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[193649_s_at] phenylalanine-4-hydroxylase (PH4H)

Description K08F8.4 /REP_DB=WormBase Gene ID /WP=CE21050 /GEN=bas-2 /TR=SW:P90925 /GB=CAA91286.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=phenylalanine-4-hydroxylase (PH4H)
Cluster 6grp_highest_10_10 > 26      6grp_high1_10_10 > 51      4grp_highest_8_8 > 54      4grp_high_8_8 > 18      6grp_highest_nonorm > 34      6grp_total > 51      4grp_total > 22      6grp_highest_sub > 03      6grp_cgc > 83      6grp_high1_sub > 03      6grp_cgc_sub > 03      6grp_total_sub > Hat      6grp_rule_based > S3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 821
1 2 3 4 range
A 3084.8
(0.7)
P 		3232.3
(3)
P 		2854.4
(-3)
P 		2975.1
(-1.1)
P 		378
B 3318.1
(3)
P 		2909.9
(-3)
P 		2986.6
(-1.9)
P 		3194.9
(1.2)
P 		408
C 3363
(2.6)
P 		2665.5
(-2.5)
P 		2598.6
(-3)
P 		3420
(3)
P 		821
avr 3255.3
(3) 		2935.9
(-1.3) 		2813.2
(-3) 		3196.7
(2.2) 		442

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 3221
1 2 3 4 5 6 range
A 2368.8
(-0.5)
P 		3102.2
(1)
P 		4087.8
(3)
P 		3440.1
(1.7)
P 		1969.2
(-1.3)
P 		1127
(-3)
P 		2961
B 1603.1
(-2.1)
P 		2930.5
(0.7)
P 		4035.4
(3)
P 		3442.8
(1.8)
P 		1929.9
(-1.4)
P 		1155
(-3)
P 		2880
C 1813.3
(-1.9)
P 		2893.5
(0.2)
P 		4348.4
(3)
P 		3487.9
(1.3)
P 		1811.7
(-1.9)
P 		1236.5
(-3)
P 		3112
avr 1928.4
(-1.5) 		2975.4
(0.6) 		4157.2
(3) 		3456.9
(1.6) 		1903.6
(-1.5) 		1172.8
(-3) 		2984
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 688
1 2 3 4 range
A 1123.2
(3)
P 		701.6
(-0.7)
P 		746.2
(-0.3)
P 		435.5
(-3)
P 		688
B 1058.1
(3)
P 		718.7
(-2.4)
P 		692.1
(-2.8)
P 		680.8
(-3)
P 		377
C 1113.2
(3)
P 		766.4
(-0.9)
P 		905.7
(0.7)
P 		576.7
(-3)
P 		537
avr 1098.2
(3) 		728.9
(-1.2) 		781.3
(-0.6) 		564.3
(-3) 		534

