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[193713_s_at] Copper type II, ascorbate-dependent monooxygenase

Description H13N06.6 /REP_DB=WormBase Gene ID /WP=CE18816 /TR=Q9XTQ6 /GB=CAB17071.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=Copper type II, ascorbate-dependent monooxygenase
Cluster 6grp_high1_10_10 > 99      4grp_high_8_8 > 27      6grp_total > 99      4grp_total > 37      6grp_cgc > 79      6grp_cgc_sub > Da      6grp_total_sub > Increase      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 108
1 2 3 4 range
A 187.5
(2.5)
P 		194.8
(3)
P 		100.9
(-3)
P 		134.7
(-0.8)
P 		94
B 191.6
(3)
P 		166.1
(1.5)
M 		86.7
(-3)
P 		153
(0.8)
P 		105
C 186.9
(3)
P 		178.1
(2.3)
P 		111.9
(-3)
P 		180.1
(2.5)
P 		75
avr 188.7
(3) 		179.7
(2.4) 		99.8
(-3) 		155.9
(0.8) 		89

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 262
1 2 3 4 5 6 range
A 212.4
(-0.7)
P 		120.4
(-2.9)
P 		122.8
(-2.8)
P 		115.9
(-3)
P 		364.5
(3)
P 		307.5
(1.6)
P 		249
B 132
(-2.5)
P 		129.2
(-2.6)
P 		121.1
(-2.8)
P 		114.7
(-3)
P 		316.6
(3)
P 		264.2
(1.4)
P 		202
C 144.2
(-1.9)
P 		110.2
(-2.8)
P 		105.9
(-2.9)
M 		103
(-3)
A 		330.6
(3)
P 		282.2
(1.7)
P 		228
avr 162.9
(-1.6) 		119.9
(-2.8) 		116.6
(-2.9) 		111.2
(-3) 		337.2
(3) 		284.6
(1.6) 		226
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 49
1 2 3 4 range
A 68.3
(3)
P 		42.3
(-0.2)
P 		26.4
(-2.2)
P 		19.7
(-3)
P 		49
B 61.1
(3)
P 		41
(0.1)
M 		20.1
(-3)
P 		32.6
(-1.2)
P 		41
C 61.9
(3)
P 		51.2
(1)
P 		39
(-1.4)
P 		30.4
(-3)
P 		32
avr 63.8
(3) 		44.8
(-0.1) 		28.5
(-2.9) 		27.6
(-3) 		36

