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[193939_at] serine/threonine kinase (CDC2/CDKX subfamily)

Description T05G5.3 /REP_DB=WormBase Gene ID /WP=CE00315 /GEN=ncc-1 /TR=SW:P34556 /GB=CAA81590.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=serine-threonine kinase (CDC2-CDKX subfamily)
Cluster 6grp_highest_10_10 > 97      6grp_high1_10_10 > 79      4grp_highest_8_8 > 08      4grp_high_8_8 > 53      6grp_highest_nonorm > 98      6grp_total > 89      4grp_total > 59      6grp_highest_sub > Cu      6grp_cgc > 69      6grp_high1_sub > Cu      6grp_cgc_sub > Da      4grp_rule_based > L2      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 925
1 2 3 4 range
A 674.9
(0.5)
P 		945.2
(2.9)
P 		959.1
(3)
P 		278.7
(-3)
P 		680
B 645.7
(-0.6)
P 		1180.4
(3)
P 		1000.7
(1.8)
P 		279.6
(-3)
P 		901
C 701.3
(0.2)
P 		1080.7
(3)
P 		933.3
(1.9)
P 		255.8
(-3)
P 		825
avr 674
(0) 		1068.8
(3) 		964.4
(2.2) 		271.4
(-3) 		797

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1275
1 2 3 4 5 6 range
A 912.1
(-0.8)
P 		651.5
(-2.1)
P 		481.9
(-3)
P 		613
(-2.3)
P 		1274.2
(1.1)
P 		1633.5
(3)
P 		1152
B 910.6
(-0.3)
P 		602.7
(-1.8)
P 		361.6
(-3)
P 		624.1
(-1.7)
P 		1301
(1.7)
P 		1561.9
(3)
P 		1200
C 791.7
(-1.5)
P 		642.2
(-2.3)
P 		502.5
(-3)
P 		549.5
(-2.8)
P 		1188.4
(0.6)
P 		1636.8
(3)
P 		1134
avr 871.5
(-0.8) 		632.1
(-2.1) 		448.7
(-3) 		595.5
(-2.2) 		1254.5
(1.2) 		1610.7
(3) 		1162
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 285
1 2 3 4 range
A 245.7
(2.9)
P 		205.2
(1.7)
P 		250.7
(3)
P 		40.8
(-3)
P 		210
B 205.9
(0.8)
P 		291.5
(3)
P 		231.9
(1.5)
P 		59.6
(-3)
P 		232
C 232.1
(1)
P 		310.7
(2.7)
P 		325.3
(3)
P 		43.1
(-3)
P 		282
avr 227.9
(1.9) 		269.1
(3) 		269.3
(3) 		47.8
(-3) 		222

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 495
1 2 3 4 5 6 range
A 168.1
(-1.7)
P 		231.7
(-0.4)
P 		104.9
(-3)
P 		155.5
(-2)
P 		384.5
(2.7)
P 		397.7
(3)
P 		293
B 316.9
(-0.2)
P 		200.6
(-1.6)
P 		87.8
(-3)
P 		165.3
(-2.1)
P 		528.6
(2.3)
P 		582.4
(3)
P 		495
C 293.4
(-0.5)
P 		195.9
(-1.8)
P 		127.9
(-2.8)
P 		110.5
(-3)
P 		384.5
(0.8)
P 		547.9
(3)
P 		437
avr 259.5
(-0.7) 		209.4
(-1.5) 		106.9
(-3) 		143.8
(-2.4) 		432.5
(1.9) 		509.3
(3) 		402
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193939_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.7783
Sequence Type Exemplar sequence
Representative Public ID T05G5.3 NCBI
Target Description T05G5.3 /REP_DB=WormBase Gene ID /WP=CE00315 /GEN=ncc-1 /TR=SW:P34556 /GB=CAA81590.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=serine-threonine kinase (CDC2-CDKX subfamily)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq,GenBank identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_001027576(11), S75262(9)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_001027576 NCBI Caenorhabditis elegans Cyclin-Dependent Kinase family member (cdk-1) (cdk-1) mRNA, complete cds. 11/11 None
S75262 NCBI ncc-1=p34cdc2 kinase [Caenorhabditis elegans, mRNA, 1190 nt]. 9/11 None
