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[193643_s_at] pyridine nucleotide-disulphide oxidoreductase

Description C06G3.7 /REP_DB=WormBase Gene ID /WP=CE26906 /TR=SW:Q17745 /GB=AAB03136.2 /SUBMIT=ST.LOUIS /CHR=4 /FEA=Sanger Annotation /DEF=pyridine nucleotide-disulphide oxidoreductase
Cluster 6grp_highest_10_10 > 76      6grp_high1_10_10 > 66      4grp_highest_8_8 > 38      4grp_high_8_8 > 04      6grp_highest_nonorm > 91      6grp_total > 67      4grp_total > 05      6grp_highest_sub > Da      6grp_cgc > 47      6grp_high1_sub > Da      6grp_total_sub > Increase      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 604
1 2 3 4 range
A 435.1
(1.1)
P 		371.3
(-1.1)
P 		317.2
(-3)
P 		488.2
(3)
P 		171
B 466.7
(-1)
P 		267.4
(-3)
P 		319.8
(-2.5)
P 		871.2
(3)
P 		604
C 411.6
(-0.8)
P 		332.9
(-3)
P 		422.9
(-0.5)
P 		551.6
(3)
P 		219
avr 437.8
(-0.8) 		323.9
(-3) 		353.3
(-2.4) 		637
(3) 		313

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 496
1 2 3 4 5 6 range
A 141.7
(0)
P 		68.4
(-3)
P 		200.1
(2.5)
P 		81.1
(-2.5)
P 		87.6
(-2.2)
P 		212.9
(3)
P 		145
B 142
(-1.7)
P 		100.8
(-2.2)
P 		149.1
(-1.6)
P 		119.4
(-2)
P 		43.5
(-3)
P 		489.7
(3)
P 		446
C 98.2
(-2.6)
P 		79
(-2.8)
P 		142.3
(-2)
P 		113.8
(-2.4)
P 		67.1
(-3)
P 		539.2
(3)
P 		472
avr 127.3
(-1.9) 		82.7
(-2.7) 		163.8
(-1.3) 		104.8
(-2.3) 		66.1
(-3) 		413.9
(3) 		348
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 120
1 2 3 4 range
A 158.4
(3)
P 		80.6
(-2.4)
P 		82.9
(-2.2)
P 		71.5
(-3)
P 		87
B 148.8
(1.2)
P 		66
(-3)
P 		74.1
(-2.6)
P 		185.6
(3)
P 		120
C 136.2
(1.8)
P 		95.7
(-2.7)
P 		147.4
(3)
P 		93
(-3)
P 		54
avr 147.8
(3) 		80.8
(-3) 		101.5
(-1.1) 		116.7
(0.2) 		67

