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[193924_at] multidrug resistance protein 3 (p-glycoprotein C)

Description ZK455.7 /REP_DB=WormBase Gene ID /WP=CE03818 /GEN=pgp-3 /TR=Q20335 /GB=CAA91495.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=multidrug resistance protein 3 (p-glycoprotein C)
Cluster 6grp_highest_10_10 > 22      6grp_high1_10_10 > 11      4grp_highest_8_8 > 42      4grp_high_8_8 > 49      6grp_highest_nonorm > 51      6grp_total > 23      4grp_total > 63      6grp_highest_sub > De      6grp_cgc > 71      6grp_high1_sub > De      6grp_cgc_sub > 03      6grp_total_sub > Decrease      6grp_rule_based > S1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1537
1 2 3 4 range
A 1706.3
(3)
P 		796.9
(-0.9)
P 		902.9
(-0.4)
P 		308.8
(-3)
P 		1398
B 1801.6
(3)
P 		778.9
(-1)
P 		812
(-0.9)
P 		265.1
(-3)
P 		1537
C 1628.6
(3)
P 		762.9
(-1.1)
P 		1009.9
(0.1)
P 		349.5
(-3)
P 		1279
avr 1712.2
(3) 		779.6
(-1) 		908.3
(-0.4) 		307.8
(-3) 		1404

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 538
1 2 3 4 5 6 range
A 690.3
(3)
P 		619.4
(1.9)
P 		646.3
(2.3)
P 		602.3
(1.7)
P 		355
(-2.1)
P 		294
(-3)
P 		396
B 768.8
(3)
P 		746.2
(2.7)
P 		722.4
(2.5)
P 		570.2
(0.8)
P 		360.6
(-1.6)
P 		231.2
(-3)
P 		538
C 662
(2)
P 		733.5
(3)
P 		638.8
(1.7)
P 		593.4
(1.1)
P 		300.5
(-3)
P 		297.8
(-3)
P 		436
avr 707
(3) 		699.7
(2.9) 		669.2
(2.5) 		588.6
(1.4) 		338.7
(-2.1) 		274.3
(-3) 		433
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 576
1 2 3 4 range
A 621.2
(3)
P 		173
(-1.7)
P 		236
(-1)
P 		45.2
(-3)
P 		576
B 574.5
(3)
P 		192.4
(-1.4)
P 		188.2
(-1.5)
P 		56.5
(-3)
P 		518
C 539.1
(3)
P 		219.3
(-1)
P 		352
(0.7)
P 		58.9
(-3)
P 		480
avr 578.3
(3) 		194.9
(-1.4) 		258.7
(-0.7) 		53.5
(-3) 		525

