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[193628_at] serine/threonine kinase (CDC2/CDKX subfamily)

Description B0285.1 /REP_DB=WormBase Gene ID /WP=CE26422 /TR=SW:P46551 /GB=CAA84302.2 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=serine-threonine kinase (CDC2-CDKX subfamily)
Cluster 6grp_highest_10_10 > 72      6grp_high1_10_10 > 27      4grp_highest_8_8 > 24      4grp_high_8_8 > 51      6grp_highest_nonorm > 70      6grp_total > 27      4grp_total > 52      6grp_highest_sub > Cu      6grp_high1_sub > Cu      6grp_total_sub > Decrease      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 145
1 2 3 4 range
A 240.4
(1.2)
P 		233.3
(0.8)
P 		270.9
(3)
P 		167
(-3)
P 		104
B 260.8
(0.7)
P 		286.3
(3)
P 		238.6
(-1.3)
P 		220.5
(-3)
P 		66
C 292.5
(1.5)
P 		312.2
(3)
P 		273.5
(0.1)
P 		233.2
(-3)
P 		79
avr 264.6
(1.9) 		277.3
(3) 		261
(1.6) 		206.9
(-3) 		70

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 217
1 2 3 4 5 6 range
A 378.6
(2)
P 		379.2
(2)
P 		289.9
(-1.1)
P 		236.7
(-3)
P 		315.8
(-0.2)
P 		408.2
(3)
P 		172
B 405.9
(3)
P 		356.2
(1.4)
P 		293.1
(-0.7)
P 		255.7
(-1.9)
P 		223.6
(-3)
P 		284.8
(-1)
P 		182
C 441
(3)
P 		332.7
(-0)
P 		311.1
(-0.6)
P 		225.5
(-3)
P 		294.2
(-1.1)
P 		290.5
(-1.2)
P 		216
avr 408.5
(3) 		356
(1.1) 		298
(-0.9) 		239.3
(-3) 		277.9
(-1.6) 		327.8
(0.1) 		169
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 72
1 2 3 4 range
A 87.5
(3)
P 		50.6
(-0.5)
P 		70.8
(1.4)
P 		24.4
(-3)
P 		63
B 83.2
(3)
P 		70.7
(0.9)
P 		55.3
(-1.6)
P 		47
(-3)
P 		36
C 96.8
(3)
P 		89.8
(2.3)
P 		95.3
(2.8)
P 		39.3
(-3)
P 		58
avr 89.2
(3) 		70.4
(0.8) 		73.8
(1.2) 		36.9
(-3) 		52

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 118
1 2 3 4 5 6 range
A 69.8
(-2.2)
P 		134.9
(3)
P 		63.1
(-2.8)
P 		60
(-3)
P 		95.3
(-0.2)
P 		99.4
(0.2)
P 		75
B 141.2
(3)
P 		118.6
(1.2)
P 		71.2
(-2.7)
P 		67.7
(-3)
P 		90.9
(-1.1)
P 		106.2
(0.1)
P 		74
C 163.5
(3)
P 		101.5
(-0.1)
P 		79.2
(-1.3)
P 		45.4
(-3)
P 		95.2
(-0.5)
P 		97.3
(-0.4)
P 		118
avr 124.8
(3) 		118.3
(2.4) 		71.2
(-1.8) 		57.7
(-3) 		93.8
(0.2) 		101
(0.9) 		67
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193628_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.6962
Sequence Type Exemplar sequence
Representative Public ID B0285.1 NCBI
Target Description B0285.1 /REP_DB=WormBase Gene ID /WP=CE26422 /TR=SW:P46551 /GB=CAA84302.2 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=serine-threonine kinase (CDC2-CDKX subfamily)
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_065472(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_065472 NCBI Caenorhabditis elegans B0285.1 (B0285.1) mRNA, complete cds. 11/11 None
SNAP00000026081 ENSEMBL cdna:SNAP chromosome:CEL140:III:4336050:4340202:1 11/11 None
GENEFINDER00000026099 ENSEMBL cdna:GeneFinder chromosome:CEL140:III:4336198:4340202:1 11/11 None
B0285.1 ENSEMBL cdna:known chromosome:CEL140:III:4333366:4340433:1 gene:B0285.1 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:4333365-4339666(+) 100.0 100.0
Public Domain and Genome References
Gene Title serine/threonine kinase (CDC2/CDKX subfamily)
Ensembl B0285.1
Entrez Gene 175559 Entrez gene
SwissProt P46551 EMBL-EBI
WormBase CE31401 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1584174_AT similar to Cell division cycle 2-like protein kinase 5 (CDC2-related protein kinase 5) (Cholinesterase-related cell division controller) cfa
CANINE:1584173_AT similar to Cell division cycle 2-like protein kinase 5 (CDC2-related protein kinase 5) (Cholinesterase-related cell division controller) cfa
CANINE_2:CFA.834.1.A1_S_AT similar to Cell division cycle 2-like protein kinase 5 (CDC2-related protein kinase 5) (Cholinesterase-related cell division controller) cfa
DROSOPHILA_2:1634492_S_AT dm
DROSGENOME1:141597_AT dm
CHICKEN:GGA.19383.1.S1_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) gga
CHICKEN:GGAAFFX.23865.1.S1_S_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) gga
