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[193777_s_at] cyclin A/CDK2-associated protein P19 like

Description F46A9.5 /REP_DB=WormBase Gene ID /WP=CE10580 /GEN=skr-1 /TR=Q93647 /GB=CAB03110.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=cyclin A-CDK2-associated protein P19 like
Cluster 6grp_highest_10_10 > 67      6grp_high1_10_10 > 86      4grp_highest_8_8 > 38      4grp_high_8_8 > 04      6grp_highest_nonorm > 58      6grp_total > 77      4grp_total > 05      6grp_highest_sub > In      6grp_cgc > 57      6grp_high1_sub > In      6grp_total_sub > Increase      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 2260
1 2 3 4 range
A 2840.8
(-0.9)
P 		2104.5
(-3)
P 		2227.5
(-2.6)
P 		4212.3
(3)
P 		2108
B 3039.7
(-0.5)
P 		2113.3
(-3)
P 		2343.9
(-2.4)
P 		4358
(3)
P 		2245
C 3069.5
(-0.4)
P 		2098.1
(-3)
P 		2288.7
(-2.5)
P 		4310.7
(3)
P 		2213
avr 2983.3
(-0.6) 		2105.3
(-3) 		2286.7
(-2.5) 		4293.7
(3) 		2188

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1240
1 2 3 4 5 6 range
A 2387.9
(-3)
P 		3115.6
(1.1)
P 		2678.3
(-1.4)
P 		2946.4
(0.2)
P 		2694.3
(-1.3)
P 		3451.1
(3)
P 		1063
B 2638.5
(0)
P 		2225.8
(-3)
P 		3041.3
(3)
P 		2470.8
(-1.2)
P 		2793.2
(1.2)
P 		3004.6
(2.7)
P 		816
C 2802.7
(-0.6)
P 		2446.5
(-2.5)
P 		3037.3
(0.7)
P 		2345.8
(-3)
P 		3035
(0.7)
P 		3465.5
(3)
P 		1120
avr 2609.7
(-2.8) 		2596
(-2.9) 		2919
(-0.2) 		2587.7
(-3) 		2840.8
(-0.9) 		3307.1
(3) 		719
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 578
1 2 3 4 range
A 1034.3
(3)
P 		456.8
(-3)
P 		582.3
(-1.7)
P 		616.6
(-1.3)
P 		578
B 969.3
(3)
P 		521.9
(-3)
P 		543.1
(-2.7)
P 		928.7
(2.5)
P 		447
C 1016.1
(3)
P 		603.2
(-3)
P 		797.7
(-0.2)
P 		726.8
(-1.2)
P 		413
avr 1006.6
(3) 		527.3
(-3) 		641
(-1.6) 		757.4
(-0.1) 		479

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 720
1 2 3 4 5 6 range
A 440.2
(-3)
P 		1108.1
(3)
P 		583.3
(-1.7)
P 		747.3
(-0.2)
P 		813
(0.3)
P 		840.2
(0.6)
P 		668
B 918.1
(0.3)
P 		740.9
(-1.9)
P 		738.5
(-1.9)
P 		654.4
(-3)
P 		1134.9
(3)
P 		1120.4
(2.8)
P 		481
C 1038.9
(1.9)
P 		746.5
(-0.6)
P 		773
(-0.4)
P 		471.8
(-3)
P 		982.1
(1.4)
P 		1160.1
(3)
P 		688
avr 799.1
(-0.5) 		865.2
(0.5) 		698.3
(-1.9) 		624.5
(-3) 		976.7
(2.1) 		1040.2
(3) 		416
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 193777_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.986
Sequence Type Exemplar sequence
Representative Public ID F46A9.5 NCBI
Target Description F46A9.5 /REP_DB=WormBase Gene ID /WP=CE10580 /GEN=skr-1 /TR=Q93647 /GB=CAB03110.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=cyclin A-CDK2-associated protein P19 like
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq,GenBank identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_060112(11), AF440505(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_060112 NCBI Caenorhabditis elegans SKp1 Related (ubiquitin ligase complex component) family member (skr-1) (skr-1) mRNA, complete cds. 11/11 None
