50
B 23
(-1.1)
A 		52.8
(3)
A 		13.3
(-2.4)
A 		9.3
(-3)
A 		44
C 23.5
(3)
A 		10.7
(-3)
A 		16.6
(-0.2)
A 		12.4
(-2.2)
A 		13
avr 34.7
(3) 		23.6
(-0.1) 		19.8
(-1.2) 		13.2
(-3) 		22

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 83
1 2 3 4 5 6 range
A 32.1
(-0.9)
A 		31.1
(-1)
A 		11.1
(-2.5)
A 		3.6
(-3)
A 		12.4
(-2.4)
A 		86.4
(3)
P 		83
B 5.7
(-3)
A 		22
(-1.2)
A 		21.1
(-1.3)
A 		54.1
(2.3)
A 		60
(3)
A 		43.1
(1.1)
P 		54
C 3.7
(-3)
A 		19.6
(-1.1)
A 		12.3
(-2)
A 		8.6
(-2.4)
A 		54.5
(3)
P 		52.9
(2.8)
A 		51
avr 13.8
(-3) 		24.2
(-1.7) 		14.8
(-2.9) 		22.1
(-1.9) 		42.3
(0.6) 		60.8
(3) 		47
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 19
1 2 3 4 range
A 21
(3)
A 		1.6
(-3)
A 		7.7
(-1.1)
A 		2.6
(-2.7)
A 		19
B 7.3
(-0.1)
A 		13.1
(3)
A 		3.1
(-2.4)
A 		2
(-3)
A 		11
C 7.8
(3)
A 		3.1
(-1.9)
A 		5.8
(0.9)
A 		2.1
(-3)
A 		6
avr 12
(3) 		5.9
(-0.7) 		5.5
(-1) 		2.2
(-3) 		10

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 24
1 2 3 4 5 6 range
A 5.9
(-1.5)
A 		11.1
(0)
A 		2.4
(-2.6)
A 		0.9
(-3)
A 		3.8
(-2.1)
A 		21
(3)
P 		20
B 2
(-3)
A 		7.3
(-1.6)
A 		5.1
(-2.2)
A 		14.3
(0.3)
A 		24.4
(3)
A 		16.1
(0.8)
P 		22
C 1.4
(-3)
A 		6
(-1.3)
A 		3.1
(-2.4)
A 		1.7
(-2.9)
A 		17.6
(3)
P 		17.7
(3)
A 		16
avr 3.1
(-3) 		8.1
(-1) 		3.5
(-2.8) 		5.6
(-2) 		15.3
(1.8) 		18.3
(3) 		15
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193964_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.9605
Sequence Type Exemplar sequence
Representative Public ID T25B9.4 NCBI
Target Description T25B9.4 /REP_DB=WormBase Gene ID /WP=CE06503 /TR=Q22765 /GB=CAA94372.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=Src homology domain 2, protein tyrosine kinase (ABL subfamily)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_069593(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_069593 NCBI Caenorhabditis elegans T25B9.4 (T25B9.4) mRNA, complete cds. 11/11 A 
SNAP00000044113 ENSEMBL cdna:SNAP chromosome:CEL140:IV:10755732:10757644:-1 11/11 None
GENEFINDER00000044126 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:10755732:10757644:-1 11/11 None
T25B9.4 ENSEMBL cdna:known chromosome:CEL140:IV:10755732:10757688:-1 gene:T25B9.4 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:10940934-10942835(+) 91.96 91.96
chrIV:10755737-10757650(-) 100.0 100.0
Public Domain and Genome References
Gene Title Src homology domain 2, protein tyrosine kinase (ABL subfamily)
Ensembl T25B9.4
Entrez Gene 188882 Entrez gene
SwissProt Q22765 EMBL-EBI
WormBase CE06503 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA94372 Hypothetical protein T25B9.4 [Caenorhabditis elegans] ref|NP_501994.1| T25B9.4 [Caenorhabditis elegans] 0.0
blast CAA93423 Hypothetical protein ZK593.9 [Caenorhabditis elegans] ref|NP_502037.1| ZK593.9 [Caenorhabditis elegans] 0.0
blast CAE65127 Hypothetical protein CBG09992 [Caenorhabditis briggsae] 0.0
Protein Families
Method ID Description E-Value
hanks 1.9.5 AGC group; AGC Other; DdK2 4.0E-63
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 2.7E-60
Sequence
Target Sequence 
>C. ELEGANS:193964_AT
ttgatccagaatcgaatcgtttcaatggaaatatgccaatccgagtagattcatcgacaa
agaagatgcgcaatgacacagtgtgtatcccaccaccagaaacagctacagttgcgcttc
caaactcattgcctccaatcacagtgtcagctcgcagcaagaactcgagaaaatccactc
taaagaggaagaagaagaagacttcgaaggactcctcgatgacaacaactacaacgaata
caaatgagagcgagccgcctgctgatggtcaagtaatttcatcggaaaccatgtccgttg
caaacaaaatggtatccgatgcaaagggaggaagtccagaaatgttgactccgtcacttg
aagagttgaagccttcttcacaag

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TTGATCCAGAATCGAATCGTTTCAA 612 701 1223 Antisense
GAAGATGCGCAATGACACAGTGTGT 174 337 1284 Antisense
CCCACCACCAGAAACAGCTACAGTT 46 259 1311 Antisense
GAAACAGCTACAGTTGCGCTTCCAA 480 355 1321 Antisense
TACAGTTGCGCTTCCAAACTCATTG 290 643 1329 Antisense
TTGCCTCCAATCACAGTGTCAGCTC 306 701 1351 Antisense
GTGTCAGCTCGCAGCAAGAACTCGA 301 487 1366 Antisense
AGAACTCGAGAAAATCCACTCTAAA 608 73 1382 Antisense
GGAAACCATGTCCGTTGCAAACAAA 567 527 1506 Antisense
GTCCAGAAATGTTGACTCCGTCACT 145 477 1556 Antisense
GAAGAGTTGAAGCCTTCTTCACAAG 43 339 1582 Antisense
Sequence Source Affymetrix Proprietary Database