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[193940_s_at] eukaryotic translation initiation factor 2 alpha kinase PEK

Description F46C3.1 /REP_DB=WormBase Gene ID /WP=CE18695 /TR=Q19192 /GB=CAA91470.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=eukaryotic translation initiation factor 2 alpha kinase PEK
Cluster 6grp_highest_10_10 > 36      6grp_high1_10_10 > 40      4grp_highest_8_8 > 39      4grp_high_8_8 > 04      6grp_highest_nonorm > 74      6grp_total > 51      4grp_total > 04      6grp_highest_sub > 03      6grp_cgc > 93      6grp_high1_sub > 03      6grp_cgc_sub > 03      6grp_total_sub > Hat      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 465
1 2 3 4 range
A 590.9
(-1.5)
P 		576.6
(-1.6)
P 		471.4
(-3)
P 		936.8
(3)
P 		465
B 599.9
(-0.9)
P 		520.1
(-3)
P 		599.1
(-1)
P 		751.6
(3)
P 		232
C 681.5
(0.2)
P 		567.5
(-2.9)
P 		564.3
(-3)
P 		780.8
(3)
P 		217
avr 624.1
(-1.3) 		554.7
(-2.8) 		544.9
(-3) 		823.1
(3) 		278

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 425
1 2 3 4 5 6 range
A 618
(-1.4)
P 		654.8
(-0.2)
P 		706.1
(1.6)
P 		671
(0.4)
P 		748.7
(3)
P 		570.9
(-3)
P 		178
B 727.6
(1)
P 		614.8
(-1)
P 		812.9
(2.5)
P 		840.6
(3)
P 		502.3
(-3)
P 		690.9
(0.3)
P 		338
C 684.2
(-0.6)
P 		733.1
(0.1)
P 		926.8
(3)
P 		779.7
(0.8)
P 		526.5
(-3)
P 		638.6
(-1.3)
P 		400
avr 676.6
(-0.7) 		667.6
(-1) 		815.3
(3) 		763.8
(1.6) 		592.5
(-3) 		633.5
(-1.9) 		223
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 102
1 2 3 4 range
A 215.1
(3)
P 		125.2
(-2.9)
P 		123.2
(-3)
P 		137.1
(-2.1)
P 		92
B 191.3
(3)
P 		128.4
(-3)
P 		138.8
(-2)
P 		160.2
(0)
P 		63
C 225.6
(3)
P 		163.2
(-1)
P 		196.7
(1.2)
P 		131.7
(-3)
P 		94
avr 210.7
(3) 		138.9
(-3) 		152.9
(-1.8) 		143
(-2.7) 		72

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 144
1 2 3 4 5 6 range
A 113.9
(-3)
P 		232.9
(3)
P 		153.8
(-1)
P 		170.2
(-0.2)
P 		225.9
(2.6)
P 		139
(-1.7)
P 		119
B 253.2
(2.6)
P 		204.6
(-2.3)
P 		197.4
(-3)
P 		222.6
(-0.5)
P 		204.1
(-2.3)
P 		257.7
(3)
P 		60
C 253.6
(3)
P 		223.7
(1.1)
P 		235.9
(1.9)
P 		156.8
(-3)
P 		170.4
(-2.2)
P 		213.8
(0.5)
P 		97
avr 206.9
(0.8) 		220.4
(3) 		195.7
(-1) 		183.2
(-3) 		200.1
(-0.3) 		203.5
(0.3) 		37
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 193940_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.16244
Sequence Type Exemplar sequence
Representative Public ID F46C3.1 NCBI
Target Description F46C3.1 /REP_DB=WormBase Gene ID /WP=CE18695 /TR=Q19192 /GB=CAA91470.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=eukaryotic translation initiation factor 2 alpha kinase PEK
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_077511(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_077511 NCBI Caenorhabditis elegans human PERK kinase homolog family member (pek-1) (pek-1) mRNA, complete cds. 11/11 A 
F46C3.1 ENSEMBL cdna:known chromosome:CEL140:X:11410118:11414735:-1 gene:F46C3.1 11/11 A 
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
SNAP00000001992 3/11 Cross Hyb Matching Probes None
GENEFINDER00000002001 3/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:11410498-11414735(-) 100.0 100.0
Public Domain and Genome References
Gene Title eukaryotic translation initiation factor 2 alpha kinase PEK