AF440505 NCBI Caenorhabditis elegans SKR-1 (skr-1) mRNA, partial cds. 11/11 None
F46A9.5.1 ENSEMBL cdna:known chromosome:CEL140:I:9479668:9480773:1 gene:F46A9.5 11/11 None
F46A9.5.2 ENSEMBL cdna:known chromosome:CEL140:I:9479673:9480765:1 gene:F46A9.5 11/11 None
F46A9.5.3 ENSEMBL cdna:known chromosome:CEL140:I:9479674:9480765:1 gene:F46A9.5 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
SNAP00000021984 8/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:9479617-9480377(+) 100.0 100.0
Public Domain and Genome References
Gene Title cyclin A/CDK2-associated protein P19 like
Gene Symbol skr-1
Ensembl F46A9.5
Entrez Gene 172775 Entrez gene
SwissProt Q93647 EMBL-EBI
WormBase CE10580 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:249228_AT E3 ubiquitin ligase SCF complex subunit SKP1/ASK1 (At2) / UFO-binding protein (UIP2) at
CANINE:1584434_AT similar to S-phase kinase-associated protein 1A isoform b cfa
CANINE_2:CFA.11240.1.S1_S_AT similar to S-phase kinase-associated protein 1A isoform b cfa
CANINE_2:CFAAFFX.13238.1.S1_AT similar to S-phase kinase-associated protein 1A isoform b cfa
CANINE_2:CFAAFFX.7777.1.S1_S_AT similar to S-phase kinase-associated protein 1A isoform b cfa
DROSOPHILA_2:1636591_AT dm
DROSGENOME1:147056_AT dm
CHICKEN:GGA.1718.1.S1_S_AT S-phase kinase-associated protein 1A (p19A) gga
HG-U133_PLUS_2:200711_S_AT S-phase kinase-associated protein 1A (p19A) hs
HG-U133A:200711_S_AT S-phase kinase-associated protein 1A (p19A) hs
HG-U133A_2:200711_S_AT S-phase kinase-associated protein 1A (p19A) hs
HG-U95AV2:2010_AT S-phase kinase-associated protein 1A (p19A) hs
HC-G110:2010_AT S-phase kinase-associated protein 1A (p19A) hs
HG-U133_PLUS_2:200718_S_AT S-phase kinase-associated protein 1A (p19A) hs
HG-U133A_2:200718_S_AT S-phase kinase-associated protein 1A (p19A) hs
HG-FOCUS:200718_S_AT S-phase kinase-associated protein 1A (p19A) hs
HG-U133A:200718_S_AT S-phase kinase-associated protein 1A (p19A) hs
HG-U133_PLUS_2:207974_S_AT S-phase kinase-associated protein 1A (p19A) hs
HG-U133A:207974_S_AT S-phase kinase-associated protein 1A (p19A) hs
HG-FOCUS:207974_S_AT S-phase kinase-associated protein 1A (p19A) hs
HG-U133A_2:207974_S_AT S-phase kinase-associated protein 1A (p19A) hs
HUGENEFL:Z47087_AT S-phase kinase-associated protein 1A (p19A) hs
U133_X3P:G5902087_3P_S_AT S-phase kinase-associated protein 1A (p19A) hs
U133_X3P:G6006030_3P_A_AT S-phase kinase-associated protein 1A (p19A) hs
U133_X3P:HS.171626.0.S1_3P_A_AT S-phase kinase-associated protein 1A (p19A) hs
HG-U95AV2:41759_AT S-phase kinase-associated protein 1A (p19A) hs
HG-U95E:70232_AT S-phase kinase-associated protein 1A (p19A) hs
HG-U133_PLUS_2:200719_AT S-phase kinase-associated protein 1A (p19A) hs
HG-U133A_2:200719_AT S-phase kinase-associated protein 1A (p19A) hs
HG-U133A:200719_AT S-phase kinase-associated protein 1A (p19A) hs
U133_X3P:HS.171626.0.S3_3P_AT S-phase kinase-associated protein 1A (p19A) hs
HG-U95E:77520_AT S-phase kinase-associated protein 1A (p19A) hs
