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[193875_s_at] serine/threonine kinase (CDC2/CDKX subfamily)

Description T27E9.3 /REP_DB=WormBase Gene ID /WP=CE21213 /GEN=cdk-5 /TR=O18142 /GB=CAB04875.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=serine-threonine kinase (CDC2-CDKX subfamily)
Cluster 6grp_highest_10_10 > 75      6grp_high1_10_10 > 66      4grp_high_8_8 > 20      6grp_highest_nonorm > 83      6grp_total > 56      4grp_total > 19      6grp_highest_sub > Cu      6grp_cgc > 47      6grp_high1_sub > Da      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 329
1 2 3 4 range
A 502.9
(-2.2)
P 		597
(-0.3)
P 		461.6
(-3)
P 		767.2
(3)
P 		306
B 525.2
(-0.2)
P 		577.1
(2.5)
P 		471.2
(-3)
P 		586.9
(3)
P 		116
C 553.7
(0.9)
P 		561.7
(1.2)
M 		438.5
(-3)
P 		616.5
(3)
P 		178
avr 527.3
(-0.9) 		578.6
(0.6) 		457.1
(-3) 		656.9
(3) 		200

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 258
1 2 3 4 5 6 range
A 515.1
(1.8)
P 		408.3
(-0.7)
P 		381.5
(-1.3)
P 		309
(-3)
P 		390.2
(-1.1)
P 		566.5
(3)
P 		258
B 430.4
(-0.6)
P 		374.2
(-2.8)
P 		509.4
(2.5)
P 		370.1
(-3)
P 		404.4
(-1.7)
P 		523.3
(3)
P 		153
C 332.4
(-3)
P 		374.1
(-1.9)
P 		421.8
(-0.6)
P 		381
(-1.7)
P 		358.8
(-2.3)
P 		551.5
(3)
P 		219
avr 426
(-0.8) 		385.5
(-2) 		437.6
(-0.4) 		353.4
(-3) 		384.5
(-2) 		547.1
(3) 		194
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 79
1 2 3 4 range
A 183.1
(3)
P 		129.6
(-1.5)
P 		120.7
(-2.3)
P 		112.3
(-3)
P 		71
B 167.5
(3)
P 		142.5
(0.4)
P 		109.2
(-3)
P 		125.1
(-1.4)
P 		58
C 183.3
(3)
P 		161.5
(1.4)
M 		152.8
(0.7)
P 		104
(-3)
P 		79
avr 178
(3) 		144.5
(-0.1) 		127.6
(-1.7) 		113.8
(-3) 		64

