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[193903_at] multidrug resistance protein (p-glycoprotein) (2 domains)

Description C47A10.1 /REP_DB=WormBase Gene ID /WP=CE15714 /TR=O45721 /GB=CAB07855.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=multidrug resistance protein (p-glycoprotein) (2 domains)
Cluster 6grp_high1_10_10 > 16      4grp_high_8_8 > 50      6grp_total > 15      4grp_total > 53      6grp_cgc > 23      6grp_high1_sub > De      6grp_cgc_sub > De      6grp_total_sub > Decrease      6grp_rule_based > S1      4grp_rule_based > L1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 620
1 2 3 4 range
A 618.4
(3)
P 		449.6
(1)
P 		317
(-0.5)
P 		102.5
(-3)
A 		516
B 655.8
(3)
P 		423.4
(0.6)
P 		419.1
(0.6)
P 		69.3
(-3)
P 		587
C 527.1
(3)
P 		393.4
(1.4)
P 		351.1
(0.8)
P 		36.3
(-3)
A 		491
avr 600.4
(3) 		422.1
(1) 		362.4
(0.3) 		69.4
(-3) 		531

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 301
1 2 3 4 5 6 range
A 340.5
(3)
P 		284.4
(1.8)
P 		130.8
(-1.4)
P 		98.1
(-2.1)
P 		55
(-3)
P 		79.1
(-2.5)
A 		286
B 293.1
(3)
P 		235.1
(1.4)
P 		158.6
(-0.6)
P 		108.3
(-2)
P 		74.7
(-2.9)
P 		70.9
(-3)
P 		222
C 296.8
(3)
P 		247.2
(1.8)
P 		153.5
(-0.3)
P 		97.4
(-1.7)
P 		84.7
(-2)
P 		39.8
(-3)
A 		257
avr 310.1
(3) 		255.6
(1.7) 		147.6
(-1) 		101.3
(-2.1) 		71.5
(-2.8) 		63.3
(-3) 		247
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 219
1 2 3 4 range
A 225.1
(3)
P 		97.6
(-0.6)
P 		82.9
(-1.1)
P 		15
(-3)
A 		210
B 209.1
(3)
P 		104.6
(-0.2)
P 		97.1
(-0.5)
P 		14.8
(-3)
P 		194
C 174.5
(3)
P 		113.1
(0.8)
P 		122.4
(1.1)
P 		6.1
(-3)
A 		168
avr 202.9
(3) 		105.1
(-0.1) 		100.8
(-0.2) 		12
(-3) 		191

