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[193740_at] NCS-2 neuronal calcium sensor protein

Description F10G8.5 /REP_DB=WormBase Gene ID /WP=CE09340 /GEN=ncs-2 /TR=SW:P36609 /GB=CAB02282.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=NCS-2 neuronal calcium sensor protein
Cluster 6grp_highest_10_10 > 40      6grp_high1_10_10 > 05      4grp_highest_8_8 > 50      4grp_high_8_8 > 33      6grp_highest_nonorm > 01      6grp_total > 05      4grp_total > 46      6grp_highest_sub > De      6grp_cgc > 22      6grp_high1_sub > De      6grp_cgc_sub > De      6grp_rule_based > S1      4grp_rule_based > L1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1131
1 2 3 4 range
A 2583.6
(3)
P 		1627.8
(-2.1)
P 		1464
(-3)
P 		1494
(-2.8)
P 		1120
B 2441.5
(3)
P 		1751.6
(-1.9)
P 		1597.5
(-2.9)
P 		1590.1
(-3)
P 		851
C 2595.3
(3)
P 		2146.7
(0.3)
P 		2027.8
(-0.4)
P 		1606.2
(-3)
P 		989
avr 2540.1
(3) 		1842
(-1.3) 		1696.4
(-2.2) 		1563.4
(-3) 		977

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 2715
1 2 3 4 5 6 range
A 1978
(0)
P 		2636.3
(3)
P 		1399.2
(-2.6)
P 		1724.9
(-1.1)
P 		1305.2
(-3)
P 		1348.7
(-2.8)
P 		1331
B 2325.7
(3)
P 		2028.1
(1.6)
P 		1247.9
(-2)
P 		1503.9
(-0.8)
P 		1436
(-1.1)
P 		1025.5
(-3)
P 		1300
C 3677
(3)
P 		1870.9
(-1)
P 		1909.2
(-0.9)
P 		1369.9
(-2.1)
P 		1594.9
(-1.6)
P 		961.6
(-3)
P 		2715
avr 2660.2
(3) 		2178.4
(1.1) 		1518.8
(-1.4) 		1532.9
(-1.4) 		1445.4
(-1.7) 		1111.9
(-3) 		1548
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 722
1 2 3 4 range
A 940.7
(3)
P 		353.3
(-1.9)
P 		382.7
(-1.6)
P 		218.7
(-3)
P 		722
B 778.6
(3)
P 		432.6
(-1.7)
P 		370.2
(-2.6)
P 		338.9
(-3)
P 		440
C 859.1
(3)
P 		617.2
(0.5)
P 		706.7
(1.4)
P 		270.8
(-3)
P 		588
avr 859.5
(3) 		467.7
(-1) 		486.5
(-0.8) 		276.1
(-3) 		583