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 832
1 2 3 4 5 6 range
A 436.7
(-1.8)
P 		1103.3
(3)
P 		890.2
(1.5)
P 		872.5
(1.3)
P 		594.2
(-0.7)
P 		274.4
(-3)
P 		829
B 557.8
(-1.6)
P 		975.5
(3)
P 		979.9
(3)
P 		911.9
(2.3)
P 		784.1
(0.9)
P 		430.7
(-3)
P 		549
C 672.1
(-0.8)
P 		882.9
(1.1)
P 		1106.7
(3)
P 		701.4
(-0.5)
P 		586.2
(-1.5)
P 		413.9
(-3)
P 		693
avr 555.5
(-1.2) 		987.2
(3) 		992.3
(3) 		828.6
(1.4) 		654.8
(-0.3) 		373
(-3) 		619
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 193649_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.2939
Sequence Type Exemplar sequence
Representative Public ID K08F8.4 NCBI
Target Description K08F8.4 /REP_DB=WormBase Gene ID /WP=CE21050 /GEN=bas-2 /TR=SW:P90925 /GB=CAA91286.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=phenylalanine-4-hydroxylase (PH4H)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_063462(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_063462 NCBI Caenorhabditis elegans PhenylAlanine Hydroxylase family member (pah-1) (pah-1) mRNA, complete cds. 11/11 None
SNAP00000029908 ENSEMBL cdna:SNAP chromosome:CEL140:II:8762635:8764357:-1 11/11 None
GENEFINDER00000029913 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:8760429:8764989:-1 11/11 None
K08F8.4 ENSEMBL cdna:known chromosome:CEL140:II:8762589:8765129:-1 gene:K08F8.4 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:8762631-8764986(-) 100.0 100.0
Public Domain and Genome References
Gene Title phenylalanine-4-hydroxylase (PH4H)
Gene Symbol pah-1
Ensembl K08F8.4
Entrez Gene 174401 Entrez gene
SwissProt P90925 EMBL-EBI
WormBase CE21050 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.11839.1.S1_AT phenylalanine hydroxylase cfa
DROSOPHILA_2:1638325_AT Henna dm
DROSGENOME1:153434_AT Henna dm
CHICKEN:GGA.12887.1.S1_AT phenylalanine hydroxylase gga
CHICKEN:GGAAFFX.23989.1.S1_S_AT phenylalanine hydroxylase gga
HG-U95AV2:33701_AT phenylalanine hydroxylase hs
HG-U133_PLUS_2:244742_AT phenylalanine hydroxylase hs
HG-U133B:244742_AT phenylalanine hydroxylase hs
HG-U133_PLUS_2:217583_AT phenylalanine hydroxylase hs
HG-U133A_2:217583_AT phenylalanine hydroxylase hs
HG-U133A:217583_AT phenylalanine hydroxylase hs
HU35KSUBD:RC_H72623_AT phenylalanine hydroxylase hs
HUGENEFL:L47726_AT phenylalanine hydroxylase hs
HG-U133A:205719_S_AT phenylalanine hydroxylase hs
HG-U133_PLUS_2:205719_S_AT phenylalanine hydroxylase hs
HG-FOCUS:205719_S_AT phenylalanine hydroxylase hs
HG-U133A_2:205719_S_AT phenylalanine hydroxylase hs
U133_X3P:G4557818_3P_S_AT phenylalanine hydroxylase hs
U133_X3P:HS.325404.0.S1_3P_AT phenylalanine hydroxylase hs
U133_X3P:HS.297257.0.A1_3P_AT phenylalanine hydroxylase hs
HG-U95B:42519_AT phenylalanine hydroxylase hs
HG-U95B:58795_AT phenylalanine hydroxylase hs
HG-U95E:70236_R_AT Phenylalanine hydroxylase hs
MU11KSUBB:X51942_S_AT phenylalanine hydroxylase mm
MG-U74AV2:95407_AT phenylalanine hydroxylase mm
MOE430A:1454638_A_AT phenylalanine hydroxylase mm
MOUSE430A_2:1454638_A_AT phenylalanine hydroxylase mm
MOUSE430_2:1454638_A_AT phenylalanine hydroxylase mm
MU19KSUBA:TC15475_AT Phenylalanine hydroxylase, mRNA (cDNA clone MGC:18609 IMAGE:4223155) mm
MU19KSUBA:TC25187_S_AT Phenylalanine hydroxylase, mRNA (cDNA clone MGC:18609 IMAGE:4223155) mm
MU19KSUBB:TC32044_AT Phenylalanine hydroxylase, mRNA (cDNA clone MGC:18609 IMAGE:4223155) mm
RG-U34A:M12337_AT phenylalanine hydroxylase rn
RAE230A:1387034_AT phenylalanine hydroxylase rn
RAT230_2:1387034_AT phenylalanine hydroxylase rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6559 L-phenylalanine catabolism inferred from electronic annotation QuickGO AmiGO
8152 metabolism inferred from electronic annotation QuickGO AmiGO
9072 aromatic amino acid family metabolism inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4497 monooxygenase activity inferred from electronic annotation QuickGO AmiGO
4505 phenylalanine 4-monooxygenase activity inferred from electronic annotation QuickGO AmiGO
5506 iron ion binding inferred from electronic annotation QuickGO AmiGO
16597 amino acid binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA91286 Hypothetical protein K08F8.4 [Caenorhabditis elegans] ref|NP_495863.1| PhenylAlanine Hydroxylase family member (pah-1) [Caenorhabditis elegans] sp|P90925|PH4H_CAEEL Probable phenylalanine-4-hydroxylase (PAH) (Phe-4-monooxygenase) (Biogenic amine synthesis protein 2) 0.0
blast CAE59730 Hypothetical protein CBG03166 [Caenorhabditis briggsae] 0.0
blast AAD31643 phenylalanine hydroxylase; phenylalanine-4-hydroxylase; phe-4-monooxygenase; PAH; PheH [Caenorhabditis elegans] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR001273 EMBL-EBI Aromatic amino acid hydroxylase 1.0E-126
Pfam IPR002912 EMBL-EBI Amino acid-binding ACT 7.7E-11
Pfam IPR001273 EMBL-EBI Aromatic amino acid hydroxylase 1.0E-126
Sequence
Target Sequence 
>C. ELEGANS:193649_S_AT
tcattccacacaatacattcgccatcattccgctccaaaatacacacctgaaccagatat
ctgccacgagcttctgggacatgttccactatttgctgatgttgaatttgcacaattctc
acaggaaatcggtcttgcttctcttggagctccagatgatgttattgaaaaacttgccac
actctactggttcacaatcgaatttggaatctgtcaacaagatggggagaaaaaagctta
cggagccggacttttgagttcatttggagagcttcaatatgcgttgagtgataagccgga
agttgtagattttgatccagctgtatgttgtgtcaccaaatatccaatcacagaatatca
gccaaagtatttcttagctgaatcatttgcaagtgctaagaacaaacttaaatcatgggc
agctaccatcaatcgtccattccaaattcgttataatgcttacactcaacgagttgaaat
tctcgacaaggtagcagcacttcaacgtctc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TCATTCCACACAATACATTCGCCAT 457 619 801 Antisense
TTCCGCTCCAAAATACACACCTGAA 200 697 828 Antisense
AGATATCTGCCACGAGCTTCTGGGA 8 67 855 Antisense
GGACATGTTCCACTATTTGCTGATG 218 525 877 Antisense
ACAGGAAATCGGTCTTGCTTCTCTT 68 97 921 Antisense
TTGCTTCTCTTGGAGCTCCAGATGA 237 703 935 Antisense
ACGGAGCCGGACTTTTGAGTTCATT 589 91 1040 Antisense
GATCCAGCTGTATGTTGTGTCACCA 316 415 1114 Antisense
CATGGGCAGCTACCATCAATCGTCC 51 211 1214 Antisense
TCAATCGTCCATTCCAAATTCGTTA 273 633 1229 Antisense
CAAGGTAGCAGCACTTCAACGTCTC 45 185 1287 Antisense
Sequence Source Affymetrix Proprietary Database