HG-U95AV2:1793_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HC-G110:1793_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HG-U133_PLUS_2:210965_X_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HG-U133A:210965_X_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HG-U133A_2:210965_X_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HG-U133_PLUS_2:207318_S_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HG-U133A_2:207318_S_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HG-FOCUS:207318_S_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HG-U133A:207318_S_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HG-U133_PLUS_2:207319_S_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HG-U133A:207319_S_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HG-U133A_2:207319_S_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HU35KSUBC:RC_AA489042_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HUGENEFL:M80629_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
U133_X3P:G4502710_3P_A_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
U133_X3P:G12654860_3P_X_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
U133_X3P:HS.59498.0.S2_3P_A_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
U133_X3P:210965_3P_X_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HG-U95AV2:41821_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HG-U95D:69895_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HG-U95E:71570_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HG-U133A:213987_S_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HG-U133A_2:213987_S_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HG-U133_PLUS_2:213987_S_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HU35KSUBB:RC_H52251_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HU35KSUBD:RC_AA608657_F_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
U133_X3P:HS.36636.0.A1_3P_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
U133_X3P:232266_3P_X_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HG-U133_PLUS_2:228991_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HG-U133B:228991_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HG-U133_PLUS_2:232266_X_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HG-U133B:232266_X_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HG-U95C:61726_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HG-U95D:84356_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HG-U133A_2:214287_S_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HG-U133_PLUS_2:214287_S_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HG-U133A:214287_S_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HG-U133_PLUS_2:242693_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HG-U133B:242693_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HG-U95AV2:40270_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HG-U95AV2:41820_S_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HG-U95C:62595_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HG-U95E:68775_R_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HG-U95E:72951_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HG-U95E:85249_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HU35KSUBC:RC_N35067_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
U133_X3P:HS.306813.0.A1_3P_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
U133_X3P:HS.59498.3.A1_3P_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
HU35KSUBD:RC_W61121_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
U133_X3P:HS.193002.0.A1_3P_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) hs
MU11KSUBB:MSA.17806.0_S_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) mm
MG-U74BV2:115789_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) mm
MG-U74CV2:130565_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) mm
MOE430B:1452897_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) mm
MOUSE430_2:1452897_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) mm
MOE430B:1440833_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) mm
MOUSE430_2:1440833_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) mm
MOE430B:1458313_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller), mRNA (cDNA clone IMAGE:5151549) mm
MOUSE430_2:1458313_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller), mRNA (cDNA clone IMAGE:5151549) mm
