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[193614_s_at] transducin-like enhancer protein

Description W02D3.9 /REP_DB=WormBase Gene ID /WP=CE14434 /GEN=unc-37 /TR=SW:O02482 /GB=AAK21487.1 /SUBMIT=ST.LOUIS /CHR=1 /FEA=Sanger Annotation /DEF=transducin-like enhancer protein
Cluster 6grp_highest_10_10 > 65      6grp_high1_10_10 > 66      4grp_highest_8_8 > 58      4grp_high_8_8 > 33      6grp_highest_nonorm > 87      6grp_total > 57      4grp_total > 47      6grp_cgc > 37      6grp_high1_sub > Da      6grp_cgc_sub > Cu      6grp_total_sub > Cup      4grp_rule_based > L1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 430
1 2 3 4 range
A 1154.6
(3)
P 		724.3
(-3)
P 		750.9
(-2.6)
P 		830.6
(-1.5)
P 		430
B 988.6
(3)
P 		896.6
(0.7)
P 		746.1
(-3)
P 		772.5
(-2.3)
P 		243
C 1146.3
(3)
P 		805
(-2.5)
P 		776.8
(-3)
P 		782.9
(-2.9)
P 		370
avr 1096.5
(3) 		808.6
(-2.1) 		757.9
(-3) 		795.3
(-2.3) 		339

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 868
1 2 3 4 5 6 range
A 827.7
(-3)
P 		1152.5
(1)
P 		861.6
(-2.6)
P 		1005.3
(-0.8)
P 		830.9
(-3)
P 		1315.2
(3)
P 		488
B 1128.2
(0.6)
P 		988.4
(-0.8)
P 		973.7
(-0.9)
P 		1095.6
(0.2)
P 		758.2
(-3)
P 		1381.5
(3)
P 		623
C 1125.5
(-1.2)
P 		1044.8
(-1.9)
P 		1020.4
(-2.1)
P 		1036.8
(-1.9)
P 		908.3
(-3)
P 		1626.1
(3)
P 		718
avr 1027.1
(-1.1) 		1061.9
(-0.7) 		951.9
(-1.8) 		1045.9
(-0.9) 		832.5
(-3) 		1440.9
(3) 		608
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 299
1 2 3 4 range
A 420.4
(3)
P 		157.2
(-2.3)
P 		196.3
(-1.5)
P 		121.6
(-3)
P 		299
B 315.3
(3)
P 		221.4
(-0.7)
P 		172.9
(-2.7)
P 		164.6
(-3)
P 		151
C 379.4
(3)
P 		231.4
(-0.6)
P 		270.7
(0.4)
P 		132
(-3)
P 		247
avr 371.7
(3) 		203.3
(-1.3) 		213.3
(-1.1) 		139.4
(-3) 		232

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 392
1 2 3 4 5 6 range
A 152.6
(-3)
P 		409.9
(3)
P 		187.6
(-2.2)
P 		255
(-0.6)
P 		250.7
(-0.7)
P 		320.2
(0.9)
P 		257
B 392.6
(0.4)
P 		329
(-1)
P 		236.4
(-3)
P 		290.2
(-1.8)
P 		308
(-1.5)
P 		515.1
(3)
P 		279
C 417.2
(0.7)
P 		318.8
(-1)
P 		259.7
(-2.1)
P 		208.5
(-3)
P 		293.9
(-1.5)
P 		544.3
(3)
P 		336
avr 320.8
(-0.6) 		352.6
(0.2) 		227.9
(-3) 		251.2
(-2.4) 		284.2
(-1.5) 		459.9
(3) 		232
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 193614_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.2025
Sequence Type Exemplar sequence
Representative Public ID W02D3.9 NCBI
Target Description W02D3.9 /REP_DB=WormBase Gene ID /WP=CE14434 /GEN=unc-37 /TR=SW:O02482 /GB=AAK21487.1 /SUBMIT=ST.LOUIS /CHR=1 /FEA=Sanger Annotation /DEF=transducin-like enhancer protein
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_059531(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_059531 NCBI Caenorhabditis elegans UNCoordinated family member (unc-37) (unc-37) mRNA, complete cds. 11/11 A 
SNAP00000042723 ENSEMBL cdna:SNAP chromosome:CEL140:I:6750658:6753458:-1 11/11 None
GENEFINDER00000042737 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:6750658:6753458:-1 11/11 None
W02D3.9.2 ENSEMBL cdna:known chromosome:CEL140:I:6750124:6753463:-1 gene:W02D3.9 11/11 None
W02D3.9.1 ENSEMBL cdna:known chromosome:CEL140:I:6750124:6753473:-1 gene:W02D3.9 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:6750586-6753387(-) 100.0 100.0
Public Domain and Genome References
Gene Title transducin-like enhancer protein
Gene Symbol unc-37
Ensembl W02D3.9
Entrez Gene 172394 Entrez gene
SwissProt O02482 EMBL-EBI
WormBase CE14434 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1605658_AT transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) cfa
