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[193623_at] protein-S isoprenylsysteine O-methyltransferase

Description F21F3.3 /REP_DB=WormBase Gene ID /WP=CE09533 /TR=P91266 /GB=AAB42280.1 /SUBMIT=ST.LOUIS /CHR=1 /FEA=Sanger Annotation /DEF=protein-S isoprenylsysteine O-methyltransferase
Cluster 6grp_total > 97      4grp_total > 03      6grp_total_sub > Increase      6grp_rule_based > S6      4grp_rule_based > L4      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 256
1 2 3 4 range
A 53.9
(-2.3)
A 		32.3
(-2.9)
A 		29.2
(-3)
A 		254.4
(3)
P 		225
B 58.2
(-2.5)
A 		63.1
(-2.4)
A 		40
(-3)
A 		279.9
(3)
P 		240
C 55.5
(-2.2)
A 		60.3
(-2)
A 		24.3
(-3)
A 		247.4
(3)
P 		223
avr 55.9
(-2.4) 		51.9
(-2.5) 		31.2
(-3) 		260.6
(3) 		229

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 765
1 2 3 4 5 6 range
A 168.1
(-2.9)
A 		161.2
(-3)
P 		182.9
(-2.8)
P 		349.7
(-1.3)
P 		561.9
(0.6)
P 		832.5
(3)
P 		671
B 110.8
(-3)
A 		137
(-2.8)
P 		137.5
(-2.8)
P 		316
(-1.4)
P 		593
(0.8)
P 		875.5
(3)
P 		765
C 118.2
(-3)
A 		135.8
(-2.8)
P 		168.9
(-2.5)
P 		271.3
(-1.5)
P 		583.4
(1.7)
P 		716.1
(3)
P 		598
avr 132.4
(-3) 		144.7
(-2.9) 		163.1
(-2.7) 		312.3
(-1.4) 		579.4
(1) 		808
(3) 		676
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 53
1 2 3 4 range
A 19.6
(-0.5)
A 		7
(-3)
A 		7.6
(-2.9)
A 		37.2
(3)
P 		30
B 18.6
(-1.9)
A 		15.6
(-2.2)
A 		9.3
(-3)
A 		59.6
(3)
P 		50
C 18.4
(-1.2)
A 		17.3
(-1.4)
A 		8.5
(-3)
A 		41.7
(3)
P 		33
avr 18.9
(-1.3) 		13.3
(-2.2) 		8.5
(-3) 		46.2
(3) 		38

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 296
1 2 3 4 5 6 range
A 31
(-3)
A 		57.3
(-2.1)
P 		39.8
(-2.7)
P 		88.7
(-1)
P 		169.6
(1.8)
P 		202.7
(3)
P 		172
B 38.5
(-2.9)
A 		45.6
(-2.8)
P 		33.4
(-3)
P 		83.7
(-2)
P 		240.9
(1.2)
P 		326.5
(3)
P 		293
C 43.8
(-2.9)
A 		41.4
(-3)
P 		43
(-3)
P 		54.6
(-2.6)
P 		188.8
(1.5)
P 		239.7
(3)
P 		198
avr 37.8
(-3) 		48.1
(-2.7) 		38.7
(-3) 		75.7
(-2) 		199.8
(1.4) 		256.3
(3) 		219
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 193623_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.2200
Sequence Type Exemplar sequence
Representative Public ID F21F3.3 NCBI
Target Description F21F3.3 /REP_DB=WormBase Gene ID /WP=CE09533 /TR=P91266 /GB=AAB42280.1 /SUBMIT=ST.LOUIS /CHR=1 /FEA=Sanger Annotation /DEF=protein-S isoprenylsysteine O-methyltransferase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_059072(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_059072 NCBI Caenorhabditis elegans F21F3.3 (F21F3.3) mRNA, complete cds. 11/11 None
SNAP00000035673 ENSEMBL cdna:SNAP chromosome:CEL140:I:4901999:4903101:1 11/11 None
GENEFINDER00000035679 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:4901999:4903101:1 11/11 None
