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[193904_s_at] tyrosine-protein kinase (KIN15/KIN16 subfamily) /// tyrosine-protein kinase (KIN15/KIN16 subfamily)

Description C08H9.5 /REP_DB=WormBase Gene ID /WP=CE02991 /GEN=old-1 /TR=Q17833 /GB=CAA91146.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=tyrosine-protein kinase (KIN15-KIN16 subfamily)
Cluster 4grp_high_8_8 > 24      6grp_total > 23      4grp_total > 47      6grp_cgc > 31      6grp_cgc_sub > De      6grp_total_sub > Decrease      6grp_rule_based > S1      4grp_rule_based > L1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 238
1 2 3 4 range
A 251.7
(3)
P 		59.5
(-2)
P 		60.9
(-1.9)
M 		20.2
(-3)
A 		232
B 236.8
(3)
P 		75.2
(-1.9)
M 		62.9
(-2.3)
A 		39.4
(-3)
P 		197
C 197.8
(3)
P 		14.1
(-3)
A 		76.2
(-1)
P 		169
(2.1)
P 		184
avr 228.8
(3) 		49.6
(-3) 		66.7
(-2.4) 		76.2
(-2.1) 		179

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 187
1 2 3 4 5 6 range
A 159
(2.7)
P 		166.5
(3)
P 		137.4
(1.8)
P 		92.3
(-0.1)
P 		69.8
(-1.1)
P 		23.8
(-3)
A 		143
B 203.7
(3)
P 		142.1
(1)
P 		118.8
(0.3)
P 		78
(-1)
P 		34.1
(-2.4)
A 		16.3
(-3)
A 		187
C 164.3
(3)
P 		136.9
(1.8)
P 		116
(0.9)
P 		84.9
(-0.5)
M 		43.6
(-2.3)
M 		26.4
(-3)
A 		138
avr 175.7
(3) 		148.5
(1.9) 		124.1
(1) 		85.1
(-0.5) 		49.2
(-1.9) 		22.2
(-3) 		154
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 89
1 2 3 4 range
A 91.6
(3)
P 		12.9
(-2.3)
P 		15.9
(-2.1)
M 		3
(-3)
A 		89
B 75.5
(3)
P 		18.6
(-2.1)
M 		14.6
(-2.4)
A 		8.4
(-3)
P 		67
C 65.5
(3)
P 		4.1
(-3)
A 		26.6
(-0.8)
P 		28.5
(-0.6)
P 		61
avr 77.5
(3) 		11.9
(-3) 		19
(-2.4) 		13.3
(-2.9) 		66

