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[193891_at] iron-responsive element-binding like protein

Description ZK455.1 /REP_DB=WormBase Gene ID /WP=CE03812 /GEN=gei-22 /TR=SW:Q23500 /GB=CAA91491.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=iron-responsive element-binding like protein
Cluster 6grp_highest_10_10 > 23      6grp_high1_10_10 > 12      4grp_highest_8_8 > 24      4grp_high_8_8 > 59      6grp_highest_nonorm > 15      6grp_total > 33      4grp_total > 60      6grp_highest_sub > 01_02_03      6grp_cgc > 71      6grp_high1_sub > De      6grp_cgc_sub > 03      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 5814
1 2 3 4 range
A 6203.2
(3)
P 		5664.6
(2.4)
P 		5978.8
(2.7)
P 		845.6
(-3)
P 		5358
B 5484.7
(2.1)
P 		5988.1
(2.7)
P 		6273.2
(3)
P 		739.3
(-3)
P 		5534
C 6552.8
(3)
P 		5526.6
(1.9)
P 		5587.3
(2)
P 		858.8
(-3)
P 		5694
avr 6080.2
(3) 		5726.4
(2.6) 		5946.4
(2.8) 		814.6
(-3) 		5266

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 4380
1 2 3 4 5 6 range
A 6440.5
(3)
P 		6455.8
(3)
P 		6411
(2.9)
P 		4716.4
(0.2)
P 		3083.9
(-2.4)
P 		2681.4
(-3)
P 		3774
B 6448.8
(3)
P 		5724.7
(1.9)
P 		5498
(1.6)
P 		4459.9
(0)
P 		3037.9
(-2.1)
P 		2469
(-3)
P 		3980
C 5692.5
(1.4)
P 		5639.1
(1.3)
P 		6848.6
(3)
P 		3886
(-1.1)
P 		3487.5
(-1.6)
P 		2469.8
(-3)
P 		4379
avr 6193.9
(2.9) 		5939.9
(2.5) 		6252.5
(3) 		4354.1
(-0.1) 		3203.1
(-1.9) 		2540.1
(-3) 		3712
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 2135
1 2 3 4 range
A 2258.6
(3)
P 		1229.6
(0.1)
P 		1563
(1)
P 		123.8
(-3)
P 		2135
B 1749
(3)
P 		1478.9
(2)
P 		1453.7
(1.9)
P 		157.5
(-3)
P 		1592
C 2169.2
(3)
P 		1588.9
(1.3)
P 		1947.3
(2.3)
P 		144.8
(-3)
P 		2024
avr 2058.9
(3) 		1432.5
(1) 		1654.7
(1.7) 		142
(-3) 		1917

