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[193724_at] serine/threonine kinase (KIN1/SNF1/Nim1 subfamily)

Description F49C5.4 /REP_DB=WormBase Gene ID /WP=CE16081 /TR=O17879 /GB=CAB04433.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=serine-threonine kinase (KIN1-SNF1-Nim1 subfamily)
Cluster 4grp_high_8_8 > 12      6grp_total > 05      4grp_total > 12      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 126
1 2 3 4 range
A 82
(-3)
P 		89.4
(-2.6)
A 		103
(-1.9)
A 		192.4
(3)
P 		110
B 145.8
(3)
P 		104.7
(-1.5)
P 		91.6
(-3)
P 		122.3
(0.4)
A 		54
C 96.4
(0)
A 		107.2
(1.1)
A 		66.4
(-3)
A 		126
(3)
P 		60
avr 108.1
(-0.9) 		100.4
(-1.7) 		87
(-3) 		146.9
(3) 		60

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 69
1 2 3 4 5 6 range
A 106.5
(3)
P 		87.1
(1.1)
M 		55.4
(-1.9)
A 		49
(-2.6)
A 		44.4
(-3)
A 		70.3
(-0.5)
A 		62
B 77.4
(1.5)
P 		54.5
(-1.3)
A 		65.2
(0)
A 		89.9
(3)
A 		67.2
(0.3)
A 		40.3
(-3)
A 		50
C 95.5
(3)
P 		82.2
(1.6)
A 		79.8
(1.4)
A 		45.3
(-2.2)
A 		75.3
(0.9)
M 		37.3
(-3)
A 		58
avr 93.1
(3) 		74.6
(0.5) 		66.8
(-0.6) 		61.4
(-1.3) 		62.3
(-1.2) 		49.3
(-3) 		44
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 27
1 2 3 4 range
A 29.9
(3)
P 		19.4
(-3)
A 		26.9
(1.3)
A 		28.2
(2)
P 		11
B 46.5
(3)
P 		25.9
(-1.9)
P 		21.2
(-3)
P 		26.1
(-1.8)
A 		25
C 31.9
(3)
A 		30.8
(2.4)
A 		23.1
(-1.9)
A 		21.2
(-3)
P 		11
avr 36.1
(3) 		25.4
(-2.2) 		23.7
(-3) 		25.2
(-2.3) 		12