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 165
1 2 3 4 5 6 range
A 26.1
(-1.9)
P 		24.3
(-2.3)
P 		43.6
(1.4)
P 		20.6
(-3)
P 		26.4
(-1.9)
P 		51.8
(3)
P 		31
B 49.4
(-1.8)
P 		33.6
(-2.4)
P 		36.2
(-2.3)
P 		31.6
(-2.5)
P 		17.7
(-3)
P 		182.6
(3)
P 		165
C 36.4
(-2.4)
P 		24.1
(-2.9)
P 		36.2
(-2.5)
P 		22.9
(-3)
P 		21.7
(-3)
P 		180.5
(3)
P 		159
avr 37.3
(-2.2) 		27.3
(-2.7) 		38.7
(-2.1) 		25
(-2.8) 		21.9
(-3) 		138.3
(3) 		116
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 193643_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.10358
Sequence Type Exemplar sequence
Representative Public ID C06G3.7 NCBI
Target Description C06G3.7 /REP_DB=WormBase Gene ID /WP=CE26906 /TR=SW:Q17745 /GB=AAB03136.2 /SUBMIT=ST.LOUIS /CHR=4 /FEA=Sanger Annotation /DEF=pyridine nucleotide-disulphide oxidoreductase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_068684(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_068684 NCBI Caenorhabditis elegans ThioRedoXin Reductase family member (trxr-1) (trxr-1) mRNA, complete cds. 11/11 A 
SNAP00000008734 ENSEMBL cdna:SNAP chromosome:CEL140:IV:7012014:7015986:1 11/11 None
GENEFINDER00000008749 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:7012014:7015986:1 11/11 None
C06G3.7 ENSEMBL cdna:known chromosome:CEL140:IV:7011987:7016743:1 gene:C06G3.7 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:7013511-7015992(+) 100.0 100.0
Public Domain and Genome References
Gene Title pyridine nucleotide-disulphide oxidoreductase
Gene Symbol trxr-1
Ensembl C06G3.7
Entrez Gene 177466 Entrez gene
SwissProt Q17745 EMBL-EBI
WormBase CE34250 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1588184_AT similar to thioredoxin reductase 1 cfa
CANINE:1588072_AT similar to thioredoxin reductase 1 cfa
CANINE_2:CFA.14903.1.S1_AT similar to thioredoxin reductase 1 cfa
CANINE_2:CFA.17422.1.S1_AT similar to thioredoxin reductase 1 cfa
CANINE_2:CFA.8894.1.A1_S_AT similar to thioredoxin reductase 1 cfa
CANINE_2:CFAAFFX.3839.1.S1_S_AT similar to thioredoxin reductase 1 cfa
CANINE_2:CFAAFFX.3844.1.S1_AT similar to thioredoxin reductase 1 cfa
CHICKEN:GGAAFFX.8063.3.S1_AT thioredoxin reductase 1 gga
CHICKEN:GGAAFFX.8063.4.S1_AT thioredoxin reductase 1 gga
CHICKEN:GGAAFFX.8063.5.S1_S_AT thioredoxin reductase 1 gga
HG-U95AV2:39425_AT thioredoxin reductase 1 hs
HG-U133_PLUS_2:201266_AT thioredoxin reductase 1 hs
HG-U133A:201266_AT thioredoxin reductase 1 hs
HG-FOCUS:201266_AT thioredoxin reductase 1 hs
HG-U133A_2:201266_AT thioredoxin reductase 1 hs
HUGENEFL:X91247_AT thioredoxin reductase 1 hs
U133_X3P:G4507746_3P_AT thioredoxin reductase 1 hs
MOUSE430A_2:1421529_A_AT thioredoxin reductase 1 mm
MOUSE430_2:1421529_A_AT thioredoxin reductase 1 mm
MOE430A:1421529_A_AT thioredoxin reductase 1 mm
MU11KSUBA:AA408677_RC_S_AT thioredoxin reductase 1 mm
MG-U74AV2:99985_AT thioredoxin reductase 1 mm
MOE430A:1424487_X_AT thioredoxin reductase 1 mm
MOUSE430A_2:1424487_X_AT thioredoxin reductase 1 mm
MOUSE430_2:1424487_X_AT thioredoxin reductase 1 mm
MOE430A:1424486_A_AT thioredoxin reductase 1 mm
MOUSE430A_2:1424486_A_AT thioredoxin reductase 1 mm
MOUSE430_2:1424486_A_AT thioredoxin reductase 1 mm
RG-U34A:RC_AA891286_AT thioredoxin reductase 1 rn
RG-U34A:U63923_AT thioredoxin reductase 1 rn
RAE230A:1386958_AT thioredoxin reductase 1 rn
RAT230_2:1386958_AT thioredoxin reductase 1 rn
RAE230A:1398791_AT thioredoxin reductase 1 rn
RAT230_2:1398791_AT thioredoxin reductase 1 rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6118 electron transport inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5737 cytoplasm inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
15036 disulfide oxidoreductase activity inferred from electronic annotation QuickGO AmiGO
16491 oxidoreductase activity inferred from electronic annotation QuickGO AmiGO
16654 oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor inferred from electronic annotation QuickGO AmiGO
46872 metal ion binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast Q17745 Thioredoxin reductase (TR-Se) (TRR) 0.0
blast AAB03136 Thioredoxin reductase protein 1 [Caenorhabditis elegans] ref|NP_501085.2| ThioRedoXin Reductase family member (trxr-1) [Caenorhabditis elegans] gb|AAD41826.1| thioredoxin reductase [Caenorhabditis elegans] 0.0
blast CAE61785 Hypothetical protein CBG05747 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR004099 EMBL-EBI Pyridine nucleotide-disulphide oxidoreductase dimerisation domain 1.6E-42
Pfam IPR001327 EMBL-EBI FAD-dependent pyridine nucleotide-disulphide oxidoreductase 7.7E-67
Sequence
Target Sequence 
>C. ELEGANS:193643_S_AT
gaagccgtaactgatgatgttggtcttacaacgattggtgtcgaaagagcaaagagcaag
aaagtactgggaagacgtgagcagtcgacaacaattccatgggtttatgcaattggtgac
gttttggagggaacacctgaattgactccagttgctattcaagctggaagagttttaatg
agacgaattttcgatggagcaaatgaattgacggaatacgatcaaatcccaacaacagtc
ttcactcctctcgaatatggttgctgtggactatcggaggaagatgcaatgatgaaatat
ggaaaggataacattataatctatcacaatgtattcaatccactggaatatacgatttca
gaaagaatggataaggaccattgctatctgaagatgatttgtttgagaaatgaagaggaa
aaagttgtgggcttccacattctcactccaaatgctggtgaagtgacacaaggattcgga
atcgcgttgaaattggctgcaaagaaagcagattttgatcgtctcattggaattcatcca
actgtcgcggagaacttcaccacgttgactcttgaaa

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GAAGCCGTAACTGATGATGTTGGTC 239 345 967 Antisense
GTGAGCAGTCGACAACAATTCCATG 421 483 1043 Antisense
GAACACCTGAATTGACTCCAGTTGC 603 351 1097 Antisense
TCTTCACTCCTCTCGAATATGGTTG 612 615 1205 Antisense
AGTTGTGGGCTTCCACATTCTCACT 702 63 1389 Antisense
CATTCTCACTCCAAATGCTGGTGAA 316 217 1404 Antisense
CGGAATCGCGTTGAAATTGGCTGCA 305 243 1443 Antisense
AGCAGATTTTGATCGTCTCATTGGA 462 77 1473 Antisense
GGAATTCATCCAACTGTCGCGGAGA 582 533 1495 Antisense
CAACTGTCGCGGAGAACTTCACCAC 6 187 1505 Antisense
AACTTCACCACGTTGACTCTTGAAA 548 139 1519 Antisense
Sequence Source Affymetrix Proprietary Database