MG-U74CV2:167995_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller), mRNA (cDNA clone IMAGE:5151549) mm
MU11KSUBA:AA267108_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller), mRNA (cDNA clone IMAGE:5151549) mm
MU19KSUBC:TC36746_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller), mRNA (cDNA clone IMAGE:5151549) mm
MU19KSUBC:TC36746_G_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller), mRNA (cDNA clone IMAGE:5151549) mm
MU19KSUBC:TC36747_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller), mRNA (cDNA clone IMAGE:5151549) mm
RG-U34A:RC_AA875127_G_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) (predicted) rn
RG-U34A:RC_AA875127_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) (predicted) rn
RG-U34C:RC_AI170800_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) (predicted) rn
RAE230A:1398574_A_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) (predicted) rn
RAT230_2:1398574_A_AT cell division cycle 2-like 5 (cholinesterase-related cell division controller) (predicted) rn
RAE230A:1386164_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) (predicted) rn
RAT230_2:1386164_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) (predicted) rn
RAE230A:1390260_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) (predicted) rn
RAT230_2:1390260_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) (predicted) rn
RAE230B:1391344_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) (predicted) rn
RAT230_2:1391344_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) (predicted) rn
RAE230B:1393534_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) (predicted) rn
RAT230_2:1393534_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) (predicted) rn
RAE230B:1394547_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) (predicted) rn
RAT230_2:1394547_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) (predicted) rn
RG-U34B:RC_AI059500_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) (predicted) rn
RG-U34C:RC_AI177766_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) (predicted) rn
RG-U34C:RC_AI229819_AT Cell division cycle 2-like 5 (cholinesterase-related cell division controller) (predicted) rn
YEAST_2:1776423_AT Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA84302 Hypothetical protein B0285.1 [Caenorhabditis elegans] ref|NP_497873.2| B0285.1 [Caenorhabditis elegans] sp|P46551|CDK9_CAEEL Putative cell division protein kinase 9 homolog 0.0
blast T18697 hypothetical protein B0285.1 - Caenorhabditis elegans 0.0
blast CAE71225 Hypothetical protein CBG18089 [Caenorhabditis briggsae] 0.0
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 8.0E-80
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 3.0E-80
hanks 3.1.1 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; CDC2Hs 7.0E-82
hanks 3.1.1 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; CDC2Hs 5.0E-82
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 4.5E-97
Pfam IPR000719 EMBL-EBI Protein kinase 4.5E-97
Pfam IPR000719 EMBL-EBI Protein kinase 4.5E-97
Sequence
Target Sequence 
>C. ELEGANS:193628_AT
gtatcgaccaccagaactacttttgggtgatgaacgttatgggcctgcaattgatgtttg
gagtacgggatgcatgctcggcgagctgttcacccgaaaaccgcttttcaatggaaataa
tgaatttggacagctcgagttgattagtaaggtttgtggatcaccgaatgtggataattg
gcctgaattaaccgaattggttggatggaacacattccgaatgaagagaacttatcagag
acgtattcgagaagagtttgagcacattatgccacgtgaagctgtcgatttactcgataa
aatgctcactttgaatccagaaaaacgaatttctgcaaaagaagctctgaatcatccgtg
gattcgaagtttggaacatacgacagttcaaccactcaaattacctcaacatcaggattg
ccatgagatgtggagcaaaaagcagaaaaaatcagctcgtcttgggcgacaagcagaagg
ttcaagtggaagtggacatagtattcgtgcaacttcacatccac

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GTATCGACCACCAGAACTACTTTTG 110 433 1464 Antisense
GGGTGATGAACGTTATGGGCCTGCA 438 497 1488 Antisense
TGGAGTACGGGATGCATGCTCGGCG 709 547 1522 Antisense
TTCACCCGAAAACCGCTTTTCAATG 105 683 1552 Antisense
GAGTTTGAGCACATTATGCCACGTG 9 399 1717 Antisense
GCCACGTGAAGCTGTCGATTTACTC 230 279 1734 Antisense
AAGAAGCTCTGAATCATCCGTGGAT 254 153 1802 Antisense
AGTTCAACCACTCAAATTACCTCAA 651 61 1848 Antisense
TACCTCAACATCAGGATTGCCATGA 661 647 1865 Antisense
AAAATCAGCTCGTCTTGGGCGACAA 523 133 1911 Antisense
AGTATTCGTGCAACTTCACATCCAC 337 63 1963 Antisense
Sequence Source Affymetrix Proprietary Database