SNAP00000019877 ENSEMBL cdna:SNAP chromosome:CEL140:III:9747369:9748563:1 11/11 None
GENEFINDER00000019888 ENSEMBL cdna:GeneFinder chromosome:CEL140:III:9747369:9748563:1 11/11 None
T05G5.3.3 ENSEMBL cdna:known chromosome:CEL140:III:9747355:9748739:1 gene:T05G5.3 11/11 None
T05G5.3.2 ENSEMBL cdna:known chromosome:CEL140:III:9747367:9748747:1 gene:T05G5.3 11/11 None
T05G5.3.1 ENSEMBL cdna:known chromosome:CEL140:III:9747367:9748747:1 gene:T05G5.3 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:9747364-9748559(+) 100.0 100.0
Public Domain and Genome References
Gene Title serine/threonine kinase (CDC2/CDKX subfamily)
Gene Symbol cdk-1
Ensembl T05G5.3
Entrez Gene 176374 Entrez gene
SwissProt P34556 EMBL-EBI
WormBase CE00315 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFA.20663.1.A1_AT similar to Cell division control protein 2 homolog (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) cfa
CANINE_2:CFA.20663.1.A1_S_AT similar to Cell division control protein 2 homolog (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) cfa
CANINE_2:CFAAFFX.20006.1.S1_AT similar to Cell division control protein 2 homolog (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) cfa
DROSOPHILA_2:1631861_AT cdc2 dm
DROSGENOME1:154844_AT cdc2 dm
CHICKEN:GGA.726.2.S1_A_AT cell division cycle 2, G1 to S and G2 to M gga
HG-U95AV2:33324_S_AT cell division cycle 2, G1 to S and G2 to M hs
HG-U95AV2:1803_AT cell division cycle 2, G1 to S and G2 to M hs
HC-G110:1803_AT cell division cycle 2, G1 to S and G2 to M hs
HG-U133A:203214_X_AT cell division cycle 2, G1 to S and G2 to M hs
HG-U133_PLUS_2:203214_X_AT cell division cycle 2, G1 to S and G2 to M hs
HG-U133A_2:203214_X_AT cell division cycle 2, G1 to S and G2 to M hs
HG-U133_PLUS_2:210559_S_AT cell division cycle 2, G1 to S and G2 to M hs
HG-U133A:210559_S_AT cell division cycle 2, G1 to S and G2 to M hs
HG-U133A_2:210559_S_AT cell division cycle 2, G1 to S and G2 to M hs
HUGENEFL:X05360_AT cell division cycle 2, G1 to S and G2 to M hs
U133_X3P:G3126638_3P_A_AT cell division cycle 2, G1 to S and G2 to M hs
HG-U95AV2:40915_R_AT Cell division cycle 2, G1 to S and G2 to M hs
U133_X3P:HS.184572.0.S2_3P_AT Cell division cycle 2, G1 to S and G2 to M hs
HG-U133A_2:203213_AT Cell division cycle 2, G1 to S and G2 to M hs
HG-FOCUS:203213_AT Cell division cycle 2, G1 to S and G2 to M hs
HG-U133_PLUS_2:203213_AT Cell division cycle 2, G1 to S and G2 to M hs
HG-U133A:203213_AT Cell division cycle 2, G1 to S and G2 to M hs
HG-U95E:91194_AT Cell division cycle 2, G1 to S and G2 to M hs
HG-U133_PLUS_2:231534_AT Cell division cycle 2, G1 to S and G2 to M hs
HG-U133B:231534_AT Cell division cycle 2, G1 to S and G2 to M hs
HU35KSUBA:AA481617_AT Cell division cycle 2, G1 to S and G2 to M hs
U133_X3P:HS.184572.2.A1_3P_AT Cell division cycle 2, G1 to S and G2 to M hs
MU11KSUBA:U58633_S_AT cell division cycle 2 homolog A (S. pombe) mm
MU11KSUBB:MSA.18569.0_S_AT cell division cycle 2 homolog A (S. pombe) mm
MG-U74AV2:100128_AT cell division cycle 2 homolog A (S. pombe) mm
