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[193952_at]

Description ZK1290.2 /REP_DB=WormBase Gene ID /WP=CE25680 /GEN=tph-1 /TR=Q23438 /GB=AAB93319.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=Biopterin-dependent aromatic amino acid hydroxylase
Cluster 4grp_high_8_8 > 17      6grp_total > 13      4grp_total > 38      6grp_cgc > 30      6grp_cgc_sub > De      6grp_total_sub > Decrease      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 154
1 2 3 4 range
A 157.6
(3)
P 		63.7
(-3)
P 		90.2
(-1.3)
A 		82.3
(-1.8)
A 		94
B 120.8
(2)
P 		130.4
(3)
P 		72.5
(-3)
P 		115.9
(1.5)
P 		58
C 187.5
(3)
P 		108.7
(-0.1)
M 		33.9
(-3)
A 		81.7
(-1.1)
A 		154
avr 155.3
(3) 		100.9
(-0.6) 		65.5
(-3) 		93.3
(-1.1) 		90

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 124
1 2 3 4 5 6 range
A 128.5
(1.1)
P 		160.8
(3)
M 		131.9
(1.3)
P 		87.2
(-1.3)
P 		113.3
(0.2)
P 		57.7
(-3)
A 		103
B 148
(3)
P 		95.3
(0.2)
P 		36.9
(-3)
A 		105.7
(0.7)
P 		65.5
(-1.5)
P 		51.5
(-2.2)
A 		111
C 128.9
(2.5)
P 		96.3
(0.5)
P 		136.4
(3)
A 		122.8
(2.1)
P 		41
(-3)
A 		53.6
(-2.2)
A 		95
avr 135.1
(3) 		117.5
(1.7) 		101.7
(0.5) 		105.2
(0.8) 		73.3
(-1.6) 		54.3
(-3) 		81
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 50
1 2 3 4 range
A 57.4
(3)
P 		13.8
(-2.8)
P 		23.6
(-1.5)
A 		12
(-3)
A 		45
B 38.5
(3)
P 		32.2
(1.3)
P 		16.8
(-3)
P 		24.7
(-0.8)
P 		22
C 62.1
(3)
P 		31.3
(-0.7)
M 		11.8
(-3)
A 		13.8
(-2.8)
A 		50
avr 52.7
(3) 		25.8
(-1.5) 		17.4
(-2.9) 		16.8
(-3) 		36

