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[193917_at] 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase

Description T01E8.3 /REP_DB=WormBase Gene ID /WP=CE02307 /TR=Q22070 /GB=CAA88745.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase
Cluster 6grp_highest_10_10 > 61      6grp_high1_10_10 > 26      4grp_highest_8_8 > 51      4grp_high_8_8 > 24      6grp_highest_nonorm > 80      6grp_total > 26      4grp_total > 39      6grp_highest_sub > De      6grp_cgc > 14      6grp_high1_sub > De      6grp_cgc_sub > Cu      6grp_total_sub > Cup      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 209
1 2 3 4 range
A 345
(3)
P 		171.7
(-3)
P 		238.4
(-0.7)
P 		234
(-0.8)
P 		173
B 232.1
(3)
P 		164.1
(-1.3)
P 		136.1
(-3)
P 		167.1
(-1.1)
P 		96
C 265.6
(3)
P 		199.6
(-0.4)
P 		149
(-3)
P 		203.3
(-0.2)
P 		117
avr 280.9
(3) 		178.5
(-2.8) 		174.5
(-3) 		201.5
(-1.5) 		106

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 200
1 2 3 4 5 6 range
A 305.8
(3)
P 		252.8
(1)
P 		142.9
(-3)
P 		147.5
(-2.8)
P 		155
(-2.6)
P 		176.4
(-1.8)
P 		163
B 311.6
(3)
P 		296.4
(2.5)
P 		162
(-1.5)
P 		189.1
(-0.7)
P 		111.2
(-3)
P 		211.8
(0)
P 		200
C 288.4
(3)
P 		229.5
(0.4)
P 		236.4
(0.7)
P 		152.8
(-3)
P 		180.6
(-1.8)
P 		166.2
(-2.4)
P 		136
avr 301.9
(3) 		259.6
(1.3) 		180.4
(-1.8) 		163.1
(-2.4) 		148.9
(-3) 		184.8
(-1.6) 		153
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 94
1 2 3 4 range
A 125.6
(3)
P 		37.3
(-2.8)
P 		62.3
(-1.2)
P 		34.2
(-3)
P 		91
B 74
(3)
P 		40.5
(-1.7)
P 		31.5
(-3)
P 		35.6
(-2.4)
P 		43
C 87.9
(3)
P 		57.4
(-0.4)
P 		51.9
(-1)
P 		34.3
(-3)
P 		54
avr 95.8
(3) 		45.1
(-2) 		48.6
(-1.6) 		34.7
(-3) 		61