MOE430A:1448314_AT cell division cycle 2 homolog A (S. pombe) mm
MOUSE430A_2:1448314_AT cell division cycle 2 homolog A (S. pombe) mm
MOUSE430_2:1448314_AT cell division cycle 2 homolog A (S. pombe) mm
MU11KSUBB:MSA.30924.0_S_AT Cell division cycle 2 homolog A (S. pombe), mRNA (cDNA clone MGC:36190 IMAGE:4977366) mm
MU19KSUBC:TC38001_AT Cell division cycle 2 homolog A (S. pombe), mRNA (cDNA clone MGC:36190 IMAGE:4977366) mm
RT-U34:X60767MRNA_S_AT cell division cycle 2 homolog A (S. pombe) rn
RG-U34A:X60767MRNA_S_AT cell division cycle 2 homolog A (S. pombe) rn
RAE230A:1367776_AT cell division cycle 2 homolog A (S. pombe) rn
RAT230_2:1367776_AT cell division cycle 2 homolog A (S. pombe) rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5634 nucleus inferred from direct assay QuickGO AmiGO
5737 cytoplasm inferred from direct assay QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
4693 cyclin-dependent protein kinase activity inferred from sequence similarity QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA81590 Hypothetical protein T05G5.3 [Caenorhabditis elegans] emb|CAA48455.1| unnamed protein product [Caenorhabditis elegans] ref|NP_001022747.1| Cyclin-Dependent Kinase family member (cdk-1) [Caenorhabditis elegans] gb|AAD37119.1| CDK1 ortholog [Caenorhabditis elegans] sp|P34556|CDC2_CAEEL Cell division control protein 2 homolog (p34 protein kinase) 0.0
blast AAC60520 p34cdc2 kinase [Caenorhabditis elegans] 0.0
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 8.0E-83
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 6.0E-83
hanks 3.1.1 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; CDC2Hs 1.0E-110
hanks 3.1.1 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; CDC2Hs 1.0E-111
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 1.3E-98
Pfam IPR000719 EMBL-EBI Protein kinase 1.6E-98
Sequence
Target Sequence 
>C. ELEGANS:193939_AT
cagcgtcgtgttattcatcgcgatcttaagccacagaacttgctggtcgacaacaatgga
gcaatcaagcttgccgatttcggacttgccagagctattggtatcccgattcgcgtttac
acgcatgaagttgtcactctctggtatagagctccagaaattctgatgggtgctcagaga
tactcgatgggcgtagacatgtggtcgattggatgcatttttgctgaaatggccacgaag
aagccactgtttcaaggagattcagaaattgatgagctgttccgcatcttcagagttctc
ggcacaccgactgagttggaatggaatggtgttgaatcacttccggactacaaggcgacg
ttcccaaaatggcgtgagaatttcctccgtgacaagttctacgacaagaagactggaaag
caccttttggacgatactgcattctctcttcttgaaggtttgctgatctacgatccatca
cttcgtct

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
CAGCGTCGTGTTATTCATCGCGATC 222 201 427 Antisense
AAGCCACAGAACTTGCTGGTCGACA 365 149 454 Antisense
CCGATTTCGGACTTGCCAGAGCTAT 480 263 500 Antisense
TTGGTATCCCGATTCGCGTTTACAC 228 663 524 Antisense
ACGCATGAAGTTGTCACTCTCTGGT 54 93 547 Antisense
GTTCCGCATCTTCAGAGTTCTCGGC 589 441 705 Antisense
TGGTGTTGAATCACTTCCGGACTAC 514 549 753 Antisense
GACTACAAGGCGACGTTCCCAAAAT 221 363 772 Antisense
GAATTTCCTCCGTGACAAGTTCTAC 80 319 804 Antisense
TTTGGACGATACTGCATTCTCTCTT 288 667 852 Antisense
TGATCTACGATCCATCACTTCGTCT 511 563 890 Antisense
Sequence Source Affymetrix Proprietary Database