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 48
1 2 3 4 5 6 range
A 23.7
(-1.7)
P 		57.2
(3)
M 		28.7
(-1)
P 		22.1
(-1.9)
P 		34.2
(-0.2)
P 		14.1
(-3)
A 		43
B 51.5
(3)
P 		31.7
(0.2)
P 		9
(-3)
A 		28
(-0.3)
P 		26.6
(-0.5)
P 		19.2
(-1.6)
A 		43
C 47.8
(3)
P 		29.4
(-0.2)
P 		34.7
(0.7)
A 		24.7
(-1)
P 		13.3
(-3)
A 		18
(-2.2)
A 		35
avr 41
(3) 		39.4
(2.6) 		24.1
(-1.2) 		24.9
(-1) 		24.7
(-1.1) 		17.1
(-3) 		24
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193952_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.4280
Sequence Type Exemplar sequence
Representative Public ID ZK1290.2 NCBI
Target Description ZK1290.2 /REP_DB=WormBase Gene ID /WP=CE25680 /GEN=tph-1 /TR=Q23438 /GB=AAB93319.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=Biopterin-dependent aromatic amino acid hydroxylase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_063183(11), NM_001027333(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_063183 NCBI Caenorhabditis elegans TryPtophan Hydroxylase family member (tph-1) (tph-1) mRNA, complete cds. 11/11 None
NM_001027333 NCBI Caenorhabditis elegans TryPtophan Hydroxylase family member (tph-1) (tph-1) mRNA, complete cds. 11/11 None
SNAP00000002678 ENSEMBL cdna:SNAP chromosome:CEL140:II:7549298:7551699:1 11/11 None
GENEFINDER00000002684 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:7549298:7551797:1 11/11 None
ZK1290.2a ENSEMBL cdna:known chromosome:CEL140:II:7549257:7551899:1 gene:ZK1290.2 11/11 None
ZK1290.2b ENSEMBL cdna:known chromosome:CEL140:II:7550345:7551699:1 gene:ZK1290.2 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:7549306-7551696(+) 100.0 100.0
Public Domain and Genome References
Ensembl ZK1290.2
Functional Annotations
Protein Similarities
Method ID Description E-Value
blast AAB93319 Tryptophan hydroxylase protein 1, isoform a [Caenorhabditis elegans] ref|NP_495584.3| TryPtophan Hydroxylase family member (tph-1) [Caenorhabditis elegans] 0.0
blast AAD30115 tryptophan hydroxylase [Caenorhabditis elegans] 0.0
blast CAE67486 Hypothetical protein CBG12991 [Caenorhabditis briggsae] 0.0
blast AAO12388 Tryptophan hydroxylase protein 1, isoform b [Caenorhabditis elegans] ref|NP_001022504.1| TryPtophan Hydroxylase family member (tph-1) [Caenorhabditis elegans] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR001273 EMBL-EBI Aromatic amino acid hydroxylase 9.2E-29
Pfam IPR001273 EMBL-EBI Aromatic amino acid hydroxylase 1.0E-126
Pfam IPR001273 EMBL-EBI Aromatic amino acid hydroxylase 1.0E-126
Pfam IPR001273 EMBL-EBI Aromatic amino acid hydroxylase 1.0E-126
Pfam IPR001273 EMBL-EBI Aromatic amino acid hydroxylase 1.0E-126
Trans Membrane
ID Number Of Domains Domain Boundaries
GENEFINDER00000002684 1 517-539
Sequence
Target Sequence 
>C. ELEGANS:193952_AT
tgcatatcgtgtcttcttctgcactcaatacgttcgccatcatgccgatccattttacac
tccagaaccagacaccgttcacgagctcatgggtcacatggctctattcgctgatccaga
ttttgctcagttttctcaagagattggattagcttctcttggagcatcagaggaagattt
gaagaagcttgcaacactctacttcttttccattgaatttggtctctcgtctgatgacgc
tgccgattctccagtaaaagaaaatggatcaaatcatgaaagatttaaagtatacggagc
aggacttctgagcagtgctggcgagttgcaacatgccgttgagggtagtgcaaccattat
tcgttttgatccggatcgtgttgttgagcaagaatgtctcattactactttccagtcagc
gtatttctatactagaaattttgaagaggcccagcagaaactcagaatgttcaccaacaa
catgaaacgtcccttcattgttcgttacaacccatacacagaaagcgtcgaagttctcaa
caactcccgttccattatgttggcag

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TGCATATCGTGTCTTCTTCTGCACT 418 579 957 Antisense
GCACTCAATACGTTCGCCATCATGC 144 317 977 Antisense
CATCATGCCGATCCATTTTACACTC 548 213 994 Antisense
TCACATGGCTCTATTCGCTGATCCA 148 629 1050 Antisense
ACACTCTACTTCTTTTCCATTGAAT 418 109 1150 Antisense
TTGAATTTGGTCTCTCGTCTGATGA 313 705 1169 Antisense
GCAGGACTTCTGAGCAGTGCTGGCG 39 311 1255 Antisense
GTGCTGGCGAGTTGCAACATGCCGT 386 477 1271 Antisense
GTCTCATTACTACTTTCCAGTCAGC 5 471 1352 Antisense
TGAAACGTCCCTTCATTGTTCGTTA 113 573 1439 Antisense
AACTCCCGTTCCATTATGTTGGCAG 393 141 1498 Antisense
Sequence Source Affymetrix Proprietary Database