MOE430A:1423149_AT S-phase kinase-associated protein 1A mm
MOUSE430_2:1423149_AT S-phase kinase-associated protein 1A mm
MOUSE430A_2:1423149_AT S-phase kinase-associated protein 1A mm
MOUSE430_2:1423148_AT S-phase kinase-associated protein 1A mm
MOUSE430A_2:1423148_AT S-phase kinase-associated protein 1A mm
MOE430A:1423148_AT S-phase kinase-associated protein 1A mm
MU11KSUBB:MSA.3974.0_S_AT S-phase kinase-associated protein 1A mm
MU11KSUBB:Z47088_S_AT S-phase kinase-associated protein 1A mm
MG-U74AV2:99607_AT S-phase kinase-associated protein 1A mm
RG-U34C:RC_AI236635_AT S-phase kinase-associated protein 1A rn
RAE230A:1372437_AT S-phase kinase-associated protein 1A rn
RAT230_2:1372437_AT S-phase kinase-associated protein 1A rn
RG-U34B:RC_AA997522_AT S-phase kinase-associated protein 1A rn
RG-U34C:RC_AI235972_AT S-phase kinase-associated protein 1A rn
YEAST_2:1778975_AT Evolutionarily conserved kinetochore protein that is part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase Sc
Protein Similarities
Method ID Description E-Value
blast CAB03110 Hypothetical protein F46A9.5 [Caenorhabditis elegans] emb|CAB03027.1| Hypothetical protein F46A9.5 [Caenorhabditis elegans] ref|NP_492513.1| SKp1 Related (ubiquitin ligase complex component) family member (skr-1) [Caenorhabditis elegans] 8.0E-89
blast AAL34093 SKR-1 [Caenorhabditis elegans] 2.0E-85
blast CAB03110 Hypothetical protein F46A9.5 [Caenorhabditis elegans] emb|CAB03027.1| Hypothetical protein F46A9.5 [Caenorhabditis elegans] ref|NP_492513.1| SKp1 Related (ubiquitin ligase complex component) family member (skr-1) [Caenorhabditis elegans] 2.0E-85
Protein Domains
Database ID Description E-Value
Pfam IPR001232 EMBL-EBI SKP1 component 2.9E-56
Pfam IPR001232 EMBL-EBI SKP1 component 8.8E-31
Pfam IPR001232 EMBL-EBI SKP1 component 2.9E-56
Pfam IPR001232 EMBL-EBI SKP1 component 8.8E-31
Sequence
Target Sequence 
>C. ELEGANS:193777_S_AT
gtatccgaggcggcaaaggaacgcgaaatcaagatatcgtcttcggataacgaaatcttc
ttggtcccacgcaatgtgatccgtctctcaaacactatcaacactctcctgatggatctt
ggactcgacgacgaagaaggaaccaacgctgagccaattccagttcaaaacgtcactgcc
tcgattctgaagaaggtcattagttggtgcaaccatcatcactccgatcctatctcgact
gaagattccgataaccgcgagaaaagaactgacgacataggcagctgggacgtcgagttt
cttaaggttgaccaaggaacccttttcgagctcatcttggctgccaactatttggacatc
aagggacttcttgatgttacctgcaagactgttgctaacatgatcaagggaaaatctcca
gaagagattcgtcgcactttcaacatcaagaacgacttcaccccggaagaggaagagc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GTATCCGAGGCGGCAAAGGAACGCG 504 455 31 Antisense
AACACTATCAACACTCTCCTGATGG 683 135 121 Antisense
TGATGGATCTTGGACTCGACGACGA 276 567 140 Antisense
CTCCGATCCTATCTCGACTGAAGAT 52 235 252 Antisense
GACTGAAGATTCCGATAACCGCGAG 349 375 267 Antisense
GAACTGACGACATAGGCAGCTGGGA 323 347 296 Antisense
GCAGCTGGGACGTCGAGTTTCTTAA 308 313 311 Antisense
AAGGGACTTCTTGATGTTACCTGCA 486 159 391 Antisense
GTTACCTGCAAGACTGTTGCTAACA 405 445 406 Antisense
GAAGAGATTCGTCGCACTTTCAACA 403 339 451 Antisense
GACTTCACCCCGGAAGAGGAAGAGC 310 369 484 Antisense
Sequence Source Affymetrix Proprietary Database