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1643
1 2 3 4 5 6 range
A 1187.3
(-1)
P 		2296
(3)
P 		1396.2
(-0.3)
P 		1196.2
(-1)
P 		930.6
(-2)
P 		652.8
(-3)
P 		1643
B 2243.9
(3)
P 		1905.5
(1.5)
P 		1335.1
(-1.1)
P 		1181.3
(-1.8)
P 		1234.3
(-1.6)
P 		920.7
(-3)
P 		1323
C 2110
(3)
P 		1720.7
(1.2)
P 		1743.1
(1.3)
P 		781.5
(-3)
P 		1128.5
(-1.4)
P 		826.8
(-2.8)
P 		1329
avr 1847.1
(2.4) 		1974.1
(3) 		1491.5
(0.5) 		1053
(-1.7) 		1097.8
(-1.5) 		800.1
(-3) 		1174
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193891_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.17247
Sequence Type Exemplar sequence
Representative Public ID ZK455.1 NCBI
Target Description ZK455.1 /REP_DB=WormBase Gene ID /WP=CE03812 /GEN=gei-22 /TR=SW:Q23500 /GB=CAA91491.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=iron-responsive element-binding like protein
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_077497(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_077497 NCBI Caenorhabditis elegans ACOnitase family member (aco-1) (aco-1) mRNA, complete cds. 11/11 None
SNAP00000004977 ENSEMBL cdna:SNAP chromosome:CEL140:X:11339800:11343086:1 11/11 None
GENEFINDER00000004985 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:11339800:11343086:1 11/11 None
ZK455.1.2 ENSEMBL cdna:known chromosome:CEL140:X:11339796:11343492:1 gene:ZK455.1 11/11 None
ZK455.1.1 ENSEMBL cdna:known chromosome:CEL140:X:11339798:11343492:1 gene:ZK455.1 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:11339799-11343086(+) 100.0 100.0
Public Domain and Genome References
Gene Title iron-responsive element-binding like protein
Gene Symbol aco-1
Ensembl ZK455.1
Entrez Gene 181324 Entrez gene
SwissProt Q23500 EMBL-EBI
WormBase CE03812 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:17857_AT aconitate hydratase, cytoplasmic, putative / citrate hydro-lyase/aconitase, putative at
ATH1-121501:263348_AT aconitate hydratase, cytoplasmic, putative / citrate hydro-lyase/aconitase, putative at
CANINE_2:CFA.3022.1.A1_AT similar to Iron-responsive element binding protein 1 (IRE-BP 1) (Iron regulatory protein 1) (IRP1) (Ferritin repressor protein) (Aconitate hydratase) (Citrate hydro-lyase) (Aconitase) cfa
CANINE_2:CFAAFFX.3594.1.S1_S_AT similar to Iron-responsive element binding protein 1 (IRE-BP 1) (Iron regulatory protein 1) (IRP1) (Ferritin repressor protein) (Aconitate hydratase) (Citrate hydro-lyase) (Aconitase) cfa
DROSOPHILA_2:1640650_AT Iron regulatory protein 1B dm
DROSGENOME1:144037_AT Iron regulatory protein 1B dm
CHICKEN:GGA.4139.1.S1_AT aconitase 1, soluble gga
HG-U133_PLUS_2:207071_S_AT aconitase 1, soluble hs
HG-U133A:207071_S_AT aconitase 1, soluble hs
HG-FOCUS:207071_S_AT aconitase 1, soluble hs
HG-U133A_2:207071_S_AT aconitase 1, soluble hs
HUGENEFL:Z11559_AT aconitase 1, soluble hs
U133_X3P:G8659554_3P_A_AT aconitase 1, soluble hs
HG-U95AV2:40077_AT aconitase 1, soluble hs
HG-U95D:72164_AT Aconitase 1, soluble hs
HG-U95E:85102_R_AT Aconitase 1, soluble hs
HG-U95D:85490_AT Aconitase 1, soluble hs
MOUSE430_2:1423644_AT aconitase 1 mm
MOE430A:1423644_AT aconitase 1 mm
MOUSE430A_2:1423644_AT aconitase 1 mm
MU11KSUBB:X61147_S_AT aconitase 1 mm
MG-U74AV2:100147_AT aconitase 1 mm
MG-U74CV2:137501_F_AT aconitase 1 mm
MOE430A:1456728_X_AT aconitase 1 mm
MOUSE430A_2:1456728_X_AT aconitase 1 mm
MOUSE430_2:1456728_X_AT aconitase 1 mm
MOE430B:1447080_AT Aconitase 1, mRNA (cDNA clone MGC:6247 IMAGE:3494686) mm
MOUSE430_2:1447080_AT Aconitase 1, mRNA (cDNA clone MGC:6247 IMAGE:3494686) mm
MU19KSUBB:TC26760_AT Aconitase 1, mRNA (cDNA clone MGC:6247 IMAGE:3494686) mm
MU19KSUBC:TC39176_S_AT Aconitase 1, mRNA (cDNA clone MGC:6247 IMAGE:3494686) mm
RN-U34:RC_AI176621_AT aconitase 1 rn
RG-U34A:RC_AI176621_AT aconitase 1 rn
RAE230A:1386916_AT aconitase 1 rn
RAT230_2:1386916_AT aconitase 1 rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
8152 metabolism inferred from electronic annotation QuickGO AmiGO
6879 iron ion homeostasis inferred from sequence similarity QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5829 cytosol inferred from direct assay QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
3723 RNA binding inferred from electronic annotation QuickGO AmiGO
3994 aconitate hydratase activity inferred from electronic annotation QuickGO AmiGO
5506 iron ion binding inferred from electronic annotation QuickGO AmiGO
16829 lyase activity inferred from electronic annotation QuickGO AmiGO
16836 hydro-lyase activity inferred from electronic annotation QuickGO AmiGO
3994 aconitate hydratase activity inferred from direct assay QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA91491 Hypothetical protein ZK455.1 [Caenorhabditis elegans] ref|NP_509898.1| ACOnitase family member (aco-1) [Caenorhabditis elegans] sp|Q23500|ACOC_CAEEL Probable aconitate hydratase, cytoplasmic (Citrate hydro-lyase) (Aconitase) 0.0
blast CAE70654 Hypothetical protein CBG17361 [Caenorhabditis briggsae] 0.0
blast AAR15297 iron regulatory protein [Aedes aegypti] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR000573 EMBL-EBI Aconitate hydratase, C-terminal 3.0E-53
Pfam IPR001030 EMBL-EBI Aconitate hydratase, N-terminal 1.0E-126
Sequence
Target Sequence 
>C. ELEGANS:193891_AT
tggatcaatctcgaagacctctcccgccgccagattccttgctggacgtggagtaacgcc
aagagatttcaacacttatggagctcgccgtggtaacgatgagatcatggctcgtggaac
attcgccaacattcgtcttgttaataagcttgcgtcgaaggttggtcctattacactcca
tgtgccatctggagaagagctcgacatctttgacgctgctcaaaagtacaaggatgccgg
aattccagccatcattcttgctggaaaagaatatggatgtggctcatctcgcgattgggc
tgcaaaggggccattcctccaaggagtcaaggctgttatcgctgaaagcttcgaaagaat
tcatcgttccaacctgattggaatgggcattattccattccaatatcaagctggtcaaaa
cgctgatagtctcggacttactggaaaagaacaattctcaattggagttccagacgattt
gaagccaggacagctcattgatgtgaatgtatccaatggttcagttttccaagtcatctg
tagatttgacactgaagtcgaactcacctattaccgc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TGGATCAATCTCGAAGACCTCTCCC 195 551 2055 Antisense
TCAACACTTATGGAGCTCGCCGTGG 115 631 2123 Antisense
AACATTCGCCAACATTCGTCTTGTT 252 139 2172 Antisense
AAGCTTGCGTCGAAGGTTGGTCCTA 260 137 2200 Antisense
CTATTACACTCCATGTGCCATCTGG 288 223 2222 Antisense
AGAGCTCGACATCTTTGACGCTGCT 233 69 2250 Antisense
GGAATTCCAGCCATCATTCTTGCTG 632 533 2293 Antisense
TATGGATGTGGCTCATCTCGCGATT 317 655 2326 Antisense
TTGGGCTGCAAAGGGGCCATTCCTC 477 707 2349 Antisense
AGAATTCATCGTTCCAACCTGATTG 113 77 2410 Antisense
TGAAGTCGAACTCACCTATTACCGC 89 341 2607 Antisense
Sequence Source Affymetrix Proprietary Database