CANINE_2:CFA.2411.1.A1_AT transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) cfa
CANINE_2:CFAAFFX.3217.1.S1_S_AT transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) cfa
CANINE_2:CFAAFFX.3254.1.S1_S_AT transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) cfa
CHICKEN:GGA.126.1.S1_AT transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) gga
HG-U95AV2:38364_AT transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) hs
HG-U133_PLUS_2:204872_AT transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) hs
HG-U133A:204872_AT transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) hs
HG-U133A_2:204872_AT transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) hs
HU35KSUBC:RC_N26398_AT transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) hs
HU35KSUBD:RC_AA491003_AT transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) hs
HUGENEFL:M99439_AT transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) hs
U133_X3P:G5921462_3P_AT transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) hs
U133_X3P:HS.83958.1.S1_3P_A_AT transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) hs
U133_X3P:HS.83958.0.A1_3P_X_AT transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) hs
U133_X3P:HS.83958.0.A1_3P_AT transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) hs
U133_X3P:HS.296039.0.A1_3P_AT transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) hs
HG-U133A_2:214688_AT transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) hs
HG-U133_PLUS_2:214688_AT transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) hs
HG-U133A:214688_AT transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) hs
HG-U133A_2:216997_X_AT transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) hs
HG-U133_PLUS_2:216997_X_AT transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) hs
HG-U133A:216997_X_AT transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) hs
HG-U133_PLUS_2:233575_S_AT transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) hs
HG-U133B:233575_S_AT transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) hs
HG-U133_PLUS_2:235765_AT transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) hs
HG-U133B:235765_AT transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) hs
HG-U95AV2:40692_AT transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) hs
HG-U95B:51042_I_AT transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) hs
HG-U95B:51044_R_AT transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) hs
HG-U95B:50137_AT Transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) hs
HG-U95D:69701_AT Transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) hs
HU35KSUBA:RC_AA236922_AT Transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) hs
MOUSE430_2:1425650_AT transducin-like enhancer of split 4, homolog of Drosophila E(spl) mm
MOE430A:1425650_AT transducin-like enhancer of split 4, homolog of Drosophila E(spl) mm
MOUSE430A_2:1425650_AT transducin-like enhancer of split 4, homolog of Drosophila E(spl) mm
MOUSE430_2:1430384_AT transducin-like enhancer of split 4, homolog of Drosophila E(spl) mm
MOE430B:1430384_AT transducin-like enhancer of split 4, homolog of Drosophila E(spl) mm
MU11KSUBA:U61363_S_AT transducin-like enhancer of split 4, homolog of Drosophila E(spl) mm
MU11KSUBA:C77702_RC_AT transducin-like enhancer of split 4, homolog of Drosophila E(spl) mm
MG-U74AV2:102959_AT transducin-like enhancer of split 4, homolog of Drosophila E(spl) mm
MG-U74CV2:166070_R_AT transducin-like enhancer of split 4, homolog of Drosophila E(spl) mm