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 78
1 2 3 4 5 6 range
A 56.4
(-0.4)
P 		89.9
(3)
P 		31.1
(-3)
P 		37.4
(-2.4)
P 		46.8
(-1.4)
P 		43
(-1.8)
P 		59
B 108.4
(3)
P 		98.7
(2.2)
P 		39.3
(-3)
P 		50.1
(-2.1)
P 		45.2
(-2.5)
P 		79
(0.4)
P 		69
C 106.9
(3)
P 		70
(0.1)
P 		60.2
(-0.7)
P 		30.7
(-3)
P 		58.4
(-0.8)
P 		55.6
(-1)
P 		76
avr 90.6
(3) 		86.2
(2.5) 		43.5
(-2.5) 		39.4
(-3) 		50.1
(-1.7) 		59.2
(-0.7) 		51
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193917_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.3818
Sequence Type Exemplar sequence
Representative Public ID T01E8.3 NCBI
Target Description T01E8.3 /REP_DB=WormBase Gene ID /WP=CE02307 /TR=Q22070 /GB=CAA88745.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_063804(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_063804 NCBI Caenorhabditis elegans PhosphoLipase C family member (plc-3) (plc-3) mRNA, complete cds. 11/11 None
SNAP00000042900 ENSEMBL cdna:SNAP chromosome:CEL140:II:10222788:10228977:1 11/11 None
GENEFINDER00000042908 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:10222788:10228977:1 11/11 None
T01E8.3 ENSEMBL cdna:known chromosome:CEL140:II:10222788:10229347:1 gene:T01E8.3 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:10222784-10228974(+) 100.0 100.0
Public Domain and Genome References
Gene Title 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase
Gene Symbol plc-3
Ensembl T01E8.3
Entrez Gene 174586 Entrez gene
SwissProt Q22070 EMBL-EBI
WormBase CE02307 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:251768_AT phosphoinositide-specific phospholipase C, putative at
CANINE_2:CFAAFFX.14355.1.S1_AT similar to 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148) cfa
CANINE_2:CFAAFFX.14355.1.S1_S_AT similar to 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148) cfa
DROSOPHILA_2:1628815_AT small wing dm
DROSGENOME1:153466_AT small wing dm
CHICKEN:GGA.2589.1.S1_AT similar to 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148) gga
CHICKEN:GGA.2589.2.S1_X_AT similar to 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148) gga
CHICKEN:GGA.2589.3.S1_AT similar to 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148) gga
CHICKEN:GGA.2589.3.S1_X_AT similar to 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148) gga
CHICKEN:GGAAFFX.25967.2.S1_S_AT similar to 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148) gga
HG-U95AV2:34351_AT phospholipase C, gamma 1 hs
HG-U95AV2:1082_AT phospholipase C, gamma 1 hs
HC-G110:1082_AT phospholipase C, gamma 1 hs
HG-U133_PLUS_2:216551_X_AT phospholipase C, gamma 1 hs
HG-U133A_2:216551_X_AT phospholipase C, gamma 1 hs
HG-U133A:216551_X_AT phospholipase C, gamma 1 hs
HU35KSUBA:AA442054_S_AT phospholipase C, gamma 1 hs
HUGENEFL:M34667_AT phospholipase C, gamma 1 hs
U133_X3P:HS.268177.1.S1_3P_A_AT phospholipase C, gamma 1 hs
U133_X3P:HS.268177.0.S2_3P_AT phospholipase C, gamma 1 hs
HG-U133A_2:202789_AT phospholipase C, gamma 1 hs
HG-FOCUS:202789_AT phospholipase C, gamma 1 hs
HG-U133_PLUS_2:202789_AT phospholipase C, gamma 1 hs
HG-U133A:202789_AT phospholipase C, gamma 1 hs
MOE430A:1450360_AT phospholipase C, gamma 1 mm
MOUSE430_2:1450360_AT phospholipase C, gamma 1 mm
MOUSE430A_2:1450360_AT phospholipase C, gamma 1 mm
MOE430B:1435149_AT phospholipase C, gamma 1 mm
MOUSE430_2:1435149_AT phospholipase C, gamma 1 mm
MU11KSUBB:MSA.15085.0_S_AT phospholipase C, gamma 1 mm
MG-U74AV2:98290_AT phospholipase C, gamma 1 mm
MG-U74BV2:107396_AT Phospholipase C, gamma 1 (Plcg1), mRNA mm
MOUSE430_2:1442963_AT Phospholipase C, gamma 1 (Plcg1), mRNA mm
MOE430B:1442963_AT Phospholipase C, gamma 1 (Plcg1), mRNA mm
RG-U34A:J03806_AT phospholipase C, gamma 1 rn
RAE230A:1368183_AT phospholipase C, gamma 1 rn
RAT230_2:1368183_AT phospholipase C, gamma 1 rn
RG-U34B:RC_AA943027_AT Phospholipase C, gamma 1 rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6629 lipid metabolism inferred from electronic annotation QuickGO AmiGO
7165 signal transduction inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4435 phosphoinositide phospholipase C activity inferred from electronic annotation QuickGO AmiGO
4629 phospholipase C activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA88745 Hypothetical protein T01E8.3 [Caenorhabditis elegans] ref|NP_496205.1| PhosphoLipase C family member (plc-3) [Caenorhabditis elegans] 0.0
blast CAE71733 Hypothetical protein CBG18715 [Caenorhabditis briggsae] 0.0
blast XP_624101 PREDICTED: similar to ENSANGP00000022029 [Apis mellifera] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR000980 EMBL-EBI SH2 motif 1.6E-25
Pfam IPR000980 EMBL-EBI SH2 motif 3.2E-21
Pfam IPR000909 EMBL-EBI Phosphatidylinositol-specific phospholipase C, X domain 1.2E-71
Pfam IPR001452 EMBL-EBI SH3 6.1E-8
Pfam IPR001711 EMBL-EBI Phosphatidylinositol-specific phospholipase C, Y domain 3.4E-45
Pfam IPR000008 EMBL-EBI C2 domain 4.6E-29
Pfam IPR000008 EMBL-EBI C2 domain 4.2E-10
Pfam IPR000008 EMBL-EBI C2 domain 3.3E-12
Pfam IPR000980 EMBL-EBI SH2 motif 1.6E-25
Pfam IPR000980 EMBL-EBI SH2 motif 3.2E-21
Pfam IPR000909 EMBL-EBI Phosphatidylinositol-specific phospholipase C, X domain 1.2E-71
Pfam IPR001452 EMBL-EBI SH3 6.1E-8
Pfam IPR001711 EMBL-EBI Phosphatidylinositol-specific phospholipase C, Y domain 3.4E-45
Pfam IPR000008 EMBL-EBI C2 domain 4.6E-29
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_496205.1 1 142-161
T01E8.3 1 142-161
Sequence
Target Sequence 
>C. ELEGANS:193917_AT
ttgagatccagtgtcccgaagtagcactgatcagattccacgtggaagacggtgactttg
tgggaccaaaaacagatccgttcattggtcaagcagtattccctgttgattcaattagat
gtggattccgatcagttccactcaaaaatcagtacagtgaggagcttgagctctcttcac
tgttagttgatgtacaaatgtgctccagagaaggaactcaattgatcaggtcgtcgtcgc
atttcttgcaggcgagtcgtctggctcctgtcttcgctcaccgtaagatcacaaatggcg
atagtatccctcgtgagatggcacctcggttacgaacatcagccaccgatcgttcactag
actctccaacaaattccgagtcaagagccactcttctgagcggccaacgaggtagccaag
actctatggacagcgctgccgaaacatcgtcc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TTGAGATCCAGTGTCCCGAAGTAGC 112 703 3371 Antisense
TGGATTCCGATCAGTTCCACTCAAA 206 551 3492 Antisense
TGAGCTCTCTTCACTGTTAGTTGAT 82 569 3537 Antisense
ACTCAATTGATCAGGTCGTCGTCGC 291 99 3586 Antisense
TCGTCGTCGCATTTCTTGCAGGCGA 463 605 3601 Antisense
TGTCTTCGCTCACCGTAAGATCACA 595 557 3639 Antisense
TAGTATCCCTCGTGAGATGGCACCT 533 651 3672 Antisense
GGCACCTCGGTTACGAACATCAGCC 608 535 3690 Antisense
CACTAGACTCTCCAACAAATTCCGA 271 191 3725 Antisense
TCTTCTGAGCGGCCAACGAGGTAGC 473 615 3762 Antisense
GGACAGCGCTGCCGAAACATCGTCC 387 525 3798 Antisense
Sequence Source Affymetrix Proprietary Database