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[193627_at] S-adenosylhomocysteine hydrolase

Description K02F2.2 /REP_DB=WormBase Gene ID /WP=CE17154 /GEN=dpy-14 /TR=SW:P27604 /GB=AAB97565.1 /SUBMIT=ST.LOUIS /CHR=1 /FEA=Sanger Annotation /DEF=S-adenosylhomocysteine hydrolase
Cluster 6grp_highest_10_10 > 24      6grp_high1_10_10 > 21      4grp_highest_8_8 > 09      4grp_high_8_8 > 61      6grp_highest_nonorm > 07      6grp_total > 31      4grp_total > 58      6grp_high1_sub > 03      6grp_total_sub > Hat      6grp_rule_based > S3      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 12049
1 2 3 4 range
A 16436
(-0.2)
P 		22017.8
(3)
P 		21672.7
(2.8)
P 		11668.5
(-3)
P 		10349
B 16442
(0.1)
P 		19711.9
(1.7)
P 		22239.8
(3)
P 		10191.1
(-3)
P 		12049
C 14544.3
(-0.7)
P 		20550.7
(2.7)
P 		21041
(3)
P 		10643.8
(-3)
P 		10397
avr 15807.4
(-0.2) 		20760.1
(2.5) 		21651.2
(3) 		10834.5
(-3) 		10817

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 9069
1 2 3 4 5 6 range
A 14913.3
(1.1)
P 		16379.8
(2.8)
P 		16136
(2.5)
P 		16569.9
(3)
P 		11306.8
(-3)
P 		12550.3
(-1.6)
P 		5263
B 15220.2
(1.9)
P 		15901.9
(2.4)
P 		16608.6
(3)
P 		14490.7
(1.2)
P 		10664.2
(-1.9)
P 		9351.8
(-3)
P 		7257
C 14229.5
(0.1)
P 		15604.1
(1)
P 		18420.7
(3)
P 		13343.7
(-0.6)
P 		12863.2
(-0.9)
P 		9858.3
(-3)
P 		8562
avr 14787.7
(0.9) 		15961.9
(2) 		17055.1
(3) 		14801.4
(0.9) 		11611.4
(-2) 		10586.8
(-3) 		6468
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 5626
1 2 3 4 range
A 5984.4
(3)
P 		4779.5
(1.3)
P 		5665.7
(2.6)
P 		1708
(-3)
P 		4276
B 5243.2
(3)
P 		4868.4
(2.3)
P 		5153.5
(2.8)
P 		2171.7
(-3)
P 		3072
C 4814.6
(0.3)
P 		5908.5
(1.5)
P 		7333.5
(3)
P 		1794.7
(-3)
P 		5539
avr 5347.4
(2) 		5185.5
(1.8) 		6050.9
(3) 		1891.5
(-3) 		4159

