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[193864_at] Apoptosis regulator proteins, Bcl-2 family

Description T07C4.8 /REP_DB=WormBase Gene ID /WP=CE25104 /GEN=ced-9 /TR=SW:P41958 /GB=CAA82573.2 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=Apoptosis regulator proteins, Bcl-2 family
Cluster 6grp_total > 14      4grp_total > 35      6grp_cgc > 24      6grp_cgc_sub > Cu      6grp_total_sub > Decrease      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 58
1 2 3 4 range
A 65.6
(-1.5)
P 		79.8
(0.1)
P 		51.2
(-3)
A 		107.1
(3)
P 		56
B 51.4
(-3)
P 		109
(3)
A 		63.6
(-1.7)
A 		60
(-2.1)
A 		58
C 87.9
(3)
P 		67.8
(-1.3)
A 		59.6
(-3)
A 		79.6
(1.2)
A 		28
avr 68.3
(-0.8) 		85.5
(3) 		58.1
(-3) 		82.2
(2.3) 		27

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 72
1 2 3 4 5 6 range
A 89.3
(3)
M 		71.8
(1.3)
A 		53.4
(-0.5)
A 		65.9
(0.7)
A 		27.6
(-3)
A 		53.2
(-0.5)
A 		62
B 90.9
(3)
P 		70.8
(-0.3)
M 		61.7
(-1.8)
P 		59.9
(-2.1)
A 		61.5
(-1.8)
A 		54.2
(-3)
P 		37
C 95
(2.5)
P 		99.5
(3)
P 		71.2
(-0.2)
A 		77.9
(0.6)
A 		46.6
(-3)
A 		57.2
(-1.8)
P 		53
avr 91.7
(3) 		80.7
(1.6) 		62.1
(-0.8) 		67.9
(-0.1) 		45.2
(-3) 		54.9
(-1.7) 		47
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 16
1 2 3 4 range
A 23.9
(3)
P 		17.3
(-0.8)
P 		13.4
(-3)
A 		15.7
(-1.7)
P 		11
B 16.4
(-1.5)
P 		26.9
(3)
A 		14.7
(-2.2)
A 		12.8
(-3)
A 		14
C 29.1
(3)
P 		19.5
(-0.7)
A 		20.8
(-0.2)
A 		13.4
(-3)
A 		16
avr 23.1
(3) 		21.2
(1.7) 		16.3
(-1.5) 		14
(-3) 		9

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 27
1 2 3 4 5 6 range
A 16.5
(-0.1)
M 		25.5
(3)
A 		11.6
(-1.8)
A 		16.7
(-0.1)
A 		8.3
(-3)
A 		12.9
(-1.4)
A 		17
B 31.6
(3)
P 		23.6
(0.1)
M 		15
(-3)
P 		15.9
(-2.7)
A 		25
(0.6)
A 		20.2
(-1.1)
P 		17
C 35.2
(3)
P 		30.4
(1.6)
P 		18.1
(-2.1)
A 		15.7
(-2.8)
A 		15.1
(-3)
A 		19.2
(-1.8)
P 		20
avr 27.8
(3) 		26.5
(2.4) 		14.9
(-3) 		16.1
(-2.4) 		16.1
(-2.4) 		17.4
(-1.8) 		13
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193864_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.6870
Sequence Type Exemplar sequence
Representative Public ID T07C4.8 NCBI
Target Description T07C4.8 /REP_DB=WormBase Gene ID /WP=CE25104 /GEN=ced-9 /TR=SW:P41958 /GB=CAA82573.2 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=Apoptosis regulator proteins, Bcl-2 family
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_066883(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_066883 NCBI Caenorhabditis elegans CEll Death abnormality family member (ced-9) (ced-9) mRNA, complete cds. 11/11 None
SNAP00000030155 ENSEMBL cdna:SNAP chromosome:CEL140:III:10335058:10336966:1 11/11 None
GENEFINDER00000030169 ENSEMBL cdna:GeneFinder chromosome:CEL140:III:10335058:10336966:1 11/11 None
T07C4.8 ENSEMBL cdna:known chromosome:CEL140:III:10335058:10337395:1 gene:T07C4.8 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
NM_066882 5/11 Cross Hyb Matching Probes None
T07C4.7.2 5/11 Cross Hyb Matching Probes None
T07C4.7.1 5/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:10335053-10336962(+) 100.0 100.0
Public Domain and Genome References
Gene Title Apoptosis regulator proteins, Bcl-2 family
Gene Symbol ced-9
Ensembl T07C4.8
Entrez Gene 3565776 Entrez gene
WormBase CE25104 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
42981 regulation of apoptosis inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA82573 Hypothetical protein T07C4.8 [Caenorhabditis elegans] ref|NP_499284.1| CEll Death abnormality family member (ced-9) [Caenorhabditis elegans] gb|AAA20080.1| CED-9 [Caenorhabditis elegans] sp|P41958|CED9_CAEEL Apoptosis regulator ced-9 (Cell death protein 9) 1.0E-152
blast H88578 protein ced-9 [imported] - Caenorhabditis elegans 1.0E-140
blast 1OHU Chain , Structure Of Caenorhabditis Elegans Ced-9 pdb|1OHU|A Chain A, Structure Of Caenorhabditis Elegans Ced-9 2.0E-90
Protein Domains
Database ID Description E-Value
Pfam IPR000712 EMBL-EBI Apoptosis regulator Bcl-2 protein, BH 2.1E-46
Pfam IPR003093 EMBL-EBI Apoptosis regulator Bcl-2 protein, BH4 4.3E-14
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_499284.1 1 255-277
T07C4.8 1 255-277
SNAP00000030155 1 255-277
GENEFINDER00000030169 1 255-277
Sequence
Target Sequence 
>C. ELEGANS:193864_AT
ttgtggtcgactatttcacgcaccgaatccggcaaaacggaatggaatggtttggagcac
cgggattgccgtgtggagtgcaaccggagcacgaaatgatgcgagttatgggaacgatat
tcgagaagaagcacgcggaaaattttgagaccttctgtgagcagctgctcgcagtgccca
gaatctcattttcactgtatcaggatgtggttcggacggttggaaatgcacagacagatc
aatgtccaatgtcttatggacgtttgataggtctaatctcgttcggcggtttcgtagctg
caaaaatgatggaatccgtggaactgcagggacaagtgcgaaacctcttcgtttacacat
cgctgttcatcaaaacgcggatccgcaacaactggaaggaacacaatcggagctgggacg
acttcatgacactcggaaaacaaatgaaagaggactacgaacgagcagaagctgaaaaag
tgggacgccggaagcagaacagacggtggtcgatgattggcgctggagt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TTGTGGTCGACTATTTCACGCACCG 358 709 260 Antisense
TCACGCACCGAATCCGGCAAAACGG 615 623 275 Antisense
GAGCACCGGGATTGCCGTGTGGAGT 80 389 314 Antisense
TGAGACCTTCTGTGAGCAGCTGCTC 165 569 405 Antisense
GTGCCCAGAATCTCATTTTCACTGT 698 477 433 Antisense
TCTAATCTCGTTCGGCGGTTTCGTA 209 249 531 Antisense
GGACAAGTGCGAAACCTCTTCGTTT 331 525 589 Antisense
TTCGTTTACACATCGCTGTTCATCA 571 695 607 Antisense
GAGCTGGGACGACTTCATGACACTC 296 387 669 Antisense
GTGGGACGCCGGAAGCAGAACAGAC 339 487 739 Antisense
GGTGGTCGATGATTGGCGCTGGAGT 290 499 764 Antisense
Sequence Source Affymetrix Proprietary Database