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[193789_at] neuronal acetylcholine receptor protein

Description T05C12.2 /REP_DB=WormBase Gene ID /WP=CE25099 /GEN=acr-14 /TR=Q22224 /GB=CAA91304.2 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=neuronal acetylcholine receptor protein
Cluster 6grp_high1_10_10 > 43      4grp_highest_8_8 > 63      4grp_high_8_8 > 28      6grp_total > 20      4grp_total > 35      6grp_cgc > 72      6grp_high1_sub > 02      6grp_cgc_sub > 02      6grp_total_sub > Hat      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 123
1 2 3 4 range
A 52.5
(-3)
P 		163.1
(3)
P 		80.9
(-1.5)
P 		128.6
(1.1)
P 		111
B 105.8
(-0.1)
P 		149.8
(3)
P 		74.1
(-2.4)
P 		65.9
(-3)
P 		84
C 114.2
(-0.6)
P 		108.9
(-1)
P 		74.7
(-3)
P 		175.2
(3)
P 		101
avr 90.8
(-1.7) 		140.6
(3) 		76.6
(-3) 		123.2
(1.4) 		64

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 125
1 2 3 4 5 6 range
A 96
(-1)
A 		101.7
(-0.6)
P 		145.8
(3)
P 		83.9
(-2)
P 		71.3
(-3)
P 		113.6
(0.4)
P 		75
B 74
(-3)
P 		114.7
(1.8)
P 		124.6
(3)
P 		112
(1.5)
P 		78.5
(-2.5)
P 		90.6
(-1)
P 		51
C 80.7
(-1.9)
P 		183.4
(3)
P 		96.4
(-1.2)
P 		86.9
(-1.6)
P 		76.4
(-2.1)
P 		58.1
(-3)
P 		125
avr 83.6
(-2.2) 		133.3
(3) 		122.3
(1.9) 		94.3
(-1) 		75.4
(-3) 		87.4
(-1.8) 		58
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 24
1 2 3 4 range
A 19.1
(-2.9)
P 		35.4
(3)
P 		21.2
(-2.1)
P 		18.8
(-3)
P 		17
B 33.7
(2.1)
P 		37
(3)
P 		17.2
(-2.2)
P 		14
(-3)
P 		23
C 37.8
(3)
P 		31.3
(-0.3)
P 		26
(-3)
P 		29.5
(-1.2)
P 		12
avr 30.2
(1.1) 		34.6
(3) 		21.5
(-2.7) 		20.8
(-3) 		14

