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[193772_s_at] Ribonucleoside-disphosphate reductase large chain

Description T23G5.1 /REP_DB=WormBase Gene ID /WP=CE00331 /TR=SW:Q03604 /GB=CAA79574.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=Ribonucleoside-disphosphate reductase large chain
Cluster 6grp_highest_10_10 > 94      6grp_high1_10_10 > 58      4grp_highest_8_8 > 08      4grp_high_8_8 > 44      6grp_highest_nonorm > 87      6grp_total > 59      4grp_total > 51      6grp_highest_sub > Cu      6grp_cgc > 18      6grp_high1_sub > Cu      6grp_cgc_sub > Cu      6grp_total_sub > Cup      4grp_rule_based > L2      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1587
1 2 3 4 range
A 884.7
(-0.7)
P 		1795
(3)
P 		1197.3
(0.6)
P 		314.5
(-3)
P 		1481
B 909.7
(0)
P 		1606.9
(3)
P 		1382.4
(2)
P 		207.7
(-3)
P 		1399
C 883.7
(0.8)
P 		1277.4
(3)
P 		1082.5
(1.9)
P 		213.3
(-3)
P 		1064
avr 892.7
(-0) 		1559.8
(3) 		1220.7
(1.5) 		245.2
(-3) 		1315

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1633
1 2 3 4 5 6 range
A 1714
(1.4)
P 		985.4
(-1.3)
P 		518
(-3)
P 		829.9
(-1.9)
P 		1138.9
(-0.7)
P 		2150.8
(3)
P 		1633
B 1207.9
(0.9)
P 		906.5
(-1.2)
P 		643.4
(-3)
P 		824.8
(-1.7)
P 		965.5
(-0.8)
P 		1513.1
(3)
P 		870
C 1499.9
(2.1)
P 		848.2
(-2.1)
P 		751.3
(-2.7)
P 		703.9
(-3)
P 		1479.4
(2)
P 		1639
(3)
P 		935
avr 1473.9
(1.4) 		913.4
(-1.5) 		637.6
(-3) 		786.2
(-2.2) 		1194.6
(-0) 		1767.6
(3) 		1130
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 361
1 2 3 4 range
A 322.1
(1.8)
P 		389.6
(3)
P 		313
(1.7)
P 		46
(-3)
P 		344
B 290.1
(1.2)
P 		396.9
(3)
P 		320.3
(1.7)
P 		44.3
(-3)
P 		353
C 292.5
(1.5)
P 		367.3
(2.8)
P 		377.3
(3)
P 		36
(-3)
P 		341
avr 301.6
(1.5) 		384.6
(3) 		336.9
(2.2) 		42.1
(-3) 		343

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 451
1 2 3 4 5 6 range
A 316
(-0)
P 		350.5
(0.5)
P 		112.8
(-3)
P 		210.5
(-1.6)
P 		343.7
(0.4)
P 		523.6
(3)
P 		411
B 420.3
(0.9)
P 		301.7
(-0.9)
P 		156.2
(-3)
P 		218.5
(-2.1)
P 		392.3
(0.5)
P 		564.2
(3)
P 		408
C 556
(3)
P 		258.8
(-1.3)
P 		191.2
(-2.3)
P 		141.6
(-3)
P 		478.7
(1.9)
P 		548.7
(2.9)
P 		414
avr 430.8
(1.2) 		303.7
(-0.7) 		153.4
(-3) 		190.2
(-2.4) 		404.9
(0.8) 		545.5
(3) 		392
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 193772_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.7540
Sequence Type Exemplar sequence
Representative Public ID T23G5.1 NCBI
Target Description T23G5.1 /REP_DB=WormBase Gene ID /WP=CE00331 /TR=SW:Q03604 /GB=CAA79574.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=Ribonucleoside-disphosphate reductase large chain
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_066638(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_066638 NCBI Caenorhabditis elegans RiboNucleotide Reductase family member (rnr-1) (rnr-1) mRNA, complete cds. 11/11 None
SNAP00000022696 ENSEMBL cdna:SNAP chromosome:CEL140:III:9225424:9228151:-1 11/11 None
GENEFINDER00000022706 ENSEMBL cdna:GeneFinder chromosome:CEL140:III:9225424:9228151:-1 11/11 None
T23G5.1.3 ENSEMBL cdna:known chromosome:CEL140:III:9225279:9228155:-1 gene:T23G5.1 11/11 None
