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[193830_at] tyrosine-protein kinase (FES/FPS subfamily)

Description W08D2.8 /REP_DB=WormBase Gene ID /WP=CE06563 /GEN=kin-21 /TR=Q21299 /GB=CAA94238.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=tyrosine-protein kinase (FES-FPS subfamily)
Cluster 6grp_total > 86      4grp_total > 18      6grp_cgc > 68      6grp_cgc_sub > In      6grp_total_sub > Increase      6grp_rule_based > S6      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 58
1 2 3 4 range
A 21.9
(-1.5)
A 		24.6
(-1.2)
A 		8.7
(-3)
A 		63.1
(3)
A 		54
B 7.1
(-3)
A 		28.3
(1.4)
A 		36.3
(3)
A 		23.8
(0.4)
A 		29
C 10
(-0.1)
A 		15
(3)
A 		5.4
(-3)
A 		14.2
(2.5)
A 		10
avr 13
(-3) 		22.6
(-0.2) 		16.8
(-1.9) 		33.7
(3) 		21

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 112
1 2 3 4 5 6 range
A 13.2
(-2.5)
A 		4.3
(-3)
A 		3.7
(-3)
A 		52.4
(-0.4)
A 		44.1
(-0.8)
A 		116.1
(3)
A 		112
B 8.7
(-2.7)
A 		7
(-3)
A 		11.5
(-2.2)
A 		10.9
(-2.3)
A 		41.1
(2.8)
A 		42
(3)
A 		35
C 4.8
(-3)
A 		25
(-0.9)
A 		43.2
(1)
A 		34.6
(0.1)
A 		51.4
(1.9)
A 		62.1
(3)
A 		57
avr 8.9
(-3) 		12.1
(-2.7) 		19.5
(-2) 		32.6
(-0.8) 		45.5
(0.4) 		73.4
(3) 		65
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 7
1 2 3 4 range
A 8
(2)
A 		5.3
(-0.4)
A 		2.3
(-3)
A 		9.2
(3)
A 		7
B 2.3
(-3)
A 		7
(1.6)
A 		8.4
(3)
A 		5.1
(-0.2)
A 		6
C 3.3
(0.5)
A 		4.3
(3)
A 		1.9
(-3)
A 		2.4
(-1.8)
A 		2
avr 4.5
(-1.7) 		5.5
(2.6) 		4.2
(-3) 		5.6
(3) 		1