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 97
1 2 3 4 5 6 range
A 62.8
(0.3)
P 		101.1
(3)
P 		28.5
(-2.2)
P 		24.9
(-2.4)
P 		16.6
(-3)
P 		19.2
(-2.8)
A 		85
B 102
(3)
P 		78.3
(1.1)
P 		38.5
(-2)
P 		28.7
(-2.8)
P 		30.3
(-2.7)
P 		26.4
(-3)
P 		76
C 110
(3)
P 		75.4
(0.9)
P 		39.1
(-1.4)
P 		19.6
(-2.6)
P 		27.4
(-2.1)
P 		13.3
(-3)
A 		97
avr 91.6
(3) 		84.9
(2.4) 		35.4
(-1.7) 		24.4
(-2.6) 		24.8
(-2.6) 		19.6
(-3) 		72
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193903_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.14497
Sequence Type Exemplar sequence
Representative Public ID C47A10.1 NCBI
Target Description C47A10.1 /REP_DB=WormBase Gene ID /WP=CE15714 /TR=O45721 /GB=CAB07855.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=multidrug resistance protein (p-glycoprotein) (2 domains)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_075086(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_075086 NCBI Caenorhabditis elegans P-GlycoProtein related family member (pgp-9) (pgp-9) mRNA, complete cds. 11/11 None
GENEFINDER00000022123 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:17758720:17767226:1 11/11 None
C47A10.1 ENSEMBL cdna:known chromosome:CEL140:V:17758473:17767318:1 gene:C47A10.1 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
SNAP00000022107 3/11 Cross Hyb Matching Probes None
SNAP00000022108 7/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:17758472-17767226(+) 100.0 100.0
Public Domain and Genome References
Gene Title multidrug resistance protein (p-glycoprotein) (2 domains)
Gene Symbol pgp-9
Ensembl C47A10.1
Entrez Gene 180165 Entrez gene
SwissProt O45721 EMBL-EBI
WormBase CE15714 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:260932_S_AT multidrug resistance P-glycoprotein, putative at
DROSOPHILA_2:1631925_AT Multiple drug resistance 65 dm
DROSGENOME1:143476_AT Multiple drug resistance 65 dm
CHICKEN:GGA.4109.1.S1_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 gga
CHICKEN:GGA.4109.1.S2_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 gga
HG-FOCUS:209994_S_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 hs
HG-U133_PLUS_2:209994_S_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 hs
HG-U133A_2:209994_S_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 hs
HG-U133A:209994_S_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 hs
HG-U95AV2:1576_G_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 hs
HC-G110:1576_G_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 hs
HG-U133_PLUS_2:207819_S_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 hs
HG-U133A:207819_S_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 hs
HG-FOCUS:207819_S_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 hs
HG-U133A_2:207819_S_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 hs
HUGENEFL:M23234_S_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 hs
U133_X3P:G9961253_3P_S_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 hs
U133_X3P:G9961253_3P_A_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 hs
U133_X3P:HS2.434244.1.S1_3P_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 hs
HG-U133_PLUS_2:1570505_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 hs
HG-U95AV2:33978_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 hs
U133_X3P:HS2.367978.1.S1_3P_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 hs
HG-U133_PLUS_2:1557641_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 hs
HG-U133_PLUS_2:237138_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 hs
HG-U133B:237138_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 hs
HG-U95C:62746_R_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 hs
HU35KSUBB:RC_F04441_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 hs
U133_X3P:HS.287827.0.A1_3P_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 hs
MOE430A:1449818_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 mm
MOUSE430_2:1449818_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 mm
MOUSE430A_2:1449818_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 mm
MU11KSUBA:J03398_S_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 mm
MG-U74AV2:94733_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 mm
MU19KSUBA:TC25710_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 (Abcb4), mRNA mm
RT-U34:L15079MRNA_S_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 rn
RG-U34A:L15079MRNA_S_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 rn
RAE230A:1369161_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 rn
RAT230_2:1369161_AT ATP-binding cassette, sub-family B (MDR/TAP), member 4 rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
6810 transport inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
16021 integral to membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
166 nucleotide binding inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
8237 metallopeptidase activity inferred from electronic annotation QuickGO AmiGO
8270 zinc ion binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB07855 Hypothetical protein C47A10.1 [Caenorhabditis elegans] emb|CAB03973.1| Hypothetical protein C47A10.1 [Caenorhabditis elegans] ref|NP_507487.1| P-GlycoProtein related family member (pgp-9) [Caenorhabditis elegans] 0.0
blast CAE61715 Hypothetical protein CBG05664 [Caenorhabditis briggsae] 0.0
blast CAE67917 Hypothetical protein CBG13514 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 1.7E-59
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 8.3E-56
Pfam IPR003439 EMBL-EBI ABC transporter 1.5E-67
Pfam IPR003439 EMBL-EBI ABC transporter 1.1E-66
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 1.1E-57
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 8.3E-56
Pfam IPR003439 EMBL-EBI ABC transporter 1.5E-67
Pfam IPR003439 EMBL-EBI ABC transporter 1.1E-66
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_507487.1 12 44-66,109-131,181-203,207-229,285-307,317-339,703-725,751-773,827-849,853-875,937-959,969-991
C47A10.1 12 44-66,109-131,181-203,207-229,285-307,317-339,703-725,751-773,827-849,853-875,937-959,969-991
GENEFINDER00000022123 11 48-70,120-142,146-168,224-246,256-278,642-664,690-712,766-788,792-814,876-898,908-930
Sequence
Target Sequence 
>C. ELEGANS:193903_AT
gacagtcgacaacaatgacctccgccaaatgaacccgaaacatctccgcaagcacattgc
tctcgtctcccaggagcccattctcttcgatacttcgattagagaaaatattgtatatgg
tcttcagcctggcgagtacacccatgaacagattgaaactgcgtgttcaaaggccaatat
tcacaagtttatcgatgaacttcctgatggctacgaaacccgtgtcggagagaagggaac
ccagttgtccggtggccaaaaacaacgtatcgccatcgcgcgagccctcattagaaatcc
aaagatcctacttctggatgaagccacaagtgctctggatacagaatctgagaagcaagt
gcaagtggccctggatgccgcggcaaaagacaggacgtgtattgtagtggctcatcggtt
atcaactatcgtcaatgctggatgtattatggttgtgaagaatggacaagttgttgagca
aggaacccacaatgaactgatcgctaaacgcggtgcctactttgccctgacgcagaaaca
gtcctcaaatcagtctggcggagcatttgatacctctgaagctcttg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GACAGTCGACAACAATGACCTCCGC 544 369 3279 Antisense
AACATCTCCGCAAGCACATTGCTCT 242 137 3317 Antisense
TGGTCTTCAGCCTGGCGAGTACACC 551 551 3396 Antisense
ACTTCCTGATGGCTACGAAACCCGT 70 103 3477 Antisense
GAGAAGGGAACCCAGTTGTCCGGTG 438 299 3508 Antisense
GAAGCAAGTGCAAGTGGCCCTGGAT 256 341 3630 Antisense
GGCTCATCGGTTATCAACTATCGTC 347 539 3687 Antisense
GGAACCCACAATGAACTGATCGCTA 18 531 3760 Antisense
TGATCGCTAAACGCGGTGCCTACTT 578 555 3776 Antisense
TGCCCTGACGCAGAAACAGTCCTCA 31 585 3801 Antisense
GCATTTGATACCTCTGAAGCTCTTG 621 307 3841 Antisense
Sequence Source Affymetrix Proprietary Database