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[193960_s_at] Domain found in Dishevelled, Egl-10, and Pleckstrin

Description K08E7.3 /REP_DB=WormBase Gene ID /WP=CE06147 /GEN=let-99 /TR=Q21341 /GB=CAB01225.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=Domain found in Dishevelled, Egl-10, and Pleckstrin
Cluster 6grp_total > 97      4grp_total > 04      6grp_cgc > 69      6grp_cgc_sub > Da      6grp_total_sub > Increase      6grp_rule_based > S6      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 65
1 2 3 4 range
A 14.4
(-2.1)
A 		5.6
(-3)
A 		27.3
(-0.7)
A 		62.8
(3)
A 		57
B 45.3
(1.5)
A 		20.4
(-2.7)
A 		18.9
(-3)
A 		54.1
(3)
M 		35
C 31.1
(-1.9)
A 		36.1
(-1.3)
A 		22.2
(-3)
A 		70.7
(3)
P 		49
avr 30.3
(-1.6) 		20.7
(-3) 		22.8
(-2.7) 		62.5
(3) 		42

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 433
1 2 3 4 5 6 range
A 2.9
(-3)
A 		10.6
(-2.8)
A 		40.7
(-2.1)
A 		108.9
(-0.6)
P 		194.9
(1.3)
P 		269.6
(3)
P 		267
B 26.7
(-3)
A 		30.2
(-2.9)
A 		53.1
(-2.6)
P 		63.5
(-2.5)
P 		270.2
(0.6)
P 		436.2
(3)
P 		410
C 12.5
(-3)
A 		47.7
(-2.4)
A 		20.1
(-2.9)
A 		67.7
(-2)
A 		263.9
(1.4)
P 		359.1
(3)
P 		347
avr 14
(-3) 		29.5
(-2.7) 		38
(-2.6) 		80
(-1.8) 		243
(1) 		355
(3) 		341
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 13
1 2 3 4 range
A 5.3
(0.1)
A 		1.2
(-3)
A 		7.1
(1.4)
A 		9.2
(3)
A 		8
B 14.4
(3)
A 		5
(-2.6)
A 		4.4
(-3)
A 		11.5
(1.3)
M 		10
C 10.3
(0.7)
A 		10.4
(0.9)
A 		7.7
(-3)
A 		11.9
(3)
P 		4
avr 10
(2) 		5.5
(-3) 		6.4
(-2) 		10.9
(3) 		5

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 162
1 2 3 4 5 6 range
A 0.5
(-3)
A 		3.8
(-2.7)
A 		8.9
(-2.2)
A 		27.6
(-0.5)
P 		58.8
(2.4)
P 		65.6
(3)
P 		65
B 9.3
(-3)
A 		10.1
(-3)
A 		12.9
(-2.9)
P 		16.8
(-2.7)
P 		109.8
(0.9)
P 		162.7
(3)
P 		153
C 4.6
(-3)
A 		14.5
(-2.5)
A 		5.1
(-3)
A 		13.6
(-2.5)
A 		85.4
(1.2)
P 		120.2
(3)
P 		116
avr 4.8
(-3) 		9.5
(-2.7) 		9
(-2.8) 		19.3
(-2.2) 		84.7
(1.3) 		116.2
(3) 		111
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 193960_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.10304
Sequence Type Exemplar sequence
Representative Public ID K08E7.3 NCBI
Target Description K08E7.3 /REP_DB=WormBase Gene ID /WP=CE06147 /GEN=let-99 /TR=Q21341 /GB=CAB01225.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=Domain found in Dishevelled, Egl-10, and Pleckstrin
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_070006(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_070006 NCBI Caenorhabditis elegans LEThal family member (let-99) (let-99) mRNA, complete cds. 11/11 A 
SNAP00000007116 ENSEMBL cdna:SNAP chromosome:CEL140:III:9504660:9506977:1 11/11 None
GENEFINDER00000007123 ENSEMBL cdna:GeneFinder chromosome:CEL140:III:9504660:9507066:1 11/11 None
SNAP00000042644 ENSEMBL cdna:SNAP chromosome:CEL140:IV:12567827:12570418:1 11/11 None
GENEFINDER00000042660 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:12567827:12570418:1 11/11 None
F55H2.4 ENSEMBL cdna:pseudogene chromosome:CEL140:III:9504660:9506977:1 gene:F55H2.4 11/11 A 
K08E7.3 ENSEMBL cdna:known chromosome:CEL140:IV:12567827:12570576:1 gene:K08E7.3 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:12567832-12570424(+) 100.0 100.0
Public Domain and Genome References
Gene Title Domain found in Dishevelled, Egl-10, and Pleckstrin
Gene Symbol let-99
Ensembl F55H2.4
K08E7.3
Entrez Gene 178210 Entrez gene
SwissProt Q21341 EMBL-EBI
WormBase CE06147 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB01225 Hypothetical protein K08E7.3 [Caenorhabditis elegans] ref|NP_502407.1| LEThal family member (let-99) [Caenorhabditis elegans] sp|Q21341|LET99_CAEEL Lethal protein 0.0
blast CAE65196 Hypothetical protein CBG10071 [Caenorhabditis briggsae] 0.0
blast P34464 Hypothetical protein F55H2.4 in chromosome III pir||S40987 hypothetical protein F55H2.4 - Caenorhabditis elegans 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR000591 EMBL-EBI Pleckstrin putative G-protein interacting domain 7.7E-18
Pfam IPR000591 EMBL-EBI Pleckstrin putative G-protein interacting domain 3.9E-15
Sequence
Target Sequence 
>C. ELEGANS:193960_S_AT
gagcttcaaagtatcgacgacgtgcgttatcaccatttgataatagagtgaatttggaaa
tacaagacgaaaaatcctacgaaatccgagagcaatggttgatcgaagcaattcaattgg
tacttctttcgcttccaacttcacgacgtcggaaacttcacaaatttgttacattcattc
aatcgatcgaaacgaatgcagttttcgacctcgctgatccttctaacggatcttccaaca
atcgggaagcggcaatcatcggactctggacaggtgtttgtagtaaatgccgaaagc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GAGCTTCAAAGTATCGACGACGTGC 204 389 1535 Antisense
GTATCGACGACGTGCGTTATCACCA 51 443 1545 Antisense
ACGACGTGCGTTATCACCATTTGAT 119 93 1551 Antisense
GAAAAATCCTACGAAATCCGAGAGC 87 353 1603 Antisense
GGTTGATCGAAGCAATTCAATTGGT 356 507 1631 Antisense
TTCAATTGGTACTTCTTTCGCTTCC 121 685 1646 Antisense
GAAACTTCACAAATTTGTTACATTC 315 357 1686 Antisense
TGTTACATTCATTCAATCGATCGAA 478 561 1701 Antisense
CAATCATCGGACTCTGGACAGGTGT 272 181 1787 Antisense
CGGACTCTGGACAGGTGTTTGTAGT 359 241 1794 Antisense
GGTGTTTGTAGTAAATGCCGAAAGC 571 499 1807 Antisense
Sequence Source Affymetrix Proprietary Database