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 3142
1 2 3 4 5 6 range
A 2749.2
(-3)
P 		5825.5
(3)
P 		3514.1
(-1.5)
P 		4202.5
(-0.2)
P 		3411.9
(-1.7)
P 		3055.6
(-2.4)
P 		3076
B 5295.9
(3)
P 		5293.1
(3)
P 		4033.1
(-1.2)
P 		3838.1
(-1.8)
P 		4332.7
(-0.2)
P 		3487.3
(-3)
P 		1809
C 5274.3
(3)
P 		4761.3
(1.8)
P 		4688.4
(1.6)
P 		2683.4
(-3)
P 		4162.3
(0.4)
P 		3300.2
(-1.6)
P 		2591
avr 4439.8
(0.5) 		5293.3
(3) 		4078.5
(-0.6) 		3574.7
(-2.1) 		3969
(-0.9) 		3281
(-3) 		2012
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193627_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.390
Sequence Type Exemplar sequence
Representative Public ID K02F2.2 NCBI
Target Description K02F2.2 /REP_DB=WormBase Gene ID /WP=CE17154 /GEN=dpy-14 /TR=SW:P27604 /GB=AAB97565.1 /SUBMIT=ST.LOUIS /CHR=1 /FEA=Sanger Annotation /DEF=S-adenosylhomocysteine hydrolase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_059554(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_059554 NCBI Caenorhabditis elegans K02F2.2 (K02F2.2) mRNA, complete cds. 11/11 None
SNAP00000018476 ENSEMBL cdna:SNAP chromosome:CEL140:I:6844617:6846066:1 11/11 None
GENEFINDER00000018484 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:6844617:6846066:1 11/11 None
K02F2.2.2 ENSEMBL cdna:known chromosome:CEL140:I:6844595:6846261:1 gene:K02F2.2 11/11 None
K02F2.2.3 ENSEMBL cdna:known chromosome:CEL140:I:6844599:6846260:1 gene:K02F2.2 11/11 None
K02F2.2.1 ENSEMBL cdna:known chromosome:CEL140:I:6844601:6846261:1 gene:K02F2.2 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:6844547-6845997(+) 100.0 100.0
Public Domain and Genome References
Gene Title S-adenosylhomocysteine hydrolase
Ensembl K02F2.2
Entrez Gene 172408 Entrez gene
SwissProt P27604 EMBL-EBI
WormBase CE17154 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:245356_AT adenosylhomocysteinase / S-adenosyl-L-homocysteine hydrolase / AdoHcyase (SAHH) at
CANINE:1597852_AT similar to Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase) (AdoHcyase) cfa
CANINE:1585157_AT similar to Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase) (AdoHcyase) cfa
CANINE_2:CFA.8960.1.A1_AT similar to Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase) (AdoHcyase) cfa
CANINE_2:CFAAFFX.12124.1.S1_S_AT similar to Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase) (AdoHcyase) cfa
DROSOPHILA_2:1629222_AT Adenosylhomocysteinase at 13 dm
DROSGENOME1:153144_AT Adenosylhomocysteinase at 13 dm
CHICKEN:GGAAFFX.21326.1.S1_AT S-adenosylhomocysteine hydrolase gga
CHICKEN:GGAAFFX.25369.2.S1_S_AT S-adenosylhomocysteine hydrolase gga
HG-U133_PLUS_2:200903_S_AT S-adenosylhomocysteine hydrolase hs
HG-U133A:200903_S_AT S-adenosylhomocysteine hydrolase hs
HG-U133A_2:200903_S_AT S-adenosylhomocysteine hydrolase hs
HG-FOCUS:200903_S_AT S-adenosylhomocysteine hydrolase hs
HUGENEFL:M61832_S_AT S-adenosylhomocysteine hydrolase hs
U133_X3P:G9951914_3P_A_AT S-adenosylhomocysteine hydrolase hs
HG-U95AV2:40821_AT S-adenosylhomocysteine hydrolase hs
HG-U95D:72366_AT S-adenosylhomocysteine hydrolase hs
MG-U74AV2:96026_AT S-adenosylhomocysteine hydrolase mm
MU11KSUBA:AA237376_S_AT S-adenosylhomocysteine hydrolase mm
MU11KSUBA:L32836_F_AT S-adenosylhomocysteine hydrolase mm
MU11KSUBB:MSA.1580.0_F_AT S-adenosylhomocysteine hydrolase mm
MG-U74AV2:96025_G_AT S-adenosylhomocysteine hydrolase mm
MG-U74AV2:96024_AT S-adenosylhomocysteine hydrolase mm
MG-U74CV2:169774_AT S-adenosylhomocysteine hydrolase mm
MOE430A:1417125_AT S-adenosylhomocysteine hydrolase mm
MOUSE430A_2:1417125_AT S-adenosylhomocysteine hydrolase mm
MOUSE430_2:1417125_AT S-adenosylhomocysteine hydrolase mm
MG-U74AV2:96025_G_AT similar to S-adenosylhomocysteine hydrolase mm
RG-U34A:M15185_S_AT S-adenosylhomocysteine hydrolase rn
RAE230A:1367798_AT S-adenosylhomocysteine hydrolase rn
RAT230_2:1367798_AT S-adenosylhomocysteine hydrolase rn
YEAST_2:1775859_AT S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6730 one-carbon compound metabolism inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4013 adenosylhomocysteinase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAB97565 Hypothetical protein K02F2.2 [Caenorhabditis elegans] ref|NP_491955.1| K02F2.2 [Caenorhabditis elegans] gb|AAB25906.1| S-adenosylhomocysteine hydrolase; AHH [Caenorhabditis elegans] sp|P27604|SAHH_CAEEL Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase) (AdoHcyase) (Dumpy-14 protein) gb|AAA28062.1| S-adenosylhomocysteine hydrolase 0.0
blast CAE67303 Hypothetical protein CBG12756 [Caenorhabditis briggsae] 0.0
blast AAQ96656 adenosylhomocysteinase [Branchiostoma belcheri tsingtaunese] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR000043 EMBL-EBI S-adenosyl-L-homocysteine hydrolase 1.1E-114
Pfam IPR000043 EMBL-EBI S-adenosyl-L-homocysteine hydrolase 2.4E-89
Pfam IPR000043 EMBL-EBI S-adenosyl-L-homocysteine hydrolase 3.2E-70
Sequence
Target Sequence 
>C. ELEGANS:193627_AT
ttcccgtgtcattgtcaccgagatcgatccaatcaatgctcttcaagccgctatggaagg
atacgaagtgaccaccctcgaggaggctgcaccaaaggctaacatcattgtcaccaccac
tggatgcaaggacatcgttaccggaaagcacttcgagcttcttccaaatgacgctatcgt
ctgcaacgttggtcacttcgattgcgagattgacgtcaaatggctcaacaccaatgccac
caagaaggacaccatcaagccacaggttgaccgttacaccctcaagaacggacgtcacgt
catcctccttgccgaaggacgtcttgtcaaccttggatgtgccaccggacatccatcttt
cgtcatgtccaactccttcaccaaccaagttctcgctcaagttgagctctggaccaagtt
cggaactccacaagaatacaagctcggactctacgttcttccaaaaacccttgacgagga
ggtcgcttatcttcact

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TTCCCGTGTCATTGTCACCGAGATC 117 699 726 Antisense
TCAATGCTCTTCAAGCCGCTATGGA 502 633 758 Antisense
TCATTGTCACCACCACTGGATGCAA 695 617 830 Antisense
GGACATCGTTACCGGAAAGCACTTC 628 525 855 Antisense
CACTTCGAGCTTCTTCCAAATGACG 190 197 874 Antisense
GACGCTATCGTCTGCAACGTTGGTC 237 381 895 Antisense
TTACACCCTCAAGAACGGACGTCAC 667 625 999 Antisense
GACGTCTTGTCAACCTTGGATGTGC 46 379 1043 Antisense
GACATCCATCTTTCGTCATGTCCAA 200 369 1073 Antisense
AATACAAGCTCGGACTCTACGTTCT 10 171 1160 Antisense
GACGAGGAGGTCGCTTATCTTCACT 394 377 1198 Antisense
Sequence Source Affymetrix Proprietary Database