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 26
1 2 3 4 5 6 range
A 19.6
(-0.6)
P 		31
(3)
M 		12.1
(-3)
A 		12.4
(-2.9)
A 		13.4
(-2.6)
A 		17.1
(-1.4)
A 		19
B 26.9
(2.8)
P 		18.2
(-1.4)
A 		15.8
(-2.6)
A 		23.8
(1.3)
A 		27.3
(3)
A 		15
(-3)
A 		12
C 35.4
(3)
P 		25.1
(0.7)
A 		20.3
(-0.4)
A 		9.1
(-3)
A 		24.4
(0.5)
M 		12.5
(-2.2)
A 		26
avr 27.3
(3) 		24.8
(1.8) 		16.1
(-2.4) 		15.1
(-2.9) 		21.7
(0.3) 		14.9
(-3) 		12
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193724_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.2974
Sequence Type Exemplar sequence
Representative Public ID F49C5.4 NCBI
Target Description F49C5.4 /REP_DB=WormBase Gene ID /WP=CE16081 /TR=O17879 /GB=CAB04433.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=serine-threonine kinase (KIN1-SNF1-Nim1 subfamily)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_064278(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_064278 NCBI Caenorhabditis elegans F49C5.4 (F49C5.4) mRNA, complete cds. 11/11 None
SNAP00000035412 ENSEMBL cdna:SNAP chromosome:CEL140:II:12539514:12542318:1 11/11 None
GENEFINDER00000035423 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:12539618:12542318:1 11/11 None
F49C5.4 ENSEMBL cdna:known chromosome:CEL140:II:12539972:12542318:1 gene:F49C5.4 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:12539968-12541558(+) 100.0 100.0
Public Domain and Genome References
Gene Title serine/threonine kinase (KIN1/SNF1/Nim1 subfamily)
Ensembl F49C5.4
Entrez Gene 186015 Entrez gene
SwissProt O17879 EMBL-EBI
WormBase CE37918 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.28387.1.S1_AT similar to F49C5.4 cfa
DROSOPHILA_2:1628886_AT dm
DROSGENOME1:142427_AT dm
DROSOPHILA_2:1623838_S_AT dm
HU35KSUBB:RC_R59487_AT hypothetical protein MGC42105 hs
U133_X3P:HS.25845.0.A1_3P_AT hypothetical protein MGC42105 hs
HG-U133_PLUS_2:230864_AT hypothetical protein MGC42105 hs
HG-U133B:230864_AT hypothetical protein MGC42105 hs
HG-U95C:64170_AT hypothetical protein MGC42105 hs
MOUSE430_2:1434297_AT RIKEN cDNA E130304F04 gene mm
MOE430B:1434297_AT RIKEN cDNA E130304F04 gene mm
MG-U74BV2:116588_AT RIKEN cDNA E130304F04 gene mm
MG-U74CV2:134678_AT RIKEN cDNA E130304F04 gene (E130304F04Rik), mRNA mm
RG-U34C:RC_AI070402_AT similar to hypothetical protein MGC42105 (predicted) rn
RAE230A:1377014_AT similar to hypothetical protein MGC42105 (predicted) rn
RAT230_2:1377014_AT similar to hypothetical protein MGC42105 (predicted) rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB04433 Hypothetical protein F49C5.4 [Caenorhabditis elegans] ref|NP_496679.2| F49C5.4 [Caenorhabditis elegans] 0.0
blast CAE56509 Hypothetical protein CBG24229 [Caenorhabditis briggsae] 0.0
blast CAE56509 Hypothetical protein CBG24229 [Caenorhabditis briggsae] 1.0E-177
blast CAE69923 Hypothetical protein CBG16284 [Caenorhabditis briggsae] 1.0E-171
blast CAE56509 Hypothetical protein CBG24229 [Caenorhabditis briggsae] 1.0E-168
blast CAE69923 Hypothetical protein CBG16284 [Caenorhabditis briggsae] 1.0E-154
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 1.0E-61
hanks 2.2.4 CaMK Group; CaMK II KIN1/SNF1/Nim1; p78 5.0E-75
hanks 2.2.4 CaMK Group; CaMK II KIN1/SNF1/Nim1; p78 2.0E-75
hanks 2.2.4 CaMK Group; CaMK II KIN1/SNF1/Nim1; p78 4.0E-76
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 1.9E-87
Pfam IPR000719 EMBL-EBI Protein kinase 1.9E-87
Pfam IPR000719 EMBL-EBI Protein kinase 1.9E-87
Sequence
Target Sequence 
>C. ELEGANS:193724_AT
gagctctacacatatgtccacgagagggggaagcttaccgaaggagatgcaaaacccttg
ttcgcgcagattgtatcagcggtgtcacatatgcacagtcgcaacattgttcatcgagac
atcaaagccgagaacgtgatgtttagcagtccaaatacagtgaaactagtggattttggc
ttttcatgtcttgtggatcgagagcaaatgcttcgtaccttttgtggaagtccgccatac
gcagctccagagctatttcaagatacatcctacgccggggagctcgtcgacgtatgggct
ctgggggtactcctcttcttcatgctgatcggcgtgacgcccttcaaggcagaaaccgtc
cccgatatgaaagtgctcatcacagctggaaaatatcaaattcccgattatgtcagtctg
ctggccactgaactcatcaaaagcatgctgaaaaccgatactgggcagagagctgatatc
gattctgtgaagaagcatttttggatgagggactgccgatttaccaa

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GAGCTCTACACATATGTCCACGAGA 306 387 406 Antisense
ATGCAAAACCCTTGTTCGCGCAGAT 402 43 452 Antisense
AGCGGTGTCACATATGCACAGTCGC 101 83 483 Antisense
GCACAGTCGCAACATTGTTCATCGA 100 317 498 Antisense
GGATTTTGGCTTTTCATGTCTTGTG 517 509 576 Antisense
GTACCTTTTGTGGAAGTCCGCCATA 158 459 620 Antisense
TTCAAGATACATCCTACGCCGGGGA 582 679 662 Antisense
GTGACGCCCTTCAAGGCAGAAACCG 273 481 739 Antisense
AACCGTCCCCGATATGAAAGTGCTC 433 145 759 Antisense
TTCCCGATTATGTCAGTCTGCTGGC 300 697 806 Antisense
GGATGAGGGACTGCCGATTTACCAA 175 507 908 Antisense
Sequence Source Affymetrix Proprietary Database