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 119
1 2 3 4 5 6 range
A 95
(-1.5)
P 		145.2
(3)
P 		83.1
(-2.6)
P 		78.4
(-3)
P 		117.7
(0.5)
P 		137.9
(2.3)
P 		67
B 149.8
(0.2)
P 		124.6
(-1.4)
P 		123.7
(-1.4)
P 		98
(-3)
P 		164.3
(1.1)
P 		195.1
(3)
P 		97
C 123.2
(-0.4)
P 		114.2
(-0.9)
P 		107.3
(-1.3)
P 		76.6
(-3)
P 		116.1
(-0.8)
P 		184.6
(3)
P 		108
avr 122.7
(-0.4) 		128
(-0) 		104.7
(-1.6) 		84.3
(-3) 		132.7
(0.3) 		172.5
(3) 		88
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 193875_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.6643
Sequence Type Exemplar sequence
Representative Public ID T27E9.3 NCBI
Target Description T27E9.3 /REP_DB=WormBase Gene ID /WP=CE21213 /GEN=cdk-5 /TR=O18142 /GB=CAB04875.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=serine-threonine kinase (CDC2-CDKX subfamily)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_067382(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_067382 NCBI Caenorhabditis elegans Cyclin-Dependent Kinase family member (cdk-5) (cdk-5) mRNA, complete cds. 11/11 A 
GENEFINDER00000014277 ENSEMBL cdna:GeneFinder chromosome:CEL140:III:13464334:13465811:-1 11/11 None
SNAP00000014265 ENSEMBL cdna:SNAP chromosome:CEL140:III:13464930:13465811:-1 11/11 None
T27E9.3 ENSEMBL cdna:known chromosome:CEL140:III:13464264:13465858:-1 gene:T27E9.3 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:13464329-13465807(-) 100.0 100.0
Public Domain and Genome References
Gene Title serine/threonine kinase (CDC2/CDKX subfamily)
Gene Symbol cdk-5
Ensembl T27E9.3
Entrez Gene 176774 Entrez gene
SwissProt O18142 EMBL-EBI
WormBase CE21213 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFA.21399.1.S1_S_AT similar to Cell division protein kinase 5 (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6) cfa
CANINE_2:CFAAFFX.8027.1.S1_AT similar to Cell division protein kinase 5 (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) (Serine/threonine-protein kinase PSSALRE) (CRK6) cfa
DROSOPHILA_2:1637085_AT Cyclin-dependent kinase 5 dm
DROSGENOME1:153451_AT Cyclin-dependent kinase 5 dm
HG-U95AV2:1206_AT cyclin-dependent kinase 5 hs
HC-G110:1206_AT cyclin-dependent kinase 5 hs
HG-U133_PLUS_2:204247_S_AT cyclin-dependent kinase 5 hs
HG-U133A_2:204247_S_AT cyclin-dependent kinase 5 hs
HG-U133A:204247_S_AT cyclin-dependent kinase 5 hs
HG-FOCUS:204247_S_AT cyclin-dependent kinase 5 hs
HU35KSUBA:X66364_AT cyclin-dependent kinase 5 hs
HUGENEFL:X66364_AT cyclin-dependent kinase 5 hs
U133_X3P:G4826674_3P_AT cyclin-dependent kinase 5 hs
HG-U95AV2:40549_AT cyclin-dependent kinase 5 hs
MU11KSUBA:D29678_S_AT cyclin-dependent kinase 5 mm
MG-U74AV2:100444_AT cyclin-dependent kinase 5 mm
MG-U74BV2:105126_AT cyclin-dependent kinase 5 mm
MOE430A:1450674_AT cyclin-dependent kinase 5 mm
MOUSE430A_2:1450674_AT cyclin-dependent kinase 5 mm
MOUSE430_2:1450674_AT cyclin-dependent kinase 5 mm
MOE430A:1422590_AT cyclin-dependent kinase 5 mm
MOUSE430A_2:1422590_AT cyclin-dependent kinase 5 mm
MOUSE430_2:1422590_AT cyclin-dependent kinase 5 mm
RT-U34:L02121_AT cyclin-dependent kinase 5 rn
RG-U34A:L02121_AT cyclin-dependent kinase 5 rn
RAE230A:1368088_AT cyclin-dependent kinase 5 rn
RAT230_2:1368088_AT cyclin-dependent kinase 5 rn
YEAST_2:1774558_AT Cyclin-dependent kinase, with ten cyclin partners; involved in environmental stress response; in phosphate-rich conditions, Pho85p-Pho80p complex phosphorylates Pho4p which in turn represses PHO5 Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB04875 Hypothetical protein T27E9.3 [Caenorhabditis elegans] ref|NP_499783.1| Cyclin-Dependent Kinase family member (cdk-5) [Caenorhabditis elegans] gb|AAD37121.1| cell division protein kinase 5 [Caenorhabditis elegans] 1.0E-170
blast CAB04875 Hypothetical protein T27E9.3 [Caenorhabditis elegans] ref|NP_499783.1| Cyclin-Dependent Kinase family member (cdk-5) [Caenorhabditis elegans] gb|AAD37121.1| cell division protein kinase 5 [Caenorhabditis elegans] 1.0E-168
blast CAE73691 Hypothetical protein CBG21202 [Caenorhabditis briggsae] 1.0E-163
blast CAE73691 Hypothetical protein CBG21202 [Caenorhabditis briggsae] 1.0E-162
blast EAA10719 ENSANGP00000018692 [Anopheles gambiae str. PEST] ref|XP_315787.2| ENSANGP00000018692 [Anopheles gambiae str. PEST] 1.0E-134
blast EAA10719 ENSANGP00000018692 [Anopheles gambiae str. PEST] ref|XP_315787.2| ENSANGP00000018692 [Anopheles gambiae str. PEST] 1.0E-132
blast CAB04875 Hypothetical protein T27E9.3 [Caenorhabditis elegans] ref|NP_499783.1| Cyclin-Dependent Kinase family member (cdk-5) [Caenorhabditis elegans] gb|AAD37121.1| cell division protein kinase 5 [Caenorhabditis elegans] 1.0E-129
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 3.0E-71
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 8.0E-84
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 4.0E-84
hanks 3.1.6 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; Cdk5 1.0E-108
hanks 3.1.6 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; Cdk5 1.0E-129
hanks 3.1.6 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; Cdk5 1.0E-131
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 8.1E-90
Pfam IPR000719 EMBL-EBI Protein kinase 2.0E-89
Pfam IPR000719 EMBL-EBI Protein kinase 2.8E-77
Sequence
Target Sequence 
>C. ELEGANS:193875_S_AT
ggatgcacaaactgcacgatccttaatgcttcaacttctccgtggtttatccttttgcca
cgctcaccatgtacttcatcgagatctcaagccgcaaaacctgctgattaatacaaatgg
gacactgaaactagctgattttggattagccagggcgtttggcgtcccagttcgatgttt
tagtgcagaagttgtcacgttatggtatagaccgccggacgtgctttttggagcgaaatt
gtacaatacttcaattgatatgtggtctgccgggtgtatttttgcagagatctcaaatgc
cggtcgtccattattccccggtgctgatgttgacgat

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GGATGCACAAACTGCACGATCCTTA 16 513 306 Antisense
CGATCCTTAATGCTTCAACTTCTCC 62 249 322 Antisense
TCTCCGTGGTTTATCCTTTTGCCAC 181 609 342 Antisense
ACGCTCACCATGTACTTCATCGAGA 459 91 365 Antisense
CGAGATCTCAAGCCGCAAAACCTGC 216 251 385 Antisense
GGATTAGCCAGGGCGTTTGGCGTCC 392 509 448 Antisense
GCGTCCCAGTTCGATGTTTTAGTGC 607 287 467 Antisense
TATAGACCGCCGGACGTGCTTTTTG 141 655 511 Antisense
TGTGGTCTGCCGGGTGTATTTTTGC 311 555 566 Antisense
GCAGAGATCTCAAATGCCGGTCGTC 513 311 589 Antisense
ATTCCCCGGTGCTGATGTTGACGAT 664 7 618 Antisense
Sequence Source Affymetrix Proprietary Database