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[193909_at] tyrosine-protein kinase (KIN15/KIN16 subfamily)

Description ZK938.5 /REP_DB=WormBase Gene ID /WP=CE03838 /GEN=old-2 /TR=Q23677 /GB=CAA90147.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=tyrosine-protein kinase (KIN15-KIN16 subfamily)
Cluster 6grp_total > 44      4grp_total > 11      6grp_cgc > 80      4grp_rule_based > L4      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 73
1 2 3 4 range
A 32.2
(-1.7)
A 		43.6
(-0.5)
A 		19
(-3)
A 		77.8
(3)
A 		59
B 38.2
(-1.9)
A 		44.8
(-1.1)
A 		29.5
(-3)
A 		78.7
(3)
A 		49
C 19.5
(-2.3)
A 		11.6
(-3)
A 		20.3
(-2.3)
A 		84.3
(3)
A 		73
avr 30
(-2.3) 		33.3
(-1.9) 		22.9
(-3) 		80.3
(3) 		57

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 52
1 2 3 4 5 6 range
A 48.7
(1.6)
A 		19.9
(-2.3)
A 		59.4
(3)
A 		14.6
(-3)
A 		34.4
(-0.3)
A 		56
(2.5)
A 		45
B 28.3
(0.6)
P 		29.4
(0.8)
A 		13.4
(-2.8)
A 		39.3
(3)
A 		14.1
(-2.6)
A 		12.3
(-3)
A 		27
C 22.5
(1.6)
A 		22.7
(1.7)
A 		26.9
(3)
A 		7.9
(-2.9)
A 		21.8
(1.4)
A 		7.6
(-3)
A 		19
avr 33.2
(3) 		24
(-1.4) 		33.2
(3) 		20.6
(-3) 		23.4
(-1.7) 		25.3
(-0.8) 		13
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 14
1 2 3 4 range
A 11.7
(3)
A 		9.5
(1)
A 		5
(-3)
A 		11.4
(2.7)
A 		7
B 12.2
(0.2)
A 		11.1
(-0.4)
A 		6.8
(-3)
A 		16.8
(3)
A 		10
C 6.5
(-1.2)
A 		3.3
(-3)
A 		7.1
(-0.9)
A 		14.2
(3)
A 		11
avr 10.1
(-0.1) 		8
(-1.7) 		6.3
(-3) 		14.1
(3) 		8

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 12
1 2 3 4 5 6 range
A 9
(0.2)
A 		7.1
(-0.9)
A 		12.9
(2.6)
A 		3.7
(-3)
A 		10.4
(1.1)
A 		13.6
(3)
A 		10
B 9.8
(2.5)
P 		9.8
(2.5)
A 		3.3
(-3)
A 		10.4
(3)
A 		5.7
(-1)
A 		4.6
(-1.9)
A 		7
C 8.3
(3)
A 		6.9
(1.7)
A 		6.8
(1.7)
A 		1.6
(-3)
A 		7
(1.8)
A 		2.5
(-2.2)
A 		7
avr 9
(3) 		7.9
(1.3) 		7.7
(0.9) 		5.2
(-3) 		7.7
(0.9) 		6.9
(-0.3) 		4
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193909_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.3049
Sequence Type Exemplar sequence
Representative Public ID ZK938.5 NCBI
Target Description ZK938.5 /REP_DB=WormBase Gene ID /WP=CE03838 /GEN=old-2 /TR=Q23677 /GB=CAA90147.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=tyrosine-protein kinase (KIN15-KIN16 subfamily)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_063722(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_063722 NCBI Caenorhabditis elegans Overexpression Longevity Determinant family member (old-2) (old-2) mRNA, complete cds. 11/11 A 
SNAP00000044681 ENSEMBL cdna:SNAP chromosome:CEL140:II:9847394:9849508:-1 11/11 None
GENEFINDER00000044684 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:9846362:9849508:-1 11/11 None
ZK938.5 ENSEMBL cdna:known chromosome:CEL140:II:9847394:9849508:-1 gene:ZK938.5 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:9847390-9849505(-) 100.0 100.0
Public Domain and Genome References
Gene Title tyrosine-protein kinase (KIN15/KIN16 subfamily)
Gene Symbol old-2
Ensembl ZK938.5
Entrez Gene 191738 Entrez gene
SwissProt Q23677 EMBL-EBI
WormBase CE03838 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
30297 transmembrane receptor protein tyrosine kinase activator activity inferred from sequence similarity QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA90147 Hypothetical protein ZK938.5 [Caenorhabditis elegans] ref|NP_496123.1| Overexpression Longevity Determinant family member (old-2) [Caenorhabditis elegans] 0.0
blast CAA91146 Hypothetical protein C08H9.5 [Caenorhabditis elegans] ref|NP_496130.1| Overexpression Longevity Determinant family member (old-1) [Caenorhabditis elegans] 0.0
blast CAE67808 Hypothetical protein CBG13386 [Caenorhabditis briggsae] 4.0E-81
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 1.2E-52
Pfam IPR000719 EMBL-EBI Protein kinase 3.4E-4
Pfam IPR000719 EMBL-EBI Protein kinase 5.3E-41
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_496123.1 2 4-26,55-77
ZK938.5 2 4-26,55-77
SNAP00000044681 2 4-26,55-77
GENEFINDER00000044684 3 4-26,55-77,487-509
Sequence
Target Sequence 
>C. ELEGANS:193909_AT
ggccttgttgatttagtctcatttgcattccaaattgcaaaagggatggagtatttgatt
cacgttccgtgcgttcatagagacttggctctccgcaatgtgctaataaagggaaatatg
gtaattcgaattgcagactttggattggctaggagacataaaaataaagattattacaaa
actcaaagtgtcgatacaccgcttccaatacactggatggcacctgaaagtatagacaaa
ttactgttcactcagaaatcagatgtttggtcatatggggtctgtctttatgaactattt
tctttgggaaaatcaccttataaaaatgtgataaaatatgatgaaagagattcctattgc
aaatatgtgctggcttacttgaatgaaggaaaacgacttgcacagcctgcacatgctgat
gctgaaata

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GGCCTTGTTGATTTAGTCTCATTTG 682 543 880 Antisense
GATTTAGTCTCATTTGCATTCCAAA 411 429 889 Antisense
ATTTGATTCACGTTCCGTGCGTTCA 663 15 932 Antisense
CGTTCCGTGCGTTCATAGAGACTTG 485 247 942 Antisense
GTTCATAGAGACTTGGCTCTCCGCA 672 443 952 Antisense
GGCTCTCCGCAATGTGCTAATAAAG 596 537 966 Antisense
GGGAAATATGGTAATTCGAATTGCA 87 495 990 Antisense
GATGAAAGAGATTCCTATTGCAAAT 171 413 1219 Antisense
TATTGCAAATATGTGCTGGCTTACT 698 663 1234 Antisense
GAAGGAAAACGACTTGCACAGCCTG 216 333 1264 Antisense
GCCTGCACATGCTGATGCTGAAATA 524 233 1284 Antisense
Sequence Source Affymetrix Proprietary Database