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1087
1 2 3 4 5 6 range
A 364.6
(-2.4)
P 		937.6
(3)
P 		304.7
(-3)
P 		437.5
(-1.7)
P 		393.9
(-2.2)
P 		328.4
(-2.8)
P 		633
B 809.2
(3)
P 		675.1
(1.4)
P 		303
(-3)
P 		398.3
(-1.9)
P 		583.4
(0.3)
P 		382.4
(-2.1)
P 		506
C 1362.9
(3)
P 		570.9
(-1.4)
P 		485.9
(-1.8)
P 		275.5
(-3)
P 		516.1
(-1.7)
P 		321.9
(-2.7)
P 		1087
avr 845.6
(3) 		727.9
(1.6) 		364.5
(-2.8) 		370.4
(-2.7) 		497.8
(-1.2) 		344.2
(-3) 		501
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193740_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.665
Sequence Type Exemplar sequence
Representative Public ID F10G8.5 NCBI
Target Description F10G8.5 /REP_DB=WormBase Gene ID /WP=CE09340 /GEN=ncs-2 /TR=SW:P36609 /GB=CAB02282.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=NCS-2 neuronal calcium sensor protein
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_060250(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_060250 NCBI Caenorhabditis elegans Neuronal Calcium Sensor family member (ncs-2) (ncs-2) mRNA, complete cds. 11/11 None
SNAP00000036094 ENSEMBL cdna:SNAP chromosome:CEL140:I:10042153:10042899:-1 11/11 None
GENEFINDER00000036099 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:10042153:10042899:-1 11/11 None
F10G8.5 ENSEMBL cdna:known chromosome:CEL140:I:10041403:10042943:-1 gene:F10G8.5 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:10042083-10042830(-) 100.0 100.0
Public Domain and Genome References
Gene Title NCS-2 neuronal calcium sensor protein
Gene Symbol ncs-2
Ensembl F10G8.5
Entrez Gene 172866 Entrez gene
SwissProt P36609 EMBL-EBI
WormBase CE09340 Wormbase
Functional Annotations
Ortholog
ID Title Organism
DROSOPHILA_2:1637457_AT dm
DROSGENOME1:149084_AT dm
DROSOPHILA_2:1627218_A_AT dm
Gene Ontology
GO Molecular Function (view graph)
ID Description Evidence Links
5509 calcium ion binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB02282 Hypothetical protein F10G8.5 [Caenorhabditis elegans] ref|NP_492651.1| Neuronal Calcium Sensor family member (ncs-2) [Caenorhabditis elegans] sp|P36609|NCS2_CAEEL Neuronal calcium sensor 2 (NCS-2) emb|CAE60217.1| Hypothetical protein CBG03785 [Caenorhabditis briggsae] gb|AAA85632.1| neuronal calcium binding protein 1.0E-107
blast AAV32835 neuronal calcium sensor [Parascaris equorum] 1.0E-106
blast AAF49083 CG7646-PA, isoform A [Drosophila melanogaster] ref|NP_649167.1| CG7646-PA, isoform A [Drosophila melanogaster] 2.0E-64
Protein Domains
Database ID Description E-Value
Pfam IPR002048 EMBL-EBI Calcium-binding EF-hand 6.4E-7
Pfam IPR002048 EMBL-EBI Calcium-binding EF-hand 2.2E-7
Pfam IPR002048 EMBL-EBI Calcium-binding EF-hand 4.5E-4
Sequence
Target Sequence 
>C. ELEGANS:193740_AT
gttccaagccaaaactctccaaagaggatttggagtttttgaaaaagaacacaaatttca
ccgaagagcagatcaaagaatggtataaaggatttgtgcaagattgtccgaaaggccact
taaccaaggagcagttcataaaggtgtataaggatttcttcccgtcaggttctgcagaag
gattctgtgaacatgtattccgaacattcgacacggataactcgggttttatcgacttca
aagaatttttattggcaattaatgtgacgagttccggaacgcccgagcagaaacttgaat
gggctttccgtatgtacgatattgatggaaatggtacgatagacgagaaggaaatgatca
agattattgaggccatctatgaaatgctcggcccagaagtgacaaaatctgctgacgact
ctccaagaaagagagccaagatgatcttcgagaagatggatgttaacaatgataaagagc
tgacattgaaggaattcgttgacggctgccttgctgataa

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GTTCCAAGCCAAAACTCTCCAAAGA 337 441 26 Antisense
GATTGTCCGAAAGGCCACTTAACCA 644 427 127 Antisense
TTCTTCCCGTCAGGTTCTGCAGAAG 480 689 181 Antisense
TCGACACGGATAACTCGGGTTTTAT 631 599 233 Antisense
TTAATGTGACGAGTTCCGGAACGCC 172 657 284 Antisense
CCGGAACGCCCGAGCAGAAACTTGA 380 263 299 Antisense
TGAATGGGCTTTCCGTATGTACGAT 451 573 321 Antisense
TGAGGCCATCTATGAAATGCTCGGC 454 567 393 Antisense
GAAATGCTCGGCCCAGAAGTGACAA 399 361 406 Antisense
TGACAAAATCTGCTGACGACTCTCC 466 571 425 Antisense
TCGTTGACGGCTGCCTTGCTGATAA 486 603 521 Antisense
Sequence Source Affymetrix Proprietary Database