F21F3.3 ENSEMBL cdna:known chromosome:CEL140:I:4901975:4903137:1 gene:F21F3.3 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:4901998-4903101(+) 100.0 100.0
Public Domain and Genome References
Gene Title protein-S isoprenylsysteine O-methyltransferase
Ensembl F21F3.3
Entrez Gene 172106 Entrez gene
SwissProt P91266 EMBL-EBI
WormBase CE09533 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:246009_AT isoprenylcysteine carboxyl methyltransferase family protein / ICMT family protein at
CANINE_2:CFAAFFX.29920.1.S1_AT similar to isoprenylcysteine carboxyl methyltransferase cfa
DROSOPHILA_2:1625268_AT dm
DROSGENOME1:148691_AT dm
CHICKEN:GGA.16529.2.S1_S_AT isoprenylcysteine carboxyl methyltransferase gga
CHICKEN:GGA.16529.1.S1_A_AT Isoprenylcysteine carboxyl methyltransferase gga
CHICKEN:GGA.16529.1.S1_AT Isoprenylcysteine carboxyl methyltransferase gga
CHICKEN:GGA.16529.2.A1_AT Isoprenylcysteine carboxyl methyltransferase gga
HG-U133A:201609_X_AT isoprenylcysteine carboxyl methyltransferase hs
HG-U133_PLUS_2:201609_X_AT isoprenylcysteine carboxyl methyltransferase hs
HG-U133A_2:201609_X_AT isoprenylcysteine carboxyl methyltransferase hs
HG-U133A:201610_AT isoprenylcysteine carboxyl methyltransferase hs
HG-U133_PLUS_2:201610_AT isoprenylcysteine carboxyl methyltransferase hs
HG-U133A_2:201610_AT isoprenylcysteine carboxyl methyltransferase hs
HG-U133A:201611_S_AT isoprenylcysteine carboxyl methyltransferase hs
HG-U133_PLUS_2:201611_S_AT isoprenylcysteine carboxyl methyltransferase hs
HG-U133A_2:201611_S_AT isoprenylcysteine carboxyl methyltransferase hs
HG-FOCUS:201611_S_AT isoprenylcysteine carboxyl methyltransferase hs
HU35KSUBA:RC_AA441802_AT isoprenylcysteine carboxyl methyltransferase hs
U133_X3P:G6912429_3P_A_AT isoprenylcysteine carboxyl methyltransferase hs
U133_X3P:HS.183212.0.S3_3P_X_AT isoprenylcysteine carboxyl methyltransferase hs
U133_X3P:HS.183212.0.S1_3P_A_AT isoprenylcysteine carboxyl methyltransferase hs
HG-U95AV2:41775_AT isoprenylcysteine carboxyl methyltransferase hs
U133_X3P:HS.101077.0.A1_3P_A_AT Isoprenylcysteine carboxyl methyltransferase hs
U133_X3P:HS.101077.0.A1_3P_AT Isoprenylcysteine carboxyl methyltransferase hs
U133_X3P:HS.101077.0.A1_3P_X_AT Isoprenylcysteine carboxyl methyltransferase hs
MG-U74BV2:106862_AT isoprenylcysteine carboxyl methyltransferase mm
MG-U74AV2:160336_AT isoprenylcysteine carboxyl methyltransferase mm
MOE430A:1426500_AT isoprenylcysteine carboxyl methyltransferase mm
MOUSE430A_2:1426500_AT isoprenylcysteine carboxyl methyltransferase mm
MOUSE430_2:1426500_AT isoprenylcysteine carboxyl methyltransferase mm
MU19KSUBB:TC30830_AT Isoprenylcysteine carboxyl methyltransferase, mRNA (cDNA clone IMAGE:3155246) mm
MU19KSUBB:TC30830_G_AT Isoprenylcysteine carboxyl methyltransferase, mRNA (cDNA clone IMAGE:3155246) mm