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 108
1 2 3 4 5 6 range
A 39.1
(-2.1)
P 		42.8
(-1.8)
P 		26.8
(-3)
P 		29.4
(-2.8)
P 		110
(3)
P 		74.9
(0.5)
P 		83
B 45.9
(-2)
P 		43
(-2.2)
P 		29.4
(-3)
P 		30.4
(-2.9)
P 		128.6
(3)
P 		98.5
(1.2)
P 		99
C 53.5
(-0.7)
P 		33.6
(-2.1)
P 		26.9
(-2.6)
M 		20.7
(-3)
A 		107
(3)
P 		94.5
(2.1)
P 		86
avr 46.2
(-1.7) 		39.8
(-2.1) 		27.7
(-2.9) 		26.8
(-3) 		115.2
(3) 		89.3
(1.2) 		88
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 193713_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.17360
Sequence Type Exemplar sequence
Representative Public ID H13N06.6 NCBI
Target Description H13N06.6 /REP_DB=WormBase Gene ID /WP=CE18816 /TR=Q9XTQ6 /GB=CAB17071.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=Copper type II, ascorbate-dependent monooxygenase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_078161(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_078161 NCBI Caenorhabditis elegans Tyramine Beta Hydroxylase family member (tbh-1) (tbh-1) mRNA, complete cds. 11/11 None
SNAP00000006580 ENSEMBL cdna:SNAP chromosome:CEL140:X:15500272:15502499:-1 11/11 None
GENEFINDER00000006587 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:15500272:15503301:-1 11/11 None
H13N06.6 ENSEMBL cdna:known chromosome:CEL140:X:15500238:15503301:-1 gene:H13N06.6 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:15500271-15503404(-) 100.0 100.0
Public Domain and Genome References
Gene Title Copper type II, ascorbate-dependent monooxygenase
Gene Symbol tbh-1
Ensembl H13N06.6
Entrez Gene 181639 Entrez gene
SwissProt Q9XTQ6 EMBL-EBI
WormBase CE31553 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFA.15803.1.S1_AT dopamine beta-hydroxylase (dopamine beta-monooxygenase) cfa
CANINE_2:CFAAFFX.30260.1.S1_S_AT dopamine beta-hydroxylase (dopamine beta-monooxygenase) cfa
DROSOPHILA_2:1627317_A_AT Tyramine hydroxylase dm
DROSGENOME1:143596_AT Tyramine hydroxylase dm
CHICKEN:GGA.295.1.S1_AT dopamine beta-hydroxylase (dopamine beta-monooxygenase) gga
CHICKEN:GGAAFFX.1867.1.S1_AT dopamine beta-hydroxylase (dopamine beta-monooxygenase) gga
HG-U133_PLUS_2:234916_AT dopamine beta-hydroxylase (dopamine beta-monooxygenase) hs
HG-U133B:234916_AT dopamine beta-hydroxylase (dopamine beta-monooxygenase) hs
HG-U133_PLUS_2:206450_AT dopamine beta-hydroxylase (dopamine beta-monooxygenase) hs
HG-U133A:206450_AT dopamine beta-hydroxylase (dopamine beta-monooxygenase) hs
HG-FOCUS:206450_AT dopamine beta-hydroxylase (dopamine beta-monooxygenase) hs
HG-U133A_2:206450_AT dopamine beta-hydroxylase (dopamine beta-monooxygenase) hs
HUGENEFL:X13255_AT dopamine beta-hydroxylase (dopamine beta-monooxygenase) hs
U133_X3P:G4503260_3P_AT dopamine beta-hydroxylase (dopamine beta-monooxygenase) hs
U133_X3P:HS.223858.1.A1_3P_AT dopamine beta-hydroxylase (dopamine beta-monooxygenase) hs
HG-U95AV2:32943_AT dopamine beta-hydroxylase (dopamine beta-monooxygenase) hs
MOE430A:1450670_AT dopamine beta hydroxylase mm
MOUSE430A_2:1450670_AT dopamine beta hydroxylase mm
MOUSE430_2:1450670_AT dopamine beta hydroxylase mm
MOE430B:1447592_AT dopamine beta hydroxylase mm
MOUSE430_2:1447592_AT dopamine beta hydroxylase mm
RN-U34:L12407_AT dopamine beta hydroxylase rn
RG-U34A:L12407_AT dopamine beta hydroxylase rn
RAE230A:1370564_AT dopamine beta hydroxylase rn
RAT230_2:1370564_AT dopamine beta hydroxylase rn
RAE230B:1397744_AT Dopamine beta hydroxylase rn
RAT230_2:1397744_AT Dopamine beta hydroxylase rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6584 catecholamine metabolism inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4497 monooxygenase activity inferred from electronic annotation QuickGO AmiGO
4500 dopamine beta-monooxygenase activity inferred from electronic annotation QuickGO AmiGO
5507 copper ion binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB17071 Hypothetical protein H13N06.6 [Caenorhabditis elegans] ref|NP_510562.2| Tyramine Beta Hydroxylase family member (tbh-1) [Caenorhabditis elegans] 0.0
blast CAE63323 Hypothetical protein CBG07714 [Caenorhabditis briggsae] 0.0
blast NP_000778 dopamine beta-hydroxylase precursor [Homo sapiens] emb|CAI13354.1| dopamine beta-hydroxylase (dopamine beta-monooxygenase) [Homo sapiens] gb|AAH17174.1| Dopamine beta-hydroxylase, precursor [Homo sapiens] sp|P09172|DOPO_HUMAN Dopamine beta-hydroxylase precursor (Dopamine beta-monooxygenase) 1.0E-89
Protein Domains
Database ID Description E-Value
Pfam IPR000323 EMBL-EBI Copper type II, ascorbate-dependent monooxygenase 4.5E-78
Pfam IPR005018 EMBL-EBI DOMON domain 2.0E-26
Pfam IPR000323 EMBL-EBI Copper type II, ascorbate-dependent monooxygenase 1.3E-98
Pfam IPR000323 EMBL-EBI Copper type II, ascorbate-dependent monooxygenase 4.5E-78
Pfam IPR000323 EMBL-EBI Copper type II, ascorbate-dependent monooxygenase 1.3E-98
Sequence
Target Sequence 
>C. ELEGANS:193713_S_AT
acattttcgccagtcaactgcacgctcatctaaccggcagaaaactgttcacatctcaat
atcgatctggagttcgcattggagacgtgaaccgagatgaacactactcccctcattggc
agcatctgcaacagcttcgaccagtggttaaggttatgccaggagacacactggtcacca
catgcgtctacgataccagaaaacgatcaaaagtgacgtttggtggatatcgaattgtgg
atgagatgtgcgtcaactatatttattactacccagcttctgatgtagaagtttgcaaat
cagcaatttctaatagtacgttgagagcctacttctcagaacgacatggtatggatggaa
agagaatgcaaatttcggatatgtacagcaacgtcaaggactggggaaatggagttgatg
aggagttttacaatgtgttgaatgttggaaacatgaacatgaactgcttgaaatccaacg
gggagccattcgaatttgaatcaaaagattcccgccagagctgggaaaacatggcaagac
caacatttgtctccggatcattcatcacaaccag

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
ACATTTTCGCCAGTCAACTGCACGC 588 105 1292 Antisense
CTGCACGCTCATCTAACCGGCAGAA 55 237 1309 Antisense
GAACCGAGATGAACACTACTCCCCT 30 347 1380 Antisense
TCCCCTCATTGGCAGCATCTGCAAC 225 597 1399 Antisense
CATCTGCAACAGCTTCGACCAGTGG 592 209 1414 Antisense
CAGGAGACACACTGGTCACCACATG 514 207 1451 Antisense
TCACCACATGCGTCTACGATACCAG 499 625 1466 Antisense
ATATTTATTACTACCCAGCTTCTGA 594 19 1550 Antisense
GAGAGCCTACTTCTCAGAACGACAT 244 393 1614 Antisense
ATCAAAAGATTCCCGCCAGAGCTGG 267 27 1791 Antisense
TCTCCGGATCATTCATCACAACCAG 368 609 1841 Antisense
Sequence Source Affymetrix Proprietary Database