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[193662_at] Helix-loop-helix DNA-binding domain

Description T19B10.11 /REP_DB=WormBase Gene ID /WP=CE16417 /GEN=mxl-1 /TR=P90982 /GB=CAA98543.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=Helix-loop-helix DNA-binding domain
Cluster 6grp_highest_10_10 > 77      6grp_high1_10_10 > 86      4grp_highest_8_8 > 31      4grp_high_8_8 > 13      6grp_highest_nonorm > 84      6grp_total > 77      4grp_total > 11      6grp_highest_sub > Da      6grp_cgc > 48      6grp_high1_sub > In      6grp_cgc_sub > Da      6grp_total_sub > Increase      4grp_rule_based > L4      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 661
1 2 3 4 range
A 411.2
(-2.2)
P 		398.6
(-2.4)
P 		344.2
(-3)
P 		880
(3)
P 		536
B 421.8
(-2.9)
P 		413.8
(-3)
P 		437.6
(-2.8)
P 		1004.7
(3)
P 		591
C 558.9
(-0.7)
P 		512.3
(-1.3)
P 		368.6
(-3)
P 		874
(3)
P 		505
avr 464
(-2.1) 		441.6
(-2.3) 		383.5
(-3) 		919.6
(3) 		536

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 469
1 2 3 4 5 6 range
A 495.5
(-3)
P 		560.9
(-1.5)
P 		634.3
(0.3)
P 		531.9
(-2.1)
P 		513.1
(-2.6)
P 		749.7
(3)
P 		254
B 538
(-0.7)
P 		406.3
(-3)
P 		631.1
(0.9)
P 		475.9
(-1.8)
P 		584.3
(0.1)
P 		756.1
(3)
P 		350
C 554.1
(-1.3)
P 		427.6
(-3)
P 		429.9
(-3)
P 		580.1
(-1)
P 		583.4
(-0.9)
P 		875.5
(3)
P 		448
avr 529.2
(-1.8) 		464.9
(-3) 		565.1
(-1.2) 		529.3
(-1.8) 		560.3
(-1.3) 		793.8
(3) 		329
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 128
1 2 3 4 range
A 149.7
(3)
P 		86.5
(-3)
P 		90
(-2.7)
P 		128.8
(1)
P 		63
B 134.5
(-1.2)
P 		102.2
(-3)
P 		101.4
(-3)
P 		214.1
(3)
P 		113
C 185
(3)
P 		147.3
(-1)
P 		128.5
(-3)
P 		147.4
(-1)
P 		57
avr 156.4
(2.3) 		112
(-2.4) 		106.6
(-3) 		163.4
(3) 		57

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 202
1 2 3 4 5 6 range
A 91.3
(-3)
P 		199.5
(3)
P 		138.1
(-0.4)
P 		134.9
(-0.6)
P 		154.8
(0.5)
P 		182.5
(2.1)
P 		108
B 187.2
(-0.6)
P 		135.2
(-2.6)
P 		153.3
(-1.9)
P 		126
(-3)
P 		237.4
(1.3)
P 		281.9
(3)
P 		156
C 205.4
(0.1)
P 		130.5
(-2.3)
P 		109.4
(-3)
P 		116.7
(-2.8)
P 		188.8
(-0.4)
P 		293.1
(3)
P 		184
avr 161.3
(-1.3) 		155.1
(-1.6) 		133.6
(-2.6) 		125.9
(-3) 		193.7
(0.2) 		252.5
(3) 		127
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193662_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.13687
Sequence Type Exemplar sequence
Representative Public ID T19B10.11 NCBI
Target Description T19B10.11 /REP_DB=WormBase Gene ID /WP=CE16417 /GEN=mxl-1 /TR=P90982 /GB=CAA98543.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=Helix-loop-helix DNA-binding domain
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_073455(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_073455 NCBI Caenorhabditis elegans MaX-Like family member (mxl-1) (mxl-1) mRNA, complete cds. 11/11 None
SNAP00000024750 ENSEMBL cdna:SNAP chromosome:CEL140:V:11247427:11247753:1 10/11 None
GENEFINDER00000024753 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:11247409:11248431:1 11/11 None
T19B10.11 ENSEMBL cdna:known chromosome:CEL140:V:11247427:11248486:1 gene:T19B10.11 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:11247426-11248431(+) 100.0 100.0
Public Domain and Genome References
Gene Title Helix-loop-helix DNA-binding domain
Gene Symbol mxl-1
Ensembl T19B10.11
Entrez Gene 179557 Entrez gene
SwissProt P90982 EMBL-EBI
WormBase CE16417 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6355 regulation of transcription, DNA-dependent inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5634 nucleus inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
3700 transcription factor activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA98543 Hypothetical protein T19B10.11 [Caenorhabditis elegans] ref|NP_505856.1| MaX-Like family member (mxl-1) [Caenorhabditis elegans] gb|AAB40926.1| MAX-like-1 homolog [Caenorhabditis elegans] 5.0E-64
blast CAA98543 Hypothetical protein T19B10.11 [Caenorhabditis elegans] ref|NP_505856.1| MaX-Like family member (mxl-1) [Caenorhabditis elegans] gb|AAB40926.1| MAX-like-1 homolog [Caenorhabditis elegans] 8.0E-55
blast CAE75200 Hypothetical protein CBG23147 [Caenorhabditis briggsae] 2.0E-43
blast CAE75200 Hypothetical protein CBG23147 [Caenorhabditis briggsae] 2.0E-39
blast AAH70710 XMax2 protein [Xenopus laevis] pir||I51586 Myc binding protein - African clawed frog gb|AAA17424.1| XMax2 2.0E-12
Protein Domains
Database ID Description E-Value
Pfam IPR001092 EMBL-EBI Basic helix-loop-helix dimerization domain bHLH 7.3E-15
Pfam IPR001092 EMBL-EBI Basic helix-loop-helix dimerization domain bHLH 7.3E-15
Sequence
Target Sequence 
>C. ELEGANS:193662_AT
gagtgacctcgaagatgaccagacaggtcactgtggttccggagaacacagcgggccgtt
tgatccgaagcggcatgctcgagaacagcacaacgctcttgaacgacgaagacgtgataa
tatcaaggatatgtacacaagtctgagagaagtagtccctgatgccaacggggaaagggt
tcaagcatcgagagctgtcattctgaaaaaagcaattgagtcgatcgaaaaaggccaatc
cgatagtgcaacgttgtcagttgatgttgccgaacaagaatcaaaaaatgcaaaactcag
agaagagatagctcgcctgaaagccaaga

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GAGTGACCTCGAAGATGACCAGACA 269 401 24 Antisense
GACCAGACAGGTCACTGTGGTTCCG 459 381 40 Antisense
AGAACACAGCGGGCCGTTTGATCCG 149 73 66 Antisense
GATCCGAAGCGGCATGCTCGAGAAC 550 415 85 Antisense
ACAGCACAACGCTCTTGAACGACGA 347 109 108 Antisense
GAGAGAAGTAGTCCCTGATGCCAAC 539 393 168 Antisense
GGGAAAGGGTTCAAGCATCGAGAGC 271 493 194 Antisense
GCATCGAGAGCTGTCATTCTGAAAA 372 309 208 Antisense
AAGGCCAATCCGATAGTGCAACGTT 663 161 254 Antisense
ACGTTGTCAGTTGATGTTGCCGAAC 380 93 274 Antisense
GAGATAGCTCGCCTGAAAGCCAAGA 200 397 328 Antisense
Sequence Source Affymetrix Proprietary Database