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[193590_s_at] sodium:neurotransmitter symporter

Description T23G5.5 /REP_DB=WormBase Gene ID /WP=CE25124 /GEN=dat-1 /TR=SW:Q03614 /GB=CAA79575.2 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=sodium:neurotransmitter symporter
Cluster 6grp_highest_10_10 > 70      6grp_high1_10_10 > 07      4grp_high_8_8 > 41      6grp_highest_nonorm > 80      6grp_total > 18      4grp_total > 55      6grp_highest_sub > De      6grp_cgc > 11      6grp_cgc_sub > De      6grp_total_sub > Decrease      4grp_rule_based > L1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 237
1 2 3 4 range
A 289.5
(3)
P 		125.2
(-3)
M 		174.1
(-1.2)
P 		138.6
(-2.5)
A 		164
B 356.9
(3)
P 		149.2
(-2.3)
P 		148.4
(-2.3)
P 		120.4
(-3)
P 		237
C 268.9
(3)
P 		217
(0.4)
P 		168.5
(-2.1)
P 		151.2
(-3)
P 		118
avr 305.1
(3) 		163.8
(-2) 		163.7
(-2) 		136.7
(-3) 		168

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 253
1 2 3 4 5 6 range
A 306.7
(3)
P 		169.5
(-1.3)
P 		140.4
(-2.2)
P 		201.5
(-0.3)
P 		113.2
(-3)
P 		122.7
(-2.7)
P 		194
B 315.4
(3)
P 		248.8
(0.8)
P 		153.6
(-2.4)
P 		212.8
(-0.4)
P 		181.3
(-1.5)
P 		136.8
(-3)
P 		179
C 332.3
(3)
P 		178.5
(-0.6)
P 		122.2
(-2)
P 		127
(-1.9)
P 		152.1
(-1.3)
P 		79.1
(-3)
P 		253
avr 318.1
(3) 		198.9
(-0.5) 		138.7
(-2.2) 		180.4
(-1) 		148.9
(-1.9) 		112.9
(-3) 		205
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 94
1 2 3 4 range
A 105.4
(3)
P 		27.2
(-2.5)
M 		45.5
(-1.2)
P 		20.3
(-3)
A 		85
B 113.8
(3)
P 		36.8
(-2.2)
P 		34.4
(-2.4)
P 		25.7
(-3)
P 		88
C 89
(3)
P 		62.4
(0.5)
P 		58.7
(0.1)
P 		25.5
(-3)
P 		64
avr 102.7
(3) 		42.1
(-1.6) 		46.2
(-1.3) 		23.8
(-3) 		79

