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[193664_s_at] DNA replication licensing factor MCM3

Description C25D7.6 /REP_DB=WormBase Gene ID /WP=CE08392 /GEN=mcm-3 /TR=Q9XVR7 /GB=CAB02770.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=DNA replication licensing factor MCM3
Cluster 6grp_highest_10_10 > 97      6grp_high1_10_10 > 79      6grp_highest_nonorm > 94      6grp_total > 69      4grp_total > 60      6grp_highest_sub > Cu      6grp_cgc > 39      6grp_high1_sub > Cu      6grp_cgc_sub > Cu      6grp_total_sub > Cup      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 292
1 2 3 4 range
A 424.7
(2.8)
P 		277.9
(-1)
P 		432.5
(3)
P 		201.5
(-3)
A 		231
B 287.5
(0.1)
P 		337.8
(1.4)
P 		395.9
(3)
P 		171.6
(-3)
A 		224
C 428.2
(2.2)
P 		393.5
(1.4)
P 		463.4
(3)
P 		199.4
(-3)
A 		264
avr 380.1
(1.7) 		336.4
(0.6) 		430.6
(3) 		190.8
(-3) 		240

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 994
1 2 3 4 5 6 range
A 340.3
(-1.8)
P 		357.3
(-1.6)
P 		209
(-3)
P 		318.8
(-2)
P 		659.5
(1.3)
P 		843.2
(3)
P 		634
B 563
(-1)
P 		361.9
(-2.3)
P 		260.6
(-3)
P 		319.4
(-2.6)
P 		622.3
(-0.6)
P 		1163.7
(3)
P 		903
C 554.6
(-1.1)
P 		359
(-2.3)
P 		247.3
(-3)
P 		317.2
(-2.6)
P 		674
(-0.3)
P 		1203.4
(3)
P 		956
avr 486
(-1.2) 		359.4
(-2.1) 		239
(-3) 		318.5
(-2.4) 		651.9
(-0) 		1070.1
(3) 		831
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 132
1 2 3 4 range
A 154.6
(3)
P 		60.3
(-1.5)
P 		113.1
(1)
P 		29.5
(-3)
A 		125
B 91.7
(3)
P 		83.4
(2.1)
P 		91.7
(3)
P 		36.6
(-3)
A 		55
C 141.7
(2.1)
P 		113.1
(0.7)
P 		161.5
(3)
P 		33.6
(-3)
A 		128
avr 129.3
(3) 		85.6
(0.3) 		122.1
(2.6) 		33.2
(-3) 		96

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 388
1 2 3 4 5 6 range
A 62.7
(-2.4)
P 		127.1
(0.1)
P 		45.5
(-3)
P 		80.8
(-1.7)
P 		199
(2.8)
P 		205.3
(3)
P 		160
B 195.9
(-0.9)
P 		120.5
(-2.1)
P 		63.3
(-3)
P 		84.6
(-2.7)
P 		252.8
(0.1)
P 		433.9
(3)
P 		371
C 205.6
(-0.5)
P 		109.5
(-2.2)
P 		62.9
(-3)
P 		63.8
(-3)
P 		218.1
(-0.3)
P 		402.8
(3)
P 		340
avr 154.7
(-1) 		119
(-1.7) 		57.2
(-3) 		76.4
(-2.6) 		223.3
(0.4) 		347.3
(3) 		290
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 193664_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.14079
Sequence Type Exemplar sequence
Representative Public ID C25D7.6 NCBI
Target Description C25D7.6 /REP_DB=WormBase Gene ID /WP=CE08392 /GEN=mcm-3 /TR=Q9XVR7 /GB=CAB02770.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=DNA replication licensing factor MCM3
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_074305(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_074305 NCBI Caenorhabditis elegans yeast MCM (licensing factor) related family member (mcm-3) (mcm-3) mRNA, complete cds. 11/11 None
SNAP00000019710 ENSEMBL cdna:SNAP chromosome:CEL140:V:15059546:15062180:-1 11/11 None
GENEFINDER00000019719 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:15059546:15062180:-1 11/11 None
C25D7.6.2 ENSEMBL cdna:known chromosome:CEL140:V:15059306:15062187:-1 gene:C25D7.6 11/11 None