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 38
1 2 3 4 5 6 range
A 17.7
(-3)
A 		36.2
(3)
P 		31.7
(1.5)
P 		21.3
(-1.8)
P 		21.5
(-1.8)
P 		27.7
(0.2)
P 		19
B 25.7
(-3)
P 		38.2
(3)
P 		30.3
(-0.8)
P 		29.7
(-1.1)
P 		31.9
(-0)
P 		33.8
(0.9)
P 		13
C 29.9
(-1.1)
P 		55.9
(3)
P 		24.5
(-1.9)
P 		17.5
(-3)
P 		24.7
(-1.9)
P 		19.4
(-2.7)
P 		38
avr 24.4
(-2.5) 		43.4
(3) 		28.8
(-1.3) 		22.8
(-3) 		26
(-2.1) 		27
(-1.8) 		21
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193789_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.3104
Sequence Type Exemplar sequence
Representative Public ID T05C12.2 NCBI
Target Description T05C12.2 /REP_DB=WormBase Gene ID /WP=CE25099 /GEN=acr-14 /TR=Q22224 /GB=CAA91304.2 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=neuronal acetylcholine receptor protein
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_063315(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_063315 NCBI Caenorhabditis elegans AcetylCholine Receptor family member (acr-14) (acr-14) mRNA, complete cds. 11/11 None
SNAP00000002110 ENSEMBL cdna:SNAP chromosome:CEL140:II:8174858:8176832:-1 11/11 None
GENEFINDER00000002127 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:8174858:8176755:-1 11/11 None
T05C12.2 ENSEMBL cdna:known chromosome:CEL140:II:8174858:8177116:-1 gene:T05C12.2 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:8174854-8177113(-) 100.0 100.0
Public Domain and Genome References
Gene Title neuronal acetylcholine receptor protein
Gene Symbol acr-14
Ensembl T05C12.2
Entrez Gene 191601 Entrez gene
SwissProt Q22224 EMBL-EBI
WormBase CE25099 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6810 transport inferred from electronic annotation QuickGO AmiGO
6811 ion transport inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
16021 integral to membrane inferred from electronic annotation QuickGO AmiGO
45211 postsynaptic membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4889 nicotinic acetylcholine-activated cation-selective channel activity inferred from electronic annotation QuickGO AmiGO
5216 ion channel activity inferred from electronic annotation QuickGO AmiGO
5230 extracellular ligand-gated ion channel activity inferred from electronic annotation QuickGO AmiGO
30594 neurotransmitter receptor activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA91304 Hypothetical protein T05C12.2 [Caenorhabditis elegans] ref|NP_495716.1| AcetylCholine Receptor family member (acr-14) [Caenorhabditis elegans] 0.0
blast CAE57718 Hypothetical protein CBG00726 [Caenorhabditis briggsae] 0.0
blast CAE57718 Hypothetical protein CBG00726 [Caenorhabditis briggsae] 1.0E-175
blast CAE63105 Hypothetical protein CBG07400 [Caenorhabditis briggsae] 1.0E-120
Protein Domains
Database ID Description E-Value
Pfam IPR006029 EMBL-EBI Neurotransmitter-gated ion-channel transmembrane region 4.5E-29
Pfam IPR006202 EMBL-EBI Neurotransmitter-gated ion-channel ligand binding domain 5.5E-23
Pfam IPR006202 EMBL-EBI Neurotransmitter-gated ion-channel ligand binding domain 0.019
Pfam IPR006029 EMBL-EBI Neurotransmitter-gated ion-channel transmembrane region 4.5E-29
Pfam IPR006202 EMBL-EBI Neurotransmitter-gated ion-channel ligand binding domain 1.7E-68
Pfam IPR006029 EMBL-EBI Neurotransmitter-gated ion-channel transmembrane region 4.5E-29
Pfam IPR006202 EMBL-EBI Neurotransmitter-gated ion-channel ligand binding domain 3.9E-87
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_495716.1 4 260-282,289-308,318-340,475-497
T05C12.2 4 260-282,289-308,318-340,475-497
SNAP00000002110 3 106-128,166-188,321-343
GENEFINDER00000002127 3 203-225,263-285,418-440
Sequence
Target Sequence 
>C. ELEGANS:193789_AT
tagaaacaacggtcttgctctcggtcattttcttcctccaaatggtgtcaagtacaagtc
ctcctcaatcacaaagtgttcccattctagctgcattcttttcttgttgcctgatgcttg
tagcctgttcatgtgtcttcacagtactcacattatcactacatcataggaaaccggaaa
cacacgaaatgagtccaacgatgagaaaaatattcatcgactggcttccttatattcttt
gtatgtgtaaaccagatcatccaaagactccgaaaccaaaagttcttggaaaatcaattg
caccgattcacagattatctactattccaatgctcaatctacctagagtgtctcaaacta
cttttccggataaaaatgtttttgtatatcatgaggttcctgcagttataaaaaacacgt
ctcggatttgcgctgag

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TAGAAACAACGGTCTTGCTCTCGGT 105 653 887 Antisense
CAAGTCCTCCTCAATCACAAAGTGT 70 185 941 Antisense
CACAAAGTGTTCCCATTCTAGCTGC 269 195 956 Antisense
TAGCTGCATTCTTTTCTTGTTGCCT 705 651 974 Antisense
CTTGTTGCCTGATGCTTGTAGCCTG 157 219 989 Antisense
TTGTAGCCTGTTCATGTGTCTTCAC 596 707 1004 Antisense
GTCTTCACAGTACTCACATTATCAC 278 469 1021 Antisense
GACTGGCTTCCTTATATTCTTTGTA 117 377 1105 Antisense
ACTATTCCAATGCTCAATCTACCTA 118 103 1207 Antisense
AGAGTGTCTCAAACTACTTTTCCGG 628 67 1231 Antisense
AAACACGTCTCGGATTTGCGCTGAG 500 129 1299 Antisense
Sequence Source Affymetrix Proprietary Database