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[193711_s_at] Amiloride-sensitive sodium channel

Description C41C4.5 /REP_DB=WormBase Gene ID /WP=CE23585 /GEN=unc-105 /TR=SW:Q09274 /GB=CAA88101.2 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=Amiloride-sensitive sodium channel
Cluster 6grp_total > 11      4grp_total > 44      6grp_cgc > 62      6grp_cgc_sub > 02      6grp_total_sub > Hat      6grp_rule_based > S2      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 128
1 2 3 4 range
A 335.4
(1.8)
A 		356.3
(3)
A 		249.8
(-3)
A 		291.3
(-0.7)
A 		107
B 268.9
(-0.9)
A 		346.4
(3)
A 		228.4
(-3)
A 		239.3
(-2.4)
A 		118
C 311.5
(-1.9)
A 		349
(3)
A 		302.9
(-3)
A 		320.3
(-0.7)
P 		46
avr 305.3
(-0) 		350.6
(3) 		260.4
(-3) 		283.6
(-1.5) 		90

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 281
1 2 3 4 5 6 range
A 255.4
(0)
A 		394.6
(3)
A 		236.3
(-0.4)
A 		290.4
(0.8)
A 		239.2
(-0.3)
A 		113.3
(-3)
A 		281
B 250.2
(-1.4)
A 		391.1
(3)
A 		263.2
(-1)
A 		223.7
(-2.2)
A 		245.8
(-1.5)
A 		197.2
(-3)
A 		194
C 267.5
(-1.1)
A 		363.6
(2.5)
A 		376.7
(3)
A 		256
(-1.6)
A 		255.7
(-1.6)
A 		218
(-3)
A 		159
avr 257.7
(-0.6) 		383.1
(3) 		292.1
(0.4) 		256.7
(-0.7) 		246.9
(-0.9) 		176.2
(-3) 		207
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 80
1 2 3 4 range
A 122.1
(3)
A 		77.3
(-0.4)
A 		65.3
(-1.3)
A 		42.6
(-3)
A 		80
B 85.8
(3)
A 		85.5
(2.9)
A 		52.9
(-2.7)
A 		51
(-3)
A 		35
C 103.1
(2.7)
A 		100.3
(2.4)
A 		105.6
(3)
A 		54
(-3)
P 		52
avr 103.7
(3) 		87.7
(1.2) 		74.6
(-0.2) 		49.2
(-3) 		55

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 113
1 2 3 4 5 6 range
A 47.1
(-2)
A 		140.3
(3)
A 		51.5
(-1.7)
A 		73.7
(-0.5)
A 		72.2
(-0.6)
A 		27.6
(-3)
A 		113
B 87.1
(-0.6)
A 		130.2
(3)
A 		63.9
(-2.6)
A 		59.2
(-3)
A 		99.9
(0.4)
A 		73.5
(-1.8)
A 		71
C 99.1
(1.8)
A 		110.9
(3)
A 		95.9
(1.5)
A 		51.5
(-3)
A 		82.7
(0.2)
A 		73
(-0.8)
A 		59
avr 77.8
(-1.3) 		127.1
(3) 		70.4
(-1.9) 		61.5
(-2.7) 		84.9
(-0.7) 		58
(-3) 		69
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 193711_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.3763
Sequence Type Exemplar sequence
Representative Public ID C41C4.5 NCBI
Target Description C41C4.5 /REP_DB=WormBase Gene ID /WP=CE23585 /GEN=unc-105 /TR=SW:Q09274 /GB=CAA88101.2 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=Amiloride-sensitive sodium channel
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_063301(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_063301 NCBI Caenorhabditis elegans UNCoordinated family member (unc-105) (unc-105) mRNA, complete cds. 11/11 None
SNAP00000036859 ENSEMBL cdna:SNAP chromosome:CEL140:II:8118353:8122631:1 11/11 None
GENEFINDER00000036866 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:8118353:8122631:1 11/11 None
C41C4.5.1 ENSEMBL cdna:known chromosome:CEL140:II:8117117:8122619:1 gene:C41C4.5 11/11 None
C41C4.5.2 ENSEMBL cdna:known chromosome:CEL140:II:8117188:8122782:1 gene:C41C4.5 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:8117184-8122264(+) 100.0 100.0
Public Domain and Genome References
Gene Title Amiloride-sensitive sodium channel
Gene Symbol unc-105
Ensembl C41C4.5
Entrez Gene 174306 Entrez gene
SwissProt Q09274 EMBL-EBI
WormBase CE23585 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6811 ion transport inferred from electronic annotation QuickGO AmiGO
6814 sodium ion transport inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
16021 integral to membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
5216 ion channel activity inferred from electronic annotation QuickGO AmiGO
5272 sodium channel activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA88101 Hypothetical protein C41C4.5 [Caenorhabditis elegans] ref|NP_495702.1| UNCoordinated family member (unc-105) [Caenorhabditis elegans] sp|Q09274|DEGX_CAEEL Degenerin-like protein C41C4.5 in chromosome II 0.0
blast H88226 protein C41C4.5 [imported] - Caenorhabditis elegans 0.0
blast CAE57739 Hypothetical protein CBG00750 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR001873 EMBL-EBI Na+ channel, amiloride-sensitive 1.0E-126
Pfam IPR001873 EMBL-EBI Na+ channel, amiloride-sensitive 1.0E-126
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_495702.1 2 55-77,659-681
C41C4.5.1 2 55-77,659-681
C41C4.5.2 2 55-77,659-681
SNAP00000036859 2 93-115,697-719
GENEFINDER00000036866 2 93-115,697-719
Sequence
Target Sequence 
>C. ELEGANS:193711_S_AT
ctctcacatcagttctcgctgatcttggtggtctcacaggtttatggatcggtgcatcag
ttgtatcacttcttgaaattgtaactttaatcgtatttgcaacacaagcttatgtcagaa
aacggaaaggctcgatttcggcccaatcacatcattcagtacccgtccatagagcttcca
gggtttcattgaatactcttcacaaaagcagtacaactcaaagtgtcaaattatctgtga
tggatattcgatcaattaagtcgatccattcgaatcattcgtcgaaaagcaaacagtcga
ttctcattgaggatcttccgccagcaattcaggagcaaagtgacgatgaagaagaaacaa
cagaatcttcaagaacaaatggttcatgtcgatatctggcgcctggagaagatcttccgt
gtctttgcaagtatcatccagatggttcaatacgaattatgaaagcattatgtcccgtac
atggctatatggttcgtcgaaactatgactacagcgtgtcgaatagtgaagaagaagacg
cagaagacgaagttcatcgagagccggagccat

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
CTCTCACATCAGTTCTCGCTGATCT 232 231 1955 Antisense
TCGCTGATCTTGGTGGTCTCACAGG 331 599 1970 Antisense
GCATCAGTTGTATCACTTCTTGAAA 196 309 2008 Antisense
GTCCATAGAGCTTCCAGGGTTTCAT 152 477 2119 Antisense
GATTCTCATTGAGGATCTTCCGCCA 589 431 2253 Antisense
GATCTTCCGCCAGCAATTCAGGAGC 207 419 2266 Antisense
TGGTTCATGTCGATATCTGGCGCCT 125 551 2334 Antisense
CTGGCGCCTGGAGAAGATCTTCCGT 191 241 2350 Antisense
GATCTTCCGTGTCTTTGCAAGTATC 638 419 2365 Antisense
AAGCATTATGTCCCGTACATGGCTA 166 149 2417 Antisense
GAAGTTCATCGAGAGCCGGAGCCAT 496 337 2503 Antisense
Sequence Source Affymetrix Proprietary Database