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[193959_at] Domain found in Dishevelled, Egl-10, and Pleckstrin

Description K08E7.3 /REP_DB=WormBase Gene ID /WP=CE06147 /GEN=let-99 /TR=Q21341 /GB=CAB01225.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=Domain found in Dishevelled, Egl-10, and Pleckstrin
Cluster 6grp_total > 87      4grp_total > 09      6grp_cgc > 59      6grp_cgc_sub > Da      6grp_total_sub > Increase      6grp_rule_based > S6      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 100
1 2 3 4 range
A 3.9
(-3)
A 		13.7
(-2.4)
A 		7.1
(-2.8)
A 		103.9
(3)
A 		100
B 6.2
(-3)
A 		13.7
(0.3)
A 		19.8
(3)
A 		16.4
(1.5)
A 		14
C 5.6
(-2.8)
A 		4.5
(-3)
A 		9.9
(-2.3)
A 		47.8
(3)
A 		43
avr 5.2
(-3) 		10.6
(-2.4) 		12.3
(-2.2) 		56
(3) 		51

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 406
1 2 3 4 5 6 range
A 3.8
(-3)
A 		9
(-2.9)
A 		2.5
(-3)
A 		60.6
(-2)
A 		182
(0.2)
P 		340.8
(3)
P 		338
B 8.8
(-2.9)
A 		3.1
(-3)
A 		49.1
(-2.3)
A 		22.4
(-2.7)
A 		193.6
(-0.2)
P 		408.9
(3)
P 		406
C 4.3
(-3)
A 		5.6
(-3)
A 		32.4
(-2.6)
A 		4.3
(-3)
A 		200.2
(-0)
P 		398
(3)
P 		394
avr 5.6
(-3) 		5.9
(-3) 		28
(-2.6) 		29.1
(-2.6) 		191.9
(-0) 		382.6
(3) 		377
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 14
1 2 3 4 range
A 1.4
(-3)
A 		3
(-2.3)
A 		1.9
(-2.8)
A 		15.2
(3)
A 		14
B 2
(-3)
A 		3.4
(0.2)
A 		4.6
(3)
A 		3.5
(0.5)
A 		3
C 1.8
(-2.6)
A 		1.3
(-3)
A 		3.4
(-1.1)
A 		8.1
(3)
A 		7
avr 1.7
(-3) 		2.6
(-2.3) 		3.3
(-1.7) 		8.9
(3) 		7

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 152
1 2 3 4 5 6 range
A 0.7
(-3)
A 		3.2
(-2.8)
A 		0.5
(-3)
A 		15.4
(-1.9)
A 		54.9
(1)
P 		83
(3)
P 		83
B 3.1
(-2.9)
A 		1
(-3)
A 		11.9
(-2.6)
A 		5.9
(-2.8)
A 		78.6
(0.1)
P 		152.5
(3)
P 		152
C 1.6
(-3)
A 		1.7
(-3)
A 		8.2
(-2.7)
A 		0.9
(-3)
A 		64.8
(-0.1)
P 		133.2
(3)
P 		132
avr 1.8
(-3) 		2
(-3) 		6.9
(-2.7) 		7.4
(-2.7) 		66.1
(0.2) 		122.9
(3) 		121
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193959_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.10304
Sequence Type Exemplar sequence
Representative Public ID K08E7.3 NCBI
Target Description K08E7.3 /REP_DB=WormBase Gene ID /WP=CE06147 /GEN=let-99 /TR=Q21341 /GB=CAB01225.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=Domain found in Dishevelled, Egl-10, and Pleckstrin
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_070006(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_070006 NCBI Caenorhabditis elegans LEThal family member (let-99) (let-99) mRNA, complete cds. 11/11 A 
SNAP00000042644 ENSEMBL cdna:SNAP chromosome:CEL140:IV:12567827:12570418:1 11/11 None
GENEFINDER00000042660 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:12567827:12570418:1 11/11 None
K08E7.3 ENSEMBL cdna:known chromosome:CEL140:IV:12567827:12570576:1 gene:K08E7.3 11/11 A 
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
SNAP00000007116 1/11 Cross Hyb Matching Probes None
GENEFINDER00000007123 1/11 Cross Hyb Matching Probes None
F55H2.4 1/11 Cross Hyb Matching Probes A 
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:12567832-12570424(+) 100.0 100.0
Public Domain and Genome References
Gene Title Domain found in Dishevelled, Egl-10, and Pleckstrin
Gene Symbol let-99
Ensembl K08E7.3
Entrez Gene 178210 Entrez gene
SwissProt Q21341 EMBL-EBI
WormBase CE06147 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB01225 Hypothetical protein K08E7.3 [Caenorhabditis elegans] ref|NP_502407.1| LEThal family member (let-99) [Caenorhabditis elegans] sp|Q21341|LET99_CAEEL Lethal protein 0.0
blast CAE65196 Hypothetical protein CBG10071 [Caenorhabditis briggsae] 0.0
blast P34464 Hypothetical protein F55H2.4 in chromosome III pir||S40987 hypothetical protein F55H2.4 - Caenorhabditis elegans 1.0E-171
Protein Domains
Database ID Description E-Value
Pfam IPR000591 EMBL-EBI Pleckstrin putative G-protein interacting domain 7.7E-18
Sequence
Target Sequence 
>C. ELEGANS:193959_AT
gaggctggattgatggtcgatggattctcccgtgatcttccagcatgcggaattcgagct
tcaaagtatcgacgacgtgcgttatcaccatttgataatagagtgaatttggaaatacaa
gacgaaaaatcctacgaaatccgagagcaatggttgatcgaagcaattcaattggtactt
ctttcgcttccaacttcacgacgtcggaaacttcacaaatttgttacattcattcaatcg
atcgaaacgaatgcagttttcgacctcgctgatccttctaacggatcttccaacaatcgg
gaagcggcaatcatcggactctggacaggtgtttgtagtaaatgccgaaagcaacaagga
atgctgataaccgctgtcctcctcgcaaactttcaatctctttttgcagtacctgttgaa
tttatcgaacaggtcaaacgattggaatgtgaagaaaaggacagatatagtggtcctcgg
tacgcaaagatcaccagaagtcgaaatgattggcaaccaccagttccggataaaccgcaa
gcatctccggcagtttttaag

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GAGGCTGGATTGATGGTCGATGGAT 632 405 1480 Antisense
CCGTGATCTTCCAGCATGCGGAATT 406 265 1509 Antisense
CAATCTCTTTTTGCAGTACCTGTTG 600 181 1873 Antisense
TGCAGTACCTGTTGAATTTATCGAA 78 577 1884 Antisense
ACAGATATAGTGGTCCTCGGTACGC 137 107 1940 Antisense
GGTCCTCGGTACGCAAAGATCACCA 46 503 1951 Antisense
GTACGCAAAGATCACCAGAAGTCGA 281 459 1959 Antisense
GAAGTCGAAATGATTGGCAACCACC 445 335 1976 Antisense
CCACCAGTTCCGGATAAACCGCAAG 216 273 1996 Antisense
ATAAACCGCAAGCATCTCCGGCAGT 551 23 2009 Antisense
GCAAGCATCTCCGGCAGTTTTTAAG 231 319 2016 Antisense
Sequence Source Affymetrix Proprietary Database