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 65
1 2 3 4 5 6 range
A 29.3
(-0.4)
P 		59.2
(3)
P 		29.9
(-0.3)
P 		23.4
(-1)
P 		21.1
(-1.3)
P 		5.8
(-3)
A 		53
B 70.9
(3)
P 		47.3
(0.8)
P 		28.8
(-0.9)
P 		20.7
(-1.6)
P 		13.9
(-2.3)
A 		6.1
(-3)
A 		65
C 60.9
(3)
P 		41.8
(0.8)
P 		29.5
(-0.6)
P 		17.1
(-2)
M 		14.1
(-2.4)
M 		8.8
(-3)
A 		52
avr 53.7
(3) 		49.4
(2.4) 		29.4
(-0.1) 		20.4
(-1.3) 		16.4
(-1.8) 		6.9
(-3) 		47
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 193904_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.2863
Sequence Type Exemplar sequence
Representative Public ID C08H9.5 NCBI
Target Description C08H9.5 /REP_DB=WormBase Gene ID /WP=CE02991 /GEN=old-1 /TR=Q17833 /GB=CAA91146.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=tyrosine-protein kinase (KIN15-KIN16 subfamily)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_063729(11), NM_063722(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_063729 NCBI Caenorhabditis elegans Overexpression Longevity Determinant family member (old-1) (old-1) mRNA, complete cds. 11/11 None
NM_063722 NCBI Caenorhabditis elegans Overexpression Longevity Determinant family member (old-2) (old-2) mRNA, complete cds. 11/11 A 
SNAP00000001373 ENSEMBL cdna:SNAP chromosome:CEL140:II:9866559:9868621:-1 11/11 None
GENEFINDER00000001383 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:9866559:9871083:-1 11/11 None
SNAP00000044681 ENSEMBL cdna:SNAP chromosome:CEL140:II:9847394:9849508:-1 11/11 None
ZK938.5 ENSEMBL cdna:known chromosome:CEL140:II:9847394:9849508:-1 gene:ZK938.5 11/11 A 
C08H9.5 ENSEMBL cdna:known chromosome:CEL140:II:9866559:9868672:-1 gene:C08H9.5 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
GENEFINDER00000044684 7/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:9866555-9868669(-) 100.0 100.0
Public Domain and Genome References
Gene Title tyrosine-protein kinase (KIN15/KIN16 subfamily)
tyrosine-protein kinase (KIN15/KIN16 subfamily)
Gene Symbol old-1
old-2
Ensembl ZK938.5
C08H9.5
Entrez Gene 191737 Entrez gene
191738 Entrez gene
SwissProt Q17833 EMBL-EBI
Q23677 EMBL-EBI
WormBase CE02991 Wormbase
CE03838 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
30297 transmembrane receptor protein tyrosine kinase activator activity inferred from sequence similarity QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA91146 Hypothetical protein C08H9.5 [Caenorhabditis elegans] ref|NP_496130.1| Overexpression Longevity Determinant family member (old-1) [Caenorhabditis elegans] 0.0
blast CAA90147 Hypothetical protein ZK938.5 [Caenorhabditis elegans] ref|NP_496123.1| Overexpression Longevity Determinant family member (old-2) [Caenorhabditis elegans] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 1.2E-52
Pfam IPR000719 EMBL-EBI Protein kinase 0.044
Pfam IPR000719 EMBL-EBI Protein kinase 3.1E-43
Pfam IPR000719 EMBL-EBI Protein kinase 1.1E-52
Pfam IPR001223 EMBL-EBI Glycoside hydrolase, family 18 3.3E-110
Pfam IPR000719 EMBL-EBI Protein kinase 1.1E-52
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_496130.1 2 20-42,76-98
NP_496123.1 2 4-26,55-77
ZK938.5 2 4-26,55-77
C08H9.5 2 20-42,76-98
SNAP00000001373 1 58-80
GENEFINDER00000001383 3 31-53,510-532,562-584
SNAP00000044681 2 4-26,55-77
Sequence
Target Sequence 
>C. ELEGANS:193904_S_AT
attgcagactttggattggctaggaggcataaaaataaagattattacaaaactcaaagt
gtcgatacaccgcttccaatacactggatggcacctgaaagtatagacaaattactgttc
actcagaaatcagatgtttggtcatatggggtctgtctttatgaactattctctttggga
aaatcaccttatgaaaatgtgataaaatatgatcaaagagatttttattggaagtatgtg
ctgtcttacttgaatgaagggaaaagacttgcacagcctgcacatgctgacgcagaaata
tataatgtaatgaaactatgctgggatctagatatgaatagtcgtacaacattcttagac
tgcattgagttttttgagaaagaattgaaaacaacatcaaatgagtattttcttgatctc
accagaaagctccgttcagaaaccaacaatcaacttcgacttagtaatt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
ATTGCAGACTTTGGATTGGCTAGGA 294 5 1021 Antisense
TCAAAGTGTCGATACACCGCTTCCA 489 629 1074 Antisense
CACCGCTTCCAATACACTGGATGGC 654 199 1088 Antisense
GGATGGCACCTGAAAGTATAGACAA 487 515 1106 Antisense
ATGGGGTCTGTCTTTATGAACTATT 371 51 1166 Antisense
GAAACTATGCTGGGATCTAGATATG 373 357 1332 Antisense
GTCGTACAACATTCTTAGACTGCAT 317 473 1361 Antisense
GAGTATTTTCTTGATCTCACCAGAA 458 399 1423 Antisense
TCTCACCAGAAAGCTCCGTTCAGAA 636 611 1437 Antisense
AGCTCCGTTCAGAAACCAACAATCA 132 65 1448 Antisense
AACAATCAACTTCGACTTAGTAATT 655 131 1465 Antisense
Sequence Source Affymetrix Proprietary Database