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 98
1 2 3 4 5 6 range
A 56.5
(2.3)
P 		60.3
(3)
P 		30.6
(-2.9)
P 		51.1
(1.2)
P 		34.2
(-2.2)
P 		29.9
(-3)
P 		30
B 109.7
(3)
P 		82.8
(0.8)
P 		37.3
(-3)
P 		56.4
(-1.4)
P 		73.6
(0)
P 		51
(-1.9)
P 		72
C 123.2
(3)
P 		54.5
(-1.2)
P 		31.1
(-2.7)
P 		25.5
(-3)
P 		49.2
(-1.5)
P 		26.5
(-2.9)
P 		98
avr 96.5
(3) 		65.9
(0.1) 		33
(-3) 		44.3
(-1.9) 		52.3
(-1.2) 		35.8
(-2.7) 		64
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 193590_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.7936
Sequence Type Exemplar sequence
Representative Public ID T23G5.5 NCBI
Target Description T23G5.5 /REP_DB=WormBase Gene ID /WP=CE25124 /GEN=dat-1 /TR=SW:Q03614 /GB=CAA79575.2 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=sodium:neurotransmitter symporter
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_066642(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_066642 NCBI Caenorhabditis elegans DopAmine transporter family member (dat-1) (dat-1) mRNA, complete cds. 11/11 A 
T23G5.5 ENSEMBL cdna:known chromosome:CEL140:III:9242809:9246703:1 gene:T23G5.5 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:9242873-9246475(+) 100.0 100.0
Public Domain and Genome References
Gene Title sodium:neurotransmitter symporter
Gene Symbol dat-1
Ensembl T23G5.5
Entrez Gene 176304 Entrez gene
SwissProt Q03614 EMBL-EBI
WormBase CE25124 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.14827.1.S1_S_AT similar to Sodium-dependent noradrenaline transporter (Norepinephrine transporter) (NET) cfa
DROSOPHILA_2:1633205_AT Dopamine transporter dm
DROSGENOME1:147316_AT Dopamine transporter dm
CHICKEN:GGA.249.1.S1_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 gga
HG-U133_PLUS_2:216610_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 hs
HG-U133A_2:216610_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 hs
HG-U133A:216610_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 hs
HG-U133_PLUS_2:216611_S_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 hs
HG-U133A_2:216611_S_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 hs
HG-U133A:216611_S_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 hs
HG-U133_PLUS_2:210353_S_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 hs
HG-U133A:210353_S_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 hs
HG-U133A_2:210353_S_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 hs
HG-U95AV2:40402_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 hs
HUGENEFL:X91117_RNA1_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 hs
U133_X3P:G189257_3P_A_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 hs
U133_X3P:HS.78036.1.S1_3P_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 hs
U133_X3P:HS.225971.0.S1_3P_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 hs
U133_X3P:HS.208021.0.A1_3P_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 hs
HG-U133A_2:215715_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 hs
HG-FOCUS:215715_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 hs
HG-U133_PLUS_2:215715_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 hs
HG-U133A:215715_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 hs
HG-U133_PLUS_2:239394_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 hs
HG-U133B:239394_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 hs
HG-U95AV2:31653_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 hs
HG-U95E:70572_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 hs
HG-U133A_2:217213_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 hs
HG-U133_PLUS_2:217213_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 hs
HG-U133A:217213_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 hs
HG-U133A_2:217214_S_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 hs
HG-U133_PLUS_2:217214_S_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 hs
HG-U133A:217214_S_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 hs
MG-U74AV2:99408_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 mm
MOUSE430_2:1447311_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 mm
MOE430B:1447311_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 mm
MOUSE430_2:1442449_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 mm
MOE430B:1442449_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 mm
MOUSE430_2:1421641_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 mm
MOUSE430A_2:1421641_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 mm
MOE430A:1421641_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 mm
MG-U74AV2:99409_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 mm
MG-U74BV2:115279_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 mm
MOE430B:1460129_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 mm
MOUSE430_2:1460129_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 mm
RAE230A:1387418_A_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 rn
RAT230_2:1387418_A_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 rn
RG-U34A:L29573_S_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 rn
RG-U34A:Y13223CDS_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 rn
RG-U34C:RC_AI170447_AT solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 rn
RAE230B:1393399_AT Solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 rn
RAT230_2:1393399_AT Solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 rn
RG-U34B:RC_AI030145_AT Solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6836 neurotransmitter transport inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5887 integral to plasma membrane inferred from electronic annotation QuickGO AmiGO
16020 membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
5328 neurotransmitter:sodium symporter activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA79575 Hypothetical protein T23G5.5 [Caenorhabditis elegans] emb|CAA79564.2| Hypothetical protein T23G5.5 [Caenorhabditis elegans] ref|NP_499043.1| DopAmine transporter family member (dat-1) [Caenorhabditis elegans] sp|Q03614|NTDO_CAEEL Sodium-dependent dopamine transporter (DA transporter) (DAT) gb|AAC83661.1| sodium- and chloride-dependent antidepressant- and cocaine-sensitive dopamine transporter [Caenorhabditis elegans] 0.0
blast CAE65260 Hypothetical protein CBG10151 [Caenorhabditis briggsae] 0.0
blast D88551 protein T23G5.5 [imported] - Caenorhabditis elegans 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR000175 EMBL-EBI Sodium:neurotransmitter symporter 1.0E-126
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_499043.1 11 78-100,121-143,229-246,258-280,307-329,342-364,397-419,440-462,472-494,515-534,549-571
T23G5.5 11 78-100,121-143,229-246,258-280,307-329,342-364,397-419,440-462,472-494,515-534,549-571
Sequence
Target Sequence 
>C. ELEGANS:193590_S_AT
atgctcatgacacttggccttgattcttcattcggaggatctgaagctatcatcaccggc
ctttcagatgaatttccaatattgaaaaagaacagagaagtgttcgttggttgtttgttt
gctttttacatggtaattggaattgctatgtgtacagagggtggaattctaatcatggaa
tggctcatcatctatggaactacatggggcttattgattgcagtgttctgtgaagcaatg
gtcattgcatacatctacggtctgcgacaatttgttcatgacgtcaaagagatgatggga
ttccgcccgggaaattattggaagttttgctggagctgtgccgcaccattcattttattg
tcgatgatcacttccaacttcatcaattatcaagccttgacctaccaggactacacatac
ccaaccgcggcaaacgttataggaattatttttgcgctctcaggc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
ATGCTCATGACACTTGGCCTTGATT 664 41 1231 Antisense
AGGATCTGAAGCTATCATCACCGGC 352 57 1266 Antisense
TGTTCGTTGGTTGTTTGTTTGCTTT 571 561 1331 Antisense
GGTCATTGCATACATCTACGGTCTG 518 503 1470 Antisense
ATGATGGGATTCCGCCCGGGAAATT 135 47 1522 Antisense
GGAAGTTTTGCTGGAGCTGTGCCGC 70 533 1550 Antisense
GCCGCACCATTCATTTTATTGTCGA 449 285 1570 Antisense
TTGTCGATGATCACTTCCAACTTCA 623 705 1588 Antisense
TCAAGCCTTGACCTACCAGGACTAC 323 631 1620 Antisense
TACCCAACCGCGGCAAACGTTATAG 565 647 1648 Antisense
AGGAATTATTTTTGCGCTCTCAGGC 187 55 1671 Antisense
Sequence Source Affymetrix Proprietary Database