MOE430A:1450853_AT transducin-like enhancer of split 4, homolog of Drosophila E(spl) mm
MOUSE430A_2:1450853_AT transducin-like enhancer of split 4, homolog of Drosophila E(spl) mm
MOUSE430_2:1450853_AT transducin-like enhancer of split 4, homolog of Drosophila E(spl) mm
MU19KSUBC:TC40639_AT transducin-like enhancer of split 4, homolog of Drosophila E(spl) mm
RG-U34A:L14463_AT transducin-like enhancer of split 4, E(spl) homolog (Drosophila) rn
RAE230A:1387495_AT transducin-like enhancer of split 4, E(spl) homolog (Drosophila) rn
RAT230_2:1387495_AT transducin-like enhancer of split 4, E(spl) homolog (Drosophila) rn
RAE230A:1376869_AT Transducin-like enhancer of split 4, E(spl) homolog (Drosophila) rn
RAT230_2:1376869_AT Transducin-like enhancer of split 4, E(spl) homolog (Drosophila) rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
7222 frizzled signaling pathway inferred from electronic annotation QuickGO AmiGO
45449 regulation of transcription inferred from electronic annotation QuickGO AmiGO
16481 negative regulation of transcription inferred from sequence similarity QuickGO AmiGO
1505 regulation of neurotransmitter levels inferred from direct assay QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5634 nucleus inferred from electronic annotation QuickGO AmiGO
5634 nucleus inferred from direct assay QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
3714 transcription corepressor activity inferred from sequence similarity QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAK21487 Uncoordinated protein 37 [Caenorhabditis elegans] ref|NP_491932.1| UNCoordinated family member (unc-37) [Caenorhabditis elegans] sp|O02482|UNC37_CAEEL Transcription factor unc-37 (Uncoordinated protein 37) gb|AAB84235.1| enhancer of split groucho [Caenorhabditis elegans] gb|AAB84234.1| enhancer of split groucho [Caenorhabditis elegans] 0.0
blast AAB49459 transcription factor UNC-37 [Caenorhabditis elegans] 0.0
blast CAE60442 Hypothetical protein CBG04050 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR005617 EMBL-EBI Groucho/TLE N-terminal Q-rich domain 1.6E-12
Pfam IPR001680 EMBL-EBI G-protein beta WD-40 repeat 0.0024
Pfam IPR001680 EMBL-EBI G-protein beta WD-40 repeat 0.14
Pfam IPR001680 EMBL-EBI G-protein beta WD-40 repeat 0.0012
Pfam IPR001680 EMBL-EBI G-protein beta WD-40 repeat 4.0E-9
Pfam IPR001680 EMBL-EBI G-protein beta WD-40 repeat 1.3E-6
Pfam IPR001680 EMBL-EBI G-protein beta WD-40 repeat 0.49
Sequence
Target Sequence 
>C. ELEGANS:193614_S_AT
gcatgctacgcgttggcgatgtcaccagatgagaaattattgttcgcatgtcttgctgat
ggaaatatcctcatttatgatatccataataaggtgaaagttggaaccctacctggacat
caagatggagcatcatgtctcgatctctcaaaagatggtacaaagctctggtcaggtggt
cttgacaattctgttagatgctgggatcttgcacaacgaaaggaagttgcgaagcatgat
tttgcgagccaagttttctctcttggatgttgtccaaatgatgaatgggtggctgttggt
atggagaataattatgtcgaggttctgtcaacaactggaaaagaaaagtatcaattgaca
caacacgaatcatgcgtcctttcgctcaaatttgcgcattccggaaagttcttcatttca
actggaaaggacaatgctctcaacgcctggcgtactccatac

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GCATGCTACGCGTTGGCGATGTCAC 627 309 1264 Antisense
ATTGTTCGCATGTCTTGCTGATGGA 326 5 1302 Antisense
GAAAGTTGGAACCCTACCTGGACAT 371 315 1359 Antisense
GATGGAGCATCATGTCTCGATCTCT 517 407 1387 Antisense
GATGGTACAAAGCTCTGGTCAGGTG 709 407 1417 Antisense
AAGTTTTCTCTCTTGGATGTTGTCC 311 157 1514 Antisense
CACAACACGAATCATGCGTCCTTTC 643 193 1622 Antisense
GCGTCCTTTCGCTCAAATTTGCGCA 260 289 1637 Antisense
TGCGCATTCCGGAAAGTTCTTCATT 411 583 1656 Antisense
GGAAAGGACAATGCTCTCAACGCCT 608 527 1687 Antisense
TCTCAACGCCTGGCGTACTCCATAC 79 613 1701 Antisense
Sequence Source Affymetrix Proprietary Database