T23G5.1.2 ENSEMBL cdna:known chromosome:CEL140:III:9225279:9228153:-1 gene:T23G5.1 11/11 None
T23G5.1.1 ENSEMBL cdna:known chromosome:CEL140:III:9225279:9228689:-1 gene:T23G5.1 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:9225419-9228147(-) 100.0 100.0
Public Domain and Genome References
Gene Title Ribonucleoside-disphosphate reductase large chain
Gene Symbol rnr-1
Ensembl T23G5.1
Entrez Gene 176301 Entrez gene
SwissProt Q03604 EMBL-EBI
WormBase CE00331 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:263882_AT ribonucleoside-diphosphate reductase small chain, putative / ribonucleotide reductase, putative at
CANINE:1592265_AT similar to Ribonucleoside-diphosphate reductase large subunit (Ribonucleoside-diphosphate reductase M1 subunit) (Ribonucleotide reductase large chain) cfa
CANINE:1592494_AT similar to Ribonucleoside-diphosphate reductase large subunit (Ribonucleoside-diphosphate reductase M1 subunit) (Ribonucleotide reductase large chain) cfa
CANINE_2:CFA.19148.1.S1_S_AT similar to Ribonucleoside-diphosphate reductase large subunit (Ribonucleoside-diphosphate reductase M1 subunit) (Ribonucleotide reductase large chain) cfa
CANINE_2:CFA.3413.1.A1_AT similar to Ribonucleoside-diphosphate reductase large subunit (Ribonucleoside-diphosphate reductase M1 subunit) (Ribonucleotide reductase large chain) cfa
CANINE_2:CFAAFFX.9942.1.S1_S_AT similar to Ribonucleoside-diphosphate reductase large subunit (Ribonucleoside-diphosphate reductase M1 subunit) (Ribonucleotide reductase large chain) cfa
DROSOPHILA_2:1631007_AT Ribonucleoside diphosphate reductase large subunit dm
DROSGENOME1:153579_AT Ribonucleoside diphosphate reductase large subunit dm
CHICKEN:GGA.4514.2.S1_S_AT ribonucleotide reductase M1 polypeptide gga
CHICKEN:GGA.4514.3.S1_S_AT ribonucleotide reductase M1 polypeptide gga
HG-U133A:201476_S_AT ribonucleotide reductase M1 polypeptide hs
HG-U133_PLUS_2:201476_S_AT ribonucleotide reductase M1 polypeptide hs
HG-U133A_2:201476_S_AT ribonucleotide reductase M1 polypeptide hs
HG-U133A:201477_S_AT ribonucleotide reductase M1 polypeptide hs
HG-U133_PLUS_2:201477_S_AT ribonucleotide reductase M1 polypeptide hs
HG-FOCUS:201477_S_AT ribonucleotide reductase M1 polypeptide hs
HG-U133A_2:201477_S_AT ribonucleotide reductase M1 polypeptide hs
HUGENEFL:X59543_AT ribonucleotide reductase M1 polypeptide hs
U133_X3P:G4506748_3P_A_AT ribonucleotide reductase M1 polypeptide hs
U133_X3P:HS.2934.0.A1_3P_A_AT ribonucleotide reductase M1 polypeptide hs
HG-U95AV2:34314_AT ribonucleotide reductase M1 polypeptide hs
U133_X3P:234134_3P_AT Transport protein, putative hs
HG-U133_PLUS_2:234134_AT Transport protein, putative hs
HG-U133B:234134_AT Transport protein, putative hs
MOE430A:1415878_AT ribonucleotide reductase M1 mm
MOUSE430A_2:1415878_AT ribonucleotide reductase M1 mm
MOUSE430_2:1415878_AT ribonucleotide reductase M1 mm
MU11KSUBA:K02927_S_AT ribonucleotide reductase M1 mm
MG-U74AV2:100612_AT ribonucleotide reductase M1 mm
MG-U74AV2:161731_AT ribonucleotide reductase M1 mm
MOE430A:1448127_AT ribonucleotide reductase M1 mm
MOUSE430A_2:1448127_AT ribonucleotide reductase M1 mm