MU19KSUBB:TC30831_AT Isoprenylcysteine carboxyl methyltransferase, mRNA (cDNA clone IMAGE:3155246) mm
RAT230_2:1388184_AT isoprenylcysteine carboxyl methyltransferase rn
RAE230A:1388184_AT isoprenylcysteine carboxyl methyltransferase rn
RAE230B:1395311_AT isoprenylcysteine carboxyl methyltransferase rn
RAT230_2:1395311_AT isoprenylcysteine carboxyl methyltransferase rn
YEAST_2:1777351_AT Farnesyl cysteine-carboxyl methyltransferase, mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum, localizes to the ER membrane Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6481 C-terminal protein amino acid methylation inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16021 integral to membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4671 protein-S-isoprenylcysteine O-methyltransferase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAB42280 Hypothetical protein F21F3.3 [Caenorhabditis elegans] ref|NP_491473.1| F21F3.3 [Caenorhabditis elegans] 1.0E-172
blast AAB37832 Hypothetical protein M01E11.1 [Caenorhabditis elegans] ref|NP_491635.1| M01E11.1 [Caenorhabditis elegans] 1.0E-122
blast CAE68916 Hypothetical protein CBG14895 [Caenorhabditis briggsae] 1.0E-114
Protein Domains
Database ID Description E-Value
Pfam IPR007269 EMBL-EBI Isoprenylcysteine carboxyl methyltransferase 1.0E-42
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_491473.1 7 24-42,49-66,76-98,105-127,142-164,171-193,228-250
F21F3.3 7 24-42,49-66,76-98,105-127,142-164,171-193,228-250
SNAP00000035673 7 24-42,49-66,76-98,105-127,142-164,171-193,228-250
GENEFINDER00000035679 7 24-42,49-66,76-98,105-127,142-164,171-193,228-250
Sequence
Target Sequence 
>C. ELEGANS:193623_AT
gcagtcgcagtgaacttggtctacacggtagctcacgaaggagagctctgggaatatttt
tctcgatatttcctcttcctctccgtgttccatttctccgaattcgtcttcacagcactg
accaatcgccgaactcttggacccgattcgttccttttgaagcattcttttggatattgg
cttgctgcatccattggttggattgagtttttgattgaggccaacttctaccccgaaatc
aagatgtattcggttctctggattggaacattcggttgtatcattggagagattgtcaga
aaagtcggtatggttcatgctggattggcattcactcatcttatggcaaggaccaaaaga
tcaggccacactcttatcaataccgggatctacgcgtacatgcgccatcctggatatttt
ggttggttcatttgggctgtctcgactcaaattgttctctgtaatccaatttcctttgtt
atctacacttttgtcacgtggcgtttct

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GCAGTCGCAGTGAACTTGGTCTACA 353 311 271 Antisense
TTCCATTTCTCCGAATTCGTCTTCA 329 699 358 Antisense
TGACCAATCGCCGAACTCTTGGACC 316 569 389 Antisense
GATTCGTTCCTTTTGAAGCATTCTT 27 433 415 Antisense
GATATTGGCTTGCTGCATCCATTGG 602 425 443 Antisense
TTTGATTGAGGCCAACTTCTACCCC 191 665 480 Antisense
TCAGGCCACACTCTTATCAATACCG 691 619 631 Antisense
TACCGGGATCTACGCGTACATGCGC 336 649 651 Antisense
GGCTGTCTCGACTCAAATTGTTCTC 262 541 705 Antisense
TGTTCTCTGTAATCCAATTTCCTTT 174 561 723 Antisense
TACACTTTTGTCACGTGGCGTTTCT 558 637 754 Antisense
Sequence Source Affymetrix Proprietary Database