Gene Symbol pek-1
Ensembl F46C3.1
Entrez Gene 181334 Entrez gene
SwissProt Q19192 EMBL-EBI
WormBase CE18695 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.11956.1.S1_AT similar to Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK) cfa
DROSOPHILA_2:1641072_AT dm
DROSGENOME1:149333_AT dm
CHICKEN:GGAAFFX.10171.1.S1_AT similar to Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK) gga
HG-U133_PLUS_2:218696_AT eukaryotic translation initiation factor 2-alpha kinase 3 hs
HG-FOCUS:218696_AT eukaryotic translation initiation factor 2-alpha kinase 3 hs
HG-U133A:218696_AT eukaryotic translation initiation factor 2-alpha kinase 3 hs
HG-U133A_2:218696_AT eukaryotic translation initiation factor 2-alpha kinase 3 hs
HU35KSUBD:RC_AA292654_AT eukaryotic translation initiation factor 2-alpha kinase 3 hs
U133_X3P:G4758891_3P_AT eukaryotic translation initiation factor 2-alpha kinase 3 hs
HG-U95B:48034_AT eukaryotic translation initiation factor 2-alpha kinase 3 hs
HG-U95D:71344_AT eukaryotic translation initiation factor 2-alpha kinase 3 hs
HU35KSUBB:RC_H16751_AT Eukaryotic translation initiation factor 2-alpha kinase 3 hs
U133_X3P:HS2.438437.1.A1_3P_AT Eukaryotic translation initiation factor 2-alpha kinase 3 hs
U133_X3P:HS.7007.0.A1_3P_X_AT Eukaryotic translation initiation factor 2-alpha kinase 3 hs
U133_X3P:HS.7007.0.A1_3P_AT Eukaryotic translation initiation factor 2-alpha kinase 3 hs
U133_X3P:236990_3P_AT Eukaryotic translation initiation factor 2-alpha kinase 3 hs
HG-U133_PLUS_2:1568804_AT Eukaryotic translation initiation factor 2-alpha kinase 3 hs
HG-U133_PLUS_2:236990_AT Eukaryotic translation initiation factor 2-alpha kinase 3 hs
HG-U133B:236990_AT Eukaryotic translation initiation factor 2-alpha kinase 3 hs
HG-U95C:60206_AT Eukaryotic translation initiation factor 2-alpha kinase 3 hs
HG-U95C:60934_AT Eukaryotic translation initiation factor 2-alpha kinase 3 hs
HG-U95E:68903_AT Eukaryotic translation initiation factor 2-alpha kinase 3 hs
HG-U95D:88004_R_AT Eukaryotic translation initiation factor 2-alpha kinase 3 hs
HG-U95E:88648_AT Eukaryotic translation initiation factor 2-alpha kinase 3 hs
MOUSE430_2:1430371_X_AT eukaryotic translation initiation factor 2 alpha kinase 3 mm
MOUSE430A_2:1430371_X_AT eukaryotic translation initiation factor 2 alpha kinase 3 mm
MOE430A:1430371_X_AT eukaryotic translation initiation factor 2 alpha kinase 3 mm
MOUSE430_2:1453505_A_AT eukaryotic translation initiation factor 2 alpha kinase 3 mm
MOUSE430A_2:1453505_A_AT eukaryotic translation initiation factor 2 alpha kinase 3 mm
MOE430A:1453505_A_AT eukaryotic translation initiation factor 2 alpha kinase 3 mm
MG-U74AV2:103537_AT eukaryotic translation initiation factor 2 alpha kinase 3 mm
MG-U74CV2:171154_AT eukaryotic translation initiation factor 2 alpha kinase 3 mm
MOE430A:1449278_AT eukaryotic translation initiation factor 2 alpha kinase 3 mm
MOUSE430A_2:1449278_AT eukaryotic translation initiation factor 2 alpha kinase 3 mm
MOUSE430_2:1449278_AT eukaryotic translation initiation factor 2 alpha kinase 3 mm
MU11KSUBB:MSA.15229.0_AT Eukaryotic translation initiation factor 2 alpha kinase 3 (Eif2ak3), mRNA mm
MU19KSUBA:TC16571_AT Eukaryotic translation initiation factor 2 alpha kinase 3 (Eif2ak3), mRNA mm