C25D7.6.1 ENSEMBL cdna:known chromosome:CEL140:V:15059306:15062314:-1 gene:C25D7.6 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:15059545-15062180(-) 100.0 100.0
Public Domain and Genome References
Gene Title DNA replication licensing factor MCM3
Gene Symbol mcm-3
Ensembl C25D7.6
Entrez Gene 180010 Entrez gene
SwissProt Q9XVR7 EMBL-EBI
WormBase CE08392 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:16823_AT DNA replication licensing factor, putative at
ATH1-121501:248891_AT DNA replication licensing factor, putative at
CANINE_2:CFAAFFX.4185.1.S1_AT similar to DNA replication licensing factor MCM3 (DNA polymerase alpha holoenzyme-associated protein P1) (RLF beta subunit) (P102 protein) (P1-MCM3) cfa
CANINE_2:CFAAFFX.4188.1.S1_AT similar to DNA replication licensing factor MCM3 (DNA polymerase alpha holoenzyme-associated protein P1) (RLF beta subunit) (P102 protein) (P1-MCM3) cfa
CANINE_2:CFAAFFX.4188.1.S1_S_AT similar to DNA replication licensing factor MCM3 (DNA polymerase alpha holoenzyme-associated protein P1) (RLF beta subunit) (P102 protein) (P1-MCM3) cfa
CANINE_2:CFAAFFX.4190.1.S1_AT similar to DNA replication licensing factor MCM3 (DNA polymerase alpha holoenzyme-associated protein P1) (RLF beta subunit) (P102 protein) (P1-MCM3) cfa
DROSOPHILA_2:1635234_AT Minichromosome maintenance 3 dm
DROSGENOME1:153592_AT Minichromosome maintenance 3 dm
CHICKEN:GGAAFFX.11455.1.S1_S_AT MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) gga
HG-U133_PLUS_2:201555_AT MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) hs
HG-U133A:201555_AT MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) hs
HG-FOCUS:201555_AT MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) hs
HG-U133A_2:201555_AT MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) hs
HUGENEFL:X62153_S_AT MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) hs
HUGENEFL:D38073_AT MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) hs
U133_X3P:G6631094_3P_X_AT MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) hs
U133_X3P:G6631094_3P_AT MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) hs
U133_X3P:201555_3P_AT MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) hs
HG-U95AV2:33252_AT MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) hs
MOUSE430_2:1426652_AT minichromosome maintenance deficient 3 (S. cerevisiae) mm
MOUSE430A_2:1426652_AT minichromosome maintenance deficient 3 (S. cerevisiae) mm
MOE430A:1426652_AT minichromosome maintenance deficient 3 (S. cerevisiae) mm
MOUSE430A_2:1426653_AT minichromosome maintenance deficient 3 (S. cerevisiae) mm
MOUSE430_2:1426653_AT minichromosome maintenance deficient 3 (S. cerevisiae) mm
MOE430A:1426653_AT minichromosome maintenance deficient 3 (S. cerevisiae) mm
MOE430A:1420028_S_AT minichromosome maintenance deficient 3 (S. cerevisiae) mm
MOUSE430A_2:1420028_S_AT minichromosome maintenance deficient 3 (S. cerevisiae) mm
MOUSE430_2:1420028_S_AT minichromosome maintenance deficient 3 (S. cerevisiae) mm
MU11KSUBB:MSA.42771.0_S_AT minichromosome maintenance deficient 3 (S. cerevisiae) mm