MOUSE430_2:1448127_AT ribonucleotide reductase M1 mm
MOE430B:1440073_AT ribonucleotide reductase M1 mm
MOUSE430_2:1440073_AT ribonucleotide reductase M1 mm
MU19KSUBA:TC24216_AT Ribonucleotide reductase M1, mRNA (cDNA clone MGC:25382 IMAGE:4485739) mm
MU19KSUBA:TC24216_G_AT Ribonucleotide reductase M1, mRNA (cDNA clone MGC:25382 IMAGE:4485739) mm
RG-U34B:RC_AA851352_AT ribonucleotide reductase M1 rn
RAE230A:1371862_AT ribonucleotide reductase M1 rn
RAT230_2:1371862_AT ribonucleotide reductase M1 rn
YEAST_2:1780044_AT Ribonucleotide-diphosphate reductase (RNR), large subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6260 DNA replication inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5971 ribonucleoside-diphosphate reductase complex inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4748 ribonucleoside-diphosphate reductase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA79574 Hypothetical protein T23G5.1 [Caenorhabditis elegans] ref|NP_499039.1| RiboNucleotide Reductase family member (rnr-1) [Caenorhabditis elegans] sp|Q03604|RIR1_CAEEL Ribonucleoside-diphosphate reductase large subunit (Ribonucleotide reductase large chain) 0.0
blast CAE65263 Hypothetical protein CBG10154 [Caenorhabditis briggsae] 0.0
blast NP_001024 ribonucleoside-diphosphate reductase M1 chain [Homo sapiens] emb|CAA42118.1| M1 subunit of ribonucleotide reductase [Homo sapiens] emb|CAA42180.1| large subunit ribonucleotide reductase [Homo sapiens] gb|AAH06498.1| Ribonucleoside-diphosphate reductase M1 chain [Homo sapiens] sp|P23921|RIR1_HUMAN Ribonucleoside-diphosphate reductase large subunit (Ribonucleoside-diphosphate reductase M1 subunit) (Ribonucleotide reductase large chain) 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR000788 EMBL-EBI Ribonucleotide reductase large subunit 1.0E-126
Pfam IPR005144 EMBL-EBI ATP cone domain 5.2E-26
Pfam IPR000788 EMBL-EBI Ribonucleotide reductase large subunit 1.3E-36
Sequence
Target Sequence 
>C. ELEGANS:193772_S_AT
atcaatgcgattgggccactcttcgcaagaaaattgcaaagcatggtatccgcaacagtc
ttctgatggctccaatgccaactgcttccactgctcaaattctcggaaacaatgaatcca
tcgagccatacacttcgaacatctactctcgccgtgttctttctggagatttccagattg
tgaatcctcacatgctcaaggatttggtggaaagaggattgtggactgatgagatgaaga
atcgtctgattgccaacaatggatccattcaaaacattgatggaattccatccgacatca
aggaactttatcgcacagtgtgggagatctctcaaaaagacattattgagatggctgctg
atcgtggagcatacattgatcaatcccaatctcttaacattcacatggccaagccaagct
acgccggtatcacatcaatgcatttctacggatggaagaagggactcaagactggaatgt
actatttgcgtaccaagccagctgtcaa

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
ATCAATGCGATTGGGCCACTCTTCG 219 27 1760 Antisense
TCCGCAACAGTCTTCTGATGGCTCC 447 595 1808 Antisense
GCTTCCACTGCTCAAATTCTCGGAA 1 307 1843 Antisense
ATGAATCCATCGAGCCATACACTTC 10 45 1871 Antisense
ATACACTTCGAACATCTACTCTCGC 697 23 1887 Antisense
TCGCCGTGTTCTTTCTGGAGATTTC 363 599 1908 Antisense
TCGCACAGTGTGGGAGATCTCTCAA 680 599 2070 Antisense
GATCAATCCCAATCTCTTAACATTC 621 421 2137 Antisense
TCACATGGCCAAGCCAAGCTACGCC 613 627 2160 Antisense
TACGCCGGTATCACATCAATGCATT 21 649 2179 Antisense
ATTTGCGTACCAAGCCAGCTGTCAA 525 15 2243 Antisense
Sequence Source Affymetrix Proprietary Database