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 28
1 2 3 4 5 6 range
A 2.4
(-2.7)
A 		1.5
(-2.8)
A 		0.8
(-3)
A 		13.3
(-0.3)
A 		13.3
(-0.3)
A 		28.3
(3)
A 		28
B 3
(-2.7)
A 		2.3
(-3)
A 		2.8
(-2.8)
A 		2.9
(-2.8)
A 		16.7
(3)
A 		15.7
(2.6)
A 		14
C 1.8
(-3)
A 		7.6
(-1.2)
A 		11
(-0.1)
A 		7
(-1.4)
A 		16.6
(1.7)
A 		20.8
(3)
A 		19
avr 2.4
(-3) 		3.8
(-2.6) 		4.9
(-2.2) 		7.7
(-1.3) 		15.5
(1.1) 		21.6
(3) 		19
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193830_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.9766
Sequence Type Exemplar sequence
Representative Public ID W08D2.8 NCBI
Target Description W08D2.8 /REP_DB=WormBase Gene ID /WP=CE06563 /GEN=kin-21 /TR=Q21299 /GB=CAA94238.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=tyrosine-protein kinase (FES-FPS subfamily)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_069357(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_069357 NCBI Caenorhabditis elegans protein KINase family member (kin-21) (kin-21) mRNA, complete cds. 11/11 None
SNAP00000004242 ENSEMBL cdna:SNAP chromosome:CEL140:IV:9833700:9834796:1 11/11 None
GENEFINDER00000004261 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:9833712:9834796:1 11/11 None
W08D2.8 ENSEMBL cdna:known chromosome:CEL140:IV:9832909:9834796:1 gene:W08D2.8 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:9832914-9834802(+) 100.0 100.0
Public Domain and Genome References
Gene Title tyrosine-protein kinase (FES/FPS subfamily)
Gene Symbol kin-21
Ensembl W08D2.8
Entrez Gene 177826 Entrez gene
SwissProt Q21299 EMBL-EBI
WormBase CE35637 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA94286 Hypothetical protein W08D2.8 [Caenorhabditis elegans] emb|CAA94238.2| Hypothetical protein W08D2.8 [Caenorhabditis elegans] ref|NP_501758.2| protein KINase family member (kin-21) [Caenorhabditis elegans] 0.0
blast CAA94286 Hypothetical protein W08D2.8 [Caenorhabditis elegans] emb|CAA94238.2| Hypothetical protein W08D2.8 [Caenorhabditis elegans] ref|NP_501758.2| protein KINase family member (kin-21) [Caenorhabditis elegans] 1.0E-179
blast CAE73698 Hypothetical protein CBG21209 [Caenorhabditis briggsae] 1.0E-168
blast CAE71276 Hypothetical protein CBG18159 [Caenorhabditis briggsae] 1.0E-142
blast CAE73698 Hypothetical protein CBG21209 [Caenorhabditis briggsae] 1.0E-96
blast CAE73698 Hypothetical protein CBG21209 [Caenorhabditis briggsae] 5.0E-95
Protein Families
Method ID Description E-Value
hanks 1.4.8 AGC group; AGC IV GPCR kinases; DmGPRK2 3.0E-61
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 2.6E-60
Pfam IPR000719 EMBL-EBI Protein kinase 8.4E-51
Pfam IPR000719 EMBL-EBI Protein kinase 1.6E-48
Trans Membrane
ID Number Of Domains Domain Boundaries
SNAP00000004242 1 13-35
Sequence
Target Sequence 
>C. ELEGANS:193830_AT
tcagatggctctctccggagacattctccaaaggattattcaatgagaaaacggacgtct
ggtcgtatggagtactgctcacggaacttatgacgagatgtgcacatgatccgttgtggc
cgaagaatctgaagcaggtgcaaaaatggatcaaagagtcggagcacccacataagattg
aagacggagatccaagtgagttgaaagagattgtggatgcttgttgtgcaaaaattccat
cggtccgcatcaacttcagagaagtcaaaaaccgtcttgcgatgcttcaacagaaaaaga
agaccctggagcttgatgctcaaaaaccaatgagccctaatccagctattgagaagaaaa
aatcggaagatcgtcgaaataatatggatcgtagaaacaagacgaatcggaagagccata
cttcgactgatcgtacaaactccaataatactcttactcggaagaaatcaagagatgctg
ggaagaacgatcgatccaatgaacggaagaacaaggcgaagggtggtaacttgagtgttg
atggaacgaataagtcgtcacgtcggaaggaacaga

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TCAGATGGCTCTCTCCGGAGACATT 157 621 1001 Antisense
GTCTGGTCGTATGGAGTACTGCTCA 564 471 1057 Antisense
GTACTGCTCACGGAACTTATGACGA 274 459 1072 Antisense
TGTGCACATGATCCGTTGTGGCCGA 95 557 1099 Antisense
AAGAGTCGGAGCACCCACATAAGAT 540 153 1154 Antisense
AAATTCCATCGGTCCGCATCAACTT 392 115 1232 Antisense
ACCAATGAGCCCTAATCCAGCTATT 395 85 1326 Antisense
AAGAGCCATACTTCGACTGATCGTA 152 155 1411 Antisense
TTCGACTGATCGTACAAACTCCAAT 163 693 1422 Antisense
AAACTCCAATAATACTCTTACTCGG 211 127 1437 Antisense
AAGTCGTCACGTCGGAAGGAACAGA 391 157 1552 Antisense
Sequence Source Affymetrix Proprietary Database