MU11KSUBB:X62154_S_AT minichromosome maintenance deficient 3 (S. cerevisiae) mm
MG-U74AV2:100062_AT minichromosome maintenance deficient 3 (S. cerevisiae) mm
MG-U74AV2:160496_S_AT minichromosome maintenance deficient 3 (S. cerevisiae) mm
MOE430A:1420029_AT Minichromosome maintenance deficient 3 (S. cerevisiae), mRNA (cDNA clone MGC:30531 IMAGE:5007886) mm
MOUSE430A_2:1420029_AT Minichromosome maintenance deficient 3 (S. cerevisiae), mRNA (cDNA clone MGC:30531 IMAGE:5007886) mm
MOUSE430_2:1420029_AT Minichromosome maintenance deficient 3 (S. cerevisiae), mRNA (cDNA clone MGC:30531 IMAGE:5007886) mm
MU19KSUBB:TC33816_AT Minichromosome maintenance deficient 3 (S. cerevisiae), mRNA (cDNA clone MGC:30531 IMAGE:5007886) mm
RG-U34C:RC_AI178684_AT minichromosome maintenance deficient 3 (S. cerevisiae) (predicted) rn
RAE230A:1372406_AT minichromosome maintenance deficient 3 (S. cerevisiae) (predicted) rn
RAT230_2:1372406_AT minichromosome maintenance deficient 3 (S. cerevisiae) (predicted) rn
YEAST_2:1775015_AT Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6270 DNA replication initiation inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5634 nucleus inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
166 nucleotide binding inferred from electronic annotation QuickGO AmiGO
3677 DNA binding inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
8094 DNA-dependent ATPase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB02770 Hypothetical protein C25D7.6 [Caenorhabditis elegans] ref|NP_506706.1| yeast MCM (licensing factor) related family member (mcm-3) [Caenorhabditis elegans] 0.0
blast CAE66328 Hypothetical protein CBG11579 [Caenorhabditis briggsae] 0.0
blast CAI11688 MCM3 minichromosome maintenance deficient 3 (S. cerevisiae), like [Danio rerio] ref|XP_702523.1| PREDICTED: hypothetical protein XP_697431 [Danio rerio] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR001208 EMBL-EBI MCM 1.0E-126
Sequence
Target Sequence 
>C. ELEGANS:193664_S_AT
aagaacgaacaatgcctgtcaccgctcgtcaactcgaaacattgattcgtttgtcaactg
ctatcgcgaaggcaagattctcgaaaaaagtcgaacgagaggatactgagaaagcttaca
atctgctccactttgcctgtttcaaggagaagccaaaggctcgtcaagagtatgagaaga
agaagcgagctccacgaattgatggtgacgatgatgaggatcagagcgataacgaggaca
tggcaacatcggaagagcctcaatctagctccgttccgactgcagccaccccgcgtcgtg
gagtcagaaggcgtgctgaagatgatgatagccaggattctatgatggatactaccattg
gagaaagtcagccaactgctaagaaagcacgtactggaccggctgccatcggagttgatc
gttataaggagcttcggaagtacgtcagaaaggcgttcgacgacattggaagcacc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AAGAACGAACAATGCCTGTCACCGC 100 153 1823 Antisense
CACCGCTCGTCAACTCGAAACATTG 656 199 1842 Antisense
GATTCGTTTGTCAACTGCTATCGCG 265 433 1866 Antisense
GAAAGCTTACAATCTGCTCCACTTT 702 359 1932 Antisense
GAAGCGAGCTCCACGAATTGATGGT 500 343 2004 Antisense
GAGCGATAACGAGGACATGGCAACA 108 387 2046 Antisense
GAAGAGCCTCAATCTAGCTCCGTTC 557 337 2074 Antisense
AGAAAGCACGTACTGGACCGGCTGC 233 71 2204 Antisense
CTGCCATCGGAGTTGATCGTTATAA 606 235 2225 Antisense
GGAGCTTCGGAAGTACGTCAGAAAG 488 519 2250 Antisense
GGCGTTCGACGACATTGGAAGCACC 16 539 2274 Antisense
Sequence Source Affymetrix Proprietary Database