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 196
1 2 3 4 5 6 range
A 127.2
(-0.8)
P 		220.3
(3)
P 		140.7
(-0.2)
P 		152.7
(0.3)
P 		107.1
(-1.6)
P 		71.6
(-3)
P 		149
B 267.5
(3)
P 		248.4
(2.4)
P 		175.4
(-0)
P 		151
(-0.9)
P 		146.5
(-1)
P 		86.2
(-3)
P 		181
C 245.4
(3)
P 		223.8
(2.1)
P 		162.6
(-0.4)
P 		119.3
(-2.1)
P 		97.2
(-3)
P 		99.7
(-2.9)
P 		148
avr 213.4
(2.3) 		230.8
(3) 		159.6
(0.1) 		141
(-0.7) 		116.9
(-1.7) 		85.8
(-3) 		145
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193924_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.16163
Sequence Type Exemplar sequence
Representative Public ID ZK455.7 NCBI
Target Description ZK455.7 /REP_DB=WormBase Gene ID /WP=CE03818 /GEN=pgp-3 /TR=Q20335 /GB=CAA91495.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=multidrug resistance protein 3 (p-glycoprotein C)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_077500(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_077500 NCBI Caenorhabditis elegans P-GlycoProtein related family member (pgp-3) (pgp-3) mRNA, complete cds. 11/11 None
SNAP00000010138 ENSEMBL cdna:SNAP chromosome:CEL140:X:11353704:11356931:1 11/11 None
GENEFINDER00000010143 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:11354068:11356931:1 11/11 None
ZK455.7 ENSEMBL cdna:known chromosome:CEL140:X:11352086:11357005:1 gene:ZK455.7 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:11352085-11356931(+) 100.0 100.0
Public Domain and Genome References
Gene Title multidrug resistance protein 3 (p-glycoprotein C)
Gene Symbol pgp-3
Ensembl ZK455.7
Entrez Gene 181326 Entrez gene
SwissProt P34713 EMBL-EBI
WormBase CE03818 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:257899_AT ABC transporter family protein at
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6810 transport inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
16021 integral to membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
166 nucleotide binding inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA91495 Hypothetical protein ZK455.7 [Caenorhabditis elegans] emb|CAA91467.1| Hypothetical protein ZK455.7 [Caenorhabditis elegans] ref|NP_509901.1| P-GlycoProtein related family member (pgp-3) [Caenorhabditis elegans] sp|P34713|MDR3_CAEEL Multidrug resistance protein 3 (P-glycoprotein C) pir||T22094 hypothetical protein ZK455.7 - Caenorhabditis elegans 0.0
blast CAA46191 P-glycoprotein C [Caenorhabditis elegans] 0.0
blast CAE70652 Hypothetical protein CBG17357 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 3.7E-75
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 7.3E-71
Pfam IPR003439 EMBL-EBI ABC transporter 2.9E-58
Pfam IPR003439 EMBL-EBI ABC transporter 2.4E-67
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 7.3E-71
Pfam IPR003439 EMBL-EBI ABC transporter 3.2E-54
Pfam IPR003439 EMBL-EBI ABC transporter 2.4E-67
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 7.3E-71
Pfam IPR003439 EMBL-EBI ABC transporter 1.7E-31
Pfam IPR003439 EMBL-EBI ABC transporter 2.4E-67
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_509901.1 12 44-66,102-124,174-196,200-217,276-298,302-324,708-730,750-772,828-850,855-874,935-957,967-989
ZK455.7 12 44-66,102-124,174-196,200-217,276-298,302-324,708-730,750-772,828-850,855-874,935-957,967-989
SNAP00000010138 6 352-374,394-416,472-494,499-518,579-601,611-633
GENEFINDER00000010143 6 235-257,277-299,355-377,382-401,462-484,494-516
Sequence
Target Sequence 
>C. ELEGANS:193924_AT
tgagcggtactacgatgcactttgtggttctgtcaaaattgatgatagtgatattcgtga
tctttctgtaaaacatttgcgtgataacattgctcttgtcgggcaagaacccactctttt
caatttaactataagagagaatatcacatatggattggaaaacataacacaggatcaggt
tgaaaaagctgcgacacttgcaaacattcacacatttgtgatgggacttcctgacggtta
cgatacgtctgtaggagcatccggtggtcgtctgtctggtggacagaagcaacgtgttgc
tattgctagagcgattgtcagagacccaaagatcttacttctcgatgaagccacgtcagc
tcttgacacagaaagtgaaaaaattgtgcaagaagctctggataaagcgagacttggaag
aacttgtgtagttattgcccatcgtc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TGAGCGGTACTACGATGCACTTTGT 315 567 3243 Antisense
GCGTGATAACATTGCTCTTGTCGGG 548 291 3321 Antisense
GGCAAGAACCCACTCTTTTCAATTT 166 535 3344 Antisense
GCGACACTTGCAAACATTCACACAT 435 289 3433 Antisense
TGGGACTTCCTGACGGTTACGATAC 348 553 3464 Antisense
ACGTCTGTAGGAGCATCCGGTGGTC 584 91 3487 Antisense
CGGTGGTCGTCTGTCTGGTGGACAG 571 243 3504 Antisense
TGCTAGAGCGATTGTCAGAGACCCA 620 579 3546 Antisense
GACCCAAAGATCTTACTTCTCGATG 402 381 3565 Antisense
GCCACGTCAGCTCTTGACACAGAAA 701 279 3592 Antisense
ACTTGTGTAGTTATTGCCCATCGTC 200 105 3664 Antisense
Sequence Source Affymetrix Proprietary Database