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[193837_at] L-methionine-alpha-deamino-gamma-mercaptomethane lyase

Description C12C8.2 /REP_DB=WormBase Gene ID /WP=CE17400 /TR=O02215 /GB=CAB03873.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=L-methionine-alpha-deamino-gamma-mercaptomethane lyase
Cluster 6grp_highest_10_10 > 25      6grp_high1_10_10 > 51      4grp_highest_8_8 > 09      4grp_high_8_8 > 53      6grp_highest_nonorm > 43      6grp_total > 51      4grp_total > 59      6grp_highest_sub > 03      6grp_high1_sub > 03      6grp_total_sub > Hat      6grp_rule_based > S3      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1168
1 2 3 4 range
A 637.1
(-0.1)
P 		937
(1.6)
P 		1184
(3)
P 		137.4
(-3)
P 		1047
B 613.5
(-0.4)
P 		1269.9
(3)
P 		899.4
(1.1)
P 		103.6
(-3)
P 		1166
C 699.5
(0.2)
P 		1099.7
(2.3)
P 		1236.2
(3)
P 		102.4
(-3)
P 		1134
avr 650
(0.2) 		1102.2
(3) 		1106.5
(3) 		114.5
(-3) 		992

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1250
1 2 3 4 5 6 range
A 739.6
(-1)
P 		890.3
(-0.3)
P 		1577.2
(3)
P 		1232.4
(1.3)
P 		656.7
(-1.4)
P 		327.6
(-3)
P 		1250
B 791.5
(-1.1)
P 		1032.9
(0.3)
P 		1530.4
(3)
P 		1076.8
(0.5)
P 		649.1
(-1.8)
P 		437.1
(-3)
P 		1093
C 713.4
(-1.2)
P 		1052.1
(0.7)
P 		1477.3
(3)
P 		1138.3
(1.1)
P 		505.7
(-2.3)
P 		383
(-3)
P 		1094
avr 748.2
(-1.1) 		991.8
(0.2) 		1528.3
(3) 		1149.2
(1) 		603.8
(-1.8) 		382.6
(-3) 		1146
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 414
1 2 3 4 range
A 232
(1.4)
P 		203.4
(0.8)
P 		309.5
(3)
P 		20.1
(-3)
P 		289
B 195.6
(0.6)
P 		313.6
(3)
P 		208.4
(0.8)
P 		22.1
(-3)
P 		292
C 231.5
(0.1)
P 		316.2
(1.3)
P 		430.8
(3)
P 		17.3
(-3)
P 		414
avr 219.7
(1) 		277.7
(2.2) 		316.2
(3) 		19.8
(-3) 		296

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 296
1 2 3 4 5 6 range
A 136.3
(-1.7)
P 		316.6
(2.4)
P 		343.5
(3)
P 		312.6
(2.3)
P 		198.2
(-0.3)
P 		79.8
(-3)
P 		264
B 275.4
(0.2)
P 		343.8
(2.2)
P 		371.6
(3)
P 		285.2
(0.5)
P 		263.7
(-0.1)
P 		163
(-3)
P 		209
C 264.4
(0.3)
P 		321
(1.7)
P 		376
(3)
P 		228.9
(-0.6)
P 		163.6
(-2.1)
P 		128.2
(-3)
P 		248
avr 225.4
(-0.5) 		327.1
(2.1) 		363.7
(3) 		275.6
(0.8) 		208.5
(-0.9) 		123.7
(-3) 		240
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193837_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.1696
Sequence Type Exemplar sequence
Representative Public ID C12C8.2 NCBI
Target Description C12C8.2 /REP_DB=WormBase Gene ID /WP=CE17400 /TR=O02215 /GB=CAB03873.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=L-methionine-alpha-deamino-gamma-mercaptomethane lyase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_060085(10)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_060085 NCBI Caenorhabditis elegans C12C8.2 (C12C8.2) mRNA, complete cds. 10/11 A 
GENEFINDER00000040485 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:9335980:9338847:1 10/11 None
SNAP00000040481 ENSEMBL cdna:SNAP chromosome:CEL140:I:9336767:9338847:1 10/11 None
C12C8.2 ENSEMBL cdna:known chromosome:CEL140:I:9335980:9339019:1 gene:C12C8.2 10/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:9335910-9338778(+) 100.0 100.0
Public Domain and Genome References
Gene Title L-methionine-alpha-deamino-gamma-mercaptomethane lyase
Ensembl C12C8.2
Entrez Gene 172759 Entrez gene
SwissProt O02215 EMBL-EBI
WormBase CE36100 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:15179_S_AT cystathionine gamma-synthase, chloroplast / O-succinylhomoserine (Thiol)-lyase (CGS) at
ATH1-121501:259279_AT cystathionine gamma-synthase, chloroplast / O-succinylhomoserine (Thiol)-lyase (CGS) at
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6520 amino acid metabolism inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB03873 Hypothetical protein C12C8.2 [Caenorhabditis elegans] ref|NP_492486.2| C12C8.2 [Caenorhabditis elegans] 0.0
blast CAE74315 Hypothetical protein CBG22025 [Caenorhabditis briggsae] 0.0
blast CAE74315 Hypothetical protein CBG22025 [Caenorhabditis briggsae] 1.0E-178
blast CAA04125 methionine gamma-lyase [Trichomonas vaginalis] 5.0E-71
Protein Domains
Database ID Description E-Value
Pfam IPR000277 EMBL-EBI Cys/Met metabolism pyridoxal-phosphate-dependent enzymes 1.0E-126
Pfam IPR000277 EMBL-EBI Cys/Met metabolism pyridoxal-phosphate-dependent enzymes 1.0E-126
Pfam IPR000277 EMBL-EBI Cys/Met metabolism pyridoxal-phosphate-dependent enzymes 1.0E-126
Sequence
Target Sequence 
>C. ELEGANS:193837_AT
gattcttacatgtcttgatgcaactttctcatctccatacaacattcaaccactgaaact
tggagcagacatcagtcttcatagctgctcaaaatacattggaggacatacggatgtgat
tgctggagttgttacagtatcatcttatgataattggaaaaaacttaaacttcaacaatt
gacgactggaagttctttgagtccatacgacgctgccctgttgaccagaggtctcaaaac
tcttggattgcgagttgataggatttcagaaaatgctcagaaaactgcagaatttctaga
atcccatccaaaagttgaacgtgtcttttatccaggacttccatcccacccacagcatca
atatgctaaacaagtaatgaaacaatttgctggaatgattgcatttgatgttggaactgc
tgaaaatgcaatcaagcttgttgaggctatatctcttggtggta

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GATTCTTACATGTCTTGATGCAACT 616 431 720 Antisense
TGATGCAACTTTCTCATCTCCATAC 216 567 735 Antisense
TCATCTCCATACAACATTCAACCAC 364 621 748 Antisense
GACATCAGTCTTCATAGCTGCTCAA 463 369 787 Antisense
TACGGATGTGATTGCTGGAGTTGTT 414 647 828 Antisense
GTTCTTTGAGTCCATACGACGCTGC 613 443 911 Antisense
CTGCCCTGTTGACCAGAGGTCTCAA 331 237 932 Antisense
GCAGAATTTCTAGAATCCCATCCAA 427 311 1006 Antisense
GTGTCTTTTATCCAGGACTTCCATC 88 487 1040 Antisense
TCCCACCCACAGCATCAATATGCTA 325 597 1063 Antisense
GTTGAGGCTATATCTCTTGGTGGTA 241 439 1159 Antisense
Sequence Source Affymetrix Proprietary Database