RG-U34A:AF096835_G_AT eukaryotic translation initiation factor 2 alpha kinase 3 rn
RG-U34A:AF096835_AT eukaryotic translation initiation factor 2 alpha kinase 3 rn
RAE230A:1368326_AT eukaryotic translation initiation factor 2 alpha kinase 3 rn
RAT230_2:1368326_AT eukaryotic translation initiation factor 2 alpha kinase 3 rn
RAE230A:1373360_AT Eukaryotic translation initiation factor 2 alpha kinase 3 rn
RAT230_2:1373360_AT Eukaryotic translation initiation factor 2 alpha kinase 3 rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6118 electron transport inferred from electronic annotation QuickGO AmiGO
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA92117 Hypothetical protein F46C3.1 [Caenorhabditis elegans] emb|CAA91470.1| Hypothetical protein F46C3.1 [Caenorhabditis elegans] ref|NP_509912.1| human PERK kinase homolog family member (pek-1) [Caenorhabditis elegans] gb|AAL30829.1| eIF2 alpha kinase [Caenorhabditis elegans] gb|AAF61201.1| eukaryotic translation initiation factor 2 alpha kinase PEK [Caenorhabditis elegans] sp|Q19192|E2AK3_CAEEL Eukaryotic translation initiation factor 2-alpha kinase precursor (PRKR-like endoplasmic reticulum kinase) (PERK) (PEK) (CePEK) 0.0
blast CAE70639 Hypothetical protein CBG17340 [Caenorhabditis briggsae] 0.0
blast AAF52028 CG2087-PA [Drosophila melanogaster] ref|NP_649538.1| CG2087-PA [Drosophila melanogaster] gb|AAM11184.1| LD41715p [Drosophila melanogaster] sp|Q9NIV1|E2AK3_DROME Eukaryotic translation initiation factor 2-alpha kinase precursor (PRKR-like endoplasmic reticulum kinase) (PERK) (PEK) (DmPEK) emb|CAC85207.1| eukaryotic initiation factor eIF-2 alpha kinase [Drosophila melanogaster] 3.0E-58
Protein Domains
Database ID Description E-Value
Pfam IPR002372 EMBL-EBI Bacterial quinoprotein 1.5E-7
Pfam IPR000719 EMBL-EBI Protein kinase 1.8E-15
Pfam IPR000719 EMBL-EBI Protein kinase 2.9E-41
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_509912.1 2 4-23,454-476
F46C3.1 2 4-23,454-476
Sequence
Target Sequence 
>C. ELEGANS:193940_S_AT
gatactggtgactgtgcctatttgtatattgtaatgcaattatgtgccgagaagaccctt
gaagattggatccgccgcagcaaaaccatggaaagtcgtccgctattcacgatgaaaaat
tggattaaacaattggcgagcggtcttgaataccttcacaacaaaggattcatccacaga
gatttgaaaccaggaaatgtatttttctctctcgactcaacacatggtcatcaaatcctc
aaaattggagatcttggattggcaactaaaactgatggagctcccaaaataacagttcgc
caggattcagacagcagtgcaaagcatacgaaaaacgtcggcactcgatcctacatgtct
ccagagcaattgaaacatcaacaatacacggagaaagtggatattttcgcactgggacta
gtcgcaacagagctcatcatttcattttctactgctagcgagagaattcacacatttgct
gatttccagaaaggagatattccagccattttggacaatgtgccagagtcgcgggatttc
cttctccaactgaccagcttggaaccatcagaacgtcctactgc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GATACTGGTGACTGTGCCTATTTGT 693 423 2629 Antisense
GGAAAGTCGTCCGCTATTCACGATG 320 527 2718 Antisense
GGCGAGCGGTCTTGAATACCTTCAC 347 541 2763 Antisense
TCTCTCTCGACTCAACACATGGTCA 449 611 2834 Antisense
GGAGCTCCCAAAATAACAGTTCGCC 97 521 2905 Antisense
GATCCTACATGTCTCCAGAGCAATT 172 417 2975 Antisense
ATTTTCGCACTGGGACTAGTCGCAA 570 13 3031 Antisense
GTCGCAACAGAGCTCATCATTTCAT 212 475 3049 Antisense
ATCATTTCATTTTCTACTGCTAGCG 74 31 3064 Antisense
ACAATGTGCCAGAGTCGCGGGATTT 12 115 3143 Antisense
TGGAACCATCAGAACGTCCTACTGC 185 547 3188 Antisense
Sequence Source Affymetrix Proprietary Database